TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.696 | Formula: C29H38N3O2S+
H donors: 1 H acceptors: 2 LogP: 5.07 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: C[NH2+]C(C/C=C/C(=O)N([C@H](C(=O)N(CCc1cccs1)C)Cc1ccc2c(c1)cccc2)C)(C)C
InChi: 1S/C29H37N3O2S/c1-29(2,30-3)17-8-13-27(33)32(5)26(28(34)31(4)18-16-25-12-9-19-35-25)21-22-14-15-23-10-6-7-11-24(23)20-22/h6-15,19-20,26,30H,16-18,21H2,1-5H3/p+1/b13-8+/t26-/m1/s1
InChiKey: LRHAXAVCVRWWKU-PVBLUSGHSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Echinococcus granulosus	aminopeptidase N	0.0359	0.0866	0.082
Trichomonas vaginalis	cyclins, putative	0.0288	0.065	0.1499
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0102	0.008	0.017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0102	0.008	0.0029
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0368	0.0896	0.0849
Echinococcus granulosus	membrane bound transcription factor site 1	0.0102	0.008	0.0029
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0368	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0482	0.1244	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Onchocerca volvulus		0.0525	0.1374	1
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.008	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0423	0.0432
Leishmania major	subtilisin-like serine peptidase	0.0102	0.008	0.0244
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0368	0.0896	0.0849
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus granulosus	integrin beta 2	0.2181	0.6438	0.642
Echinococcus granulosus	g protein coupled receptor	0.0368	0.0896	0.0849
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0102	0.008	0.017
Toxoplasma gondii	subtilisin SUB8	0.0102	0.008	0.0482
Brugia malayi	G protein-coupled receptor F59B2.13	0.0368	0.0896	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0462	0.0476
Trypanosoma cruzi	cyclin, putative	0.0482	0.1244	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2412	0.7145	0.7131
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0208	0.0186
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Loa Loa (eye worm)	TYRA-2 protein	0.0368	0.0896	0.0971
Echinococcus granulosus	mitogen activated protein kinase 14	0.027	0.0594	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Echinococcus granulosus	endothelin converting enzyme 1	0.029	0.0654	0.0607
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Trypanosoma brucei	mitotic cyclin 6	0.0482	0.1244	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0368	0.0896	0.0849
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.046	0.1175	0.281
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.008	0.0073
Brugia malayi	Dopamine receptor protein 1	0.0368	0.0896	0.0965
Plasmodium falciparum	subtilisin-like protease 3	0.0102	0.008	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Schistosoma mansoni	neuropeptide receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	expressed protein	0.038	0.0932	0.0886
Echinococcus multilocularis	fmrfamide receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	neuropeptide F receptor	0.0368	0.0896	0.0971
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0368	0.0896	0.0896
Onchocerca volvulus		0.0368	0.0896	0.6303
Toxoplasma gondii	subtilisin SUB4	0.0102	0.008	0.0482
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus multilocularis	g protein coupled receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0368	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0368	0.0896	0.0971
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0543	0.0569
Echinococcus granulosus	somatostatin receptor	0.0368	0.0896	0.0849
Onchocerca volvulus		0.0482	0.1244	0.8992
Echinococcus multilocularis	neuropeptides capa receptor	0.0568	0.1508	0.1464
Giardia lamblia	G2/mitotic-specific cyclin B	0.0482	0.1244	0.5221
Onchocerca volvulus		0.0359	0.0866	0.6076
Onchocerca volvulus		0.0368	0.0896	0.6303
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0368	0.0896	0.0896
Echinococcus granulosus	allatostatin A receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0482	0.1244	0.1362
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0482	0.1244	1
Brugia malayi	proprotein convertase 2	0.1447	0.4196	0.4732
Echinococcus multilocularis	integrin beta 2	0.2181	0.6438	0.642
Echinococcus granulosus	7tm_1 domain containing protein	0.0368	0.0896	0.0849
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Echinococcus multilocularis	cyclin B	0.0482	0.1244	0.1199
Brugia malayi	RE15519p	0.0368	0.0896	0.0965
Loa Loa (eye worm)	neuropeptide F receptor	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.029	0.0654	0.0696
Echinococcus multilocularis	serotonin receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1233	0.1356
Echinococcus granulosus	cyclins	0.0256	0.0551	0.0503
