Detailed information for compound 452396

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 870.258 | Formula: C52H55NO3S4
  • H donors: 1 H acceptors: 3 LogP: 14.78 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1C[C@@H](/C=C/c2cnc3c(c2Sc2ccc(cc2)C(C)C)cc(c(c3Sc2ccc(cc2)C(C)C)Sc2ccc(cc2)C(C)C)Sc2ccc(cc2)C(C)C)OC(=O)C1
  • InChi: 1S/C52H55NO3S4/c1-31(2)35-10-19-42(20-11-35)57-47-29-46-49(52(60-45-25-16-38(17-26-45)34(7)8)51(47)59-44-23-14-37(15-24-44)33(5)6)53-30-39(9-18-41-27-40(54)28-48(55)56-41)50(46)58-43-21-12-36(13-22-43)32(3)4/h9-26,29-34,40-41,54H,27-28H2,1-8H3/b18-9+/t40-,41-/m1/s1
  • InChiKey: KHMQQEBCBKBVEB-ILMYPJIJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus HMG-CoA reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus CoRest homolog 0.0175 0.0951 0.7286
Echinococcus granulosus expressed protein 0.0361 0.2128 0.2128
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus survival motor neuron protein 1 0.0162 0.0869 0.0869
Schistosoma mansoni site-1 peptidase (S08 family) 0.0045 0.0129 0.0129
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0069 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus hypothetical protein 0.0125 0.0636 0.0636
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.0636 0.0988
Echinococcus granulosus cyclin b3 0.0127 0.065 0.065
Echinococcus multilocularis integrin alpha ps 0.0066 0.0266 0.0266
Schistosoma mansoni amine oxidase 0.0028 0.0023 0.0023
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0202 0.1123 0.2836
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Entamoeba histolytica cyclin family protein 0.0127 0.065 0.4879
Schistosoma mansoni patched 1 0.0097 0.0459 0.0459
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0122 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Brugia malayi Integrin beta pat-3 precursor 0.0959 0.5898 0.916
Brugia malayi proprotein convertase 2 0.0656 0.399 0.6196
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0136 0.0709 0.0709
Trypanosoma cruzi cyclin, putative 0.0228 0.129 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0033 0.0056 0.0056
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) proprotein convertase 2 0.0247 0.1404 0.2181
Loa Loa (eye worm) hypothetical protein 0.0228 0.129 0.2003
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.0891 0.8596
Loa Loa (eye worm) subtilase 0.0045 0.0129 0.0201
Echinococcus granulosus cyclins 0.0127 0.065 0.065
Entamoeba histolytica cyclin, putative 0.0127 0.065 0.4879
Onchocerca volvulus 0.0125 0.0636 0.4767
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis protein patched 0.0097 0.0459 0.0459
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0122 0.0212
Echinococcus granulosus neuropeptide receptor A26 0.044 0.2624 0.2624
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0122 0.0122
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0125 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Loa Loa (eye worm) integrin beta-2 0.0959 0.5898 0.916
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.0636 0.0636
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Echinococcus multilocularis allatostatin A receptor 0.0125 0.0636 0.0636
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0045 0.0129 0.1051
Leishmania major mitotic cyclin, putative 0.0031 0.0041 0.0143
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis cyclin t1 0.0031 0.0041 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.0636 0.0636
Echinococcus granulosus integrin alpha ps 0.0066 0.0266 0.0266
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0459 0.1097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0066 0.0102
Schistosoma mansoni integrin alpha 0.0148 0.0782 0.0782
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus dro:myosuppressin receptor 0.0125 0.0636 0.0636
Brugia malayi G-protein coupled receptor 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0139 0.0723 0.1123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0041 0.1703
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0891 0.6848
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.0276 0.1879
Echinococcus granulosus neuropeptide FF receptor 2 0.0565 0.3416 0.3416
Brugia malayi ORL1-like opioid receptor 0.0125 0.0636 0.0988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0045 0.0129 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Toxoplasma gondii hypothetical protein 0.0031 0.0041 0.0179
Brugia malayi Dopamine receptor protein 1 0.0125 0.0636 0.0988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis dnaJ subfamily B 0.1608 1 1
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0337 0.0775
Trichomonas vaginalis cyclin B, putative 0.0228 0.129 0.3275
Echinococcus granulosus cyclin B3 1 0.0127 0.065 0.065
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0069 0.0363
Schistosoma mansoni alpha-1 adrenergic receptor 0.0125 0.0636 0.0636
Giardia lamblia G2/mitotic-specific cyclin B 0.0228 0.129 0.5535
Echinococcus granulosus sex peptide receptor 0.0125 0.0636 0.0636
