Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparasitic activity against Trypanosoma cruzi T2 epimastigotes assessed as growth inhibition at 25 uM after 5 days | ChEMBL. | 20889239 | |
Activity (functional) | 0 | Nitric oxide releasing activity at 6 uM to 1 mM in presence of 30 uM to 5 mM cysteine | ChEMBL. | 17627828 |
Activity (functional) | = 46 % | Vasodilation of noradrenaline-induced contraction of Wistar Kyoto rat thoracic aorta at 20 uM | ChEMBL. | 17627828 |
IC50 (functional) | > 500 uM | Cytotoxicity against human THP1 cells by MTT assay | ChEMBL. | 17627828 |
IC50 (ADMET) | > 500 uM | Cytotoxicity against mouse J774 cells by MTT assay | ChEMBL. | 17627828 |
IC50 (functional) | > 500 uM | Cytotoxicity against human THP1 cells by MTT assay | ChEMBL. | 17627828 |
IC50 (ADMET) | > 500 uM | Cytotoxicity against mouse J774 cells by MTT assay | ChEMBL. | 17627828 |
Inhibition (binding) | = 7 % | Inhibition of Trypanosoma cruzi triosephosphate isomerase at 400 uM after 2 hrs | ChEMBL. | 20889239 |
Kd (binding) | = 0.6 10'-4M | Displacement of NBD-Toc from human recombinant alphaTTP | ChEMBL. | 19897374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.