Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 120 nM | Inhibitory activity of the compound against cAMP production in CHO cells transfectedwith human A2B adenosine receptor | ChEMBL. | 14998332 |
IC50 (functional) | = 120 nM | Inhibitory activity of the compound against cAMP production in CHO cells transfectedwith human A2B adenosine receptor | ChEMBL. | 14998332 |
Ki (binding) | = 32 nM | Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells | ChEMBL. | 14998332 |
Ki (binding) | = 32 nM | Binding affinity of compound for displacement of [3H]-DPCPX binding in HEK-293 membranes expressing human A2B adenosine receptors | ChEMBL. | 14998332 |
Ki (binding) | = 32 nM | Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells | ChEMBL. | 14998332 |
Ki (binding) | = 32 nM | Binding affinity of compound for displacement of [3H]-DPCPX binding in HEK-293 membranes expressing human A2B adenosine receptors | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Binding affinity of compound for displacement of specific [3H]-ZM-241,385 binding at human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Binding affinity of compound for displacement of specific [3H]-MRE3008-F20 binding at human A3 receptors expressed in CHO cells | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Binding affinity of compound for displacement of specific [3H]-ZM-241,385 binding at human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ki (binding) | > 1000 nM | Binding affinity of compound for displacement of specific [3H]-MRE3008-F20 binding at human A3 receptors expressed in CHO cells | ChEMBL. | 14998332 |
Ratio (binding) | > 32 | Ratio of binding affinity of human A2A receptor to human A2B receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ratio (binding) | > 32 | Ratio of binding affinity of human A1 receptor to human A2B receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ratio (binding) | > 32 | Ratio of binding affinity of human A2A receptor to human A2B receptor expressed in CHO cells | ChEMBL. | 14998332 |
Ratio (binding) | > 32 | Ratio of binding affinity of human A3 receptor to human A2B receptor expressed in CHO cells | ChEMBL. | 14998332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.