Onchocerca volvulus		0.0177	0.031	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis		0.0098	0.007	0.0019
Brugia malayi	hypothetical protein	0.0106	0.0092	0.0047
Echinococcus multilocularis	neuropeptide Y receptor	0.0368	0.0896	0.0849
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0368	0.0896	0.0849
Toxoplasma gondii	subtilisin SUB12	0.0102	0.008	0.0482
Echinococcus granulosus	cyclin b3	0.0256	0.0551	0.0503
Onchocerca volvulus		0.0143	0.0208	0.0989
Loa Loa (eye worm)	hypothetical protein	0.029	0.0654	0.0696
Loa Loa (eye worm)	proprotein convertase 2	0.0561	0.1486	0.1644
Brugia malayi	Subtilase family protein	0.0102	0.008	0.0033
Schistosoma mansoni	furin-1 (S08 family)	0.0988	0.2789	0.2789
Schistosoma mansoni	amine GPCR	0.0368	0.0896	0.0896
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus multilocularis	cyclin b3	0.0256	0.0551	0.0503
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0051	0.0051
Echinococcus granulosus	neuropeptide receptor	0.0368	0.0896	0.0849
Trypanosoma cruzi	subtilisin peptidase	0.0102	0.008	0.0244
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Brugia malayi	neuropeptide F receptor	0.0368	0.0896	0.0965
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1401	0.4053	0.4023
Trichomonas vaginalis	cyclins, putative	0.0482	0.1244	0.2981
Loa Loa (eye worm)	hypothetical protein	0.1752	0.5128	0.5799
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0102	0.008	0.0029
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0106	0.0092	0.0347
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0106	0.0092	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	neuropeptide f receptor 76f	0.0368	0.0896	0.0896
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0102	0.008	0.017
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0223	0.0452	0.0452
Brugia malayi	G-protein coupled receptor	0.0368	0.0896	0.0965
Leishmania major	UDP-galactopyranose mutase	0.0098	0.007	0.0161
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0368	0.0896	0.0849
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1401	0.4053	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	neuropeptide receptor	0.0368	0.0896	0.0896
Brugia malayi	hypothetical protein	0.0455	0.1159	0.1266
Echinococcus granulosus	neuroendocrine convertase 2	0.1447	0.4196	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0423	0.0432
Trichomonas vaginalis	cyclins, putative	0.0482	0.1244	0.2981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1249	0.1374
Echinococcus granulosus	serotonin receptor	0.0368	0.0896	0.0849
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0106	0.0092	0.0347
Brugia malayi	Peptidase family M13 containing protein	0.029	0.0654	0.0689
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0098	0.007	0.0897
Giardia lamblia	Cyclin A	0.0256	0.0551	0.219
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0368	0.0896	0.0965
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0368	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1249	0.1374
Trichomonas vaginalis	cyclin B, putative	0.0256	0.0551	0.1251
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0106	0.0092	0.0347
Entamoeba histolytica	cyclin family protein	0.0256	0.0551	0.4195
Schistosoma mansoni	serine-type protease inhibitor	0.0879	0.2457	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0195	0.0172
Loa Loa (eye worm)	integrin beta-2	0.2956	0.881	1
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0423	0.0432
Echinococcus granulosus	tm gpcr rhodopsin	0.2412	0.7145	0.7131
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0102	0.008	0.0029
Echinococcus granulosus	orexin receptor type 2	0.0368	0.0896	0.0849
Schistosoma mansoni	amine oxidase	0.0098	0.007	0.007
Plasmodium falciparum	subtilisin-like protease 2	0.0102	0.008	0.0582
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0098	0.007	0.007
Echinococcus granulosus	mitogen activated protein kinase 11	0.027	0.0594	0.0546
Trichomonas vaginalis	cyclin B, putative	0.0482	0.1244	0.2981
Echinococcus multilocularis	integrin alpha ps	0.0273	0.0605	0.0557
Loa Loa (eye worm)	hypothetical protein	0.029	0.0654	0.0696
Entamoeba histolytica	aminopeptidase, putative	0.0106	0.0092	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0106	0.0092	0.0103
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0886	0.2479	0.2777
Entamoeba histolytica	cyclin, putative	0.0256	0.0551	0.4195
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0455	0.1159	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0461	0.1179	0.1295
Echinococcus granulosus	integrin alpha 3	0.0467	0.1198	0.1154
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0368	0.0896	0.0849
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Schistosoma mansoni	histamine h1 receptor	0.0368	0.0896	0.0896
