Detailed information for compound 45192

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.253 | Formula: C15H23BrNO2-
  • H donors: 2 H acceptors: 2 LogP: 4.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C1Cc2c(C1)c(O)c(cc2)O)CCC.[Br-]
  • InChi: 1S/C15H23NO2.BrH/c1-3-7-16(8-4-2)12-9-11-5-6-14(17)15(18)13(11)10-12;/h5-6,12,17-18H,3-4,7-10H2,1-2H3;1H/p-1
  • InChiKey: GGTZVYWJQYDYPG-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni zinc finger protein 0.0046 0.0217 0.0351
Echinococcus granulosus zinc finger protein 0.0059 0.0327 0.0528
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0101 0.0163
Echinococcus multilocularis zinc finger protein 0.0059 0.0327 0.0528
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0084 0.0541 0.0541
Onchocerca volvulus 0.0125 0.09 0.1432
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0084 0.0541 0.8869
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0197 0.0318
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0009 0.0015
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0172 0.0277
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0541 0.8869
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0028 0.0061 0.0098
Schistosoma mansoni SET domain protein 0.003 0.0086 0.0139
Loa Loa (eye worm) TK/ABL protein kinase 0.0645 0.5357 0.8652
Brugia malayi Pre-SET motif family protein 0.0092 0.061 0.0985
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0474 0.7779
Loa Loa (eye worm) carboxylesterase 0.0125 0.09 0.1454
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0315 0.5158
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1526 0.2464
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.0971 0.1568
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0386 0.0623
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0172 0.0277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0143 0.023
Echinococcus multilocularis tyrosine protein kinase Srms 0.0028 0.0061 0.0098
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.0392 0.2307
Echinococcus multilocularis 0.0131 0.095 0.1535
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0049 0.008
Echinococcus granulosus Chromo domain 0.0034 0.0117 0.0189
Brugia malayi Carboxylesterase family protein 0.0125 0.09 0.1454
Schistosoma mansoni tyrosine kinase 0.0632 0.5243 0.8468
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0354 0.0572
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0289 0.0467
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0084 0.0541 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0143 0.1048 0.1692
Loa Loa (eye worm) TK/EGFR protein kinase 0.0452 0.3704 0.5983
Onchocerca volvulus 0.0126 0.0903 0.1436
Schistosoma mansoni tyrosine kinase 0.0452 0.3704 0.5983
Loa Loa (eye worm) hypothetical protein 0.0054 0.029 0.0468
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0066 0.0392 0.0632
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0056 0.0307 0.1808
Loa Loa (eye worm) hypothetical protein 0.0212 0.164 0.2649
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0172 0.0277
Mycobacterium leprae Probable lipase LipE 0.0036 0.013 0.1667
Leishmania major DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus multilocularis para nitrobenzyl esterase 0.0125 0.09 0.1454
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0262 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0115 0.081 0.1308
Brugia malayi Stress-activated protein kinase jnk-1 0.0229 0.1788 0.2888
Onchocerca volvulus 0.0092 0.0611 0.0938
Brugia malayi Bromodomain containing protein 0.0115 0.0808 0.1305
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0125 0.09 0.1454
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.013 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0341 0.0341
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0098 0.0664 0.1072
Schistosoma mansoni hypothetical protein 0.0037 0.0143 0.023
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0117 0.0189
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0009 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0028 0.0045
Brugia malayi Tyrosine-protein kinase abl-1 0.0276 0.2197 0.3548
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0386 0.0623
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0474 1
Schistosoma mansoni tyrosine kinase 0.004 0.0172 0.0277
Onchocerca volvulus 0.0062 0.0355 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0827 0.1396
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Echinococcus granulosus c src tyrosine kinase 0.004 0.0172 0.0277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0055
Mycobacterium ulcerans oxidoreductase 0.0084 0.0541 0.0541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.0392 0.0632
Echinococcus multilocularis BC026374 protein (S09 family) 0.0125 0.09 0.1454
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Brugia malayi beta-lactamase family protein 0.0036 0.013 0.0211
Echinococcus multilocularis Chromo domain 0.0034 0.0117 0.0189
Schistosoma mansoni DNA polymerase eta 0.0022 0.0009 0.0015
Schistosoma mansoni tyrosine kinase 0.0666 0.5541 0.8949
Brugia malayi RNA, U transporter 1 0.0092 0.061 0.0985
Brugia malayi Protein kinase domain containing protein 0.0028 0.0061 0.0098
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0081 0.0131
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0043 0.0197 0.3227
