TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 405.514 | Formula: C19H27N5O3S
H donors: 1 H acceptors: 3 LogP: 1.89 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CSCC1)[C@H]1NC[C@H](C1)N1CCCN(CC1)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C19H27N5O3S/c25-19(23-10-11-28-14-23)18-12-17(13-20-18)22-7-1-6-21(8-9-22)15-2-4-16(5-3-15)24(26)27/h2-5,17-18,20H,1,6-14H2/t17-,18-/m0/s1
InChiKey: ITTDLZYGHITPFM-ROUUACIJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Rattus norvegicus	Dipeptidyl peptidase IV	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Dipeptidyl peptidase IV	767 aa	637 aa	27.0 %
Candida albicans	dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor	Dipeptidyl peptidase IV	767 aa	814 aa	25.6 %
Candida albicans	dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor	Dipeptidyl peptidase IV	767 aa	814 aa	25.6 %
Onchocerca volvulus		Dipeptidyl peptidase IV	767 aa	789 aa	30.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	prolyl oligopeptidase	0.0418	0.268	0.268
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Schistosoma mansoni	neuropeptide receptor	0.0072	0.0183	0.037
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0266	0.1577	0.1577
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.0183	0.0226
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0173	0.0909	0.1839
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Onchocerca volvulus		0.0072	0.0183	0.0683
Onchocerca volvulus	Cirhin homolog	0.0194	0.1064	0.3971
Brugia malayi	Serotonin receptor	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.0183	0.0226
Trichomonas vaginalis	hypothetical protein	0.0142	0.0683	0.0602
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0072	0.0183	0.037
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0141	0.0677	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Onchocerca volvulus		0.0072	0.0183	0.0683
Plasmodium falciparum	membrane associated erythrocyte binding-like protein	0.0067	0.0147	0.0858
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0141	0.0677	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.0183	0.0183
Brugia malayi	Serotonin receptor	0.0072	0.0183	0.0183
Echinococcus granulosus	neuropeptide receptor A26	0.0538	0.3545	0.4385
Onchocerca volvulus		0.0072	0.0183	0.0683
Schistosoma mansoni	growth hormone secretagogue receptor	0.0072	0.0183	0.037
Brugia malayi	G protein-coupled receptor F59B2.13	0.0072	0.0183	0.0183
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0445	0.2871	0.3551
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0072	0.0183	0.0183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0445	0.2871	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0072	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Onchocerca volvulus		0.0072	0.0183	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Schistosoma mansoni	opsin-like receptor	0.0072	0.0183	0.037
Brugia malayi	Protein set-1	0.0065	0.0129	0.0129
Schistosoma mansoni	amine GPCR	0.0072	0.0183	0.037
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0123	0.0548	0.0678
Brugia malayi	neuroendocrine convertase 1 precursor	0.046	0.298	0.298
Brugia malayi	Dopamine receptor	0.0072	0.0183	0.0183
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0122	0.0543	0.0543
Echinococcus granulosus	neuroendocrine convertase 2	0.046	0.298	0.3686
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0122	0.0543	0.0672
Brugia malayi	G-protein coupled receptor	0.0072	0.0183	0.0183
Loa Loa (eye worm)	TYRA-2 protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Onchocerca volvulus		0.0072	0.0183	0.0683
Echinococcus multilocularis	g-protein coupled receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0445	0.2871	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.0183	0.037
Schistosoma mansoni	biogenic amine receptor	0.0072	0.0183	0.037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Onchocerca volvulus		0.0072	0.0183	0.0683
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.0183	0.037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	neuropeptide FF receptor 2	0.0072	0.0183	0.0226
Plasmodium vivax	apical membrane antigen 1	0.0285	0.1717	1
Schistosoma mansoni	histamine h1 receptor	0.0072	0.0183	0.037
Echinococcus granulosus	neuropeptide receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	neuropeptide receptor	0.0591	0.3925	0.4855
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0072	0.0183	0.0226
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.0183	0.0226
Brugia malayi	larval opioid receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	adenoreceptor	0.0072	0.0183	0.037
Plasmodium falciparum	membrane associated erythrocyte binding-like protein	0.0067	0.0147	0.0858
Brugia malayi	endoprotease bli-4 precursor	0.0732	0.4942	0.4942
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0732	0.4942	0.4942
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0418	0.268	0.5423
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0332	0.0672
