Detailed information for compound 455251

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.486 | Formula: C19H26N2O3S
  • H donors: 2 H acceptors: 3 LogP: 2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CC(CC1C)C)CNS(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C19H26N2O3S/c1-14-9-15(2)21(12-14)13-18(22)11-20-25(23,24)19-8-7-16-5-3-4-6-17(16)10-19/h3-8,10,14-15,18,20,22H,9,11-13H2,1-2H3/t14?,15?,18-/m0/s1
  • InChiKey: XTEIDNBHYNANFK-JMLCCBQJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium-dependent proline transporter, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis serotonin transporter solute carrier family 6 (neurotransmitter transporter, glycine), member 9 633 aa 616 aa 38.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0103 0.0103
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.0058 0.1739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0057 0.0057
Onchocerca volvulus Pyruvate kinase homolog 0.0094 0.0152 0.0885
Onchocerca volvulus 0.004 0.0039 0.0183
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.0058 0.0058
Echinococcus granulosus pyruvate kinase 0.0094 0.0152 0.0152
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0028 0.005
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0109
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0038 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0029 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0088 0.014 0.014
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0041 0.0041
Schistosoma mansoni alpha-glucosidase 0.0274 0.0532 0.0532
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0096 0.0155 0.0155
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0065 0.0091 0.28
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0041 0.0041
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0596
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0099 0.0163 0.507
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0041 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Treponema pallidum NADH oxidase 0.006 0.0081 0.0422
Toxoplasma gondii hypothetical protein 0.0024 0.0004 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0041 0.0041
Mycobacterium ulcerans hypothetical protein 0.0063 0.0087 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0231 0.0441 0.0441
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.0155 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0041 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0397 0.079 0.238
Mycobacterium leprae conserved hypothetical protein 0.0065 0.0091 0.0245
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0049 0.0058 0.1739
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0041 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.024 0.024
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0031 0.0031
Echinococcus granulosus Protein patched homolog 1 0.1965 0.409 0.409
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0031 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0063 0.0087 0.0051
Treponema pallidum recombinase A 0.015 0.027 0.1563
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0041 0.0041
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.2239 0.4667 1
Echinococcus multilocularis protein patched 0.1965 0.409 0.409
Echinococcus multilocularis lysine specific demethylase 6a 0.0049 0.0058 0.0058
Echinococcus granulosus geminin 0.012 0.0207 0.0207
Brugia malayi intermediate filament protein 0.0075 0.0112 0.0112
Onchocerca volvulus 0.0063 0.0087 0.0482
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.0155 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0093 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.0087 0.0087
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0018 0.0495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0041 0.0041
Echinococcus multilocularis pyruvate kinase 0.0048 0.0056 0.0056
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0117 0.02 0.02
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0537 0.1084 0.3277
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0058 0.0058
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0062 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0226 0.0191
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.015 0.027 0.079
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.0025 0.0025
Onchocerca volvulus 0.0184 0.0342 0.2076
Loa Loa (eye worm) X11 protein 0.0092 0.0147 0.0147
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Mycobacterium tuberculosis Probable lipase LipD 0.0063 0.0087 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0103 0.0208
Onchocerca volvulus 0.0075 0.0112 0.0639
Loa Loa (eye worm) glutaminase 0.0266 0.0514 0.0514
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0397 0.079 0.0757
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0058 0.0076 0.0076
Brugia malayi hypothetical protein 0.0088 0.014 0.014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.006 0.0081 0.008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0103 0.0584
Brugia malayi Intermediate filament tail domain containing protein 0.0075 0.0112 0.0112
Echinococcus granulosus neuropeptide s receptor 0.0947 0.1947 0.1947
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0036 0.0064
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.0058 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0184 0.0341 0.0341
Echinococcus multilocularis lamin 0.0075 0.0112 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0093 0.0523
Echinococcus granulosus voltage dependent calcium channel 0.003 0.0018 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.001 0.0007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.3681
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Mycobacterium ulcerans flavoprotein disulfide reductase 0.006 0.0081 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0041 0.0041
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.006 0.0081 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0052 0.0051