Trypanosoma cruzi ISWI complex protein 0.0046 0.0217 0.128
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0262 0.0424
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Echinococcus granulosus tyrosine protein kinase Blk 0.0028 0.0061 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0669 0.5561 0.8981
Mycobacterium tuberculosis Carboxylesterase LipT 0.0125 0.09 0.097
Loa Loa (eye worm) beta-lactamase 0.0036 0.013 0.0211
Loa Loa (eye worm) hypothetical protein 0.0143 0.1048 0.1692
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Mycobacterium ulcerans lipase LipD 0.0036 0.013 0.013
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0306 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Schistosoma mansoni hypothetical protein 0.0304 0.243 0.3925
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.013 0.013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.069
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0117 0.0189
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0247 0.0399
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.013 0.0141
Schistosoma mansoni tyrosine kinase 0.0666 0.5541 0.8949
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Schistosoma mansoni hypothetical protein 0.0046 0.0217 0.0351
Brugia malayi hypothetical protein 0.0034 0.0117 0.0189
Schistosoma mansoni chromobox protein 0.0034 0.0117 0.0189
Echinococcus granulosus Chromobox protein 3 0.0034 0.0117 0.0189
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0262 0.2694
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0534 0.0902
Echinococcus granulosus neuroligin 0.0125 0.09 0.1454
Echinococcus granulosus tyrosine kinase 0.0028 0.0061 0.0098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0048 0.0082
Leishmania major GTP-binding protein, putative 0.0024 0.0028 0.0285
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.069 0.1114
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0153
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0262 0.0422
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0009 0.0009
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0316 0.2537 0.4097
Echinococcus granulosus dna polymerase eta 0.0022 0.0009 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0289 0.0467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Loa Loa (eye worm) carboxylesterase 0.0125 0.09 0.1454
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0032 0.0051
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0262 0.0424
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0067 0.0403 0.0651
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0043 0.0197 0.0318
Loa Loa (eye worm) hypothetical protein 0.0293 0.2336 0.3773
Echinococcus granulosus acetylcholinesterase 0.0742 0.6191 1
Leishmania major DNA polymerase eta, putative 0.0022 0.0009 0.0096
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0474 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0009 0.0055
Leishmania major hypothetical protein, conserved 0.0036 0.013 0.1344
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0043 0.0197 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0028 0.0061 0.0098
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0251 0.0405
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0117 0.0189
Echinococcus multilocularis carboxylesterase 5A 0.0742 0.6191 1
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.069
Brugia malayi Protein kinase domain containing protein 0.0028 0.0061 0.0098
Entamoeba histolytica Ran family GTPase 0.0024 0.0028 0.0163
Entamoeba histolytica hypothetical protein 0.0034 0.0117 0.069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.5188 0.8379
Trypanosoma brucei ISWI complex protein 0.0046 0.0217 0.2238
Brugia malayi Protein kinase domain containing protein 0.0343 0.277 0.4475
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0066 0.0392 0.4033
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0474 0.0766
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0032 0.0051
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0247 0.0318
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0117 0.0827 0.1307
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.013 0.0141
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0009 0.0096
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0143 0.023
Loa Loa (eye worm) hypothetical protein 0.0117 0.0827 0.1336
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.022
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0026 0.0049 0.008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0009 0.0015
Onchocerca volvulus 0.0125 0.09 0.1432
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0512
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0179 0.1357 0.2192
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.022
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0306 0.0494
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0043 0.0197 0.3639
Mycobacterium ulcerans beta-lactamase 0.0036 0.013 0.013
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0474 0.7779
Brugia malayi CHD4 protein 0.004 0.0166 0.0269
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0262 0.0424
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0474 0.0766
Schistosoma mansoni gliotactin 0.0125 0.09 0.1454
Echinococcus granulosus epidermal growth factor receptor 0.0374 0.3033 0.4898
