Detailed information for compound 452915

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.847 | Formula: C20H21ClN2O
  • H donors: 2 H acceptors: 1 LogP: 3.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C20H21ClN2O/c21-17-5-3-4-16(12-17)20(24)8-10-23(11-9-20)14-15-13-22-19-7-2-1-6-18(15)19/h1-7,12-13,22,24H,8-11,14H2
  • InChiKey: KGPBZECHWRAGLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens dopamine receptor D4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.001 0.0019 0.0538
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0009 0.0015 0.0221
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0015 0.1106
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0138 0.391
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0012 0.0178
Onchocerca volvulus 0.001 0.0019 0.075
Mycobacterium ulcerans epoxide hydrolase EphA 0.0055 0.0158 0.0151
Onchocerca volvulus Putative organic anion transporter 0.0015 0.0034 0.1372
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0012 0.0336
Echinococcus granulosus carbonic anhydrase II 0.0018 0.0043 0.1226
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0138 0.5661
Brugia malayi ORL1-like opioid receptor 0.0049 0.0138 0.207
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.3246
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0138 0.207
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0007 0.0008 0.0114
Trypanosoma brucei DNA polymerase eta, putative 0.0007 0.0008 0.0526
Brugia malayi Protein kinase domain containing protein 0.0005 0.0003 0.0041
Brugia malayi Death domain containing protein 0.0005 0.0002 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0012 0.0178
Onchocerca volvulus 0.0049 0.0138 0.5661
Schistosoma mansoni organic anion transporter 0.0015 0.0034 0.2478
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0012 0.086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0012 0.0336
Onchocerca volvulus 0.0049 0.0138 0.5661
Onchocerca volvulus Protein ultraspiracle homolog 0.0008 0.0012 0.045
Onchocerca volvulus Bile acid receptor homolog 0.0008 0.0012 0.045
Echinococcus granulosus lamin dm0 0.0017 0.0039 0.1104
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0138 1
Echinococcus granulosus death domain containing protein 0.0005 0.0002 0.0064
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0138 0.207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0012 0.0178
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0041 0.3246
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0179
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Onchocerca volvulus 0.0015 0.0034 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0014 0.0543
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0138 0.207
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0012 0.0025 0.0978
Brugia malayi follicle stimulating hormone receptor 0.0129 0.0386 0.5803
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0014 0.0543
Trypanosoma brucei unspecified product 0.0007 0.0008 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.3231 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0017 0.0039 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0012 0.0178
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0138 0.391
Onchocerca volvulus 0.0015 0.0034 0.1372
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0044 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.001 0.0019 0.0538
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0005 0.0001 0.0027
Giardia lamblia DINP protein human, muc B family 0.0007 0.0008 0.5
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0012 0.086
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0138 0.391
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0014 0.1065
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0005 0.0002 0.0064
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0015 0.0034 0.0969
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.001 0.0019 0.1377
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0138 0.391
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.001 0.0019 0.1377
Echinococcus multilocularis expressed protein 0.001 0.0019 0.0542
Echinococcus granulosus hypothetical protein 0.0049 0.0138 0.391
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0138 0.391
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0138 0.207
Schistosoma mansoni cellular tumor antigen P53 0.0017 0.004 0.2922
Echinococcus granulosus allatostatin A receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0012 0.0025 0.037
Echinococcus granulosus cathepsin L cysteine proteinase 0.0005 0.0001 0.0027
Trichomonas vaginalis adenylate cyclase, putative 0.0009 0.0014 0.0543
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0138 0.391
Echinococcus granulosus carbonic anhydrase 0.0018 0.0043 0.1226
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0138 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0021 0.161
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0014 0.0543
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0011 0.0021 0.4727
Brugia malayi putative neuropeptide receptor 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0007 0.0008 0.055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0114
Echinococcus granulosus neuropeptide receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0012 0.0178
Echinococcus multilocularis carbonic anhydrase 0.0018 0.0043 0.1226