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0123 0.0789
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0122 0.0648
Toxoplasma gondii subtilisin SUB2 0.0045 0.0129 0.1051
Echinococcus multilocularis integrin alpha ps 0.0032 0.0048 0.0048
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi neuropeptide F receptor 0.0125 0.0636 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Echinococcus granulosus neuropeptide receptor 0.043 0.2561 0.2561
Schistosoma mansoni histamine h1 receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0125 0.0636 0.0988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.0636 0.0636
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0122 0.0648
Echinococcus granulosus Niemann Pick C1 protein 0.0067 0.0273 0.0273
Echinococcus multilocularis Niemann Pick C1 protein 0.0067 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0162 0.0869 0.135
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0202 0.1123 0.2836
Brugia malayi hypothetical protein 0.0028 0.0023 0.0036
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0891 0.6802
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0125 0.0636 0.0988
Schistosoma mansoni cyclin l 0.0031 0.0041 0.0041
Schistosoma mansoni cyclin d 0.0031 0.0041 0.0041
Brugia malayi Serotonin receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Brugia malayi Dopamine receptor 0.0125 0.0636 0.0988
Schistosoma mansoni neuropeptide receptor 0.0125 0.0636 0.0636
Onchocerca volvulus 0.0125 0.0636 0.4767
Toxoplasma gondii subtilisin SUB11 0.0045 0.0129 0.1051
Plasmodium falciparum subtilisin-like protease 1 0.0045 0.0129 0.1691
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis sex peptide receptor 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0129 0.0231
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0045 0.0129 0.0129
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0069 0.0223
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0045 0.0129 0.1051
Toxoplasma gondii subtilisin SUB5 0.0045 0.0129 0.1051
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0031 0.0041 0.0064
Echinococcus multilocularis cyclin k 0.0031 0.0041 0.0041
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0136 0.0136
Plasmodium vivax subtilisin-like protease 2, putative 0.0045 0.0129 1
Schistosoma mansoni opsin-like receptor 0.0125 0.0636 0.0636
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Leishmania major cathepsin L-like protease 0.0044 0.0123 0.0789
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0129 0.0231
Echinococcus multilocularis endothelin converting enzyme 1 0.0188 0.1032 0.1032
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.0885 0.0885
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0247 0.1404 0.1404
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0125 0.0636 0.0988
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0101 0.0487 0.0756
Brugia malayi neuroendocrine convertase 1 precursor 0.0656 0.399 0.6196
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0068 0.0276 0.1879
Loa Loa (eye worm) hypothetical protein 0.017 0.092 0.1428
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0635 0.3854 1
Echinococcus granulosus fmrfamide receptor 0.0125 0.0636 0.0636
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0125 0.0636 0.0636
Echinococcus granulosus cyclins 0.0127 0.065 0.065
Echinococcus multilocularis neuroendocrine convertase 2 0.0656 0.399 0.399
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.0636 0.0636
Plasmodium vivax subtilisin-like protease 1 0.0045 0.0129 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0125 0.0636 0.0636
Onchocerca volvulus 0.0035 0.0069 0.0223
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.0636 0.0636
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0069 0.0363
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0036
Brugia malayi Protein kinase domain containing protein 0.0044 0.0122 0.019
Trichomonas vaginalis cyclins, putative 0.0228 0.129 0.3275
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0125 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.1608 1 1
Trichomonas vaginalis cyclins, putative 0.0228 0.129 0.3275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.0276 0.1879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0125 0.0636 0.0988
Echinococcus granulosus sterol regulatory element binding protein 0.0097 0.0459 0.0459
Schistosoma mansoni hypothetical protein 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Trichomonas vaginalis cyclin B3, putative 0.0127 0.065 0.1598
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0125 0.0636 0.0636
Brugia malayi Niemann-Pick C1 protein precursor 0.0067 0.0273 0.0424
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.0636 0.0636
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0139 0.0723 0.1123
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0122 0.0122
Onchocerca volvulus 0.0125 0.0636 0.4767
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0122 0.098