Brugia malayi Muscleblind-like protein 0.0102 0.0168 0.0168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0132 0.0232 0.0232
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0023 0.0002 0.0002
Echinococcus multilocularis protein dispatched 1 0.1965 0.409 0.409
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0103 0.0584
Echinococcus multilocularis lysosomal alpha glucosidase 0.0319 0.0625 0.0625
Echinococcus multilocularis pyruvate kinase 0.0074 0.011 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0041 0.0041
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.044 0.0881 0.2657
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0066 0.0093 0.0251
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0813 0.1665 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0023 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0041 0.0041
Giardia lamblia Pyruvate kinase 0.0048 0.0056 0.0102
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.4773 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Loa Loa (eye worm) glutaminase 2 0.0266 0.0514 0.0514
Schistosoma mansoni hypothetical protein 0.012 0.0207 0.0207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0057 0.0057
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0103 0.0208
Mycobacterium tuberculosis Conserved protein 0.0063 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0041 0.0041
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0066 0.0093 0.0057
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0038 0.0035 0.0035
Mycobacterium ulcerans beta-lactamase 0.0063 0.0087 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0063 0.0087 0.0087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0397 0.079 0.0799
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0065 0.0091 0.009
Schistosoma mansoni tar DNA-binding protein 0.0092 0.0147 0.0147
Echinococcus multilocularis thioredoxin glutathione reductase 0.0175 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0039 0.0039
Echinococcus granulosus sterol regulatory element binding protein 0.1965 0.409 0.409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0057 0.0057
Trypanosoma cruzi transcription factor btf3, putative 0.0025 0.0006 0.0004
Trypanosoma brucei glycosyl hydrolase-like protein 0.0026 0.001 0.0007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.0226 0.0226
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0102 0.0168 0.0168
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0009
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0065 0.0091 0.0525
Onchocerca volvulus 0.0041 0.0041 0.0193
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0065 0.0091 0.0484
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0058 0.0058
Schistosoma mansoni inositol monophosphatase 0.0039 0.0036 0.0036
Trypanosoma cruzi DNA repair protein, putative 0.0046 0.0051 0.0049
Trypanosoma brucei transcription factor BTF3, putative 0.0025 0.0006 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0088 0.014 0.014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0033 0.0024 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0058 0.0055
Schistosoma mansoni myelin transcription factor 1 myt1 0.0038 0.0035 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0103 0.0103
Plasmodium falciparum acyl-CoA synthetase 0.0049 0.0058 0.1754
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0093 0.0057
Plasmodium vivax JmjC domain containing protein 0.0049 0.0058 0.1739
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0036 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0041 0.0041
Loa Loa (eye worm) RNA binding protein 0.0092 0.0147 0.0147
Loa Loa (eye worm) calcium channel 0.0132 0.0232 0.0232
Trichomonas vaginalis pyruvate kinase, putative 0.0094 0.0152 0.0311
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0036 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0041 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0226 0.0226
Brugia malayi beta-lactamase 0.0063 0.0087 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0018
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.4705 0.9858 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0058 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Echinococcus multilocularis isocitrate dehydrogenase 0.0023 0.0002 0.0002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0103 0.0208
Mycobacterium tuberculosis Probable oxidoreductase 0.044 0.0881 0.0891
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0093 0.0093
Leishmania major hypothetical protein, conserved 0.0033 0.0023 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.001 0.0007
Brugia malayi Pre-SET motif family protein 0.0692 0.1411 0.1411
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0041 0.0041
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0133 0.0234 0.0234
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0062 0.0061
Trypanosoma cruzi trypanothione reductase, putative 0.0174 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0092 0.0147 0.0147
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0396 0.0788 0.2373
Brugia malayi PHD-finger family protein 0.0055 0.0071 0.0071
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.001 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.004 0.0039 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0188 0.035 0.035
Schistosoma mansoni loxhd1 0.004 0.0039 0.0039
Trichomonas vaginalis pyruvate kinase, putative 0.0094 0.0152 0.0311
Toxoplasma gondii ABC1 family protein 0.0063 0.0087 0.2669
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0028
Schistosoma mansoni alpha-glucosidase 0.0274 0.0532 0.0532
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0041 0.0041
Leishmania major trypanothione reductase 0.0174 0.032 0.0317
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0231 0.0441 0.0441
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0115 0.0196 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0052 0.0051
Schistosoma mansoni hypothetical protein 0.0115 0.0196 0.0196
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0137 0.0242 0.0239
