TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.433 | Formula: C20H28O6
H donors: 0 H acceptors: 3 LogP: 3.16 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@H]2[C@H]1C[C@H](C2)OC(=O)C
InChi: 1S/C20H28O6/c1-13-7-5-4-6-8-16-11-17(25-14(2)21)12-18(16)19(26-15(3)22)9-10-20(23)24-13/h6,8-10,13,16-19H,4-5,7,11-12H2,1-3H3/b8-6-,10-9+/t13-,16+,17-,18+,19+/m0/s1
InChiKey: ILLPGJFSCLASDH-AXVQZLFFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1183	0.6349	0.6344
Brugia malayi	sulfakinin receptor protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0167	0.0723	0.1138
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Schistosoma mansoni	amine GPCR	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	putative neuropeptide receptor	0.1183	0.6349	0.6344
Schistosoma mansoni	glutamate receptor NMDA	0.0073	0.0204	0.0251
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1183	0.6349	0.7801
Echinococcus multilocularis	glutamate receptor 2	0.0073	0.0204	0.0322
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0135	0.0548	0.0535
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0167	0.0723	0.0888
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0014	0.0017
Onchocerca volvulus		0.0095	0.0322	0.0387
Echinococcus granulosus	alpha 1A adrenergic receptor	0.1183	0.6349	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1183	0.6349	0.7801
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0305	0.1488	0.2938
Schistosoma mansoni	neuropeptide receptor	0.1183	0.6349	0.7801
Schistosoma mansoni	ATP-binding cassette transporter	0.0073	0.0204	0.0251
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0014	0.0017
Mycobacterium ulcerans	hypothetical protein	0.004	0.002	0.0012
Echinococcus multilocularis	neuropeptide FF receptor 2	0.1183	0.6349	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.029	0.0277
Echinococcus multilocularis	orexin receptor type 2	0.1183	0.6349	1
Echinococcus multilocularis	glutamate receptor 2	0.0092	0.0308	0.0485
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0984	0.5245	0.6444
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	1
Schistosoma mansoni	hypothetical protein	0.1183	0.6349	0.7801
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.1183	0.6349	1
Echinococcus multilocularis	geminin	0.0166	0.0717	0.113
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.0363	0.035
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0092	0.0308	0.0485
Onchocerca volvulus		0.1183	0.6349	1
Schistosoma mansoni	opsin-like receptor	0.1183	0.6349	0.7801
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.1183	0.6349	1
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0062	0.014	0.0252
Echinococcus multilocularis	neuropeptides capa receptor	0.1183	0.6349	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0526	0.271	0.27
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.008	0.0066
Brugia malayi	Bromodomain containing protein	0.0079	0.0237	0.0223
Echinococcus multilocularis	neuropeptide receptor	0.1183	0.6349	1
Onchocerca volvulus		0.1183	0.6349	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.004	0.002	0.0007
Brugia malayi	Serotonin receptor	0.1183	0.6349	0.6344
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.1183	0.6349	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	0.071
Trichomonas vaginalis	glucosylceramidase, putative	0.0364	0.1812	0.6667
Echinococcus multilocularis	G protein coupled receptor 139	0.1183	0.6349	1
Brugia malayi	SWIRM domain containing protein	0.0095	0.0322	0.0309
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Schistosoma mansoni	sodium/chloride dependent transporter	0.0167	0.0723	0.0888
Plasmodium vivax	amine transporter, putative	0.0167	0.0723	0.5
Entamoeba histolytica	hypothetical protein	0.0073	0.0204	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0092	0.0308	0.0485
Echinococcus multilocularis	nmda type glutamate receptor	0.0098	0.0343	0.054
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.1183	0.6349	0.6344
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0945	0.5031	1
Schistosoma mansoni	neuropeptide receptor	0.1183	0.6349	0.7801
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0167	0.0723	0.1138
Onchocerca volvulus		0.1183	0.6349	1
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus granulosus	serotonin receptor	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.0773	0.4077	0.4069
Trypanosoma brucei	Emopamil binding protein, putative	0.0135	0.0548	0.0535
Brugia malayi	Melatonin receptor type 1A	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	Abnormal catecholamine distribution protein 1	0.0773	0.4077	0.4069
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.1183	0.6349	0.6344
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1183	0.6349	1
Brugia malayi	Dopamine receptor protein 1	0.1183	0.6349	0.6344
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Schistosoma mansoni	neuropeptide F-like receptor	0.1183	0.6349	0.7801
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0167	0.0723	0.071
Brugia malayi	G-protein coupled receptor	0.1183	0.6349	0.6344
Echinococcus granulosus	sodium and chloride dependent glycine	0.0167	0.0723	0.1138