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0072	0.0183	0.037
Echinococcus multilocularis	Furin 1	0.0173	0.0909	0.1124
Loa Loa (eye worm)	melatonin receptor type 1A	0.0072	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	neuropeptide receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	neuropeptide receptor	0.0072	0.0183	0.037
Echinococcus granulosus	orexin receptor type 2	0.0072	0.0183	0.0226
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	Latrophilin receptor protein 2	0.0123	0.0548	0.0548
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0548	0.0548
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0065	0.0129	0.0753
Brugia malayi	Melatonin receptor type 1A	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Onchocerca volvulus		0.0072	0.0183	0.0683
Onchocerca volvulus		0.0072	0.0183	0.0683
Brugia malayi	prolyl oligopeptidase family protein	0.0418	0.268	0.268
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0418	0.268	0.3315
Toxoplasma gondii	apical membrane antigen 1 protein	0.0067	0.0147	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0072	0.0183	0.0683
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Schistosoma mansoni	neuropeptide receptor	0.0072	0.0183	0.037
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0093	0.0332	0.0411
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.0183	0.037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus granulosus	7tm_1 domain containing protein	0.0072	0.0183	0.0226
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0141	0.0677	0.1369
Loa Loa (eye worm)	endoprotease bli-4	0.0732	0.4942	0.4942
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Schistosoma mansoni	amine GPCR	0.0072	0.0183	0.037
Brugia malayi	celfurPC protein	0.059	0.392	0.392
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Brugia malayi	neuropeptide F receptor	0.0072	0.0183	0.0183
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	dro:myosuppressin receptor	0.0072	0.0183	0.0226
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0072	0.0183	0.0683
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.0183	0.0226
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus granulosus	allatostatin A receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0437	0.0437
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0072	0.0183	0.037
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0123	0.0548	0.111
Onchocerca volvulus		0.0072	0.0183	0.0683
Schistosoma mansoni	biogenic amine receptor	0.0072	0.0183	0.037
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.0183	0.037
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.0183	0.0226
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Schistosoma mansoni	hypothetical protein	0.0072	0.0183	0.037
Onchocerca volvulus		0.0072	0.0183	0.0683
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0141	0.0677	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0072	0.0183	0.037
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Echinococcus multilocularis	G protein coupled receptor 139	0.0591	0.3925	0.4855
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0072	0.0183	0.0226
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0389	0.2464	0.2464
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	follicle stimulating hormone receptor	0.0072	0.0183	0.0183
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0141	0.0677	0.0837
Echinococcus multilocularis	sex peptide receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	serine-type protease inhibitor	0.0452	0.2919	0.5907
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0093	0.0332	0.0332
Schistosoma mansoni	furin-1 (S08 family)	0.0318	0.1958	0.3963
Schistosoma mansoni	hypothetical protein	0.0123	0.0548	0.111
Schistosoma mansoni	hypothetical protein	0.0142	0.0683	0.1382
Echinococcus multilocularis	serotonin receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0093	0.0332	0.0411
Brugia malayi	G protein-coupled receptor	0.0072	0.0183	0.0183
Brugia malayi	GnHR receptor homolog	0.0072	0.0183	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0141	0.0677	0.0837
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	latrophilin 2 splice variant baaae	0.0266	0.1577	0.1577
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0141	0.0677	0.5
Onchocerca volvulus		0.0072	0.0183	0.0683
Schistosoma mansoni	opsin-like receptor	0.0072	0.0183	0.037
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0141	0.0677	0.5
Onchocerca volvulus		0.0072	0.0183	0.0683
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0332	0.0672
Schistosoma mansoni	neuropeptide f receptor 76f	0.0072	0.0183	0.037
Echinococcus granulosus	serotonin receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.0183	0.0183
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.0183	0.0226
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0123	0.0548	0.0678
Echinococcus multilocularis	neuropeptide s receptor	0.0538	0.3545	0.4385