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0063 0.0087 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0041 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0029 0.0029
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0241 0.0462 0.0462
Trypanosoma cruzi ISWI complex protein 0.0033 0.0023 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0041 0.0041
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0028 0.0014 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.0087 0.0173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0036 0.0064
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.2239 0.4667 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0038 0.0035 0.0035
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0132 0.0232 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.001 0.0007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.0226 0.0224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0033 0.0024 0.0024
Brugia malayi hypothetical protein 0.0025 0.0008 0.0008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0396 0.0788 0.0797
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.4773 1 1
Onchocerca volvulus 0.0788 0.1612 1
Giardia lamblia Kinase, PLK 0.0137 0.0242 0.0501
Echinococcus multilocularis Niemann Pick C1 protein 0.1965 0.409 0.409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.006 0.0081 0.0079
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0396 0.0788 0.0797
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0038 0.0035 0.0035
Entamoeba histolytica serine/threonine protein kinase, putative 0.0137 0.0242 0.1418
Schistosoma mansoni rab6-interacting 0.004 0.0039 0.0039
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.4318 0.9044 0.9174
Echinococcus multilocularis transcription factor btf3 0.0025 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.0087 0.0173
Brugia malayi Isocitrate dehydrogenase 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0093 0.0093
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0041 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0249 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0136 0.024 0.024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.006 0.0081 0.0045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.001 0.002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.006 0.0081 0.0081
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.4773 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0136 0.024 0.024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.006 0.0081 0.2475
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0596
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0058 0.0058
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0132 0.0232 0.0232
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0149 0.0149
Mycobacterium ulcerans hypothetical protein 0.0066 0.0093 0.0057
Plasmodium falciparum glutathione reductase 0.0174 0.032 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0319 0.0625 0.0625
Trypanosoma cruzi pyruvate kinase 2, putative 0.0094 0.0152 0.0149
Echinococcus granulosus lysosomal alpha glucosidase 0.0319 0.0625 0.0625
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0537 0.1084 0.1051
Brugia malayi isocitrate dehydrogenase 0.0023 0.0002 0.0002
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.0058 0.0058
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0065 0.0091 0.28
Loa Loa (eye worm) hypothetical protein 0.0115 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0044 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0041 0.0041
Brugia malayi glutathione reductase 0.0174 0.032 0.032
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0103 0.0208
Mycobacterium tuberculosis Probable dehydrogenase 0.0396 0.0788 0.0797
Leishmania major 4-coumarate:coa ligase-like protein 0.0066 0.0093 0.0091
Brugia malayi jmjC domain containing protein 0.0188 0.035 0.035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0052 0.0051
Mycobacterium ulcerans lipase LipD 0.0063 0.0087 0.0051
Brugia malayi jmjC domain containing protein 0.0049 0.0058 0.0058
Schistosoma mansoni jumonji domain containing protein 0.0184 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.0025 0.0025
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0133 0.0234 0.0234
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.006 0.0081 0.2475
Echinococcus multilocularis neuropeptide s receptor 0.0947 0.1947 0.1947
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0094 0.0152 0.0151
Loa Loa (eye worm) apoptosis regulator protein 0.0115 0.0196 0.0196
Echinococcus granulosus voltage dependent calcium channel 0.0132 0.0232 0.0232
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1965 0.409 0.409
Entamoeba histolytica acyl-coA synthetase, putative 0.0066 0.0093 0.0523
Echinococcus multilocularis pyruvate kinase 0.0094 0.0152 0.0152
Trichomonas vaginalis mercuric reductase, putative 0.006 0.0081 0.016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.006 0.0081 0.0081
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.4773 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.0226 0.0226
Brugia malayi jmjC domain containing protein 0.0184 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0078 0.0119 0.0119
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0096 0.0155 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0058 0.0058
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0065 0.0091 0.28
Echinococcus multilocularis pyruvate kinase 0.0048 0.0056 0.0056
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0119
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0033 0.0024 0.0671
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.0156 0.0156
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.0025 0.0025
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0132 0.0232 0.0232
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0081 0.0126 0.0123
Brugia malayi TAR-binding protein 0.0092 0.0147 0.0147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0036 0.0034
