Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 633 aa | 616 aa | 38.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1793 | 0.3553 | 0.3553 |
Schistosoma mansoni | patched 1 | 0.1793 | 0.3553 | 0.3553 |
Loa Loa (eye worm) | hypothetical protein | 0.1793 | 0.3553 | 0.3553 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1793 | 0.3553 | 0.3553 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1793 | 0.3553 | 0.3553 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1793 | 0.3553 | 0.3553 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.4354 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.4354 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1793 | 0.3553 | 0.3553 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4354 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4354 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4354 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4354 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.1793 | 0.3553 | 0.3553 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.4354 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.4354 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2043 | 0.4182 | 1 |
Brugia malayi | CHE-14 protein | 0.1793 | 0.3553 | 0.3553 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1793 | 0.3553 | 0.3553 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2043 | 0.4182 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1793 | 0.3553 | 0.3553 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1793 | 0.3553 | 0.3553 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2043 | 0.4182 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4354 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.2043 | 0.4182 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -5.9 | Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells | ChEMBL. | 17234406 |
IC50 (binding) | = -5.8 | Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells | ChEMBL. | 17234406 |
Log IC50 (binding) | = 5.8 | Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells | ChEMBL. | 17234406 |
Log IC50 (binding) | = 5.9 | Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells | ChEMBL. | 17234406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.