Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0422 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0422 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0422 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0422 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0422 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0422 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0422 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0422 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0422 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0422 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0422 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0422 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0422 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0422 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.06 ug ml-1 | Antimicrobial activity against rifampin-sensitive Staphylococcus aureus ATCC 29213 | ChEMBL. | 17070048 |
MIC (functional) | = 0.06 ug ml-1 | Antimicrobial activity against Arr-1 positive Mycobacterium smegmatis DSM 43756 | ChEMBL. | 17070048 |
MIC (functional) | = 0.06 ug ml-1 | Antimicrobial activity against Arr-1 negative Mycobacterium smegmatis DSM 43756Kml | ChEMBL. | 17070048 |
MIC (functional) | = 1 ug ml-1 | Antimicrobial activity against Arr-2 negative Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104P | ChEMBL. | 17070048 |
MIC (functional) | = 1 ug ml-1 | Antimicrobial activity against Arr-2 negative Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104P | ChEMBL. | 17070048 |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Arr-2 positive Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104 | ChEMBL. | 17070048 |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Arr-2 positive Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104 | ChEMBL. | 17070048 |
MIC (functional) | > 63 ug ml-1 | Antimicrobial activity against rifampin-resistant Staphylococcus aureus ATCC 29213 rpoB (His481Tyr) mutant | ChEMBL. | 17070048 |
MIC (functional) | = 63 ug ml-1 | Antimicrobial activity against Arr-2 negative Escherichia coli DH5alpha bearing pCTF104P | ChEMBL. | 17070048 |
MIC (functional) | = 63 ug ml-1 | Antimicrobial activity against Arr-2 negative Escherichia coli DH5alpha bearing pCTF104P | ChEMBL. | 17070048 |
MIC (functional) | > 250 ug ml-1 | Antimicrobial activity against Arr-2 positive Escherichia coli DH5alpha bearing pCTF104 | ChEMBL. | 17070048 |
MIC (functional) | > 250 ug ml-1 | Antimicrobial activity against Arr-2 positive Escherichia coli DH5alpha bearing pCTF104 | ChEMBL. | 17070048 |
Ratio (functional) | = 1 | Ratio of MIC for Arr-1 positive Mycobacterium smegmatis DSM 43756 to MIC for Arr-1 negative Mycobacterium smegmatis DSM 43756Kml | ChEMBL. | 17070048 |
Ratio (functional) | > 4 | Ratio of MIC for Arr-2 positive Escherichia coli DH5alpha bearing pCTF104 to MIC for Arr-2 negative Escherichia coli DH5alpha bearing pCTF104P | ChEMBL. | 17070048 |
Ratio (functional) | = 16 | Ratio of MIC for Arr-2 positive Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104 to MIC for Arr-2 negative Escherichia coli CGSC 5163 lpxC101 mutant bearing pCTV104P | ChEMBL. | 17070048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.