Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0142 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0142 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0142 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0142 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0142 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0142 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0142 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0142 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0142 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0142 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 mM | Inhibition of bovine brain PKC | ChEMBL. | 17609123 |
Inhibition (functional) | = 64.7 % | Antiinflammatory activity in Kunming mouse assessed as inhibition of xylene-induced ear edema at 20 mg/kg, po after 24 hrs | ChEMBL. | 17609123 |
Inhibition (functional) | = 64.7 % | Antiinflammatory activity in Kunming mouse assessed as inhibition of xylene-induced ear edema at 20 mg/kg, po after 24 hrs | ChEMBL. | 17609123 |
Time (ADMET) | = 118.7 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 60 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 118.7 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 60 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 118.9 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 45 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 118.9 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 45 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 119 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 30 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 119 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 30 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 119.6 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 90 mins | ChEMBL. | 17609123 |
Time (ADMET) | = 119.6 s | Gastrointestinal toxicity in mouse assessed as tail bleeding time at 200 mg/kg, po after 90 mins | ChEMBL. | 17609123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.