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.1183	0.6349	1
Brugia malayi	Bromodomain containing protein	0.004	0.0022	0.0008
Schistosoma mansoni	adenoreceptor	0.1183	0.6349	0.7801
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0167	0.0723	0.0888
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	larval opioid receptor	0.1183	0.6349	0.6344
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1183	0.6349	1
Brugia malayi	G protein-coupled receptor	0.1183	0.6349	0.6344
Echinococcus multilocularis	g protein coupled receptor	0.1183	0.6349	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.0363	0.035
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.1183	0.6349	0.6344
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0204	0.025
Toxoplasma gondii	hypothetical protein	0.0167	0.0723	1
Brugia malayi	RE15519p	0.1183	0.6349	0.6344
Schistosoma mansoni	neuropeptide f receptor 76f	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Echinococcus granulosus	dro:myosuppressin receptor	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	sodium and chloride dependent glycine	0.0167	0.0723	0.1138
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0008	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Echinococcus multilocularis	g protein coupled receptor	0.1183	0.6349	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Echinococcus granulosus	neuropeptides capa receptor	0.1183	0.6349	1
Echinococcus granulosus	g protein coupled receptor	0.1183	0.6349	1
Echinococcus granulosus	muscleblind protein	0.0158	0.0672	0.1058
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.1183	0.6349	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	fmrfamide receptor	0.1183	0.6349	1
Onchocerca volvulus		0.1183	0.6349	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.1183	0.6349	0.7801
Loa Loa (eye worm)	norepinephrine transporter	0.0984	0.5245	0.5239
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.007	0.0184	0.0171
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	histamine h1 receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Schistosoma mansoni	lipoxygenase	0.0125	0.0488	0.0599
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.0363	0.035
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Echinococcus granulosus	neuropeptide Y receptor	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Onchocerca volvulus		0.1183	0.6349	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0167	0.0723	0.0888
Echinococcus multilocularis	S formylglutathione hydrolase	0.004	0.002	0.0032
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0073	0.0204	0.0322
Loa Loa (eye worm)	G-protein coupled receptor	0.1183	0.6349	0.6344
Mycobacterium ulcerans	hypothetical protein	0.004	0.002	0.0012
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0184	0.0171
Brugia malayi	G protein-coupled receptor F59B2.13	0.1183	0.6349	0.6344
Echinococcus granulosus	serotonin transporter	0.0984	0.5245	0.8262
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0672	0.0659
Schistosoma mansoni	glutamate receptor NMDA	0.0092	0.0308	0.0378
Schistosoma mansoni	sodium/chloride dependent transporter	0.0167	0.0723	0.0888
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.1183	0.6349	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0167	0.0723	0.1138
Echinococcus granulosus	sex peptide receptor	0.1183	0.6349	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0984	0.5245	0.5239
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	biogenic amine receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	orexin receptor type 2	0.1183	0.6349	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1183	0.6349	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0014	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.1183	0.6349	0.6344
Schistosoma mansoni	hypothetical protein	0.0051	0.008	0.0098
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0167	0.0723	0.1138
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Onchocerca volvulus		0.007	0.0183	0.0165
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1183	0.6349	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0008	0.0013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0322	0.0309
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	amine GPCR	0.1183	0.6349	0.7801
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0073	0.0204	0.0322
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	0.071
Echinococcus multilocularis	survival motor neuron protein 1	0.025	0.1181	0.1861
Brugia malayi	Esterase D	0.004	0.002	0.0006
Mycobacterium ulcerans	hypothetical protein	0.004	0.002	0.0012
Brugia malayi	PAS domain containing protein	0.007	0.0183	0.017
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.004	0.002	0.0012
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Schistosoma mansoni	amine GPCR	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0167	0.0723	1
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.004	0.002	0.0012
Schistosoma mansoni	amine GPCR	0.1506	0.8139	1
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0135	0.0548	0.0535
Schistosoma mansoni	growth hormone secretagogue receptor	0.1183	0.6349	0.7801