Brugia malayi Furin-like cysteine rich region family protein 0.0452 0.3704 0.5983
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0048 0.0793
Echinococcus granulosus para nitrobenzyl esterase 0.0125 0.09 0.1454
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0316 0.2537 0.4097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0054
Schistosoma mansoni chromobox protein 0.0034 0.0117 0.0189
Schistosoma mansoni amine oxidase 0.0084 0.0541 0.0874
Onchocerca volvulus 0.0034 0.0117 0.0097
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0262 0.2694
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Echinococcus granulosus insulin receptor 0.0666 0.5541 0.8949
Echinococcus multilocularis ephrin type A receptor 4 A 0.0091 0.0604 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0262 0.0422
Schistosoma mansoni jumonji domain containing protein 0.0149 0.11 0.1777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.061 0.0985
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0092 0.0611 0.0986
Echinococcus multilocularis epidermal growth factor receptor 0.0452 0.3704 0.5983
Echinococcus granulosus tyrosine protein kinase shark 0.0028 0.0061 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.029 0.0468
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0467 0.0754
Brugia malayi Carboxylesterase family protein 0.0125 0.09 0.1454
Plasmodium vivax hypothetical protein, conserved 0.0036 0.013 0.2139
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0293 0.2336 0.3773
Brugia malayi PHD-finger family protein 0.0075 0.0464 0.0749
Onchocerca volvulus 0.0125 0.09 0.1432
Plasmodium vivax importin-beta 2, putative 0.0032 0.0101 0.165
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.013 0.013
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0117 0.0189
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0563 0.0909
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.09 0.1454
Schistosoma mansoni tyrosine kinase 0.0374 0.3033 0.4898
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0028 0.0061 0.0357
Brugia malayi Carboxylesterase family protein 0.0742 0.6191 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0084 0.0541 0.0874
Brugia malayi mbt repeat family protein 0.0049 0.0247 0.0399
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0117 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0341 0.0341
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0262 0.2694
Echinococcus multilocularis muscleblind protein 0.0293 0.2336 0.3773
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0055
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0049 0.008
Brugia malayi TAR-binding protein 0.0065 0.0386 0.0623
Brugia malayi PHD-finger family protein 0.0024 0.0034 0.0054
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0117 0.2166
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0066 0.0392 0.0661
Brugia malayi Protein kinase domain containing protein 0.0028 0.0061 0.0098
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0117 0.0198
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0117 0.1921
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0066 0.0392 0.0661
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0117 0.2166
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0306 0.0494
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0341 0.0341
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0048 0.0894
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0009 0.001
Brugia malayi RNA binding protein 0.0065 0.0386 0.0623
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0084 0.0541 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0184 0.1399 0.2361
Brugia malayi SH2 domain containing protein 0.0028 0.0061 0.0098
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0172 0.0277
Schistosoma mansoni BC026374 protein (S09 family) 0.0125 0.09 0.1454
Echinococcus multilocularis neuroligin 0.0125 0.09 0.1454
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0251 0.027
Brugia malayi hypothetical protein 0.0084 0.0541 0.0874
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0262 0.0441
Loa Loa (eye worm) hypothetical protein 0.0057 0.0315 0.0508
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0033 0.0104 0.0861
Toxoplasma gondii hypothetical protein 0.0026 0.0048 0.0793
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.0198
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.007 0.0422 0.0681
Echinococcus multilocularis dna polymerase eta 0.0022 0.0009 0.0015
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0009 0.0055
Echinococcus multilocularis tyrosine kinase 0.0028 0.0061 0.0098
Brugia malayi hypothetical protein 0.0125 0.09 0.1454
Brugia malayi PHD-finger family protein 0.0057 0.0315 0.0508
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0101 0.1037
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0101 0.1037
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0126 0.0903 0.1437
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0541 0.3187
Brugia malayi hypothetical protein 0.0028 0.0061 0.0098
Toxoplasma gondii histone lysine-specific demethylase 0.0084 0.0541 0.8869
Echinococcus multilocularis snurportin 1 0.0344 0.2774 0.448
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.0971 0.1568
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0043 0.0197 0.116
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0541 0.8869
