Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.3188 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 5.824 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6.1367 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 730 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 730 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 1500 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 1500 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 4800 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 4800 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 0.73 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.73 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 1.5 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 1.5 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 4.8 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 4.8 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 5.3188 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 5.8239 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.1367 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity ratio (binding) | = 0.3 | Selectivity ratio is defined as IC50 rlDHFR/IC50 pcDHFR | ChEMBL. | 8691474 |
Selectivity ratio (binding) | = 2.1 | Selectivity ratio is defined as IC50 rlDHFR/IC50 tgDHFR | ChEMBL. | 8691474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.