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.1183	0.6349	0.6344
Echinococcus granulosus	synaptic vesicular amine transporter	0.0773	0.4077	0.6422
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0014	0.0022
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	opsin-like receptor	0.1183	0.6349	0.7801
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0167	0.0723	0.1138
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	somatostatin receptor	0.1183	0.6349	1
Echinococcus granulosus	allatostatin A receptor	0.1183	0.6349	1
Echinococcus multilocularis	somatostatin receptor	0.1183	0.6349	1
Echinococcus granulosus	single minded 2	0.007	0.0183	0.0289
Echinococcus granulosus	hypothetical protein	0.1183	0.6349	1
Echinococcus granulosus	g protein coupled receptor	0.1183	0.6349	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	0.071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Echinococcus granulosus	glutamate receptor 2	0.0092	0.0308	0.0485
Echinococcus granulosus	neuropeptide receptor A26	0.1183	0.6349	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0167	0.0723	0.1138
Loa Loa (eye worm)	hypothetical protein	0.1842	1	1
Brugia malayi	Glutamate receptor 2 precursor	0.0073	0.0204	0.0191
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Echinococcus multilocularis	neuropeptide receptor A26	0.1183	0.6349	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0984	0.5245	0.6444
Trypanosoma cruzi	Emopamil binding protein, putative	0.0135	0.0548	0.0535
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0167	0.0723	0.1138
Brugia malayi	G-protein coupled receptor	0.1183	0.6349	0.6344
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.1183	0.6349	1
Echinococcus multilocularis	serotonin receptor	0.1183	0.6349	1
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Onchocerca volvulus		0.1183	0.6349	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.1183	0.6349	0.6344
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	1
Schistosoma mansoni	lipoxygenase	0.0087	0.028	0.0344
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	neuropeptide s receptor	0.1183	0.6349	1
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.004	0.002	0.0328
Onchocerca volvulus		0.0167	0.0723	0.1025
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1183	0.6349	1
Schistosoma mansoni	glutamate receptor kainate	0.0073	0.0204	0.0251
Brugia malayi	Muscleblind-like protein	0.0158	0.0672	0.0659
Schistosoma mansoni	glutamate receptor AMPA	0.0073	0.0204	0.0251
Echinococcus granulosus	7TM GPCR rhodopsin	0.1183	0.6349	1
Echinococcus granulosus	S formylglutathione hydrolase	0.004	0.002	0.0032
Mycobacterium ulcerans	putative regulatory protein	0.007	0.0183	0.0338
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	follicle stimulating hormone receptor	0.1183	0.6349	0.6344
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0092	0.0308	0.0485
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Echinococcus granulosus	tm gpcr rhodopsin	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Brugia malayi	hypothetical protein	0.0167	0.0723	0.071
Onchocerca volvulus		0.0984	0.5245	0.8239
Schistosoma mansoni	vesicular amine transporter	0.0773	0.4077	0.5009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Plasmodium vivax	hypothetical protein, conserved	0.0167	0.0723	0.5
Treponema pallidum	sodium- and chloride- dependent transporter	0.0984	0.5245	1
Schistosoma mansoni	hypothetical protein	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	rhodopsin orphan GPCR	0.1183	0.6349	1
Onchocerca volvulus		0.0167	0.0723	0.1025
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	neuropeptide FF receptor 2	0.1183	0.6349	1
Brugia malayi	hypothetical protein	0.0073	0.0204	0.019
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1183	0.6349	0.7801
Brugia malayi	Serotonin receptor	0.1183	0.6349	0.6344
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1183	0.6349	0.7801
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.1183	0.6349	0.6344
Echinococcus granulosus	neuropeptide Y receptor	0.1183	0.6349	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0204	0.0321
Echinococcus multilocularis	sex peptide receptor	0.1183	0.6349	1
Toxoplasma gondii	hypothetical protein	0.0167	0.0723	1
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.029	0.0277
Echinococcus multilocularis	g-protein coupled receptor	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	bHLH-PAS transcription factor	0.007	0.0183	0.017
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.004	0.002	0.0012
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0092	0.0308	0.0485
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	neuropeptide Y receptor	0.1183	0.6349	1
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0305	0.1488	0.2938
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1183	0.6349	0.7801
Echinococcus multilocularis	serotonin transporter	0.0984	0.5245	0.8262
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Entamoeba histolytica	hypothetical protein	0.0073	0.0204	1
Schistosoma mansoni	opsin-like receptor	0.1183	0.6349	0.7801
Echinococcus multilocularis	transfer RNA-Lys	0.007	0.0183	0.0289