Leishmania major hypothetical protein, conserved 0.0157 0.0285 0.0282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0036 0.0034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0096 0.0156 0.0156
Schistosoma mansoni amyloid beta A4 protein related 0.0092 0.0147 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0041 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0025 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0099 0.0163 0.0163
Echinococcus multilocularis lamin dm0 0.0075 0.0112 0.0112
Brugia malayi steroid hormone receptor 0.0041 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0205 0.0386 0.0386
Toxoplasma gondii hypothetical protein 0.0027 0.0011 0.0275
Echinococcus multilocularis lysine specific demethylase 5A 0.0184 0.0341 0.0341
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.006 0.0081 0.0223
Trichomonas vaginalis esterase, putative 0.0063 0.0087 0.0173
Leishmania major basic transcription factor 3a, putative 0.0025 0.0006 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.145 0.3005 0.3005
Echinococcus multilocularis amyloid beta A4 protein 0.0092 0.0147 0.0147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0041 0.0041
Onchocerca volvulus 0.0117 0.02 0.1187
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Trypanosoma cruzi pyruvate kinase 2, putative 0.0094 0.0152 0.0149
Leishmania major phosphopantetheinyl transferase-like protein 0.0065 0.0091 0.0089
Schistosoma mansoni glutaminase 0.0266 0.0514 0.0514
Leishmania major acetoin dehydrogenase e3 component-like protein 0.006 0.0081 0.0079
Schistosoma mansoni kinase 0.0069 0.01 0.01
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0231 0.0441 0.0441
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.2239 0.4667 1
Mycobacterium tuberculosis Probable esterase LipL 0.0063 0.0087 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0285 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0041 0.0041
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0041 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0041 0.0041
Echinococcus multilocularis geminin 0.012 0.0207 0.0207
Trypanosoma cruzi polo-like protein kinase, putative 0.0137 0.0242 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Brugia malayi RNA binding protein 0.0092 0.0147 0.0147
Brugia malayi serine/threonine-protein kinase plk-2 0.0137 0.0242 0.0242
Schistosoma mansoni pyruvate kinase 0.0094 0.0152 0.0152
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0041 0.0041
Brugia malayi nuclear receptor NHR-88 0.0041 0.0041 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.4773 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0066 0.0093 0.0057
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0044 0.0047 0.0047
Plasmodium vivax basic transcription factor 3b, putative 0.0025 0.0006 0.0127
Schistosoma mansoni survival motor neuron protein 0.0117 0.02 0.02
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0132 0.0232 0.0232
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.0058 0.0058
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0396 0.0788 0.0797
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0319 0.0625 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0041 0.0041
Echinococcus granulosus intermediate filament protein 0.0075 0.0112 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Echinococcus granulosus phd:f box containing protein 0.0049 0.0058 0.0058
Schistosoma mansoni apoptosis regulator bax 0.0115 0.0196 0.0196
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0055 0.0055
Brugia malayi beta-NAC-like protein 0.0025 0.0006 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0813 0.1665 0.3556
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0184 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0094 0.0152 0.0152
Onchocerca volvulus 0.0063 0.0087 0.0482
Schistosoma mansoni hypothetical protein 0.0117 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0075 0.0112 0.0112
Onchocerca volvulus 0.004 0.0039 0.0183
Echinococcus granulosus Niemann Pick C1 protein 0.1965 0.409 0.409
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0041 0.0193
Schistosoma mansoni polycystin 1-related 0.004 0.0039 0.0039
Schistosoma mansoni transcription factor btf3 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0062 0.0061
Onchocerca volvulus Pyruvate kinase homolog 0.0094 0.0152 0.0885
Echinococcus multilocularis pyruvate kinase 0.0048 0.0056 0.0056
Loa Loa (eye worm) beta-lactamase 0.0063 0.0087 0.0087
Echinococcus granulosus transcription factor btf3 0.0025 0.0006 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0083
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0103 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0041 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0041 0.0041
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0174 0.032 0.0322
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0065 0.0091 0.0055
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0792
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0087 0.0173
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0065 0.0091 0.28
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0011 0.0275
Schistosoma mansoni hypothetical protein 0.0115 0.0196 0.0196
Brugia malayi Bromodomain containing protein 0.0084 0.0131 0.0131
Mycobacterium ulcerans glutaminase 0.0266 0.0514 0.048
Onchocerca volvulus 0.0099 0.0163 0.0958
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0041 0.0041
Brugia malayi mbt repeat family protein 0.0034 0.0025 0.0025
Echinococcus granulosus expressed protein 0.0275 0.0534 0.0534
Brugia malayi Pyruvate kinase, muscle isozyme 0.0094 0.0152 0.0152
Brugia malayi Doublecortin family protein 0.004 0.0039 0.0039
Mycobacterium leprae Probable pyruvate kinase PykA 0.0094 0.0152 0.0429
Schistosoma mansoni lipoxygenase 0.0241 0.0462 0.0462
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.044 0.0881 0.0891