Schistosoma mansoni	neuropeptide receptor	0.0591	0.3925	0.7943
Brugia malayi	prolyl oligopeptidase family protein	0.0141	0.0677	0.0677
Trichomonas vaginalis	WD repeat domain, putative	0.0131	0.0607	0.0276
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0142	0.0683	0.0602
Onchocerca volvulus		0.0072	0.0183	0.0683
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0083	0.0263	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	sulfakinin receptor protein	0.0072	0.0183	0.0183
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.0183	0.0226
Plasmodium falciparum	apical membrane antigen 1	0.0285	0.1717	1
Brugia malayi	Dopamine receptor protein 1	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0072	0.0183	0.037
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.0183	0.0226
Plasmodium vivax	merozoite adhesive erythrocytic binding protein	0.0067	0.0147	0.0858
Echinococcus granulosus	g-protein coupled receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0065	0.0129	0.0262
Echinococcus multilocularis	GPCR, family 2	0.0123	0.0548	0.0678
Echinococcus multilocularis	neuroendocrine convertase 2	0.046	0.298	0.3686
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1733	0.1733
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0072	0.0183	0.037
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0072	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0108	0.0437	0.0437
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.0183	0.0226
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0142	0.0683	0.0602
Toxoplasma gondii	apical membrane antigen 1 domain-containing protein	0.0285	0.1717	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Loa Loa (eye worm)	WD40 repeat protein	0.0131	0.0607	0.0607
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0072	0.0183	0.0183
Onchocerca volvulus		0.0072	0.0183	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	amine GPCR	0.0072	0.0183	0.037
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.0183	0.037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.0183	0.037
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	g protein coupled receptor	0.0072	0.0183	0.0226
Onchocerca volvulus		0.0072	0.0183	0.0683
Giardia lamblia	Furin precursor putative serine protease	0.0142	0.0683	0.1296
Brugia malayi	proprotein convertase 2	0.046	0.298	0.298
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	amine GPCR	0.0072	0.0183	0.037
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0072	0.0183	0.037
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.0183	0.0226
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	allatostatin A receptor	0.0072	0.0183	0.0226
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0123	0.0548	0.0548
Brugia malayi	ORL1-like opioid receptor	0.0072	0.0183	0.0183
Echinococcus granulosus	hypothetical protein	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0141	0.0677	0.394
Giardia lamblia	High cysteine membrane protein Group 2	0.0272	0.1624	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0732	0.4942	1
Schistosoma mansoni	myosin xvIII	0.0072	0.0183	0.037
Schistosoma mansoni	biogenic amine receptor	0.0072	0.0183	0.037
Echinococcus granulosus	dro:myosuppressin receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0072	0.0183	0.0226
Brugia malayi	Dopamine receptor protein 2	0.0072	0.0183	0.0183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0445	0.2871	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.1434	1	1
Echinococcus granulosus	beta catenin	0.0196	0.1074	0.1328
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	orexin receptor type 2	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Echinococcus granulosus	fmrfamide receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	beta-catenin	0.0196	0.1074	0.2172
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	chromatin regulatory protein sir2	0.0122	0.0543	0.1099
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0072	0.0183	0.037
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0072	0.0183	0.037
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	serine-type protease inhibitor	0.0452	0.2919	0.5907
Echinococcus granulosus	GPCR family 2	0.0123	0.0548	0.0678
Toxoplasma gondii	apical membrane antigen AMA1	0.0067	0.0147	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0072	0.0183	0.037
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0072	0.0183	0.037
Plasmodium falciparum	SET domain protein, putative	0.0065	0.0129	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	Will die slowly protein	0.0131	0.0607	0.0607
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0122	0.0543	0.0672
Onchocerca volvulus		0.0072	0.0183	0.0683
Schistosoma mansoni	hypothetical protein	0.0131	0.0607	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0266	0.1577	0.3192
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0418	0.268	0.3315
Echinococcus multilocularis	neuropeptide receptor	0.0591	0.3925	0.4855