Loa Loa (eye worm)	glutamate receptor 1	0.0073	0.0204	0.0191
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus granulosus	g protein coupled receptor	0.1183	0.6349	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.1183	0.6349	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.1183	0.6349	0.7801
Schistosoma mansoni	hypothetical protein	0.007	0.0184	0.0226
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Echinococcus granulosus	g-protein coupled receptor	0.1183	0.6349	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	biogenic amine 5HT receptor	0.1183	0.6349	1
Echinococcus multilocularis	neuropeptides capa receptor	0.1183	0.6349	1
Plasmodium falciparum	amino acid transporter, putative	0.0167	0.0723	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.1183	0.6349	0.6344
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.1183	0.6349	1
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0168	0.0206
Schistosoma mansoni	biogenic amine receptor	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0984	0.5245	0.5239
Brugia malayi	neuropeptide F receptor	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0945	0.5031	1
Brugia malayi	GnHR receptor homolog	0.1183	0.6349	0.6344
Echinococcus multilocularis	dro:myosuppressin receptor	0.1183	0.6349	1
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0089	0.029	0.0457
Loa Loa (eye worm)	TYRA-2 protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0363	0.035
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	0.071
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.1183	0.6349	0.7801
Mycobacterium leprae	SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)	0.0945	0.5031	1
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	g protein coupled receptor	0.1183	0.6349	1
Echinococcus granulosus	glutamate receptor 2	0.0056	0.0106	0.0166
Brugia malayi	AKH receptor	0.1183	0.6349	0.6344
Schistosoma mansoni	neuropeptide F-like receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0125	0.0488	0.0768
Echinococcus granulosus	7tm_1 domain containing protein	0.1183	0.6349	1
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0092	0.0308	0.0485
Schistosoma mansoni	neuropeptide receptor	0.1183	0.6349	0.7801
Onchocerca volvulus		0.0135	0.0548	0.0746
Brugia malayi	Glutamate receptor 1 precursor	0.0073	0.0204	0.0191
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0125	0.0488	0.0768
Echinococcus granulosus	neuropeptide receptor	0.1183	0.6349	1
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus granulosus	neuropeptide s receptor	0.1183	0.6349	1
Echinococcus granulosus	G protein coupled receptor 139	0.1183	0.6349	1
Onchocerca volvulus		0.1183	0.6349	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0672	0.0659
Loa Loa (eye worm)	glutamate receptor 2	0.0073	0.0204	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Schistosoma mansoni	amine GPCR	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0092	0.0308	0.0485
Trichomonas vaginalis	glucosylceramidase, putative	0.0364	0.1812	0.6667
Brugia malayi	Tachykinin-like peptides receptor 99D	0.1183	0.6349	0.6344
Schistosoma mansoni	glutamate receptor AMPA	0.0073	0.0204	0.0251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Plasmodium falciparum	transporter, putative	0.0167	0.0723	0.5
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	muscleblind protein	0.0158	0.0672	0.1058
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Entamoeba histolytica	hypothetical protein	0.0073	0.0204	1
Echinococcus multilocularis	muscleblind protein 1	0.0158	0.0672	0.1058
Echinococcus multilocularis	glutamate receptor 2	0.0056	0.0106	0.0166
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0147	0.0232
Schistosoma mansoni	hypothetical protein	0.0073	0.0204	0.025
Schistosoma mansoni	hypothetical protein	0.1183	0.6349	0.7801
Trichomonas vaginalis	glucosylceramidase, putative	0.0345	0.1709	0.6286
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.1183	0.6349	0.6344
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	neuropeptides capa receptor	0.1183	0.6349	1
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.1842	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0167	0.0723	0.071
Echinococcus granulosus	biogenic amine 5HT receptor	0.1183	0.6349	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0204	1
Loa Loa (eye worm)	hypothetical protein	0.0984	0.5245	0.5239
Loa Loa (eye worm)	esterase D	0.004	0.002	0.0006
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0167	0.0723	0.0888
Echinococcus multilocularis	neuropeptide receptor	0.1183	0.6349	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.1183	0.6349	1
Brugia malayi	ORL1-like opioid receptor	0.1183	0.6349	0.6344
Schistosoma mansoni	biogenic amine receptor	0.1183	0.6349	0.7801
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1183	0.6349	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0526	0.271	0.27
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0089	0.029	0.0357
Schistosoma mansoni	survival motor neuron protein	0.0051	0.008	0.0098
Echinococcus granulosus	nmda type glutamate receptor	0.0098	0.0343	0.054
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0212	0.0198
