Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | sex peptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 1 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | somatostatin receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | somatostatin receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g-protein coupled receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 1 | 1 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 1 | 1 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | fmrfamide receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0013 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 1 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | orexin receptor type 2 | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | opsin-like receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 1 | 1 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | fmrfamide receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | allatostatin A receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD100 (functional) | > 100 uM | Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs | ChEMBL. | 17950610 |
CD100 (functional) | > 100 uM | Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs | ChEMBL. | 17950610 |
IC50 (functional) | = 84.3 uM | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay | ChEMBL. | 17158054 |
IC50 (functional) | > 100 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.