Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0.1093 | 0.5 |
Onchocerca volvulus | 0.0022 | 0.1093 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0333 | 0.0333 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.2912 | 0.2912 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.1093 | 0.1093 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.2912 | 0.2912 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.1093 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.1093 | 0.1093 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.1093 | 0.4089 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0.1093 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2673 | 1 |
Onchocerca volvulus | 0.0022 | 0.1093 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1093 | 0.1093 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.3245 | 0.3245 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1093 | 0.1093 |
Onchocerca volvulus | 0.0022 | 0.1093 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.1093 | 0.1093 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0333 | 0.0333 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.2912 | 0.2912 |
Brugia malayi | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.1093 | 0.1093 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.1093 | 0.1093 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2673 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1093 | 0.1093 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.1093 | 0.1093 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0.1093 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.3245 | 0.3245 |
Onchocerca volvulus | 0.0022 | 0.1093 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0333 | 0.0333 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.2912 | 0.2912 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.1093 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1093 | 0.1093 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.1093 | 0.4089 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1093 | 0.1093 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.1093 | 0.1093 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0333 | 0.0333 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.023 uM | Displacement of [125I]MCH from MCHR1 expressed in IMR32 cells | ChEMBL. | 17350253 |
IC50 (binding) | = 0.023 uM | Displacement of [125I]MCH from MCHR1 expressed in IMR32 cells | ChEMBL. | 17350253 |
IC50 (functional) | = 0.12 uM | Antagonist activity at MCHR1 assessed as inhibition of MCH-mediated calcium release in IMR32 cells | ChEMBL. | 17350253 |
IC50 (functional) | = 0.12 uM | Antagonist activity at MCHR1 assessed as inhibition of MCH-mediated calcium release in IMR32 cells | ChEMBL. | 17350253 |
IC50 (binding) | = 9.18 uM | Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane | ChEMBL. | 17350253 |
IC50 (binding) | = 9.18 uM | Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane | ChEMBL. | 17350253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.