Brugia malayi Muscleblind-like protein 0.0293 0.2336 0.3773
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0117 0.1921
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0262 0.1541
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.013 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0534 0.0902
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0341 0.3509
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.013 0.0141
Brugia malayi amine oxidase, flavin-containing family protein 0.0084 0.0541 0.0874
Schistosoma mansoni neuroligin 3 (S09 family) 0.0125 0.09 0.1454
Trichomonas vaginalis hypothetical protein 0.0034 0.0117 0.0198
Trichomonas vaginalis ran, putative 0.0024 0.0028 0.0047
Loa Loa (eye worm) TK/EPH protein kinase 0.0093 0.0623 0.1007
Echinococcus multilocularis Zinc finger, PHD finger 0.0043 0.0197 0.0318
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0306 0.0494
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0418 0.0675
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0474 0.0766
Echinococcus granulosus BC026374 protein S09 family 0.0125 0.09 0.1454
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0541 0.0583
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0247 0.0399
Loa Loa (eye worm) MBCTL1 0.0056 0.0306 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.022
Loa Loa (eye worm) TK/INSR protein kinase 0.0666 0.5541 0.8949
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0315 0.5158
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0025 0.0037 0.006
Toxoplasma gondii ABC1 family protein 0.0036 0.013 0.2139
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0045
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0374 0.3033 0.4898
Loa Loa (eye worm) hypothetical protein 0.0062 0.0355 0.0574
Schistosoma mansoni importin beta-1 0.0032 0.0101 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.1048 0.1692
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0117 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0386 0.0623
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0172 0.0277
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.013 0.0141
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0048 0.0082
Onchocerca volvulus 0.0125 0.09 0.1432
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.0179 0.029
Echinococcus multilocularis acetylcholinesterase 0.0742 0.6191 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0067 0.0403 0.0651
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0467 0.0754
Schistosoma mansoni tyrosine kinase 0.036 0.2911 0.4701
Entamoeba histolytica hypothetical protein 0.0026 0.0048 0.0285
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0262 0.0441
Onchocerca volvulus 0.0084 0.0541 0.0819
Schistosoma mansoni tyrosine kinase 0.036 0.2911 0.4701
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.1697 0.2741
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.143 0.231
Plasmodium falciparum protoporphyrinogen oxidase 0.0084 0.0541 1
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0488 0.0788
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0341 0.0367
Loa Loa (eye worm) hypothetical protein 0.0101 0.069 0.1114
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0125 0.09 0.097
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0306 0.0494
Brugia malayi Carboxylesterase family protein 0.0125 0.09 0.1454
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0125 0.09 0.1519
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Loa Loa (eye worm) hypothetical protein 0.0742 0.6191 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0289 0.0467
Echinococcus granulosus NCK adaptor protein 0.0026 0.0049 0.008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1526 0.2464
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Schistosoma mansoni zinc finger protein 0.0059 0.0327 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Echinococcus multilocularis c src tyrosine kinase 0.004 0.0172 0.0277
Brugia malayi Probable ClpP-like protease 0.0076 0.0474 0.0766
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0028 0.0061 0.0098
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0262 0.4287
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0251 0.4104
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0184 0.1399 0.2361
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0315 0.0508
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0058 0.0093
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0125 0.09 0.1454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.013 0.0211
Schistosoma mansoni hypothetical protein 0.0034 0.0117 0.0189
Schistosoma mansoni tyrosine kinase 0.004 0.0172 0.0277
Echinococcus multilocularis muscleblind protein 1 0.0293 0.2336 0.3773
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0172 0.0277
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0163
Plasmodium vivax SET domain protein, putative 0.0092 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0015
Echinococcus granulosus acetylcholinesterase 0.0742 0.6191 1
Loa Loa (eye worm) hypothetical protein 0.0329 0.2648 0.4277
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.061 1
Echinococcus multilocularis acetylcholinesterase 0.0742 0.6191 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.1697 0.2864
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.013 0.0211