Loa Loa (eye worm) ICD-1 protein 0.0025 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0097 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Echinococcus multilocularis expressed protein 0.0275 0.0534 0.0534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0226 0.0191
Schistosoma mansoni coup transcription factor 0.0041 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0092 0.0147 0.0147
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.006 0.0081 0.0079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0065 0.0092 0.0092
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.0025 0.0025
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0115 0.0196 0.0196
Giardia lamblia NADH oxidase lateral transfer candidate 0.006 0.0081 0.0156
Giardia lamblia Pyruvate kinase 0.0094 0.0152 0.0308
Treponema pallidum replicative DNA helicase (dnaB) 0.0537 0.1084 0.6484
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0041 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0066 0.0093 0.0091
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.0058 0.0058
Mycobacterium tuberculosis Probable reductase 0.0396 0.0788 0.0797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0041 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.0226 0.0226
Echinococcus multilocularis voltage dependent calcium channel 0.0132 0.0232 0.0232
Leishmania major glycosyl hydrolase-like protein 0.0026 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0024 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.145 0.3005 0.3005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus granulosus lamin 0.0075 0.0112 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0087 0.2669
Schistosoma mansoni pyruvate kinase 0.0094 0.0152 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0103 0.0101
Echinococcus multilocularis survival motor neuron protein 1 0.0572 0.1159 0.1159
Schistosoma mansoni rab6-interacting 0.004 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0057 0.0057
Plasmodium vivax acyl-CoA synthetase, putative 0.0049 0.0058 0.1754
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0115 0.0196 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0087 0.0173
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1965 0.409 0.409
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0226 0.0191
Brugia malayi hypothetical protein 0.0218 0.0414 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0057 0.0057
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0103 0.0208
Echinococcus multilocularis histone acetyltransferase MYST2 0.0038 0.0035 0.0035
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0103 0.0208
Loa Loa (eye worm) hypothetical protein 0.0572 0.1159 0.1159
Brugia malayi RNA recognition motif domain containing protein 0.0092 0.0147 0.0147
Onchocerca volvulus 0.0034 0.0025 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Plasmodium vivax pyruvate kinase 2, putative 0.0048 0.0056 0.1675
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0039 0.0039
Schistosoma mansoni phd/f-box containing protein 0.0049 0.0058 0.0058
Toxoplasma gondii pyruvate kinase PyK1 0.0094 0.0152 0.4701
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0055 0.0055
Brugia malayi ecdysteroid receptor 0.0041 0.0041 0.0041
Trypanosoma brucei pyruvate kinase 1, putative 0.0094 0.0152 0.0149
Schistosoma mansoni protein phosphatase 2C 0.0049 0.0058 0.0058
Chlamydia trachomatis replicative DNA helicase 0.0537 0.1084 1
Plasmodium falciparum pyruvate kinase 0.0094 0.0152 0.4701
Brugia malayi Inositol-1 0.0039 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.006 0.0081 0.0427
Trypanosoma cruzi DNA repair protein, putative 0.0046 0.0051 0.0049
Brugia malayi Thioredoxin reductase 0.0174 0.032 0.032
Plasmodium falciparum basic transcription factor 3b, putative 0.0025 0.0006 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0041 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0226 0.0226
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.4773 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.006 0.0081 0.2475
Leishmania major hypothetical protein, conserved 0.0049 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0089 0.0142 0.0142
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0115 0.0196 0.0196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0066 0.0093 0.0251
Loa Loa (eye worm) thioredoxin reductase 0.0174 0.032 0.032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0063 0.0087 0.0087
Brugia malayi Bromodomain containing protein 0.0162 0.0295 0.0295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0041 0.0041
Plasmodium falciparum pyruvate kinase 2 0.0048 0.0056 0.1675
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0119 0.033
Entamoeba histolytica acetyltransferase, GNAT family 0.0026 0.0008 0.0011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0066 0.0093 0.0092
Loa Loa (eye worm) acetyltransferase 0.01 0.0165 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0103 0.0208
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0041 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0075 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0082 0.0126 0.0126
Plasmodium vivax SET domain protein, putative 0.0099 0.0163 0.507
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0231 0.0441 0.0441
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0041 0.0041
Loa Loa (eye worm) inositol-1 0.0039 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0092 0.0147 0.0147
Plasmodium vivax glutathione reductase, putative 0.0174 0.032 1
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0009
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.01 0.0165 0.0165
Loa Loa (eye worm) voltage-dependent calcium channel 0.003 0.0018 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0011 0.0275
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.01 0.0165 0.0165
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0813 0.1665 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0065 0.0091 0.0511
Schistosoma mansoni jumonji/arid domain-containing protein 0.0188 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Mycobacterium ulcerans pyruvate kinase 0.0094 0.0152 0.0116
