Detailed information for compound 452255

Basic information

Technical information
  • TDR Targets ID: 452255
  • Name: 2-(2,6-dichlorophenyl)acetic acid
  • MW: 205.038 | Formula: C8H6Cl2O2
  • H donors: 1 H acceptors: 2 LogP: 2.64 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1c(Cl)cccc1Cl
  • InChi: 1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)
  • InChiKey: SFAILOOQFZNOAU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2,6-dichlorophenyl)ethanoic acid
  • EINECS 229-504-0
  • 2CL
  • InChI=1/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12
  • 259241_ALDRICH
  • SBB003503
  • 2,6-Dichlorophenylacetic acid
  • Benzeneacetic acid, 2,6-dichloro-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Brugia malayi Dopamine receptor protein 2 0.0037 0.9256 0.871
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus granulosus aldo keto reductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.4234 0.4234
Loa Loa (eye worm) oxidoreductase 0.0038 1 1
Echinococcus granulosus aldo keto reductase 0.0038 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 1 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Leishmania major prostaglandin f synthase, putative 0.0038 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.9256 0.9256
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis g protein coupled receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.9256 0.8747
Leishmania major aldo-keto reductase-like protein 0.0038 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.9256 0.9256
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Toxoplasma gondii aldose reductase, putative 0.0038 1 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Brugia malayi neuropeptide F receptor 0.0037 0.9256 0.871
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Onchocerca volvulus 0.0038 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.9256 0.8747
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Schistosoma mansoni pol-related 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Echinococcus granulosus neuropeptide receptor 0.0037 0.9256 0.8747
Giardia lamblia Aldose reductase 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Schistosoma mansoni aldo-keto reductase 0.0038 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.9256 0.9256
Echinococcus granulosus g protein coupled receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) oxidoreductase 0.0038 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Echinococcus granulosus hypothetical protein 0.0038 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.9256 0.8747
Brugia malayi Serotonin receptor 0.0037 0.9256 0.871
Onchocerca volvulus 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptide receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.9256 0.8747
Echinococcus granulosus g protein coupled receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.9256 0.871
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus granulosus allatostatin A receptor 0.0037 0.9256 0.8747
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.9256 0.871
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Brugia malayi Dopamine receptor protein 1 0.0037 0.9256 0.871
Brugia malayi sulfakinin receptor protein 0.0037 0.9256 0.871
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.9256 0.8747
Brugia malayi Dopamine receptor 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Onchocerca volvulus 0.0038 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 1 1
Echinococcus granulosus somatostatin receptor 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.9256 0.9256
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.9256 0.8747
Brugia malayi RE15519p 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase 0.0038 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 1 0.5
Echinococcus multilocularis allatostatin A receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.9256 0.8747
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Brugia malayi GnHR receptor homolog 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 1 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.9256 0.871
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Schistosoma mansoni aldo-keto reductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0038 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Echinococcus granulosus g protein coupled receptor 0.0037 0.9256 0.8747
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.9256 0.8747
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis fmrfamide receptor 0.0037 0.9256 0.8747
Brugia malayi follicle stimulating hormone receptor 0.0037 0.9256 0.871
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.9256 0.8747
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.0037 0.9256 0.8747
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.9256 0.8747
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.9256 0.8747
Entamoeba histolytica aldose reductase, putative 0.0038 1 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.9256 0.8747
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.4234 0.4234
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.9256 0.871
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 1 1
Echinococcus granulosus fmrfamide receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.9256 0.8747
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.9256 0.8747
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Entamoeba histolytica aldose reductase, putative 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.9256 0.8747
Brugia malayi Serotonin receptor 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 1 0.5
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.9256 0.8747
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Onchocerca volvulus 0.0038 1 1
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Brugia malayi Melatonin receptor type 1A 0.0037 0.9256 0.871
Brugia malayi AKH receptor 0.0037 0.9256 0.871
Echinococcus multilocularis somatostatin receptor 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Brugia malayi ORL1-like opioid receptor 0.0037 0.9256 0.871
Echinococcus multilocularis orexin receptor type 2 0.0037 0.9256 0.8747
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.9256 0.8747
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.9256 0.8747
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Giardia lamblia Aldose reductase 0.0038 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.9256 0.9256
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase 0.0038 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.9256 0.8747
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.9256 0.8747
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.9256 0.8747
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.9256 0.8747
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.9256 0.8747
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.9256 0.8747
Brugia malayi G-protein coupled receptor 0.0037 0.9256 0.871
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis aldo keto reductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis fmrfamide receptor 0.0037 0.9256 0.8747
Echinococcus granulosus neuropeptide s receptor 0.0037 0.9256 0.8747
Echinococcus granulosus neuropeptide receptor 0.0037 0.9256 0.8747
Echinococcus granulosus g-protein coupled receptor 0.0037 0.9256 0.8747
Brugia malayi G-protein coupled receptor 0.0037 0.9256 0.871
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.9256 0.8747
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.9256 0.9256
Brugia malayi putative neuropeptide receptor 0.0037 0.9256 0.871
Brugia malayi G protein-coupled receptor 0.0037 0.9256 0.871
Loa Loa (eye worm) oxidoreductase 0.0038 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.9256 0.8747
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.9256 0.8747
Brugia malayi hypothetical protein 0.0037 0.9256 0.871
Echinococcus granulosus orexin receptor type 2 0.0037 0.9256 0.8747
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Echinococcus multilocularis aldo keto reductase 0.0038 1 1
Trypanosoma cruzi aldo-keto reductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.9256 0.8747
Onchocerca volvulus 0.0038 1 1
Onchocerca volvulus 0.0038 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 1 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.9256 0.8747
Mycobacterium ulcerans oxidoreductase 0.0038 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trypanosoma brucei prostaglandin f synthase 0.0038 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptide receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.9256 0.8747
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.9256 0.9256
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.9256 0.8747
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.9256 0.871
Trypanosoma brucei aldo-keto reductase, putative 0.0038 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.9256 0.871
Echinococcus granulosus serotonin receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) CYP4Cod1 0.0027 0.4234 0.4234
Echinococcus granulosus hypothetical protein 0.0037 0.9256 0.8747
Echinococcus multilocularis serotonin receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 1 0.5
Echinococcus multilocularis sex peptide receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Loa Loa (eye worm) oxidoreductase 0.0038 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.9256 0.8747
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) oxidoreductase 0.0038 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 1 1
Brugia malayi neuropeptide F receptor 0.0037 0.9256 0.871
Echinococcus multilocularis serotonin receptor 0.0037 0.9256 0.8747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 1 1
Echinococcus multilocularis g protein coupled receptor 0.0037 0.9256 0.8747
Brugia malayi larval opioid receptor 0.0037 0.9256 0.871
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 1 0.5
Echinococcus granulosus sex peptide receptor 0.0037 0.9256 0.8747
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.9256 0.9256
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.9256 0.8747
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.9256 0.9256
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 1 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.9256 0.8747
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.9256 0.8747
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.9256 0.8747

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.4 uM Inhibition of aldose reductase ChEMBL. 17870536
IC50 (binding) = 4.4 uM Inhibition of aldose reductase ChEMBL. 17870536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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