Schistosoma mansoni Cyclin fold protein 0.0031 0.0041 0.0041
Echinococcus granulosus cyclin y 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0084 0.0379 0.0588
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis neuropeptide s receptor 0.044 0.2624 0.2624
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Brugia malayi hypothetical protein 0.0031 0.0041 0.0064
Loa Loa (eye worm) hypothetical protein 0.0228 0.129 0.2003
Loa Loa (eye worm) CYL-1 protein 0.0031 0.0041 0.0064
Schistosoma mansoni amine GPCR 0.0125 0.0636 0.0636
Echinococcus granulosus lysine specific histone demethylase 1A 0.0137 0.0712 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Plasmodium falciparum protein kinase 5 0.0044 0.0122 0.1577
Plasmodium falciparum subtilisin-like protease 3 0.0045 0.0129 0.1691
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Trypanosoma brucei mitotic cyclin 6 0.0228 0.129 1
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0031 0.0041 0.0041
Schistosoma mansoni furin-1 (S08 family) 0.0454 0.2715 0.2715
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0122 0.0781
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis expressed conserved protein 0.0063 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0031 0.0041 0.0041
Brugia malayi peptidase family M13 containing protein 0.0046 0.0136 0.0211
Onchocerca volvulus 0.0125 0.0636 0.4767
Brugia malayi Subtilase family protein 0.0045 0.0129 0.0201
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0056 0.0087
Echinococcus granulosus neuroendocrine convertase 2 0.0656 0.399 0.399
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Chlamydia trachomatis protoporphyrinogen oxidase 0.0028 0.0023 0.5
Toxoplasma gondii subtilisin SUB7 0.0045 0.0129 0.1051
Echinococcus granulosus aminopeptidase N 0.0119 0.06 0.06
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0044 0.0123 0.0789
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0125 0.0636 0.0988
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0125 0.0636 0.0988
Trypanosoma brucei RNA helicase, putative 0.0103 0.0495 0.3635
Echinococcus multilocularis cyclin B 0.0228 0.129 0.129
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0891 0.0891
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0565 0.3416 0.5305
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0069 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Brugia malayi Tachykinin-like peptides receptor 99D 0.0565 0.3416 0.5305
Schistosoma mansoni biogenic amine receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.026 0.026
Onchocerca volvulus 0.0228 0.129 1
Schistosoma mansoni adenoreceptor 0.0125 0.0636 0.0636
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0125 0.0636 0.0636
Brugia malayi Peptidase family M13 containing protein 0.0188 0.1032 0.1603
Schistosoma mansoni cyclin B 0.0228 0.129 0.129
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.0636 0.0636
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.0891 0.1383
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.0636 0.0636
Brugia malayi AKH receptor 0.0125 0.0636 0.0988
Brugia malayi cell division control protein 2 homolog 0.0044 0.0122 0.019
Trypanosoma cruzi mitotic cyclin, putative 0.0031 0.0041 0.0143
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0123 0.0789
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.011
Schistosoma mansoni neuropeptide receptor 0.043 0.2561 0.2561
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0125 0.0636 0.0636
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0041 0.0288
Brugia malayi jmjC domain containing protein 0.0065 0.026 0.0404
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1044 0.6439 0.6439
Brugia malayi endoprotease bli-4 precursor 0.1044 0.6439 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0112 0.0554 0.0861
Loa Loa (eye worm) hypothetical protein 0.0068 0.0276 0.0428
Echinococcus granulosus cyclin t1 0.0031 0.0041 0.0041
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0782 0.1214
Plasmodium falciparum subtilisin-like protease 2 0.0045 0.0129 0.1691
Loa Loa (eye worm) zinc metallopeptidase 4 0.0046 0.0136 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus g protein coupled receptor 0.0125 0.0636 0.0636
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0069 0.0223
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0136 0.0136
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Trypanosoma cruzi CYC2-like cyclin, putative 0.0228 0.129 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0139 0.0723 0.1123
Trichomonas vaginalis cyclin B, putative 0.0228 0.129 0.3275
Loa Loa (eye worm) hypothetical protein 0.0107 0.0523 0.0812
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0045 0.0129 0.0837
Entamoeba histolytica cyclin family protein 0.0127 0.065 0.4879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0122 0.019
Loa Loa (eye worm) peptidase family M13 containing protein 0.0139 0.0723 0.1123
Echinococcus multilocularis integrin beta 2 0.0707 0.4311 0.4311