Brugia malayi hypothetical protein 0.0015 0.0034 0.0513
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Echinococcus multilocularis serotonin receptor 0.0049 0.0138 0.391
Schistosoma mansoni amine GPCR 0.0049 0.0138 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0138 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0018 0.0043 0.3427
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.001 0.0019 0.4264
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0008 0.0526
Echinococcus multilocularis mitogen activated protein kinase 14 0.0044 0.0124 0.3524
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0021 0.0594
Brugia malayi Dopamine receptor 0.0049 0.0138 0.207
Onchocerca volvulus 0.0049 0.0138 0.5661
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0138 0.391
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0138 0.391
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Toxoplasma gondii hypothetical protein 0.0018 0.0043 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0138 1
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0039 0.0585
Schistosoma mansoni neuropeptide receptor 0.0049 0.0138 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0044 0.0124 0.3524
Schistosoma mansoni transcription factor LCR-F1 0.0025 0.0065 0.4688
Echinococcus granulosus orexin receptor type 2 0.0049 0.0138 0.391
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0039 0.0585
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0165
Echinococcus multilocularis sex peptide receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Onchocerca volvulus 0.0049 0.0138 0.5661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0287
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0021 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni amine GPCR 0.0049 0.0138 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0138 0.391
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0009 0.0014 0.04
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0018 0.0043 0.3135
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.001 0.0019 0.0287
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0138 1
Onchocerca volvulus 0.001 0.0019 0.0745
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0287
Onchocerca volvulus 0.0025 0.0065 0.2635
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0138 0.391
Onchocerca volvulus 0.0008 0.0012 0.045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0012 0.086
Trichomonas vaginalis guanylate cyclase, putative 0.0009 0.0014 0.0543
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus single minded 2 0.0025 0.0065 0.1835
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Leishmania major protein kinase, putative 0.0009 0.0015 0.1106
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0008 0.0012 0.0338
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0138 0.391
Brugia malayi sodium-independent organic anion transporter family protein 0.0015 0.0034 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.001 0.0019 0.4295
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.001 0.0019 0.4295
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0138 0.207
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0073 0.0211 0.3178
Entamoeba histolytica replication factor A protein 1, putative 0.0005 0.0003 0.0322
Leishmania major DNA polymerase kappa, putative 0.0007 0.0008 0.0536
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0138 0.207
Echinococcus multilocularis mitogen activated protein kinase 11 0.0044 0.0124 0.3524
Echinococcus granulosus g protein coupled receptor 0.0049 0.0138 0.391
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.001 0.0019 0.4295
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0138 0.391
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0015 0.1106
Loa Loa (eye worm) agrin synaptic family protein 0.001 0.0019 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0138 1
Brugia malayi ecdysteroid receptor 0.0008 0.0012 0.0178
Onchocerca volvulus 0.0017 0.0039 0.157
Brugia malayi Pre-SET motif family protein 0.0073 0.0211 0.3178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0007 0.0008 0.0215
Schistosoma mansoni follistatin 0.001 0.0019 0.1386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0138 0.391
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0015 0.0034 0.0969
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0138 0.391
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0014 0.0543
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni cathepsin F (C01 family) 0.0005 0.0001 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0012 0.0178
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0138 0.391
Echinococcus multilocularis transfer RNA-Lys 0.0025 0.0065 0.1835
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0016 0.0036 0.2864
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0018 0.0043 0.0649
Brugia malayi Melatonin receptor type 1A 0.0049 0.0138 0.207
Echinococcus granulosus aryl hydrocarbon receptor 0.0009 0.0014 0.04
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0138 0.391
Echinococcus granulosus carbonic anhydrase 0.0018 0.0043 0.1226
Schistosoma mansoni amine GPCR 0.0049 0.0138 1
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Onchocerca volvulus 0.0049 0.0138 0.5661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0012 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0026 0.0066 0.188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.001 0.0019 0.1377
