Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.0225 | 0.3363 | 0.4918 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.008 | 0.0926 | 0.1272 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.008 | 0.0926 | 0.1354 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0226 | 0.3385 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0225 | 0.3363 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0537 | 0.8645 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0225 | 0.3363 | 0.4918 |
Giardia lamblia | Kinesin-5 | 0.008 | 0.0926 | 0.5 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0469 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.6838 | 1 |
Brugia malayi | hypothetical protein | 0.043 | 0.6838 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.3385 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0112 | 0.146 | 0.3423 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0469 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0112 | 0.146 | 0.3193 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.3385 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0112 | 0.146 | 0.1032 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0112 | 0.146 | 0.1204 |
Loa Loa (eye worm) | runx1 | 0.0054 | 0.0482 | 0.0706 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.3385 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0225 | 0.3363 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0618 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0567 | 0.0111 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.3385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.6838 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0567 | 0.0338 |
Schistosoma mansoni | dihydrofolate reductase | 0.0225 | 0.3363 | 0.3533 |
Schistosoma mansoni | lozenge | 0.0054 | 0.0482 | 0.0007 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0225 | 0.3363 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0567 | 0.0095 |
Echinococcus granulosus | dihydrofolate reductase | 0.0225 | 0.3363 | 0.3031 |
Entamoeba histolytica | kinesin, putative | 0.008 | 0.0926 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0225 | 0.3363 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0112 | 0.146 | 0.2135 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0567 | 0.0111 |
Schistosoma mansoni | kinesin eg-5 | 0.008 | 0.0926 | 0.055 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.3385 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0054 | 0.0482 | 0.0006 |
Brugia malayi | Kinesin motor domain containing protein | 0.008 | 0.0926 | 0.1354 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0567 | 0.0095 |
Onchocerca volvulus | 0.043 | 0.6838 | 1 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0225 | 0.3363 | 0.3031 |
Brugia malayi | Dihydrofolate reductase | 0.0225 | 0.3363 | 0.4918 |
Echinococcus granulosus | thymidylate synthase | 0.0112 | 0.146 | 0.1032 |
Brugia malayi | thymidylate synthase | 0.0112 | 0.146 | 0.2135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 92.5 uM | Inhibition of CETP in human plasma | ChEMBL. | 17331716 |
IC50 (binding) | = 92.5 uM | Inhibition of CETP in human plasma | ChEMBL. | 17331716 |
IC50 (binding) | = 93.4 uM | Inhibition of CETP in human plasma | ChEMBL. | 17331716 |
IC50 (binding) | = 93.4 uM | Inhibition of CETP in human plasma | ChEMBL. | 17331716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.