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0072	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0123	0.0548	0.111
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0072	0.0183	0.0226
Plasmodium vivax	SET domain protein, putative	0.0065	0.0129	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0129	0.0129
Echinococcus granulosus	G protein coupled receptor 139	0.0072	0.0183	0.0226
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Echinococcus granulosus	protein will die slowly	0.0131	0.0607	0.0751
Brugia malayi	G-protein coupled receptor	0.0072	0.0183	0.0183
Onchocerca volvulus		0.0131	0.0607	0.2266
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	somatostatin receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0072	0.0183	0.0226
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.0183	0.037
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0072	0.0183	0.0226
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0072	0.0183	0.0226
Loa Loa (eye worm)	HMP-2 protein	0.0196	0.1074	0.1074
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0072	0.0183	0.0183
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0389	0.2464	0.2464
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0065	0.0129	0.016
Brugia malayi	putative neuropeptide receptor NPR1	0.0072	0.0183	0.0183
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0065	0.0129	0.016
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Brugia malayi	RE15519p	0.0072	0.0183	0.0183
Echinococcus granulosus	Furin 1	0.0173	0.0909	0.1124
Echinococcus granulosus	g protein coupled receptor	0.0072	0.0183	0.0226
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0418	0.268	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.1168	0.8085	1
Brugia malayi	neuropeptide F receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	amine GPCR	0.0072	0.0183	0.037
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Loa Loa (eye worm)	proprotein convertase 2	0.0173	0.0909	0.0909
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.0183	0.037
Echinococcus granulosus	sex peptide receptor	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0543	0.0543
Echinococcus multilocularis	neuropeptide receptor A26	0.0538	0.3545	0.4385
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0427	0.0427
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0123	0.0548	0.0548
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0072	0.0183	0.037
Echinococcus multilocularis	beta catenin	0.0196	0.1074	0.1328
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Echinococcus granulosus	neuropeptide s receptor	0.0538	0.3545	0.4385
Echinococcus granulosus	somatostatin receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	hypothetical protein	0.0123	0.0548	0.111
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0083	0.0263	0.0325
Echinococcus multilocularis	serotonin receptor	0.0072	0.0183	0.0226
Echinococcus granulosus	7TM GPCR rhodopsin	0.0072	0.0183	0.0226
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0072	0.0183	0.0226
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0173	0.0909	0.1571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.0183	0.0226
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0142	0.0683	0.0602
Brugia malayi	putative neuropeptide receptor	0.0072	0.0183	0.0183
Brugia malayi	AKH receptor	0.0072	0.0183	0.0183
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.0183	0.037
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.1168	0.8085	1
Brugia malayi	Armadillo/beta-catenin-like repeat family protein	0.0196	0.1074	0.1074
Echinococcus granulosus	g protein coupled receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.0183	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0683	0.0602
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.0183	0.0226
Echinococcus multilocularis	protein will die slowly	0.0131	0.0607	0.0751
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.0183	0.0226
Schistosoma mansoni	opsin-like receptor	0.0072	0.0183	0.037
Echinococcus granulosus	furin	0.0732	0.4942	0.6112
Echinococcus multilocularis		0.059	0.392	0.4849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.0183	0.0226
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0072	0.0183	0.0183
Onchocerca volvulus		0.0072	0.0183	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0183	0.0183
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.0183	0.037
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0072	0.0183	0.0183

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 nmol/L	Inhibition of DPP4 in human plasma by fluorescence assay	ChEMBL.	17317162
IC50 (binding)	= 2.4 nmol/L	Inhibition of DPP4 in human plasma by fluorescence assay	ChEMBL.	17317162
IC50 (binding)	= 2.9 nmol/L	Inhibition of DPP4 in rat plasma by fluorescence assay	ChEMBL.	17317162
IC50 (binding)	= 2.9 nmol/L	Inhibition of DPP4 in rat plasma by fluorescence assay	ChEMBL.	17317162

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL239356

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 454637