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0049 0.0157 0.0157
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0045 0.0129 0.1051
Plasmodium vivax cyclin homologue, putative 0.0031 0.0041 0.1703
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Toxoplasma gondii subtilisin SUB10 0.0045 0.0129 0.1051
Onchocerca volvulus 0.0093 0.0434 0.3149
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0045 0.0129 0.1051
Echinococcus granulosus integrin alpha ps 0.0032 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis aminopeptidase N 0.0119 0.06 0.06
Echinococcus granulosus furin 0.1044 0.6439 0.6439
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0045 0.0129 0.0201
Schistosoma mansoni hypothetical protein 0.0116 0.058 0.058
Schistosoma mansoni neuropeptide f receptor 76f 0.0125 0.0636 0.0636
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Brugia malayi amine oxidase, flavin-containing family protein 0.0039 0.0096 0.015
Onchocerca volvulus 0.0125 0.0636 0.4767
Schistosoma mansoni site-1 peptidase (S08 family) 0.0045 0.0129 0.0129
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0188 0.1032 0.1032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Toxoplasma gondii cyclin 4, putative 0.0031 0.0041 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0127 0.065 0.065
Echinococcus granulosus cyclin k 0.0031 0.0041 0.0041
Loa Loa (eye worm) melatonin receptor type 1A 0.0125 0.0636 0.0988
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0891 0.0891
Schistosoma mansoni hypothetical protein 0.0032 0.0048 0.0048
Brugia malayi SWIRM domain containing protein 0.0149 0.0785 0.1219
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0031 0.0041 0.0288
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0122 0.0358
Schistosoma mansoni g1/s-specific cyclin C 0.0031 0.0041 0.0041
Echinococcus multilocularis G-protein coupled receptor, putative 0.0125 0.0636 0.0636
Toxoplasma gondii subtilisin SUB1 0.0045 0.0129 0.1051
Onchocerca volvulus 0.0125 0.0636 0.4767
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0125 0.0636 0.0636
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0122 0.0648
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0045 0.0129 0.1051
Schistosoma mansoni cyclin G2 0.0031 0.0041 0.0041
Trichomonas vaginalis cyclin D, putative 0.0127 0.065 0.1598
Echinococcus multilocularis cyclin B3 1 0.0127 0.065 0.065
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0069 0.0107
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0137 0.0712 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Brugia malayi Peptidase family M1 containing protein 0.0119 0.06 0.0933
Brugia malayi Cyclin, N-terminal domain containing protein 0.0127 0.065 0.101
Loa Loa (eye worm) hypothetical protein 0.0165 0.0891 0.1383
Echinococcus granulosus lysine specific histone demethylase 1A 0.0028 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis somatostatin receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.0885 0.0885
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.0636 0.0636
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Schistosoma mansoni hypothetical protein 0.0202 0.1123 0.1123
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0031 0.0041 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis neuropeptide FF receptor 2 0.0565 0.3416 0.3416
Leishmania major cyclin 0.0228 0.129 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0125 0.0636 0.0636
Echinococcus granulosus cyclin B 0.0228 0.129 0.129
Echinococcus multilocularis cyclin G2 0.0031 0.0041 0.0041
Echinococcus granulosus integrin beta 2 0.0707 0.4311 0.4311
Schistosoma mansoni neuropeptide receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0635 0.3854 0.3854
Brugia malayi CHE-14 protein 0.0097 0.0459 0.0714
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.0636 0.0636
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.065 0.1598
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0064 0.0323
Brugia malayi Dopamine receptor protein 2 0.0125 0.0636 0.0988
Brugia malayi GnHR receptor homolog 0.0125 0.0636 0.0988
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.004 0.0099 0.06
Echinococcus granulosus expressed conserved protein 0.0063 0.0247 0.0247
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0125 0.0636 0.0636
Echinococcus multilocularis integrin alpha 3 0.0113 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0188 0.1032 0.1603
Trichomonas vaginalis cyclin D, putative 0.0127 0.065 0.1598
Echinococcus granulosus membrane bound transcription factor site 1 0.0045 0.0129 0.0129
Brugia malayi cyclin fold protein 1 variant b 0.0031 0.0041 0.0064
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0084 0.0084
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0028 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Echinococcus granulosus neuropeptide receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0125 0.0636 0.0636
Echinococcus granulosus peptide allatostatin:somatostatin 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0188 0.1032 0.1603
