TDR Targets

Basic information

Technical information

TDR Targets ID: 453094
Name: 6-[4-(morpholin-4-ylmethyl)phenyl]-5-phenyl-N -(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin- 4-amine
MW: 498.619 | Formula: C29H34N6O2
H donors: 2 H acceptors: 2 LogP: 3.39 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N1CCN(CC1)CCNc1ncnc2c1c(c1ccccc1)c(o2)c1ccc(cc1)CN1CCOCC1
InChi: 1S/C29H34N6O2/c1-2-4-23(5-3-1)25-26-28(31-12-15-34-13-10-30-11-14-34)32-21-33-29(26)37-27(25)24-8-6-22(7-9-24)20-35-16-18-36-19-17-35/h1-9,21,30H,10-20H2,(H,31,32,33)
InChiKey: YKMSWECJITXGJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[4-(morpholinomethyl)phenyl]-5-phenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine
6-[4-(morpholinomethyl)phenyl]-5-phenyl-N-[2-(1-piperazinyl)ethyl]-4-furo[2,3-d]pyrimidinamine
[6-[4-(morpholinomethyl)phenyl]-5-phenyl-furo[2,3-d]pyrimidin-4-yl]-(2-piperazinoethyl)amine
6-[4-(morpholin-4-ylmethyl)phenyl]-5-phenyl-N-(2-piperazin-1-ylethyl)furo[4,5-e]pyrimidin-4-amine
6-[4-(morpholinomethyl)phenyl]-5-phenyl-N-(2-piperazin-1-ylethyl)furo[4,5-e]pyrimidin-4-amine
6-[4-(morpholinomethyl)phenyl]-5-phenyl-N-[2-(1-piperazinyl)ethyl]-4-furo[4,5-e]pyrimidinamine
[6-[4-(morpholinomethyl)phenyl]-5-phenyl-furo[4,5-e]pyrimidin-4-yl]-(2-piperazin-1-ylethyl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tyrosine kinase, non-receptor, 2	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	activated cdc42 kinase 1	Get druggable targets OG5_131365	All targets in OG5_131365
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131365	All targets in OG5_131365
Schistosoma japonicum	IPR011009,Protein kinase-like;IPR010993,Sterile alpha motif homology;IPR000719,Protein kinase;IPR015779,ACK tyrosine protein ki	Get druggable targets OG5_131365	All targets in OG5_131365
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_131365	All targets in OG5_131365
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131365	All targets in OG5_131365
Echinococcus multilocularis	activated cdc42 kinase 1	Get druggable targets OG5_131365	All targets in OG5_131365
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131365	All targets in OG5_131365
Echinococcus granulosus	activated cdc42 kinase 1	Get druggable targets OG5_131365	All targets in OG5_131365
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131365	All targets in OG5_131365
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131365	All targets in OG5_131365
Echinococcus multilocularis	transfer RNA-Thr	Get druggable targets OG5_131365	All targets in OG5_131365
Echinococcus multilocularis	protein KINase family member (kin 25)	Get druggable targets OG5_131365	All targets in OG5_131365
Schistosoma japonicum	Activated CDC42 kinase 2, putative	Get druggable targets OG5_131365	All targets in OG5_131365
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131365	All targets in OG5_131365
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131365	All targets in OG5_131365

