Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0129 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0762 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0762 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0762 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0163 | 0.0533 | 0.0533 |
Echinococcus granulosus | carboxylesterase 5A | 0.0762 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0129 | 0 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0163 | 0.0533 | 0.0533 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0163 | 0.0533 | 0.0533 |
Brugia malayi | Choline O-acetyltransferase | 0.0163 | 0.0533 | 0.0533 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0762 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0762 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0129 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0762 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0163 | 0.0533 | 0.0533 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0533 | 0.0533 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0163 | 0.0533 | 0.0533 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 11 nM | Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge | ChEMBL. | 20621485 |
IC50 (functional) | = 15 nM | Ex vivo inhibition of LTD4 induced contraction of guinea pig ileum. | ChEMBL. | 9554876 |
Kd (binding) | = 11 nM | In vitro affinity for CysLT1 receptors on guinea pig lung membranes, measured by displacement of [3H]-LTD4. | ChEMBL. | 9554876 |
Kd (binding) | = 11 nM | In vitro affinity for CysLT1 receptors on guinea pig lung membranes, measured by displacement of [3H]-LTD4. | ChEMBL. | 9554876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.