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0635 0.3854 1
Giardia lamblia Cyclin A 0.0127 0.065 0.27
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) transcription factor SMAD2 0.0082 0.0363 0.0564
Onchocerca volvulus 0.0119 0.06 0.4479
Echinococcus granulosus cyclins 0.0127 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0093 0.0434 0.0675
Trypanosoma cruzi cyclin 6, putative 0.0228 0.129 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0723 0.1123
Onchocerca volvulus 0.0125 0.0636 0.4767
Plasmodium vivax cyclin 4, putative 0.0031 0.0041 0.1703
Schistosoma mansoni cyclin G 0.0031 0.0041 0.0041
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0031 0.0041 0.0041
Brugia malayi larval opioid receptor 0.0125 0.0636 0.0988
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0045 0.0129 0.0129
Echinococcus granulosus g protein coupled receptor 0.0125 0.0636 0.0636
Brugia malayi HSF-type DNA-binding domain containing protein 0.0068 0.0276 0.0428
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0337 0.131
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.0445 0.0445
Toxoplasma gondii subtilisin SUB4 0.0045 0.0129 0.1051
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0045 0.0129 0.0705
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Onchocerca volvulus Neuropeptide F receptor homolog 0.0125 0.0636 0.4767
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Echinococcus granulosus Furin 1 0.0247 0.1404 0.1404
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0031 0.0041 0.1703
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0043 0.0119 0.0185
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0045 0.0129 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0554 0.0861
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.0636 0.0636
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0122 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0175 0.0951 0.1477
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0122 0.019
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0136 0.0136
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.0276 0.1879
Schistosoma mansoni hypothetical protein 0.0125 0.0636 0.0636
Onchocerca volvulus 0.0125 0.0636 0.4767
Loa Loa (eye worm) hypothetical protein 0.0067 0.0273 0.0424
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0108 0.0167
Schistosoma mansoni cyclin k 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0122 0.0781
Echinococcus multilocularis orexin receptor type 2 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0031 0.0041 0.0064
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0188 0.1032 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0136 0.0136
Brugia malayi Kelch motif family protein 0.0147 0.0778 0.1209
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0031 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Schistosoma mansoni myosin xvIII 0.0125 0.0636 0.0636
Echinococcus granulosus orexin receptor type 2 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0129 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Echinococcus granulosus serotonin receptor 0.0125 0.0636 0.0636
Trichomonas vaginalis cyclins, putative 0.0127 0.065 0.1598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis survival motor neuron protein 1 0.0162 0.0869 0.0869
Brugia malayi G protein-coupled receptor 0.0125 0.0636 0.0988
Onchocerca volvulus 0.0125 0.0636 0.4767
Mycobacterium leprae Possible secreted protease 0.0045 0.0129 0.1051
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0147 0.0778 0.1209
Schistosoma mansoni amine oxidase 0.0028 0.0023 0.0023
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0095 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) peptidase family M1 containing protein 0.0097 0.0457 0.0709
Echinococcus granulosus 7TM GPCR rhodopsin 0.0125 0.0636 0.0636
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0095 0.0445 0.0445
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0188 0.1032 0.1603
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.0445 0.0445
Brugia malayi putative neuropeptide receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis 0.0842 0.5164 0.5164
Schistosoma mansoni amine GPCR 0.0125 0.0636 0.0636
Echinococcus multilocularis fmrfamide receptor 0.0125 0.0636 0.0636
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0228 0.129 1
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0122 0.0781
Loa Loa (eye worm) cyclin C 0.0031 0.0041 0.0064
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0137 0.0712 0.0712
Echinococcus multilocularis integrin alpha ps 0.0066 0.0266 0.0266
Echinococcus multilocularis cyclin 0.0031 0.0041 0.0041
Trypanosoma cruzi cyclin, putative 0.0228 0.129 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0122 0.0122
Echinococcus multilocularis G protein coupled receptor 139 0.043 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.1044 0.6439 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Onchocerca volvulus 0.0125 0.0636 0.4767