Mycobacterium ulcerans	zinc metalloprotease	0.029	0.0654	1
Schistosoma mansoni	adenoreceptor	0.0368	0.0896	0.0896
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0368	0.0896	0.0965
Mycobacterium leprae	probable zinc metalloprotease	0.029	0.0654	1
Echinococcus granulosus	integrin alpha ps	0.0273	0.0605	0.0557
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Onchocerca volvulus		0.0368	0.0896	0.6303
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0102	0.008	0.017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0102	0.008	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0102	0.008	0.004
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0102	0.008	0.017
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0102	0.008	0.0244
Schistosoma mansoni	myosin xvIII	0.0368	0.0896	0.0896
Schistosoma mansoni	amine GPCR	0.0368	0.0896	0.0896
Schistosoma mansoni	amine oxidase	0.0098	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0798	0.0859
Echinococcus granulosus	g protein coupled receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Loa Loa (eye worm)	subtilase	0.0102	0.008	0.004
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0102	0.008	0.0033
Brugia malayi	celfurPC protein	0.1827	0.5356	0.6057
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0385	0.0388
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0368	0.0896	0.0849
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Brugia malayi	Tachykinin-like peptides receptor 99D	0.1752	0.5128	0.5797
Schistosoma mansoni	hypothetical protein	0.0131	0.017	0.017
Brugia malayi	G protein-coupled receptor	0.0368	0.0896	0.0965
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0102	0.008	0.0244
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	cyclin B3, putative	0.0256	0.0551	0.1251
Echinococcus multilocularis		0.1827	0.5356	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus granulosus	g protein coupled receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	sex peptide receptor	0.0368	0.0896	0.0849
Echinococcus granulosus	cyclins	0.0256	0.0551	0.0503
Schistosoma mansoni	cyclin B3	0.0256	0.0551	0.0551
Echinococcus multilocularis	integrin alpha ps	0.0131	0.017	0.012
Trichomonas vaginalis	cyclins, putative	0.0482	0.1244	0.2981
Echinococcus multilocularis	dnaJ subfamily B	0.3345	1	1
Loa Loa (eye worm)	hypothetical protein	0.0322	0.0753	0.0808
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0368	0.0896	0.0965
Echinococcus granulosus	neuropeptide receptor A26	0.0368	0.0896	0.0849
Echinococcus multilocularis	endothelin converting enzyme 1	0.029	0.0654	0.0607
Trichomonas vaginalis	hypothetical protein	0.046	0.1175	0.281
Schistosoma mansoni	neuropeptide receptor	0.0843	0.2346	0.2346
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0368	0.0896	0.6303
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0368	0.0896	0.0896
Mycobacterium ulcerans	aminopeptidase N PepN	0.0106	0.0092	0.038
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	allatostatin A receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	integrin alpha	0.061	0.1634	0.1634
Schistosoma mansoni	growth hormone secretagogue receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Echinococcus multilocularis	neuropeptide Y receptor	0.0368	0.0896	0.0849
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0482	0.1244	0.1362
Echinococcus granulosus	neuropeptide FF receptor 2	0.1752	0.5128	0.5103
Brugia malayi	endoprotease bli-4 precursor	0.2287	0.6763	0.7663
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0482	0.1244	1
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0201	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0482	0.1244	0.1368
Schistosoma mansoni	hypothetical protein	0.0368	0.0896	0.0896
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Trichomonas vaginalis	cyclin A, putative	0.0482	0.1244	0.2981
Brugia malayi	Integrin alpha pat-2 precursor	0.061	0.1634	0.1807
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0368	0.0896	0.6303
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0102	0.008	0.017
Brugia malayi	Kelch motif family protein	0.0455	0.1159	0.1266
Toxoplasma gondii	cathepsin CPC2	0.0162	0.0264	0.3538
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Echinococcus multilocularis	fmrfamide receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Trypanosoma cruzi	aminopeptidase, putative	0.0106	0.0092	0.0347
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0368	0.0896	0.0896
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1401	0.4053	0.4023
Toxoplasma gondii	subtilisin SUB5	0.0102	0.008	0.0482
Schistosoma mansoni	hypothetical protein	0.0368	0.0896	0.0896
Loa Loa (eye worm)	G-protein coupled receptor	0.0368	0.0896	0.0971
Echinococcus granulosus	furin	0.2287	0.6763	0.6746
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0368	0.0896	0.0849
