Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0919 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.3948 | 1 | 1 |
Onchocerca volvulus | 0.3948 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.3948 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.3948 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.3948 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.3948 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | 0.3948 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.3948 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3948 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0919 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.3948 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.3948 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.3948 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.3948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3948 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3948 | 1 | 1 |
Onchocerca volvulus | 0.3948 | 1 | 1 | |
Brugia malayi | Blistered cuticle protein 3 | 0.3948 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.3 uM | Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells | ChEMBL. | 17317171 |
Ki (binding) | = 5.3 uM | Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells | ChEMBL. | 17317171 |
Ki (binding) | = 12 uM | Displacement of [3H]N-methylscopolamine from muscarinic M4 receptor | ChEMBL. | 17317171 |
Ki (binding) | = 12 uM | Displacement of [3H]N-methylscopolamine from muscarinic M4 receptor | ChEMBL. | 17317171 |
Ki (binding) | = 42 uM | Displacement of [3H]spiperone from dopamine D2 receptor | ChEMBL. | 17317171 |
Ki (binding) | = 42 uM | Displacement of [3H]spiperone from dopamine D2 receptor | ChEMBL. | 17317171 |
Ratio Ki (binding) | = 8 | Selectivity for 5HT7 receptor over dopamine D2 receptor | ChEMBL. | 17317171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.