Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0963 | 1 | 1 |
Giardia lamblia | CDC8 | 0.0074 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0458 | 0.432 | 0.432 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0458 | 0.432 | 0.432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0458 | 0.432 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0963 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0074 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0963 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0963 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0963 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0963 | 1 | 1 |
Onchocerca volvulus | 0.0963 | 1 | 1 | |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0074 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0074 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0963 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0458 | 0.432 | 0.432 |
Chlamydia trachomatis | thymidylate kinase | 0.0074 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.00000003 M | Ability to induce differentiation of human promyelocytic leukemia cell line HL-60 to mature granulocytes. | ChEMBL. | 2329565 |
ED50 (functional) | = 0.00000003 M | Ability to induce differentiation of human promyelocytic leukemia cell line HL-60 to mature granulocytes. | ChEMBL. | 2329565 |
Relative activity (functional) | = 13 | Relative activity against human promyelocytic leukemia HL-60 cells. | ChEMBL. | 2329565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.