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Plasmodium vivax	subtilisin-like protease 1	0.0102	0.008	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0201	0.0385	0.0385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Toxoplasma gondii	peptidase family M13 protein	0.029	0.0654	1
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.029	0.0654	0.0689
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0131	0.017	0.0143
Echinococcus multilocularis	neuroendocrine convertase 2	0.1447	0.4196	0.4166
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0102	0.008	0.017
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0368	0.0896	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0455	0.1159	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0051	0.0051
Toxoplasma gondii	subtilisin SUB2	0.0102	0.008	0.0482
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586
Echinococcus multilocularis	aminopeptidase N	0.0359	0.0866	0.082
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Leishmania major	cyclin	0.0482	0.1244	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0139	0.0195	0.0145
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	hypothetical protein	0.3345	1	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.027	0.0594	0.0546
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1229	0.3526	0.3526
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Brugia malayi	Serotonin receptor	0.0368	0.0896	0.0965
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0102	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	neuropeptide s receptor	0.0368	0.0896	0.0849
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0098	0.007	0.0383
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0092	0.0051	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0368	0.0896	0.0849
Trichomonas vaginalis	conserved hypothetical protein	0.0256	0.0551	0.1251
Echinococcus granulosus	tm gpcr rhodopsin	0.0368	0.0896	0.0849
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Echinococcus multilocularis	orexin receptor type 2	0.0368	0.0896	0.0849
Schistosoma mansoni	hypothetical protein	0.046	0.1175	0.1175
Trichomonas vaginalis	cyclin D, putative	0.0256	0.0551	0.1251
Brugia malayi	neuropeptide F receptor	0.0368	0.0896	0.0965
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.027	0.0594	0.4551
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0368	0.0896	0.0896
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.027	0.0594	0.0626
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.027	0.0594	0.4551
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	hypothetical protein	0.0368	0.0896	0.0896
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0368	0.0896	0.0849
Trichomonas vaginalis	cyclins, putative	0.0256	0.0551	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus granulosus	7TM GPCR rhodopsin	0.0368	0.0896	0.0849
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Loa Loa (eye worm)	melatonin receptor type 1A	0.0368	0.0896	0.0971
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Plasmodium vivax	subtilisin-like protease 2, putative	0.0102	0.008	0.1363
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Brugia malayi	G-protein coupled receptor	0.0368	0.0896	0.0965
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0102	0.008	0.017
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus multilocularis	g-protein coupled receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0204	0.0182
Loa Loa (eye worm)	integrin alpha pat-2	0.094	0.2643	0.2965
Echinococcus granulosus	cyclins	0.0256	0.0551	0.0503
Plasmodium falciparum	cyclin	0.0256	0.0551	1
Schistosoma mansoni	tyrosine kinase	0.0139	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Schistosoma mansoni	cyclins	0.0256	0.0551	0.0551
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Onchocerca volvulus		0.0368	0.0896	0.6303
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0179	0.0317	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Entamoeba histolytica	cyclin family protein	0.0256	0.0551	0.4195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Brugia malayi	ORL1-like opioid receptor	0.0368	0.0896	0.0965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0256	0.0551	0.0503
Brugia malayi	GnHR receptor homolog	0.0368	0.0896	0.0965
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	hypothetical protein	0.0315	0.0731	0.0731
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0162	0.0264	0.4268
Schistosoma mansoni	neuropeptide F-like receptor	0.0368	0.0896	0.0896
Plasmodium vivax	subtilisin-like serine protease, putative	0.0102	0.008	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0368	0.0896	0.0849
Schistosoma mansoni	neuropeptide F-like receptor	0.0368	0.0896	0.0896
