Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isoprenylcysteine carboxyl methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.007 | 0.3975 | 0.4387 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.007 | 0.3975 | 0.3796 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0113 | 0.7116 | 0.7116 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0139 | 0.9061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2362 | 0.2362 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.007 | 0.3975 | 0.4387 |
Onchocerca volvulus | 0.0037 | 0.1518 | 1 | |
Brugia malayi | TAZ zinc finger family protein | 0.0109 | 0.6807 | 0.6807 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2362 | 0.2362 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.007 | 0.3975 | 0.4387 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.007 | 0.3975 | 0.3975 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.007 | 0.3975 | 0.3796 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.007 | 0.3975 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4003 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2188 | 0.2188 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0049 | 0.2369 | 0.2369 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0022 | 0.0398 | 0.0439 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0139 | 0.9061 | 0.9033 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.007 | 0.3975 | 0.5 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4203 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.007 | 0.3975 | 0.4203 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0139 | 0.9061 | 0.9481 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.007 | 0.3975 | 0.3796 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1233 | 0.1233 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.007 | 0.3975 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0152 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2362 | 0.2362 |
Echinococcus granulosus | CREB binding protein | 0.0109 | 0.6807 | 0.7106 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Loa Loa (eye worm) | CBP-B | 0.0077 | 0.4441 | 0.4441 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.007 | 0.3975 | 0.4387 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2362 | 0.2362 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0024 | 0.058 | 0.058 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4387 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0139 | 0.9061 | 1 |
Schistosoma mansoni | phospholipase C-like protein 2 plc-L2 | 0.0027 | 0.079 | 0.0518 |
Loa Loa (eye worm) | Plcb4 protein | 0.0036 | 0.145 | 0.145 |
Brugia malayi | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 0.9061 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1233 | 0.1233 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.007 | 0.3975 | 0.3796 |
Brugia malayi | phospholipase C homolog | 0.0027 | 0.079 | 0.079 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0139 | 0.9061 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4387 |
Onchocerca volvulus | 0.0037 | 0.1518 | 1 | |
Brugia malayi | hypothetical protein | 0.002 | 0.0288 | 0.0288 |
Brugia malayi | ThiF family protein | 0.0048 | 0.2362 | 0.2362 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0045 | 0.2137 | 0.1904 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.007 | 0.3975 | 1 |
Echinococcus multilocularis | RUN | 0.002 | 0.0288 | 0.0227 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.7734 | 0.8083 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0109 | 0.6807 | 0.6712 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.9554 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Echinococcus multilocularis | 1 phosphatidylinositol 4,5 bisphosphate | 0.0037 | 0.1518 | 0.1465 |
Echinococcus granulosus | CREB binding protein | 0.0069 | 0.3839 | 0.398 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0046 | 0.2188 | 0.1896 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0288 | 0.0237 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0022 | 0.0398 | 0.0439 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1777 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2428 | 0.2428 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.007 | 0.3975 | 0.4387 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0046 | 0.2185 | 0.2411 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.007 | 0.3975 | 0.4387 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0046 | 0.2188 | 0.1896 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0048 | 0.2362 | 0.2136 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0288 | 0.0237 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4387 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0288 | 0.0288 |
Schistosoma mansoni | phospholipase C beta | 0.0036 | 0.145 | 0.1196 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0022 | 0.0398 | 0.0398 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0048 | 0.2362 | 0.2365 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.007 | 0.3975 | 0.4387 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4003 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.007 | 0.3975 | 0.3937 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1233 | 0.0973 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.2184 | 0.1892 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.7734 | 0.772 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0024 | 0.0582 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.7734 | 0.7667 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0288 | 0.0227 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.007 | 0.3975 | 0.3017 |
Echinococcus multilocularis | CREB binding protein | 0.0076 | 0.4374 | 0.4339 |
Brugia malayi | hypothetical protein | 0.002 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0288 | 0.0288 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0109 | 0.6807 | 0.6712 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4003 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.007 | 0.3975 | 0.4122 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0046 | 0.2184 | 0.2236 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0022 | 0.0398 | 0.0439 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0046 | 0.2185 | 0.056 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2362 | 0.2362 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.007 | 0.3975 | 0.4387 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0046 | 0.2188 | 0.2239 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0046 | 0.2184 | 0.2411 |
Leishmania major | glyceraldehyde-3-phosphate dehydrogenase-like protein | 0.0046 | 0.2185 | 0.2411 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.3017 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4003 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0048 | 0.2362 | 0.2315 |
Brugia malayi | Variant SH3 domain containing protein | 0.0113 | 0.7116 | 0.7116 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0049 | 0.2369 | 0.2369 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0288 | 0.0237 |
Loa Loa (eye worm) | acetyltransferase | 0.0152 | 1 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0048 | 0.2362 | 0.2365 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0061 | 0.3276 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0022 | 0.0398 | 0.0439 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4003 |
Echinococcus granulosus | RUN | 0.002 | 0.0288 | 0.0237 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.3017 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 0.9061 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.007 | 0.3975 | 0.4387 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0139 | 0.9061 | 0.9061 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.007 | 0.3975 | 0.4387 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0046 | 0.2185 | 0.2411 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0046 | 0.2185 | 0.2411 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0046 | 0.2188 | 0.2139 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1518 | 0.1518 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.2184 | 0.1892 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.2362 | 0.2607 |
Echinococcus granulosus | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 0.0037 | 0.1518 | 0.1534 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0046 | 0.2188 | 0.2188 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0288 | 0.0288 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0022 | 0.0398 | 0.0439 |
Echinococcus multilocularis | 0.0139 | 0.9061 | 0.9055 | |
Brugia malayi | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | 0.0036 | 0.145 | 0.145 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.4387 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.007 | 0.3975 | 0.3017 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0048 | 0.2362 | 0.2423 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0046 | 0.2184 | 0.2162 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.007 | 0.3975 | 0.3937 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0288 | 0.0227 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.007 | 0.3975 | 0.4122 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.5044 | 0.4897 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0288 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1518 | 0.1518 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0046 | 0.2188 | 0.2188 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0288 | 0.0288 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0046 | 0.2184 | 0.2411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.