Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.2589 | 0.5535 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.2824 | 0.6071 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.2589 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.4547 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.2824 | 0.6071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3063 | 0.3063 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | 0.0024 | 0.4547 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.3063 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2589 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2589 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | 0.001 | 0.118 | 0.1878 | |
Brugia malayi | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0401 | 0.0401 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.4547 | 0.4547 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0401 | 0.0546 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.3063 | 0.6617 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0401 | 0.0546 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.4547 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.4547 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.118 | 0.118 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0401 | 0.0401 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.3063 | 0.6421 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0401 | 0.0546 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.4547 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0401 | 0.0546 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.2824 | 0.6071 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.118 | 0.1878 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.4547 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0401 | 0.0546 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.4547 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0401 | 0.0401 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.3063 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.2824 | 0.6071 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0401 | 0.0546 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0401 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.118 | 0.1878 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.118 | 0.1878 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.118 | 0.118 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3063 | 0.3063 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.2589 | 0.8218 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.0401 | 0.0401 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.2589 | 0.2589 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.3063 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.4547 | 0.4547 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.4547 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0401 | 0.0546 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.4547 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.4547 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.118 | 0.118 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.4547 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0401 | 0.0546 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.4547 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.2589 | 0.8218 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.4547 | 0.4547 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.4547 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3063 | 0.3063 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.4547 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.2589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.4547 | 0.4547 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0401 | 0.0401 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3063 | 0.3063 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0401 | 0.0546 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.4547 | 0.4547 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.118 | 0.118 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.4547 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0401 | 0.0401 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0401 | 0.0546 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 0.5277 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.4547 | 0.4547 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0401 | 0.0401 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0401 | 0.0546 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.4547 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3063 | 0.3063 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.4547 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0401 | 0.0401 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.4547 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.4547 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.118 | 0.118 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0401 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.