Schistosoma mansoni	biogenic amine receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	cyclin B	0.0482	0.1244	0.1199
Brugia malayi	Furin-like cysteine rich region family protein	0.0139	0.0195	0.0165
Schistosoma mansoni	biogenic amine receptor	0.0368	0.0896	0.0896
Brugia malayi	P38 map kinase family protein 2	0.027	0.0594	0.062
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0256	0.0551	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus granulosus	biogenic amine 5HT receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	G protein coupled receptor 139	0.0843	0.2346	0.2307
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Giardia lamblia	Furin precursor putative serine protease	0.046	0.1175	0.4921
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	neuropeptide receptor	0.0843	0.2346	0.2307
Echinococcus multilocularis	Furin 1	0.0561	0.1486	0.1443
Echinococcus multilocularis	mitogen activated protein kinase 14	0.027	0.0594	0.0546
Echinococcus granulosus	dro:myosuppressin receptor	0.0368	0.0896	0.0849
Brugia malayi	Dopamine receptor	0.0368	0.0896	0.0965
Echinococcus granulosus	epidermal growth factor receptor	0.0139	0.0195	0.0145
Entamoeba histolytica	cyclin, putative	0.0482	0.1244	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0098	0.007	0.0019
Schistosoma mansoni	opsin-like receptor	0.0368	0.0896	0.0896
Brugia malayi	AKH receptor	0.0368	0.0896	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	cyclin B	0.0482	0.1244	0.1244
Brugia malayi	follicle stimulating hormone receptor	0.0368	0.0896	0.0965
Echinococcus multilocularis	mitogen activated protein kinase 11	0.027	0.0594	0.0546
Toxoplasma gondii	hypothetical protein	0.0194	0.0362	0.5163
Loa Loa (eye worm)	hypothetical protein	0.0525	0.1374	0.1517
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0368	0.0896	0.0849
Mycobacterium leprae	Possible secreted protease	0.0102	0.008	0.017
Echinococcus granulosus	neuropeptide Y receptor	0.0368	0.0896	0.0849
Onchocerca volvulus		0.0201	0.0385	0.2358
Schistosoma mansoni	opsin-like receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	Furin 1	0.0561	0.1486	0.1443
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0214	0.0423	0.0432
Toxoplasma gondii	subtilisin SUB7	0.0102	0.008	0.0482
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0368	0.0896	0.0849
Brugia malayi	Trypsin family protein	0.0201	0.0385	0.0382
Trichomonas vaginalis	cyclins, putative	0.0482	0.1244	0.2981
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1401	0.4053	1
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Brugia malayi	putative neuropeptide receptor NPR1	0.0368	0.0896	0.0965
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0368	0.0896	0.0849
Loa Loa (eye worm)	G-protein coupled receptor	0.0368	0.0896	0.0971
Trypanosoma cruzi	cyclin 6, putative	0.0482	0.1244	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0098	0.007	0.0019
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	tm gpcr rhodopsin	0.0368	0.0896	0.0849
Giardia lamblia	High cysteine membrane protein Group 2	0.0839	0.2336	1
Schistosoma mansoni	integrin alpha-ps	0.0273	0.0605	0.0605
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0368	0.0896	0.0849
Echinococcus granulosus	sex peptide receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	somatostatin receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0368	0.0896	0.0849
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0368	0.0896	0.0849
Toxoplasma gondii	histone lysine-specific demethylase	0.0098	0.007	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0317	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0098	0.007	0.0161
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Plasmodium vivax	hypothetical protein, conserved	0.0098	0.007	0.0897
Echinococcus multilocularis	neuropeptide FF receptor 2	0.1752	0.5128	0.5103
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Brugia malayi	sulfakinin receptor protein	0.0368	0.0896	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0385	0.0388
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0102	0.008	0.008
Trichomonas vaginalis	cyclin D, putative	0.0256	0.0551	0.1251
Loa Loa (eye worm)	aminopeptidase N	0.0106	0.0092	0.0054
Schistosoma mansoni	amine GPCR	0.0368	0.0896	0.0896
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.029	0.0654	0.0654
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0368	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.008	0.0073
Plasmodium falciparum	protoporphyrinogen oxidase	0.0098	0.007	0.0383
Loa Loa (eye worm)	hypothetical protein	0.2287	0.6763	0.7664
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0368	0.0896	0.0849
Schistosoma mansoni	opsin-like receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	G protein coupled receptor 139	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0102	0.008	0.008
