Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0266 | 0.5086 | 1 |
Treponema pallidum | NADH oxidase | 0.0092 | 0.0628 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0266 | 0.5086 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0092 | 0.0628 | 0.1234 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0092 | 0.0628 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0266 | 0.5086 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0266 | 0.5086 | 0.4757 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0266 | 0.5086 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0457 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0.0628 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0266 | 0.5086 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0092 | 0.0628 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0266 | 0.5086 | 0.5 |
Leishmania major | trypanothione reductase | 0.0266 | 0.5086 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0092 | 0.0628 | 0.5 |
Brugia malayi | glutathione reductase | 0.0266 | 0.5086 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0266 | 0.5086 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0092 | 0.0628 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0266 | 0.5086 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0092 | 0.0628 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0092 | 0.0628 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0092 | 0.0628 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0266 | 0.5086 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0092 | 0.0628 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0266 | 0.5086 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0266 | 0.5086 | 0.4757 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0266 | 0.5086 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0.0628 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0457 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [3H]spiperone from dopamine D2 receptor | ChEMBL. | 17317171 | |
Ki (binding) | 0 | Displacement of [3H]spiperone from dopamine D2 receptor | ChEMBL. | 17317171 |
Ki (binding) | = 0.035 uM | Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells | ChEMBL. | 17317171 |
Ki (binding) | = 0.035 uM | Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells | ChEMBL. | 17317171 |
Ki (binding) | = 95 uM | Displacement of [3H]N-methylscopolamine from muscarinic M4 receptor | ChEMBL. | 17317171 |
Ki (binding) | = 95 uM | Displacement of [3H]N-methylscopolamine from muscarinic M4 receptor | ChEMBL. | 17317171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.