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0198	0.0203
Brugia malayi	SH2 domain containing protein	0.0007	0.0021	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0198	0.0203
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0198	0.0645
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0198	0.024
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0079	0.3072	0.3722
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0011	0.0208	0.0252
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0079	0.3072	0.3722
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0021	0.0021
Echinococcus granulosus	tyrosine protein kinase shark	0.0007	0.0021	0.0025
Schistosoma mansoni	tyrosine kinase	0.0011	0.0208	0.0677
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0198	0.024
Echinococcus granulosus	activated cdc42 kinase 1	0.0202	0.8253	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0198	0.024
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0198	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0198	0.0203
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Brugia malayi	steroid hormone receptor	0.0011	0.0198	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0021	0.0021
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0021	0.0021
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0007	0.0021	0.0025
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0198	0.024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0198	0.024
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3072	0.315
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0111	0.0114
Loa Loa (eye worm)	TK/ABL protein kinase	0.0007	0.0021	0.0021
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0198	0.024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Echinococcus multilocularis	activated cdc42 kinase 1	0.0202	0.8253	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0011	0.0192	0.0625
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0198	0.0203
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0198	0.024
Schistosoma mansoni	tyrosine kinase	0.0009	0.0102	0.0331
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0198	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0198	0.0203
Echinococcus multilocularis	c src tyrosine kinase	0.0011	0.0208	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Onchocerca volvulus		0.0007	0.0021	0.0021
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0111	0.0114
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0111	0.0361
Schistosoma mansoni	adapter molecule crk	0.0009	0.0111	0.0361
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0011	0.0208	0.0252
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Loa Loa (eye worm)	TK protein kinase	0.0007	0.0021	0.0021
Schistosoma mansoni	tyrosine kinase	0.0007	0.0021	0.0068
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2975	0.305
Onchocerca volvulus		0.0011	0.0198	0.0198
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0198	0.0645
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0198	0.0203
Brugia malayi	hypothetical protein	0.0007	0.0021	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0011	0.0208	0.0252
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0007	0.0021	0.0025
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0111	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0232	0.9533	0.9774
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0007	0.0021	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0198	0.0203
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0011	0.0208	0.0252
Leishmania major	hypothetical protein, conserved	0.0006	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0011	0.0208	0.0677
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0011	0.0208	0.0252
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0198	0.0645
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0198	0.0645
Onchocerca volvulus		0.0007	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0198	0.0203
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0007	0.0021	0.0025
Echinococcus granulosus	tyrosine kinase	0.0007	0.0021	0.0025
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0007	0.0021	0.0025
Echinococcus granulosus	tyrosine protein kinase Srms	0.0007	0.0021	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0198	0.0203
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0198	0.024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Brugia malayi	ecdysteroid receptor	0.0011	0.0198	0.0203
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0198	0.0645
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0198	0.0203
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0011	0.0208	0.0252
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Schistosoma mansoni	nck2/grb4	0.0009	0.0111	0.0361
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0198	0.0203
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0011	0.0208	0.0252
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0198	0.024
Schistosoma mansoni	tyrosine kinase	0.0011	0.0208	0.0677
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0111	0.0114
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0007	0.0021	0.0025
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0198	0.0645
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0198	0.0645
Brugia malayi	nuclear hormone receptor	0.0237	0.9754	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0111	0.0135
Echinococcus granulosus	growth factor receptor bound protein 2	0.0011	0.0192	0.0233
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0198	0.0203
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0011	0.0208	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0202	0.8253	0.8461
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0011	0.0208	0.0252
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0237	0.9754	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0011	0.0208	0.0252
Echinococcus multilocularis	tyrosine protein kinase shark	0.0007	0.0021	0.0025
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0198	0.024
Brugia malayi	SRC-1	0.0011	0.0208	0.0213
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0021	0.0021
Onchocerca volvulus		0.0007	0.0021	0.0021
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0011	0.0208	0.0252
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0007	0.0021	0.0025
Brugia malayi	nuclear hormone receptor	0.0011	0.0198	0.0203
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2975	0.305
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Echinococcus granulosus	c src tyrosine kinase	0.0011	0.0208	0.0252
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0198	0.0203
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0198	0.0203
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0198	0.0203
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0198	0.024
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0011	0.0208	0.0252
Onchocerca volvulus		0.0007	0.0021	0.0021
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0198	0.024
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0198	0.0203
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0111	0.0135
Schistosoma mansoni	tyrosine kinase	0.0011	0.0208	0.0677
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0198	0.024
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0198	0.024
Echinococcus granulosus	tyrosine protein kinase Blk	0.0007	0.0021	0.0025
Schistosoma mansoni	tyrosine kinase	0.0079	0.3072	1
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0198	0.024
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0006	0.0005	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0202	0.8253	0.8461
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0198	0.0198
Schistosoma mansoni	tyrosine kinase	0.0011	0.0208	0.0677
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0198	0.0645
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0198	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0011	0.0208	0.0252
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0198	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0198	0.0203
Echinococcus multilocularis	NCK adaptor protein	0.0011	0.0192	0.0233
Echinococcus multilocularis	transfer RNA-Thr	0.0202	0.8253	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.8156	0.8362
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0198	0.0645
Echinococcus granulosus	activated cdc42 kinase 1	0.0202	0.8253	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0198	0.0203
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0011	0.0208	0.0252
Echinococcus multilocularis	tyrosine kinase	0.0007	0.0021	0.0025
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0111	0.0114
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0021	0.0021
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0198	0.024
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0006	0.0005	0.0006
Onchocerca volvulus		0.0007	0.0021	0.0021
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0007	0.0021	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0111	0.0114
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0198	0.024
Echinococcus granulosus	tyrosine kinase	0.0007	0.0021	0.0025
Onchocerca volvulus		0.0007	0.0021	0.0021
Schistosoma mansoni	coup transcription factor	0.0011	0.0198	0.0645
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0198	0.0645
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0198	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0016	0.0052
Loa Loa (eye worm)	SRC-1	0.0011	0.0208	0.0213
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0198	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0198	0.0203
Brugia malayi	protein-tyrosine kinase	0.0007	0.0021	0.0021
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0111	0.0114
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0198	0.0645
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0198	0.0203
Brugia malayi	Tyrosine-protein kinase abl-1	0.0011	0.0208	0.0213
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0021	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0198	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0198	0.0203
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0011	0.0208	0.0252
Brugia malayi	SH2 domain containing protein	0.0007	0.0021	0.0021
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0198	0.0198

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.027 uM	Inhibition of Lck	ChEMBL.	17280833
IC50 (binding)	= 0.027 uM	Inhibition of Lck	ChEMBL.	17280833
IC50 (binding)	= 0.091 uM	Inhibition of Ack1	ChEMBL.	17280833
IC50 (binding)	= 0.091 uM	Inhibition of Ack1	ChEMBL.	17280833
IC50 (functional)	= 0.138 uM	Inhibition of T cell activation in human mixed lymphocyte reaction	ChEMBL.	17280833
Ratio IC50 (binding)	= 4	Selectivity for Lck over Ack1	ChEMBL.	17280833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL248080
PubChem: 11620266

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 453094