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Echinococcus granulosus	g-protein coupled receptor	0.0368	0.0896	0.0849
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0162	0.0264	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0256	0.0551	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0333	0.0329
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0146	0.0216	0.0216
Echinococcus multilocularis	integrin alpha ps	0.0273	0.0605	0.0557
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0146	0.0216	0.0216
Onchocerca volvulus		0.0368	0.0896	0.6303
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.046	0.1175	0.281
Trichomonas vaginalis	cyclin B, putative	0.0482	0.1244	0.2981
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Giardia lamblia	Hypothetical protein	0.0256	0.0551	0.219
Loa Loa (eye worm)	endoprotease bli-4	0.2287	0.6763	0.7664
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0106	0.0092	0.0092
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Brugia malayi	hypothetical protein	0.0098	0.007	0.0022
Schistosoma mansoni	serine-type protease inhibitor	0.0879	0.2457	0.2457
Onchocerca volvulus		0.0368	0.0896	0.6303
Brugia malayi	Integrin beta pat-3 precursor	0.2956	0.881	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0484	0.1249	0.1205
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0561	0.1486	0.1486
Echinococcus granulosus	neuropeptide receptor	0.0843	0.2346	0.2307
Brugia malayi	hypothetical protein	0.0368	0.0896	0.0965
Brugia malayi	Melatonin receptor type 1A	0.0368	0.0896	0.0965
Schistosoma mansoni	amine GPCR	0.0368	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Schistosoma mansoni	neuropeptide receptor	0.0368	0.0896	0.0896
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	integrin alpha 3	0.0467	0.1198	0.1154
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0098	0.007	0.0161
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0102	0.008	0.0244
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Echinococcus granulosus	cyclins	0.0256	0.0551	0.0503
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0102	0.008	0.008
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0146	0.0216	0.0216
Trypanosoma brucei	Aminopeptidase M1, putative	0.0106	0.0092	0.0347
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Brugia malayi	amine oxidase, flavin-containing family protein	0.0139	0.0195	0.0165
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0484	0.1249	0.1249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Brugia malayi	Peptidase family M1 containing protein	0.0106	0.0092	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0102	0.008	0.0244
Echinococcus granulosus	cyclins	0.0256	0.0551	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0106	0.0092	0.0042
Schistosoma mansoni	amine GPCR	0.0368	0.0896	0.0896
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0098	0.007	0.0897
Echinococcus multilocularis	expressed protein	0.038	0.0932	0.0886
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0484	0.1249	0.1205
Brugia malayi	SWIRM domain containing protein	0.0525	0.1374	0.1511
Trypanosoma brucei	RNA helicase, putative	0.0315	0.0731	0.5704
Trypanosoma brucei	subtilisin peptidase	0.0102	0.008	0.0244
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0098	0.007	0.0317
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0092	0.0051	0.0007
Brugia malayi	Dopamine receptor protein 2	0.0368	0.0896	0.0965
Echinococcus multilocularis	g protein coupled receptor	0.0368	0.0896	0.0849
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0102	0.008	0.017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Schistosoma mansoni	hypothetical protein	0.0368	0.0896	0.0896
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.2287	0.6763	0.6763
Echinococcus multilocularis	cyclin B3 1	0.0256	0.0551	0.0503
Toxoplasma gondii	subtilisin SUB10	0.0102	0.008	0.0482
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0461	0.1179	0.1289
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.008	0.0073
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0368	0.0896	0.0971
Echinococcus multilocularis	neuropeptide receptor	0.0368	0.0896	0.0849
Onchocerca volvulus		0.0368	0.0896	0.6303
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0092	0.0051	0.0007
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Brugia malayi	Serotonin receptor	0.0368	0.0896	0.0965
Trichomonas vaginalis	cyclin B, putative	0.0482	0.1244	0.2981
Echinococcus granulosus	cyclin B3 1	0.0256	0.0551	0.0503
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.029	0.0654	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.029	0.0657	0.0698
Trypanosoma brucei	Aminopeptidase M1, putative	0.0106	0.0092	0.0347