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.001 0.0019 0.1377
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0138 0.391
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0012 0.0023 0.0901
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0138 0.391
Brugia malayi hypothetical protein 0.0114 0.034 0.5109
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0036
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0138 0.391
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0005 0.0002 0.0173
Echinococcus granulosus agrin 0.001 0.0019 0.0542
Schistosoma mansoni carbonic anhydrase-related 0.0018 0.0043 0.3135
Loa Loa (eye worm) cysteine protease 0.0005 0.0001 0.0015
Entamoeba histolytica hypothetical protein 0.0025 0.0065 1
Brugia malayi steroid hormone receptor 0.0008 0.0012 0.0178
Schistosoma mansoni amine GPCR 0.0049 0.0138 1
Echinococcus granulosus g protein coupled receptor 0.0049 0.0138 0.391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Brugia malayi G-protein coupled receptor 0.0049 0.0138 0.207
Brugia malayi Dopamine receptor protein 2 0.0049 0.0138 0.207
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Dopamine receptor protein 1 0.0049 0.0138 0.207
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0138 0.207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0002 0.0034
Onchocerca volvulus 0.0017 0.0039 0.157
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0012 0.086
Loa Loa (eye worm) hypothetical protein 0.0219 0.0665 1
Schistosoma mansoni adenoreceptor 0.0049 0.0138 1
Schistosoma mansoni cathepsin F (C01 family) 0.0005 0.0001 0.007
Loa Loa (eye worm) carbonic anhydrase 3 0.0018 0.0043 0.0649
Onchocerca volvulus 0.0049 0.0138 0.5661
Onchocerca volvulus 0.0049 0.0138 0.5661
Onchocerca volvulus 0.0009 0.0014 0.0543
Echinococcus multilocularis agrin 0.001 0.0019 0.0542
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0018 0.0043 0.0649
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0012 0.0025 0.0698
Schistosoma mansoni carbonic anhydrase-related 0.0018 0.0043 0.3135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0138 0.391
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0041 0.3246
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0012 0.0178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Echinococcus multilocularis dna polymerase kappa 0.0007 0.0008 0.0215
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0138 0.391
Schistosoma mansoni hypothetical protein 0.0018 0.0043 0.3135
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0021 0.0594
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.3246
Schistosoma mansoni terminal deoxycytidyl transferase 0.0007 0.0008 0.055
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0021 0.162
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Schistosoma mansoni coup transcription factor 0.0008 0.0012 0.086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0014 0.0543
Echinococcus multilocularis follistatin 0.001 0.0019 0.0542
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0011 0.0021 1
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0138 0.391
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0021 0.0594
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0138 0.391
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0138 0.391
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0012 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Onchocerca volvulus 0.0049 0.0138 0.5661
Echinococcus multilocularis cathepsin L cysteine protease 0.0005 0.0001 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0138 0.391
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0012 0.0178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Trypanosoma brucei carbonic anhydrase-like protein 0.0018 0.0043 0.3419
Schistosoma mansoni agrin 0.001 0.0019 0.1386
Onchocerca volvulus 0.0049 0.0138 0.5661
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis dna polymerase eta 0.0007 0.0008 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni DNA polymerase eta 0.0007 0.0008 0.055
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0138 0.391
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0008 0.0536
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0138 0.391
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0138 0.391
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.3231 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0212
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Schistosoma mansoni hypothetical protein 0.0025 0.0065 0.4688
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Onchocerca volvulus 0.0015 0.0034 0.1372
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0009 0.0014 0.0543
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0012 0.0336
Echinococcus multilocularis cysteine protease 0.0005 0.0001 0.0027
Echinococcus multilocularis mitogen activated protein kinase 14 0.0044 0.0124 0.3524
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Brugia malayi ImpB/MucB/SamB family protein 0.0007 0.0008 0.0114
Echinococcus multilocularis mitogen activated protein kinase 11 0.0044 0.0124 0.3524
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0138 0.391
Echinococcus multilocularis musashi 0.0017 0.0039 0.1104
Brugia malayi hypothetical protein 0.0025 0.0065 0.0971