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0119 0.3681
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0036 0.0036
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0036 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0041 0.0041
Toxoplasma gondii pyruvate kinase PyKII 0.0048 0.0056 0.1675
Echinococcus granulosus pyruvate kinase 0.0048 0.0056 0.0056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0099 0.0163 0.0163
Trypanosoma cruzi ISWI complex protein 0.0033 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.0088 0.014 0.014
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0065 0.0091 0.0055
Mycobacterium ulcerans recombinase A 0.015 0.027 0.0234
Schistosoma mansoni hypothetical protein 0.012 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.006 0.0081 0.0427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0057 0.0057
Echinococcus granulosus RUN 0.004 0.0039 0.0039
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0132 0.0232 0.0232
Loa Loa (eye worm) isocitrate dehydrogenase 0.0023 0.0002 0.0002
Schistosoma mansoni Replicative DNA helicase 0.0537 0.1084 0.1084
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0115 0.0196 0.0196
Echinococcus granulosus pyruvate kinase 0.0048 0.0056 0.0056
Toxoplasma gondii NAC domain-containing protein 0.0025 0.0006 0.0127
Echinococcus granulosus beta LACTamase domain containing family member 0.0063 0.0087 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0103 0.0101
Mycobacterium tuberculosis Probable lipase LipE 0.0063 0.0087 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Echinococcus multilocularis RUN 0.004 0.0039 0.0039
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0653
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0041 0.0041
Echinococcus granulosus amyloid beta A4 protein 0.0092 0.0147 0.0147
Brugia malayi mbt repeat family protein 0.0034 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0052 0.0051
Brugia malayi nuclear hormone receptor 0.0041 0.0041 0.0041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0092 0.0147 0.0147
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0049 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0087 0.0173
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.006 0.0081 0.0079
Onchocerca volvulus 0.0218 0.0414 0.2523
Schistosoma mansoni lipoxygenase 0.0168 0.0309 0.0309
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0063 0.0087 0.0051
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.2239 0.4667 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0041 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0115 0.0115
Loa Loa (eye worm) pyruvate kinase 0.0094 0.0152 0.0152
Chlamydia trachomatis pyruvate kinase 0.0094 0.0152 0.0912
Trypanosoma cruzi polo-like protein kinase, putative 0.0137 0.0242 0.0239
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0115 0.0196 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0093 0.0057
Onchocerca volvulus 0.0075 0.0112 0.0639
Brugia malayi acetyltransferase, GNAT family protein 0.01 0.0165 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Schistosoma mansoni patched 1 0.1965 0.409 0.409
Mycobacterium tuberculosis Conserved protein 0.0063 0.0087 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0088 0.014 0.014
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0132 0.0232 0.0232
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0033 0.0024 0.0671
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.001 0.0007
Chlamydia trachomatis recombinase RecA 0.015 0.027 0.2064
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.4773 1 1
Schistosoma mansoni lamin 0.0075 0.0112 0.0112
Echinococcus multilocularis phd:f box containing protein 0.0049 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Brugia malayi glutaminase DH11.1 0.0266 0.0514 0.0514
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0119 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0137 0.0242 0.0505
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0137 0.0242 0.0242
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0053 0.0066 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.006 0.0081 0.0045
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0119 0.3681
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.001 0.0007
Onchocerca volvulus Pyruvate kinase homolog 0.0094 0.0152 0.0885
Leishmania major pyruvate kinase 0.0094 0.0152 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0041 0.0041
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0396 0.0788 0.0797
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0241 0.0462 0.0462
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0103 0.3178
Loa Loa (eye worm) hypothetical protein 0.0102 0.0168 0.0168
Treponema pallidum fructose-bisphosphate aldolase 0.0813 0.1665 1
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0005 0.0005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.0155 0.0155
Echinococcus multilocularis muscleblind protein 1 0.0102 0.0168 0.0168
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0058 0.0055
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0053 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0087 0.0085
Brugia malayi hypothetical protein 0.0572 0.1159 0.1159
Mycobacterium tuberculosis Conserved protein 0.0063 0.0087 0.0086
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0039 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0063 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0096 0.0155 0.0155
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0103 0.0103
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0044 0.0047 0.0047
Plasmodium falciparum histone acetyltransferase GCN5 0.0026 0.0008 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0093 0.0523
Brugia malayi jmjC domain containing protein 0.0049 0.0058 0.0058
Trypanosoma cruzi transcription factor btf3, putative 0.0025 0.0006 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0285 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0041 0.0041
