Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0098 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.2104 | 0.9749 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2058 | 0.9524 | 0.977 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2104 | 0.9749 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 4.3 | Relative binding affinity for the calf uterine estrogen receptor measured as the ratio of molar concentration of 17-beta-estradiol (E2) and inhibitor required to decrease the amount of bound [3H]-E2 by 50% | ChEMBL. | 6492074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.