Echinococcus multilocularis g protein coupled receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.1404 0.3575
Loa Loa (eye worm) hypothetical protein 0.041 0.2433 0.3778
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0123 0.0789
Trichomonas vaginalis hypothetical protein 0.0202 0.1123 0.2836
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Echinococcus granulosus g protein coupled receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0023 0.0023
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0045 0.0129 0.1051
Schistosoma mansoni neprilysin 0.0049 0.0157 0.0157
Schistosoma mansoni neprilysin-2 (M13 family) 0.0095 0.0445 0.0445
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0337 0.0775
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0045 0.0129 0.0837
Mycobacterium ulcerans zinc metalloprotease 0.0188 0.1032 1
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Toxoplasma gondii subtilisin SUB9 0.0045 0.0129 0.1051
Schistosoma mansoni integrin alpha-ps 0.0066 0.0266 0.0266
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0069 0.0223
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0069 0.0455
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis cyclins 0.0127 0.065 0.065
Echinococcus granulosus Cyclin L1 0.0031 0.0041 0.0041
Trichomonas vaginalis cyclins, putative 0.0228 0.129 0.3275
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Toxoplasma gondii subtilisin SUB12 0.0045 0.0129 0.1051
Brugia malayi hypothetical protein 0.0147 0.0778 0.1209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0075
Echinococcus granulosus endothelin converting enzyme 1 0.0188 0.1032 0.1032
Leishmania major cyclin 9, putative 0.0031 0.0041 0.0143
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0067 0.0273 0.1855
Echinococcus multilocularis g protein coupled receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Schistosoma mansoni opsin-like receptor 0.0125 0.0636 0.0636
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0041 0.0143
Echinococcus granulosus G protein coupled receptor 139 0.0125 0.0636 0.0636
Trichomonas vaginalis cyclins, putative 0.0228 0.129 0.3275
Brugia malayi hypothetical protein 0.0035 0.0069 0.0107
Brugia malayi Cyclin, N-terminal domain containing protein 0.0228 0.129 0.2003
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0891 0.6848
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0122 0.0781
Echinococcus granulosus cyclin G2 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni cyclins 0.0127 0.065 0.065
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0031 0.0041 0.0041
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0122 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Toxoplasma gondii subtilisin SUB6 0.0045 0.0129 0.1051
Onchocerca volvulus 0.0045 0.0129 0.0705
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0045 0.0129 0.1051
Echinococcus granulosus allatostatin A receptor 0.0125 0.0636 0.0636
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0202 0.1123 0.2836
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0064
Schistosoma mansoni biogenic amine receptor 0.0125 0.0636 0.0636
Brugia malayi sulfakinin receptor protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) endoprotease bli-4 0.1044 0.6439 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0069 0.0223
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0045 0.0129 0.1051
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0125 0.0636 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0069 0.0363
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0069 0.0363
Onchocerca volvulus 0.0125 0.0636 0.4767
Onchocerca volvulus 0.0125 0.0636 0.4767
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.1288 0.2
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni jumonji domain containing protein 0.0052 0.0175 0.0175
Trypanosoma cruzi subtilisin peptidase 0.0045 0.0129 0.0837
Loa Loa (eye worm) hypothetical protein 0.0137 0.0712 0.1106
Echinococcus granulosus geminin 0.0116 0.058 0.058
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.015
Brugia malayi Cyclin, N-terminal domain containing protein 0.0228 0.129 0.2003
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0122 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trypanosoma cruzi mitotic cyclin, putative 0.0031 0.0041 0.0143
Schistosoma mansoni integrin alpha-ps 0.0035 0.0066 0.0066
Toxoplasma gondii hypothetical protein 0.0097 0.0457 0.4296
Brugia malayi neuropeptide F receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Echinococcus granulosus Protein patched homolog 1 0.0097 0.0459 0.0459
Echinococcus multilocularis Furin 1 0.0247 0.1404 0.1404
Loa Loa (eye worm) hypothetical protein 0.0139 0.0723 0.1123
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0045 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis protoporphyrinogen oxidase 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0137 0.0712 0.1106
Trichomonas vaginalis cyclin B, putative 0.0228 0.129 0.3275