Echinococcus granulosus	tm gpcr rhodopsin	0.1183	0.6349	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.007	0.0183	0.0225
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0098	0.0343	0.054
Echinococcus granulosus	survival motor neuron protein 1	0.025	0.1181	0.1861
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0984	0.5245	0.5239
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0062	0.014	0.024
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	synaptic vesicular amine transporter	0.0773	0.4077	0.6422
Loa Loa (eye worm)	hypothetical protein	0.0942	0.5012	0.5005
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Brugia malayi	Dopamine receptor protein 2	0.1183	0.6349	0.6344
Onchocerca volvulus		0.1183	0.6349	1
Echinococcus multilocularis	fmrfamide receptor	0.1183	0.6349	1
Loa Loa (eye worm)	G-protein coupled receptor	0.1183	0.6349	0.6344
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.1183	0.6349	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.1183	0.6349	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0167	0.0723	0.1138
Onchocerca volvulus		0.0167	0.0723	0.1025
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Onchocerca volvulus	Glucosylceramidase homolog	0.0345	0.1709	0.2598
Brugia malayi	putative neuropeptide receptor NPR1	0.1183	0.6349	0.6344
Echinococcus multilocularis	neuropeptide Y receptor	0.1183	0.6349	1
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0092	0.0308	0.0485
Schistosoma mansoni	glutamate receptor kainate	0.0073	0.0204	0.0251
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1183	0.6349	0.7801
Brugia malayi	hypothetical protein	0.025	0.1181	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0723	0.071
Schistosoma mansoni	single-minded	0.007	0.0183	0.0225
Echinococcus multilocularis	serotonin receptor	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0984	0.5245	0.5239
Loa Loa (eye worm)	hypothetical protein	0.004	0.002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	serotonin transporter b	0.0984	0.5245	0.5239
Echinococcus multilocularis	G-protein coupled receptor, putative	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	hypothetical protein	0.1183	0.6349	0.7801
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1183	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.025	0.1181	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0047	0.0033
Trichomonas vaginalis	glucosylceramidase, putative	0.0526	0.271	1
Echinococcus granulosus	geminin	0.0166	0.0717	0.113
Brugia malayi	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0147	0.0232
Brugia malayi	Dopamine receptor	0.1183	0.6349	0.6344
Schistosoma mansoni	alpha-1 adrenergic receptor	0.1183	0.6349	0.7801
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0014	0.0022
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0204	0.0321
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.1183	0.6349	0.7801
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Echinococcus granulosus	neuropeptide receptor	0.1183	0.6349	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0092	0.0308	0.0485
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.1183	0.6349	1
Schistosoma mansoni	hypothetical protein	0.0166	0.0717	0.0881
Schistosoma mansoni	neuropeptide receptor	0.1183	0.6349	0.7801
Leishmania major	hypothetical protein, conserved	0.0135	0.0548	0.0535
Brugia malayi	neuropeptide F receptor	0.1183	0.6349	0.6344
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0089	0.029	0.0457
Loa Loa (eye worm)	neuropeptide F receptor	0.1183	0.6349	0.6344
Echinococcus multilocularis	fmrfamide receptor	0.1183	0.6349	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0271	0.1297	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0036	0.0022
Schistosoma mansoni	myosin xvIII	0.1183	0.6349	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0022	0.0008
Schistosoma mansoni	glutamate receptor kainate	0.0073	0.0204	0.0251
Loa Loa (eye worm)	hypothetical protein	0.1183	0.6349	0.6344
Echinococcus granulosus	peptide allatostatin:somatostatin	0.1183	0.6349	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1183	0.6349	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.1183	0.6349	0.6344
Echinococcus granulosus	tachykinin peptides receptor 99D	0.1183	0.6349	1
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0135	0.0548	0.0535
Echinococcus multilocularis	allatostatin A receptor	0.1183	0.6349	1
Trypanosoma brucei	C-8 sterol isomerase, putative	0.1842	1	1
Leishmania major	C-8 sterol isomerase-like protein	0.1842	1	1
Schistosoma mansoni	hypothetical protein	0.0166	0.0717	0.0881
Trypanosoma cruzi	Emopamil binding protein, putative	0.0135	0.0548	0.0535
Mycobacterium ulcerans	hypothetical protein	0.004	0.002	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1183	0.6349	0.7801
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0167	0.0723	0.1138

Activities

Activity type	Activity value	Assay description	Source	Reference
DNA fragmentation (functional)	0	Effect of the compound on apoptotic DNA fragmentation to differentitiate HCT 116 cells, at a concentration of 0.27 microM, 0.1 ug/ml was determined; + = Potent	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 45499