Brugia malayi Uncoordinated protein 44 0.0005 0.0002 0.0034
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0018 0.0043 0.0649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0138 0.391
Trypanosoma cruzi Replication factor A protein 1 0.0006 0.0005 0.0318
Schistosoma mansoni aryl hydrocarbon receptor 0.0034 0.0092 0.6679
Echinococcus multilocularis carbonic anhydrase 0.0018 0.0043 0.1226
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0018 0.0043 0.0649
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0012 0.0178
Brugia malayi AKH receptor 0.0049 0.0138 0.207
Echinococcus granulosus lamin 0.0017 0.0039 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Echinococcus multilocularis cysteine protease 0.0005 0.0001 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0021 0.0594
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0138 0.391
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0138 0.391
Brugia malayi ImpB/MucB/SamB family protein 0.0007 0.0008 0.0114
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0018 0.0043 0.0649
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0007 0.0008 0.0273
Onchocerca volvulus 0.0049 0.0138 0.5661
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0012 0.0178
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Brugia malayi RE15519p 0.0049 0.0138 0.207
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0012 0.0336
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Trypanosoma cruzi major cysteine proteinase, putative 0.0014 0.0029 0.2304
Schistosoma mansoni histamine h1 receptor 0.0049 0.0138 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0138 1
Brugia malayi G protein-coupled receptor 0.0049 0.0138 0.207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0007 0.0008 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0008 0.0536
Brugia malayi small heat shock protein 0.0219 0.0665 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0021 0.0314
Loa Loa (eye worm) fibroinase 0.0005 0.0001 0.0015
Echinococcus multilocularis somatostatin receptor 0.0049 0.0138 0.391
Onchocerca volvulus 0.0049 0.0138 0.5661
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0044 0.0124 1
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0138 0.391
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0015 0.1106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Echinococcus granulosus fmrfamide receptor 0.0049 0.0138 0.391
Toxoplasma gondii protease inhibitor PI2 0.001 0.0019 0.4295
Brugia malayi hypoxia-induced factor 1 0.0105 0.0313 0.4697
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0138 0.391
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0006 0.0005 0.0162
Echinococcus granulosus dna polymerase kappa 0.0007 0.0008 0.0215
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0138 0.207
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0021 0.4727
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0138 1
Schistosoma mansoni biogenic amine receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Echinococcus multilocularis carbonic anhydrase 0.0018 0.0043 0.1226
Echinococcus multilocularis cathepsin L cysteine protease 0.0005 0.0001 0.0027
Echinococcus granulosus g protein coupled receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) ctsf protein 0.0005 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0012 0.0178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0138 0.391
Brugia malayi GnHR receptor homolog 0.0049 0.0138 0.207
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.001 0.0019 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0138 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0007 0.0008 0.1038
Echinococcus multilocularis carbonic anhydrase II 0.0018 0.0043 0.1226
Onchocerca volvulus 0.0049 0.0138 0.5661
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0012 0.0178
Onchocerca volvulus Putative organic anion transporter 0.0015 0.0034 0.1372
Trichomonas vaginalis DNA polymerase eta, putative 0.0007 0.0008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0012 0.086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0012 0.086
Schistosoma mansoni opsin-like receptor 0.0049 0.0138 1
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0138 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0138 1
Schistosoma mansoni netrin receptor unc5 0.0005 0.0002 0.0164
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0138 0.391
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0138 0.391
Echinococcus multilocularis lamin 0.0017 0.0039 0.1104
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi replication factor A 73 kDa subunit 0.0012 0.0025 0.037
Schistosoma mansoni replication factor A 1 rfa1 0.0012 0.0025 0.1785
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0018 0.0043 0.3135
Schistosoma mansoni neuropeptide receptor 0.0049 0.0138 1
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0018 0.0043 0.0649
Schistosoma mansoni intermediate filament proteins 0.0017 0.0039 0.2823
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0138 0.391
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Echinococcus granulosus dna polymerase eta 0.0007 0.0008 0.0215
Brugia malayi hypothetical protein 0.0015 0.0034 0.0513
Echinococcus granulosus carbonic anhydrase 0.0018 0.0043 0.1226
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0008 0.0012 0.045