Schistosoma mansoni hypothetical protein 0.0103 0.0495 0.0495
Entamoeba histolytica cyclin, putative 0.0228 0.129 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Echinococcus granulosus integrin alpha 3 0.0113 0.0564 0.0564
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus G1:S specific cyclin D1 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Onchocerca volvulus 0.0125 0.0636 0.4767
Schistosoma mansoni integrin beta subunit 0.056 0.338 0.338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0041 0.0064
Echinococcus multilocularis cyclin y 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0127 0.065 0.065
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0031 0.0041 0.0041
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0122 0.0122
Plasmodium falciparum cyclin 1 0.0031 0.0041 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis expressed protein 0.0361 0.2128 0.2128
Brugia malayi follicle stimulating hormone receptor 0.0125 0.0636 0.0988
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0122 0.0781
Echinococcus granulosus cyclin y 0.0031 0.0041 0.0041
Trypanosoma brucei subtilisin peptidase 0.0045 0.0129 0.0705
Echinococcus multilocularis serotonin receptor 0.0125 0.0636 0.0636
Echinococcus granulosus cyclins 0.0127 0.065 0.065
Brugia malayi hypothetical protein 0.0031 0.0041 0.0064
Trichomonas vaginalis cyclin B, putative 0.0127 0.065 0.1598
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni neuropeptide receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0122 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0125 0.0636 0.0636
Leishmania major subtilisin-like serine peptidase 0.0045 0.0129 0.0837
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Brugia malayi Myb-like DNA-binding domain containing protein 0.017 0.092 0.1428
Leishmania major cathepsin L-like protease 0.0044 0.0123 0.0789
Echinococcus multilocularis g-protein coupled receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0097 0.0459 0.0714
Onchocerca volvulus 0.0125 0.0636 0.4767
Loa Loa (eye worm) hypothetical protein 0.0142 0.0744 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0123 0.0656
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0635 0.3854 0.3854
Echinococcus multilocularis membrane bound transcription factor site 1 0.0045 0.0129 0.0129
Echinococcus multilocularis protein dispatched 1 0.0101 0.0485 0.0485
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0122 0.0122
Trichomonas vaginalis cyclins, putative 0.0132 0.0681 0.1677
Loa Loa (eye worm) TYRA-2 protein 0.0125 0.0636 0.0988
Echinococcus multilocularis cyclin G2 0.0031 0.0041 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis 0.0028 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus multilocularis dro:myosuppressin receptor 0.0125 0.0636 0.0636
Leishmania major mitotic cyclin, putative 0.0031 0.0041 0.0143
Schistosoma mansoni growth hormone secretagogue receptor 0.0125 0.0636 0.0636
Brugia malayi G-protein coupled receptor 0.0125 0.0636 0.0988
Onchocerca volvulus 0.0125 0.0636 0.4767
Schistosoma mansoni amine GPCR 0.0125 0.0636 0.0636
Schistosoma mansoni endothelin-converting enzyme-related 0.0046 0.0136 0.0136
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0045 0.0129 0.0129
Echinococcus multilocularis geminin 0.0116 0.058 0.058
Echinococcus granulosus cyclin 0.0031 0.0041 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0123 0.0789
Brugia malayi celfurPC protein 0.0842 0.5164 0.802
Loa Loa (eye worm) hypothetical protein 0.0147 0.0778 0.1209
Schistosoma mansoni opsin-like receptor 0.0125 0.0636 0.0636
Schistosoma mansoni amine GPCR 0.0125 0.0636 0.0636
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0122 0.0122
Toxoplasma gondii subtilisin SUB8 0.0045 0.0129 0.1051
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni cyclin B3 0.0127 0.065 0.065
Schistosoma mansoni hypothetical protein 0.0116 0.058 0.058
Echinococcus multilocularis cyclin b3 0.0127 0.065 0.065
Plasmodium vivax subtilisin-like serine protease, putative 0.0045 0.0129 1
Schistosoma mansoni survival motor neuron protein 0.0033 0.0056 0.0056
Echinococcus granulosus neuropeptide s receptor 0.044 0.2624 0.2624
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0125 0.0636 0.0988
Mycobacterium leprae probable zinc metalloprotease 0.0188 0.1032 1
Onchocerca volvulus 0.0033 0.0056 0.0117
Onchocerca volvulus 0.0149 0.0785 0.5959
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0069 0.0363
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0125 0.0636 0.0988
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi Cyclin C 0.0031 0.0041 0.0064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis cyclin y 0.0031 0.0041 0.0041
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0122 0.0122
Toxoplasma gondii peptidase family M13 protein 0.0188 0.1032 1
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Brugia malayi RE15519p 0.0125 0.0636 0.0988
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0122 0.0122
Echinococcus multilocularis cyclin A3 4 0.0031 0.0041 0.0041