Onchocerca volvulus 0.0231 0.0441 0.2691
Brugia malayi Probable ClpP-like protease 0.0078 0.0119 0.0119
Loa Loa (eye worm) pyruvate kinase 0.0094 0.0152 0.0152
Trypanosoma brucei polo-like protein kinase 0.0137 0.0242 0.0239
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0025 0.0025
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.001 0.0007
Trichomonas vaginalis glutaminase, putative 0.0266 0.0514 0.109
Echinococcus granulosus lysine specific demethylase 5A 0.0188 0.035 0.035
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0119 0.0119
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0033 0.0024 0.0671
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0041 0.0193
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0063 0.0087 0.0086
Echinococcus granulosus tar DNA binding protein 0.0092 0.0147 0.0147
Brugia malayi beta-lactamase family protein 0.0063 0.0087 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0119 0.3681
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0046 0.0051 0.0049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0066 0.0093 0.0057
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0081 0.0126 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0157 0.0285 0.0282
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus granulosus muscleblind protein 0.0102 0.0168 0.0168
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.0226 0.0227
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.0025 0.0025
Onchocerca volvulus 0.0032 0.0022 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0087 0.0085
Echinococcus multilocularis muscleblind protein 0.0102 0.0168 0.0168
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0066 0.0093 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0035
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.0226 0.705
Echinococcus granulosus zinc finger protein 0.0044 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0041 0.0041
Brugia malayi CHE-14 protein 0.1965 0.409 0.409
Mycobacterium tuberculosis Probable hydrolase 0.0063 0.0087 0.0086
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0039 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0063 0.0087 0.0232
Trypanosoma brucei glucosidase, putative 0.0071 0.0103 0.0101
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0038 0.0035 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0403 0.0802 0.0812
Echinococcus multilocularis voltage dependent calcium channel 0.0132 0.0232 0.0232
Toxoplasma gondii thioredoxin reductase 0.0174 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0232 0.0232
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0137 0.0242 0.0242
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0132 0.0232 0.0232
Echinococcus multilocularis pyruvate kinase 0.0094 0.0152 0.0152
Mycobacterium leprae Conserved hypothetical protein 0.1582 0.3284 1
Loa Loa (eye worm) TAR-binding protein 0.0092 0.0147 0.0147
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0025 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0075 0.0112 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0041 0.0041
Echinococcus granulosus pyruvate kinase 0.0048 0.0056 0.0056
Echinococcus granulosus thioredoxin glutathione reductase 0.0175 0.0323 0.0323
Plasmodium falciparum thioredoxin reductase 0.0174 0.032 1
Trypanosoma brucei trypanothione reductase 0.0174 0.032 0.0317
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.115 0.2375 0.2375
Echinococcus granulosus neuropeptide receptor A26 0.0947 0.1947 0.1947
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0099 0.0163 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0188 0.035 0.035
Echinococcus multilocularis lysosomal alpha glucosidase 0.0319 0.0625 0.0625
Echinococcus multilocularis musashi 0.0075 0.0112 0.0112
Schistosoma mansoni lamin 0.0075 0.0112 0.0112
Brugia malayi Pyruvate kinase, M2 isozyme 0.0094 0.0152 0.0152
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Plasmodium falciparum glutathione reductase 0.006 0.0081 0.2475
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.044 0.0881 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0092 0.0147 0.0147
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0039 0.0039
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.0025 0.0097
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0028 0.0026
Trypanosoma brucei pyruvate kinase 1 0.0094 0.0152 0.0149
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0023 0.0002 0.0002
Mycobacterium leprae Probable lipase LipE 0.0063 0.0087 0.0232
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.001 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.0087 0.0085
Echinococcus multilocularis tar DNA binding protein 0.0092 0.0147 0.0147
Echinococcus granulosus histone lysine methyltransferase setb 0.0136 0.024 0.024
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0062 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0033 0.0024 0.0037
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0082 0.0127 0.0127
Toxoplasma gondii NADPH-glutathione reductase 0.006 0.0081 0.2475
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0132 0.0232 0.0232
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0096 0.0155 0.0155
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.001 0.0007
Schistosoma mansoni zinc finger protein 0.0033 0.0023 0.0023
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0103 0.0103
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0039 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.1965 0.409 0.8762
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0041 0.0193
Loa Loa (eye worm) hypothetical protein 0.0218 0.0414 0.0414
Onchocerca volvulus 0.0063 0.0087 0.0482
Loa Loa (eye worm) glutathione reductase 0.0174 0.032 0.032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Brugia malayi beta-lactamase family protein 0.0063 0.0087 0.0087
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0031 0.0031
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0115 0.0196 0.0196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.001 0.001