Schistosoma mansoni acetylcholinesterase 0.0125 0.09 0.1454
Echinococcus multilocularis insulin receptor 0.0666 0.5541 0.8949
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.013 0.1344
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0285
Loa Loa (eye worm) acetylcholinesterase 1 0.0742 0.6191 1
Schistosoma mansoni tyrosine kinase 0.004 0.0172 0.0277
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0218 0.1697 0.2864
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0009 0.0016
Brugia malayi Sex muscle abnormal protein 5 0.0026 0.0049 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.09 0.1454
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0049 0.008
Brugia malayi jmjC domain containing protein 0.0187 0.143 0.231
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0009 0.0015
Schistosoma mansoni chromodomain helicase DNA binding protein 0.004 0.0166 0.0269
Echinococcus multilocularis chromobox protein 1 0.0209 0.1613 0.2606
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.007 0.0422 0.0681
Brugia malayi Heterochromatin protein 1 0.0209 0.1613 0.2606
Echinococcus granulosus muscleblind protein 0.0293 0.2336 0.3773
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.0903 0.1458
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0043 0.0197 0.116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0541 0.0583
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.0198
Brugia malayi SH2 domain containing protein 0.0028 0.0061 0.0098
Entamoeba histolytica hypothetical protein 0.0196 0.1503 0.8853
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0043 0.0197 0.0318
Echinococcus granulosus tyrosine kinase 0.0028 0.0061 0.0098
Echinococcus granulosus carboxylesterase 5A 0.0742 0.6191 1
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0827 0.1396
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.013 0.0211
Schistosoma mansoni hypothetical protein 0.0057 0.0315 0.0508
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.013 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0837 0.1351
Mycobacterium ulcerans hypothetical protein 0.0036 0.013 0.013
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0043 0.0197 0.0318
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0117 0.1921
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0108 0.0747 0.1207
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0386 0.0623
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0971 0.5719
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0049 0.008
Loa Loa (eye worm) hypothetical protein 0.0117 0.0832 0.1343
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0141
Echinococcus granulosus epidermal growth factor receptor 0.0452 0.3704 0.5983
Brugia malayi jmjC domain containing protein 0.0075 0.0467 0.0754
Brugia malayi SWIRM domain containing protein 0.0084 0.0541 0.0874
Echinococcus granulosus tyrosine protein kinase ABL1 0.0645 0.5357 0.8652
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0474 0.8771
Brugia malayi mbt repeat family protein 0.0049 0.0247 0.0399
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.013 0.0211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0108 0.0747 0.1207
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.09 0.1454
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0048 0.1019
Brugia malayi Bromodomain containing protein 0.0224 0.175 0.2827
Leishmania major hypothetical protein, conserved 0.0046 0.0217 0.2238
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0262 0.0422
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0101 0.165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.1048 0.1692
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.004 0.0172 0.0277
Echinococcus multilocularis peregrin 0.0083 0.0541 0.0873
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.029 0.0468
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0172 0.0277
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.013 0.0141
Brugia malayi Pre-SET motif family protein 0.0625 0.5188 0.8379
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0143 0.1048 0.1692
Brugia malayi protein-tyrosine kinase 0.0028 0.0061 0.0098
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0971 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0049 0.008
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0386 0.0623
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0043 0.0197 0.0318
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.0971 0.1568
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1186 1 1
Leishmania major UDP-galactopyranose mutase 0.0084 0.0541 0.5573
Echinococcus granulosus peregrin 0.0083 0.0541 0.0873
Plasmodium falciparum phd finger protein, putative 0.0057 0.0315 0.5815
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0117 0.0189
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0315 0.0508
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0495 0.2918
Entamoeba histolytica hypothetical protein 0.0034 0.0117 0.069
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0386 0.0623
Loa Loa (eye worm) hypothetical protein 0.0098 0.0665 0.1074
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0341 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0488 0.0788
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0386 0.0623
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0125 0.09 0.097