Schistosoma mansoni	integrin beta subunit	0.1726	0.5047	0.5047
Onchocerca volvulus	CoRest homolog	0.0185	0.0333	0.1958
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0368	0.0896	0.0965
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Onchocerca volvulus		0.0368	0.0896	0.6303
Onchocerca volvulus		0.0368	0.0896	0.6303
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.027	0.0594	0.4551
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.027	0.0594	0.4551
Toxoplasma gondii	subtilisin SUB9	0.0102	0.008	0.0482
Onchocerca volvulus		0.0106	0.0092	0.0095
Echinococcus multilocularis	neuropeptide receptor A26	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0423	0.0432
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Echinococcus multilocularis	g protein coupled receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0439	0.045
Onchocerca volvulus		0.0368	0.0896	0.6303
Brugia malayi	neuroendocrine convertase 1 precursor	0.1447	0.4196	0.4732
Echinococcus multilocularis	neuropeptides capa receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	integrin alpha-ps	0.0142	0.0204	0.0204
Brugia malayi	Peptidase family M1 containing protein	0.0359	0.0866	0.0931
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0368	0.0896	0.0849
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0098	0.007	0.0383
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0368	0.0896	0.0971
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0146	0.0216	0.0216
Echinococcus granulosus	hypothetical protein	0.0368	0.0896	0.0849
Trichomonas vaginalis	cyclin B, putative	0.0482	0.1244	0.2981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.013	0.0167	0.0167
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0139	0.0195	0.0172
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0146	0.0216	0.0216
Echinococcus multilocularis	cyclins	0.0256	0.0551	0.0503
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0098	0.007	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0368	0.0896	0.0849
Toxoplasma gondii	subtilisin SUB1	0.0102	0.008	0.0482
Plasmodium falciparum	subtilisin-like protease 1	0.0102	0.008	0.0582
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0106	0.0092	0.0347
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0368	0.0896	0.0971
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0368	0.0896	0.0896
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0214	0.0423	0.0432
Echinococcus granulosus	fmrfamide receptor	0.0368	0.0896	0.0849
Toxoplasma gondii	subtilisin SUB6	0.0102	0.008	0.0482
Trypanosoma cruzi	cyclin, putative	0.0482	0.1244	1
Echinococcus granulosus	neuropeptides capa receptor	0.0568	0.1508	0.1464
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.1175	0.281
Brugia malayi	larval opioid receptor	0.0368	0.0896	0.0965
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	biogenic amine receptor	0.0368	0.0896	0.0896
Brugia malayi	putative neuropeptide receptor	0.0368	0.0896	0.0965
Echinococcus granulosus	integrin alpha ps	0.0131	0.017	0.012
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0106	0.0092	0.0347
Plasmodium vivax	hypothetical protein, conserved	0.0098	0.007	0.0897
Onchocerca volvulus		0.0368	0.0896	0.6303
Loa Loa (eye worm)	hypothetical protein	0.0098	0.007	0.0029
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus granulosus	neuropeptides capa receptor	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Echinococcus multilocularis	serotonin receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.0092	0.0042
Echinococcus granulosus	neuropeptide s receptor	0.0368	0.0896	0.0849
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0368	0.0896	0.0896
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.046	0.1175	0.281
Toxoplasma gondii	subtilisin SUB11	0.0102	0.008	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0098	0.007	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0256	0.0551	0.0571
Echinococcus granulosus	neuropeptide Y receptor	0.0368	0.0896	0.0849
Echinococcus multilocularis	mitogen activated protein kinase 11	0.027	0.0594	0.0546
Onchocerca volvulus		0.0368	0.0896	0.6303
Echinococcus granulosus	biogenic amine 5HT receptor	0.0368	0.0896	0.0849
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0102	0.008	0.0073
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0368	0.0896	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0896	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.008	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0561	0.1486	0.3586

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.8 nM	Agonist activity at human GHS-R1	ChEMBL.	17329109
Log EC50 (functional)	= 9.1	Agonist activity at human GHS-R1	ChEMBL.	17329109

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 507403

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 452495