Schistosoma mansoni hypothetical protein 0.0049 0.0138 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0012 0.0178
Brugia malayi isocitrate dehydrogenase 0.0011 0.0021 0.0314
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0005 0.0002 0.0064
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0041 0.3246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0012 0.0336
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0138 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0044 0.0124 0.3524
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0649
Trichomonas vaginalis guanylate cyclase, putative 0.0009 0.0014 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0008 0.0536
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0025 0.0065 0.1833
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0014 0.1065
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Brugia malayi prostaglandin transporter 0.0015 0.0034 0.0513
Brugia malayi sulfakinin receptor protein 0.0049 0.0138 0.207
Echinococcus multilocularis aryl hydrocarbon receptor 0.0009 0.0014 0.04
Onchocerca volvulus 0.0049 0.0138 0.5661
Schistosoma mansoni biogenic amine receptor 0.0049 0.0138 1
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0138 0.391
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0138 0.391
Leishmania major protein kinase, putative 0.0009 0.0015 0.1106
Onchocerca volvulus 0.0049 0.0138 0.5661
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.001 0.0019 0.0287
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0138 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Echinococcus granulosus Ankyrin 0.0005 0.0002 0.0068
Brugia malayi Pre-SET motif family protein 0.001 0.0019 0.0285
Echinococcus multilocularis tumor protein p63 0.0118 0.0352 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.034 0.5109
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0138 0.207
Mycobacterium leprae Isocitrate lyase 0.1515 0.468 0.4673
Schistosoma mansoni neuropeptide receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0006 0.0005 0.0927
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0021 0.161
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0138 0.391
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.001 0.0018 0.0505
Trypanosoma brucei Replication factor A protein 1 0.0006 0.0005 0.0307
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0012 0.086
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0012 0.0025 0.0698
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0138 0.391
Schistosoma mansoni biogenic amine receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi P38 map kinase family protein 2 0.0044 0.0124 0.1866
Onchocerca volvulus 0.0015 0.0034 0.1372
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0015 0.0034 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Echinococcus granulosus neuropeptide receptor 0.0049 0.0138 0.391
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0138 0.5661
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0014 0.1065
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0009 0.0014 0.0543
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.3231 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0018 0.0043 0.0649
Brugia malayi cytoplasmic intermediate filament protein 0.0009 0.0015 0.0221
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0138 0.207
Brugia malayi neuropeptide F receptor 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus Solute carrier organic anion transporter family 0.0015 0.0034 0.0969
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0138 0.391
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0285
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.001 0.0019 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0138 1
Echinococcus granulosus netrin receptor unc 5 0.0005 0.0002 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi secreted modular calcium-binding protein 1 0.001 0.0019 0.0287
Echinococcus granulosus sex peptide receptor 0.0049 0.0138 0.391
Schistosoma mansoni opsin-like receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0178
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0021 0.0594
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0138 0.391
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0005 0.0001 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Schistosoma mansoni hypothetical protein 0.0049 0.0138 1
Schistosoma mansoni organic anion transporter 0.0015 0.0034 0.2478
Leishmania major DNA polymerase eta, putative 0.0007 0.0008 0.0536
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0138 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0138 0.391
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0011 0.0021 0.0813
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0287
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0138 0.391
Mycobacterium ulcerans putative regulatory protein 0.0025 0.0065 0.0057
Leishmania major replication factor A, 51kDa subunit, putative 0.0006 0.0005 0.0318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0008 0.0536
Brugia malayi neuropeptide F receptor 0.0049 0.0138 0.207
Schistosoma mansoni carbonic anhydrase 0.0018 0.0043 0.3135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Plasmodium falciparum carbonic anhydrase 0.0018 0.0043 1
Schistosoma mansoni single-minded 0.0034 0.0092 0.6679
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0138 0.391