Leishmania major importin beta-1 subunit, putative 0.0026 0.0048 0.0499
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0541 0.0874
Loa Loa (eye worm) RNA binding protein 0.0065 0.0386 0.0623
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Echinococcus granulosus snurportin 1 0.0344 0.2774 0.448
Echinococcus multilocularis tyrosine protein kinase Blk 0.0028 0.0061 0.0098
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Schistosoma mansoni SET domain protein 0.007 0.0422 0.0681
Loa Loa (eye worm) hypothetical protein 0.0742 0.6191 1
Schistosoma mansoni tyrosine kinase 0.004 0.0172 0.0277
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0172 0.0277
Echinococcus granulosus fetal alzheimer antigen falz 0.0067 0.0403 0.0651
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0208 0.1613 0.9501
Leishmania major phosphatidylinositol 3-kinase, putative 0.0043 0.0197 0.2028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.013 0.0211
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0262 0.1541
Onchocerca volvulus 0.0125 0.09 0.1432
Schistosoma mansoni adapter molecule crk 0.0026 0.0049 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Onchocerca volvulus 0.0036 0.013 0.0119
Loa Loa (eye worm) carboxylesterase 0.0742 0.6191 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.143 0.231
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0541 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0117 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.013 0.0211
Mycobacterium ulcerans monoamine oxidase 0.0084 0.0541 0.0541
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.2774 0.448
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.0971 0.1568
Loa Loa (eye worm) hypothetical protein 0.0076 0.0474 0.0766
Echinococcus granulosus dna polymerase kappa 0.0022 0.0009 0.0015
Onchocerca volvulus 0.0054 0.0289 0.0389
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0048 0.0082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0009 0.001
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0645 0.5357 0.8652
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0541 0.3187
Trypanosoma cruzi ISWI complex protein 0.0046 0.0217 0.128
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0098
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0218 0.1697 0.2864
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.0198
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0101 0.069 0.1114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.0198
Loa Loa (eye worm) hypothetical protein 0.0056 0.0306 0.0494
Echinococcus multilocularis tyrosine protein kinase shark 0.0028 0.0061 0.0098
Schistosoma mansoni chromobox protein 0.0209 0.1613 0.2606
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0117 0.0189
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0197 0.3227
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.004 0.0166 0.0269
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0341 0.055
Schistosoma mansoni chromobox protein 0.0209 0.1613 0.2606
Brugia malayi Protein kinase domain containing protein 0.0028 0.0061 0.0098
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0541 0.8869
Schistosoma mansoni amine oxidase 0.0084 0.0541 0.0874
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0163
Echinococcus granulosus chromobox protein 1 0.0209 0.1613 0.2606
Schistosoma mansoni ephrin receptor 0.0076 0.0478 0.0771
Loa Loa (eye worm) hypothetical protein 0.025 0.1972 0.3185
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0262 0.1541
Schistosoma mansoni tyrosine kinase 0.036 0.2911 0.4701
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0467 0.0754
Schistosoma mansoni bromodomain containing protein 0.0189 0.1449 0.2341
Brugia malayi Importin beta-1 subunit 0.0032 0.0101 0.0163
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0474 0.7779
Loa Loa (eye worm) CHromoDomain protein family member 0.004 0.0166 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0061 0.0098
Loa Loa (eye worm) TK protein kinase 0.0028 0.0061 0.0098
Trichomonas vaginalis chromobox protein, putative 0.0126 0.0903 0.1524
Giardia lamblia PHD finger protein 15 0.0057 0.0315 0.2613
Brugia malayi MAP kinase sur-1 0.0051 0.0262 0.0422
Onchocerca volvulus Alhambra homolog 0.0057 0.0315 0.0433
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0043 0.0197 0.0332
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.0392 0.2307
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.013 0.0769
Echinococcus multilocularis tyrosine protein kinase Abl 0.0276 0.2197 0.3548
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0315 0.0508
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.1697 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0028 0.0045
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0117 0.2166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0247 0.0399
Trichomonas vaginalis chromobox protein, putative 0.0209 0.1613 0.2723
Trichomonas vaginalis spcc417.12 protein, putative 0.0125 0.09 0.1519
Mycobacterium ulcerans dehydrogenase 0.0084 0.0541 0.0541
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0043 0.0197 0.0318
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0084 0.0541 0.8869
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.013 0.022
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0386 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.013 0.0769
