Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0027 | 0.0532 | 0.5 |
Leishmania major | 0.0322 | 1 | 1 | |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.012 | 0.3512 | 0.337 |
Echinococcus multilocularis | glutathione S transferase | 0.002 | 0.0325 | 0.0279 |
Brugia malayi | vesicle-fusing ATPase | 0.0017 | 0.0204 | 0.0158 |
Echinococcus multilocularis | glutathione S-transferase | 0.0026 | 0.0519 | 0.0474 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.012 | 0.3512 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0325 | 0.0279 |
Brugia malayi | glutathione transferase | 0.0026 | 0.0519 | 0.0474 |
Echinococcus granulosus | glutathione s transferase mu | 0.0026 | 0.0519 | 0.02 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.0117 | 0.3412 | 0.3191 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0028 | 0.0579 | 1 |
Toxoplasma gondii | fructose-bisphospatase I | 0.012 | 0.3512 | 0.337 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.012 | 0.3512 | 0.3148 |
Mycobacterium ulcerans | ATPase | 0.0017 | 0.0214 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0322 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0322 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0322 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0322 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0322 | 1 | 1 |
Echinococcus granulosus | glutathione S transferase | 0.0026 | 0.0519 | 0.02 |
Brugia malayi | valosin containing protein | 0.0017 | 0.0204 | 0.0158 |
Echinococcus multilocularis | glutathione S transferase | 0.002 | 0.0325 | 0.0279 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0322 | 1 | 1 |
Schistosoma mansoni | GST class-mu | 0.0026 | 0.0519 | 0.0474 |
Echinococcus multilocularis | glutathione S transferase | 0.009 | 0.2565 | 0.253 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0017 | 0.0214 | 0.00000036464 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0519 | 0.0474 |
Giardia lamblia | AAA family ATPase | 0.0017 | 0.0214 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0028 | 0.0579 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0204 | 0.0158 |
Echinococcus multilocularis | glutathione S transferase | 0.0026 | 0.0519 | 0.0474 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.012 | 0.3512 | 0.3148 |
Echinococcus multilocularis | glutathione s transferase mu | 0.0026 | 0.0519 | 0.0474 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0028 | 0.0579 | 0.0372 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0027 | 0.0532 | 0.1559 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0027 | 0.0532 | 0.0488 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0322 | 1 | 1 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0117 | 0.3412 | 0.3381 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0027 | 0.0532 | 0.5 |
Schistosoma mansoni | glutathione-S-transferase | 0.0026 | 0.0519 | 0.0474 |
Echinococcus multilocularis | glutathione S transferase | 0.0026 | 0.0519 | 0.0474 |
Brugia malayi | Glutathione S-transferase 4 | 0.002 | 0.0325 | 0.0279 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0028 | 0.0579 | 0.0535 |
Echinococcus multilocularis | glutathione S transferase | 0.0026 | 0.0519 | 0.0474 |
Plasmodium vivax | glutathione S-transferase, putative | 0.0117 | 0.3412 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0017 | 0.0204 | 0.0158 |
Echinococcus granulosus | glutathione S transferase | 0.009 | 0.2565 | 0.2315 |
Echinococcus granulosus | glutathione S transferase Mu 1 | 0.0026 | 0.0519 | 0.02 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0028 | 0.0579 | 0.0263 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0027 | 0.0532 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0028 | 0.0579 | 1 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0117 | 0.3412 | 0.3381 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0017 | 0.0214 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 5 % | Inhibition of Dengue virus NS5MTase assessed as methylation of 7MeGpppAC5 at 100 uM | ChEMBL. | 17888664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.