Brugia malayi Serotonin receptor 0.0049 0.0138 0.207
Echinococcus granulosus nuclear factor of activated T cells 5 0.0026 0.0066 0.188
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0138 0.391
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0138 0.391
Mycobacterium ulcerans isocitrate lyase Icl 0.3231 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0012 0.0336
Leishmania major carbonic anhydrase-like protein 0.0018 0.0043 0.3427
Brugia malayi G-protein coupled receptor 0.0049 0.0138 0.207
Trypanosoma cruzi MFS transporter, putative 0.0015 0.0034 0.2692
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0649
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0138 0.207
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0012 0.086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Echinococcus granulosus histone lysine methyltransferase setb 0.001 0.0019 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0012 0.0178
Onchocerca volvulus Putative organic anion transporter 0.0015 0.0034 0.1372
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0021 0.162
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0011 0.0021 0.0013
Mycobacterium ulcerans isocitrate lyase AceAb 0.3231 1 1
Brugia malayi SPARC precursor 0.001 0.0019 0.0287
Schistosoma mansoni neuropeptide receptor 0.0049 0.0138 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0138 0.391
Schistosoma mansoni myosin xvIII 0.0049 0.0138 1
Echinococcus multilocularis lamin dm0 0.0017 0.0039 0.1104
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus multilocularis netrin receptor unc 5 0.0005 0.0002 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0012 0.0178
Schistosoma mansoni lamin 0.0017 0.0039 0.2823
Trichomonas vaginalis set domain proteins, putative 0.0083 0.0242 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0138 1
Brugia malayi Papain family cysteine protease containing protein 0.0005 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0585
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0012 0.086
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0605
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0012 0.0336
Brugia malayi sodium-independent organic anion transporter family protein 0.0015 0.0034 0.0513
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0012 0.0178
Schistosoma mansoni opsin-like receptor 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0034
Brugia malayi sodium-independent organic anion transporter family protein 0.0015 0.0034 0.0513
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0012 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0012 0.0178
Entamoeba histolytica hypothetical protein 0.0025 0.0065 1
Schistosoma mansoni ankyrin 23/unc44 0.0005 0.0002 0.0164
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0138 0.391
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0055 0.0158 0.0151
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0001 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0012 0.086
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0138 0.391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Brugia malayi bHLH-PAS transcription factor 0.0025 0.0065 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0012 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0041 0.3239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0015 0.0034 0.0969
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0129 0.0386 0.5803
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0012 0.0336
Onchocerca volvulus Netrin receptor homolog 0.0005 0.0002 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0287
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0021 0.1519
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0005 0.0001 0.0015
Brugia malayi PAS domain containing protein 0.0034 0.0092 0.1383
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0044 0.0124 1
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0008 0.0526
Echinococcus multilocularis serotonin receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0012 0.0178
Echinococcus granulosus serotonin receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0012 0.0178
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0138 0.207
Schistosoma mansoni hypothetical protein 0.0049 0.0138 1
Brugia malayi Cathepsin L-like precursor 0.0005 0.0001 0.0015
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0044 0.0124 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0021 0.162
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0138 1
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0012 0.0336
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0138 0.391
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0021 0.4727
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0044 0.0124 0.1866
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0009 0.0014 0.0543
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0138 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0005 0.0002 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0138 0.207
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0018 0.0043 0.0649
Schistosoma mansoni amine GPCR 0.0049 0.0138 1
Echinococcus multilocularis Ankyrin 0.0005 0.0002 0.0068
Brugia malayi intermediate filament protein 0.0017 0.0039 0.0585
Entamoeba histolytica hypothetical protein 0.0025 0.0065 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0007 0.0008 0.0536