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0196 0.1503 0.8853
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0341 0.5584
Loa Loa (eye worm) bromodomain containing protein 0.0053 0.0278 0.0449
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Echinococcus granulosus growth factor receptor bound protein 2 0.0026 0.0049 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0474 0.0474
Loa Loa (eye worm) heterochromatin protein 1 0.0209 0.1613 0.2606
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0197 0.2028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0032 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0315 0.5158
Chlamydia trachomatis protoporphyrinogen oxidase 0.0084 0.0541 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0262 0.0424
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0009 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0474 0.865
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0467 0.0754
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0009 0.0015
Mycobacterium ulcerans carboxylesterase, LipT 0.0125 0.09 0.09
Echinococcus multilocularis growth factor receptor bound protein 2 0.0026 0.0049 0.008
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.004 0.0166 0.0269
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0084 0.0541 0.0874
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0742 0.6191 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0669 0.5561 0.8981
Echinococcus multilocularis chromobox protein 2 0.0034 0.0117 0.0189
Brugia malayi SRC-1 0.004 0.0172 0.0277
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0289 0.0467
Brugia malayi Protein kinase domain containing protein 0.0028 0.0061 0.0098
Brugia malayi SET domain containing protein 0.004 0.0164 0.0266
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0161 0.1204 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0048 0.0285
Trichomonas vaginalis esterase, putative 0.0036 0.013 0.022
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0229 0.1788 0.2888
Echinococcus granulosus tyrosine protein kinase Srms 0.0028 0.0061 0.0098
Echinococcus granulosus jumonji domain containing protein 0.008 0.0507 0.0818
Loa Loa (eye worm) hypothetical protein 0.0125 0.09 0.1454
Echinococcus multilocularis epidermal growth factor receptor 0.0374 0.3033 0.4898
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0197 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Loa Loa (eye worm) hypothetical protein 0.0122 0.087 0.1406
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0009 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0711 0.5926 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.008
Onchocerca volvulus 0.0036 0.013 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0262 0.0441
Trypanosoma brucei unspecified product 0.0022 0.0009 0.0096
Schistosoma mansoni hypothetical protein 0.0062 0.0354 0.0572
Echinococcus granulosus chromobox protein 1 0.0209 0.1613 0.2606
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.178 0.1917
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0306 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0211
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0251 0.0405
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0507 0.0818
Loa Loa (eye worm) phosphatidylinositol 3 0.0293 0.2342 0.3783
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.0198
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0025 0.0037 0.006
Echinococcus multilocularis protoporphyrinogen oxidase 0.0084 0.0541 0.0874
Loa Loa (eye worm) helicase 0.0034 0.0117 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0117 0.0198
Brugia malayi Carboxylesterase family protein 0.0125 0.09 0.1454
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.0971 0.5719
Echinococcus granulosus ephrin type A receptor 4 A 0.0091 0.0604 0.0976
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0315 0.0508
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0061 0.0098
Mycobacterium leprae conserved hypothetical protein 0.0036 0.013 0.1667
Brugia malayi beta-lactamase 0.0036 0.013 0.0211
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0101 0.069 0.1114
Schistosoma mansoni tyrosine kinase 0.0374 0.3033 0.4898
Echinococcus granulosus importin subunit beta 1 0.0032 0.0101 0.0163
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0541 0.0874
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0341 0.055
Brugia malayi Tyrosine-protein kinase abl-1 0.0381 0.3096 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0262 0.2172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.029 0.0468
Brugia malayi beta-lactamase family protein 0.0036 0.013 0.0211
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.0971 0.1568
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0117 0.069
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0009 0.0015
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0247 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0307 0.0496
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1102 0.9283 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0141
Echinococcus multilocularis chromobox protein 1 0.0209 0.1613 0.2606
Echinococcus multilocularis 0.0084 0.0541 0.0874
Brugia malayi ephrin receptor 1 precursor 0.0043 0.0197 0.0318
Schistosoma mansoni tyrosine kinase 0.0028 0.0061 0.0098
