Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dipeptidyl peptidase IV | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 637 aa | 27.0 % | |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 789 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0416 | 0.484 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0559 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0559 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0416 | 0.484 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.05 | 0.7888 | 0.5907 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0416 | 0.484 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.05 | 0.7888 | 0.5907 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0281 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | nuclear receptor NHR-88 | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0559 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | FTZ F1 alpha | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.05 | 0.7888 | 0.5907 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0416 | 0.484 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | thyroid hormone receptor | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | coup transcription factor | 0.05 | 0.7888 | 0.5907 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0416 | 0.484 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0559 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.05 | 0.7888 | 0.5907 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0559 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | nuclear hormone receptor | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | FTZ F1 alpha | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.05 | 0.7888 | 0.5907 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.05 | 0.7888 | 0.5907 |
Schistosoma mansoni | thyroid hormone receptor | 0.05 | 0.7888 | 0.5907 |
Brugia malayi | ecdysteroid receptor | 0.05 | 0.7888 | 0.5907 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.05 | 0.7888 | 0.5907 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 1.6 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 1.6 nmol/L | Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry | ChEMBL. | 22824762 |
IC50 (binding) | = 1.6 nmol/L | Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | ChEMBL. | 22959556 |
IC50 (binding) | = 2.2 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 2.2 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 12 nmol/L | Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | ChEMBL. | 22959556 |
IC50 (binding) | = 12.2 nmol/L | Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometry | ChEMBL. | 22824762 |
IC50 (binding) | = 30 nmol/L | Inhibition of human DPP9 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | ChEMBL. | 22959556 |
IC50 (binding) | = 30.2 nmol/L | Inhibition of human recombinant DPP9 using Gly-Pro-MCA as substrate after 30 mins by fluorometry | ChEMBL. | 22824762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.