Schistosoma mansoni hypothetical protein 0.0049 0.0138 1
Echinococcus granulosus cathepsin l1 0.0005 0.0001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0513
Brugia malayi Serotonin receptor 0.0049 0.0138 0.207
Brugia malayi hypothetical protein 0.0049 0.0138 0.207
Brugia malayi nuclear hormone receptor 0.0008 0.0012 0.0178
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0138 0.207
Onchocerca volvulus 0.0017 0.004 0.1626
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0008 0.0012 0.0338
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0012 0.086
Echinococcus granulosus tumor protein p63 0.0118 0.0352 1
Onchocerca volvulus 0.0083 0.0243 1
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0012 0.0336
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0138 0.391
Echinococcus granulosus intermediate filament protein 0.0017 0.0039 0.1104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0021 0.0594
Plasmodium vivax SET domain protein, putative 0.001 0.0019 0.9019
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0138 0.391
Plasmodium falciparum replication protein A1, large subunit 0.0006 0.0005 0.0927
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0165
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0034 0.7857
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0138 0.391
Plasmodium vivax replication protein A1, large subunit, putative 0.0006 0.0005 0.1961
Onchocerca volvulus 0.0049 0.0138 0.5661
Loa Loa (eye worm) hypoxia-induced factor 1 0.0105 0.0313 0.4697
Schistosoma mansoni hypothetical protein 0.0005 0.0002 0.0164
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0009 0.0014 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0007 0.0008 0.0536
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0012 0.0025 0.0978
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Brugia malayi larval opioid receptor 0.0049 0.0138 0.207
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0008 0.0526
Onchocerca volvulus 0.0049 0.0138 0.5661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0138 1
Schistosoma mansoni carbonic anhydrase-related 0.0018 0.0043 0.3135
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0138 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0009 0.0014 0.0212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0025 0.0065 0.1833
Schistosoma mansoni lamin 0.0017 0.0039 0.2823
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.001 0.0019 0.0287
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Onchocerca volvulus 0.0049 0.0138 0.5661
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0138 0.391
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0138 0.207
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0041 0.3246
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.001 0.0019 0.4295
Echinococcus granulosus cathepsin l cysteine peptidase 0.0005 0.0001 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0012 0.0178
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0138 0.391
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0012 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0012 0.0178
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0138 0.207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.207
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0138 0.391
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0018 0.0043 0.3427
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0526
Echinococcus granulosus follistatin 0.001 0.0019 0.0542
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0009 0.0014 0.04
Brugia malayi nuclear receptor NHR-88 0.0008 0.0012 0.0178
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0138 0.391
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0018 0.0043 0.0649
Onchocerca volvulus 0.0015 0.0034 0.1372
Entamoeba histolytica hypothetical protein 0.0025 0.0065 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0015 0.1106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.057
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.3246
Echinococcus granulosus somatostatin receptor 0.0049 0.0138 0.391

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis ChEMBL. 17095222
EC50 (functional) 0 Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis ChEMBL. 17095222
EC50 (functional) = 83.4 nM Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis ChEMBL. 17095222
EC50 (functional) = 83.4 nM Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis ChEMBL. 17095222
Ki (binding) = 129 nM Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells ChEMBL. 17095222
Ki (binding) = 129 nM Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells ChEMBL. 17095222
Ki (binding) = 450 nM Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells ChEMBL. 17095222
Ki (binding) = 450 nM Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells ChEMBL. 17095222
Ki (binding) = 3540 nM Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells ChEMBL. 17095222
Ki (binding) = 3540 nM Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells ChEMBL. 17095222
Ratio Ki (binding) = 3 Selectivity for human dopamine D2L receptor over human dopamine D3 receptor ChEMBL. 17095222
Ratio Ki (binding) = 27 Selectivity for human dopamine D2L receptor over human dopamine D4 receptor ChEMBL. 17095222

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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