Echinococcus granulosus 7tm_1 domain containing protein 0.0125 0.0636 0.0636
Echinococcus multilocularis serotonin receptor 0.0125 0.0636 0.0636
Brugia malayi hypothetical protein 0.0125 0.0636 0.0988
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0069 0.0107
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0122 0.0358
Brugia malayi Serotonin receptor 0.0125 0.0636 0.0988
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0122 0.0212
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.0636 0.0636
Brugia malayi putative neuropeptide receptor NPR1 0.0125 0.0636 0.0988
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Onchocerca volvulus 0.0125 0.0636 0.4767
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0045 0.0129 0.0837
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.0636 0.0636
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0891 0.6848
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0129 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.0636 0.0636
Plasmodium falciparum cyclin 0.0127 0.065 1
Echinococcus multilocularis neuropeptide receptor A26 0.044 0.2624 0.2624
Schistosoma mansoni hypothetical protein 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0082 0.0363 0.0564
Echinococcus granulosus cyclin A3 4 0.0031 0.0041 0.0041
Giardia lamblia Hypothetical protein 0.0127 0.065 0.27
Echinococcus granulosus cyclin G2 0.0031 0.0041 0.0041
Loa Loa (eye worm) cyclin domain-containing protein 0.0127 0.065 0.101
Echinococcus multilocularis Cyclin L1 0.0031 0.0041 0.0041
Echinococcus granulosus cyclins 0.0127 0.065 0.065
Echinococcus multilocularis neuropeptide receptor 0.0125 0.0636 0.0636
Echinococcus granulosus somatostatin receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis G1:S specific cyclin D1 0.0031 0.0041 0.0041
Brugia malayi Melatonin receptor type 1A 0.0125 0.0636 0.0988
Echinococcus granulosus alpha 1A adrenergic receptor 0.0125 0.0636 0.0636
Echinococcus multilocularis sterol regulatory element binding protein 0.0097 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0116 0.0581 0.0903
Brugia malayi G protein-coupled receptor F59B2.13 0.0125 0.0636 0.0988
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0125 0.0636 0.4767
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus g-protein coupled receptor 0.0125 0.0636 0.0636
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) MH2 domain-containing protein 0.0082 0.0363 0.0564
Echinococcus multilocularis fmrfamide receptor 0.0125 0.0636 0.0636
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0125 0.0636 0.0636
Schistosoma mansoni amine GPCR 0.0125 0.0636 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0045 0.0129 0.0231
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Echinococcus multilocularis g protein coupled receptor 0.0125 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.0157
Toxoplasma gondii cyclin dependent kinase binding protein 0.0031 0.0041 0.0179
Onchocerca volvulus 0.0125 0.0636 0.4767
Loa Loa (eye worm) hypothetical protein 0.0045 0.0129 0.0201
Loa Loa (eye worm) hypothetical protein 0.0097 0.0459 0.0714
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Trichomonas vaginalis cyclin A, putative 0.0228 0.129 0.3275
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0031 0.0041 0.0179
Schistosoma mansoni biogenic amine receptor 0.0125 0.0636 0.0636
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.0636 0.0636
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0337 0.0775
Giardia lamblia Furin precursor putative serine protease 0.0202 0.1123 0.4794
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.0636 0.0636
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0149 0.0785 0.1219
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0129 0.0231
Giardia lamblia High cysteine membrane protein Group 2 0.0388 0.2297 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.1032 0.1603
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.0891 0.0891
Echinococcus granulosus tachykinin peptides receptor 99D 0.0125 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.1123 0.2836
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0099
Trypanosoma cruzi cyclin 9, putative 0.0031 0.0041 0.0143
Plasmodium vivax protein kinase Crk2 0.0044 0.0122 0.9327
Loa Loa (eye worm) hypothetical protein 0.0125 0.0636 0.0988
Brugia malayi MH2 domain containing protein 0.0082 0.0363 0.0564
Echinococcus multilocularis neuropeptide receptor 0.043 0.2561 0.2561
Trichomonas vaginalis cyclin B, putative 0.0228 0.129 0.3275
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.0636 0.0636
Brugia malayi hypothetical protein 0.0162 0.0869 0.135

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.35 uM Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 mins ChEMBL. 17851082
IC50 (binding) = 4.35 uM Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 mins ChEMBL. 17851082

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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