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0117 0.0189
Entamoeba histolytica hypothetical protein 0.0034 0.0117 0.069
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0262 0.0422
Onchocerca volvulus 0.0036 0.013 0.0119
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.004 0.0172 0.0277
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0009 0.0015
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0172 0.0277
Onchocerca volvulus 0.0711 0.5926 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0262 0.0422
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0218 0.1697 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0262 0.0441
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0026 0.0049 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1788 0.2888
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0251 0.027
Schistosoma mansoni hypothetical protein 0.0344 0.2774 0.448
Schistosoma mansoni nck2/grb4 0.0026 0.0049 0.008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0189
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0028 0.0454
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0197 0.116
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0117 0.1921
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0197 0.116
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0341 0.055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0163
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0117 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0117 0.0198
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0197 0.0332
Echinococcus granulosus chromobox protein 2 0.0034 0.0117 0.0189
Trypanosoma brucei protein kinase, putative 0.0051 0.0262 0.2694
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.0096
Echinococcus granulosus c-Jun N-terminal kinases 0.0229 0.1788 0.2888
Brugia malayi Bromodomain containing protein 0.0064 0.0375 0.0606
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0197 0.3227
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0117 0.0189
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0009 0.0096
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0971 0.5719
Brugia malayi Protein kinase domain containing protein 0.0666 0.5541 0.8949
Schistosoma mansoni ran 0.0024 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0197 0.2028
Brugia malayi Carboxylesterase family protein 0.0742 0.6191 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0117 0.0198
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0262 0.1541
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0229 0.1788 0.2888
Onchocerca volvulus 0.0034 0.0117 0.0097
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0247 0.0399
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0386 0.0623
Echinococcus granulosus tyrosine protein kinase Btk29A 0.004 0.0172 0.0277
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0009 0.0016
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0028 0.0454
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0066 0.0392 0.2307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.061 0.0985
Giardia lamblia DINP protein human, muc B family 0.0022 0.0009 0.0077
Echinococcus multilocularis NCK adaptor protein 0.0026 0.0049 0.008
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0172 0.0277
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.0971 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0209 0.1613 0.2723
Schistosoma mansoni ran 0.0024 0.0028 0.0045
Loa Loa (eye worm) SRC-1 0.004 0.0172 0.0277
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.0392 0.0661
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0117 0.1921
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0179 0.1357 0.2192
Loa Loa (eye worm) hypothetical protein 0.0084 0.0541 0.0874
Schistosoma mansoni tyrosine kinase 0.0028 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0128 0.0919 0.1485
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0084 0.0541 0.0874
Plasmodium falciparum importin beta, putative 0.0032 0.0101 0.186
Brugia malayi chromobox protein homolog 3 0.0117 0.0827 0.1336
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0316 0.2537 0.4097
Schistosoma mansoni phd finger protein 0.0026 0.005 0.0081
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0172 0.0277
Echinococcus granulosus tar DNA binding protein 0.0065 0.0386 0.0623
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0218 0.1697 1
Brugia malayi Protein cec-1. 0.0034 0.0117 0.0189
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0117 0.1921
Trichomonas vaginalis chromobox protein, putative 0.0126 0.0903 0.1524

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10000 nM Inhibitory binding activity against dopamine receptor using [3H]-ADTN as the radioligand in striatal tissue of calf brain. ChEMBL. 7154005
IC50 (binding) = 53860 nM Inhibitory binding activity against dopamine receptor using [3H]-spiperone as the radioligand in striatal tissue of calf brain. ChEMBL. 7154005
ID50 (functional) = 0.02 uM kg-1 The compound was evaluated for its ability to inhibit the positive chronotropic effect of the cardioaccelerator ChEMBL. 7154005
Potency ratio (functional) = 1.24 The compound was tested for its emetic activity in dog, activity expressed as potency ratio. ChEMBL. 7154005

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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