Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Type-1A angiotensin II receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 404 nM | Displacement of [125I]Ang 2 from AT2 receptor in pig uterus membranes | ChEMBL. | 17825570 |
Ki (binding) | > 10000 nM | Displacement of [125I]Ang 2 from AT1 receptor in rat liver membranes | ChEMBL. | 17825570 |
Ki (binding) | > 10000 nM | Displacement of [125I]Ang 2 from AT1 receptor in rat liver membranes | ChEMBL. | 17825570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.