Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0183 | 0.0073 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0783 | 0.4496 | 0.8394 |
Loa Loa (eye worm) | serotonin transporter b | 0.0476 | 0.2452 | 0.2463 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0476 | 0.2452 | 0.2364 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.0081 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0476 | 0.2452 | 0.2463 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0183 | 0.0073 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0136 | 0.0183 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.2452 | 0.2463 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0761 | 0.1239 |
Schistosoma mansoni | hypothetical protein | 0.0783 | 0.4496 | 0.8394 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.0183 | 0.0132 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1549 | 0.9605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.2452 | 0.2463 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.1144 | 0.2351 |
Schistosoma mansoni | thyroid hormone receptor | 0.0909 | 0.5334 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0476 | 0.2452 | 0.4478 |
Loa Loa (eye worm) | hypothetical protein | 0.1542 | 0.9557 | 0.995 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1549 | 0.9605 | 0.96 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0783 | 0.4496 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0476 | 0.2452 | 0.4478 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.1798 | 0.1774 |
Echinococcus multilocularis | serotonin transporter | 0.0476 | 0.2452 | 0.4478 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.1144 | 0.1973 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.031 | 0.1343 | 0.2354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1549 | 0.9605 | 0.96 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.031 | 0.1343 | 0.1243 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0909 | 0.5334 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.0081 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.0183 | 0.0132 |
Echinococcus granulosus | serotonin transporter | 0.0476 | 0.2452 | 0.5334 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0476 | 0.2452 | 0.2463 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.0081 | 1 |
Brugia malayi | Serotonin receptor | 0.0474 | 0.2439 | 0.2351 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.2452 | 0.2463 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1343 | 0.1295 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.1798 | 0.1703 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0136 | 0.0183 | 0.0132 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0476 | 0.2452 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0909 | 0.5334 | 1 |
Onchocerca volvulus | 0.0476 | 0.2452 | 1 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.0081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1343 | 0.1295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.6 uM | Inhibition of integrin alphavbeta3 receptor-mediated human SK-MEL-24 cell adhesion to fibronectin by fluorometry | ChEMBL. | 17289386 |
IC50 (binding) | = 2.6 uM | Inhibition of integrin alphavbeta3 receptor-mediated human SK-MEL-24 cell adhesion to fibronectin by fluorometry | ChEMBL. | 17289386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.