Leishmania major pyruvate kinase 0.0094 0.0152 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0036 0.1065
Brugia malayi jmjC domain containing protein 0.0049 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0031
Plasmodium vivax thioredoxin reductase, putative 0.0174 0.032 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0049 0.0058 0.0056
Echinococcus multilocularis zinc finger protein 0.0044 0.0047 0.0047
Onchocerca volvulus 0.0066 0.0093 0.052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.006 0.0081 0.0079
Loa Loa (eye worm) pyruvate kinase-PB 0.0065 0.0092 0.0092
Leishmania major hypothetical protein, conserved 0.0063 0.0087 0.0085
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.0226 0.0226
Echinococcus multilocularis sterol regulatory element binding protein 0.1965 0.409 0.409
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0041 0.0041
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0055 0.0055
Onchocerca volvulus Serine\/threonine kinase homolog 0.0137 0.0242 0.1447
Loa Loa (eye worm) hypothetical protein 0.0066 0.0093 0.0093
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0062 0.0062
Brugia malayi jmjC domain containing protein 0.0049 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.015 0.0271 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0097 0.0193
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0041 0.0041
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0132 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0041 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0025 0.0008 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0039 0.1158
Echinococcus granulosus lamin dm0 0.0075 0.0112 0.0112
Trypanosoma cruzi trypanothione reductase, putative 0.006 0.0081 0.0079
Trichomonas vaginalis glutathione reductase, putative 0.006 0.0081 0.016
Echinococcus granulosus survival motor neuron protein 1 0.0572 0.1159 0.1159
Plasmodium falciparum JmjC domain-containing protein, putative 0.0049 0.0058 0.1739
Leishmania major dihydrolipoamide dehydrogenase, putative 0.006 0.0081 0.0079
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.006 0.0081 0.0079
Loa Loa (eye worm) hypothetical protein 0.1965 0.409 0.409
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0093 0.0057
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0537 0.1084 1
Entamoeba histolytica pyruvate kinase, putative 0.0065 0.0092 0.0515
Loa Loa (eye worm) doublecortin family protein 0.004 0.0039 0.0039
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.4773 1 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0036 0.0036
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0066 0.0093 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.006 0.0081 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0692 0.1411 0.1411
Schistosoma mansoni zinc finger protein 0.0044 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0103 0.0101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0031 0.0031
Schistosoma mansoni pyruvate kinase 0.0048 0.0056 0.0056
Schistosoma mansoni intermediate filament proteins 0.0075 0.0112 0.0112
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0036 0.0179
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0137 0.0242 0.0242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0057 0.0057
Echinococcus granulosus lysine specific demethylase 6a 0.0049 0.0058 0.0058
Schistosoma mansoni alpha glucosidase 0.0071 0.0103 0.0103
Plasmodium vivax pyruvate kinase, putative 0.0094 0.0152 0.4701
Schistosoma mansoni hypothetical protein 0.004 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0041 0.0041
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0041 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0057 0.0057
Echinococcus granulosus microtubule associated protein 2 0.145 0.3005 0.3005
Leishmania major 4-coumarate:coa ligase-like protein 0.0066 0.0093 0.0091
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0093 0.015 0.015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0036 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0788 0.1612 0.3445
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.004 0.0039 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.0087 0.0087
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0041
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.4773 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0058
Echinococcus multilocularis sodium channel protein 0.0058 0.0076 0.0076
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0047 0.0047
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0065 0.0091 0.0324
Echinococcus granulosus L aminoadipate semialdehyde 0.0231 0.0441 0.0441
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0041 0.0041
Plasmodium falciparum thioredoxin reductase 0.006 0.0081 0.2475
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0115 0.0115
Loa Loa (eye worm) pyruvate kinase 0.0094 0.0152 0.0152
Trypanosoma brucei ISWI complex protein 0.0033 0.0023 0.002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0063 0.0087 0.0086
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.006 0.0081 0.2475
Loa Loa (eye worm) twinkle helicase 0.0153 0.0277 0.0277
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.0155 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0813 0.1665 0.3559
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0103 0.0208
Echinococcus multilocularis neuropeptide receptor A26 0.0947 0.1947 0.1947
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0041 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.006 0.0081 0.0079
Schistosoma mansoni bromodomain containing protein 0.0137 0.0242 0.0242
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0093 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0041 0.0041
Echinococcus granulosus pyruvate kinase 0.0094 0.0152 0.0152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.024 0.024
Loa Loa (eye worm) MBCTL1 0.0038 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0063 0.0087 0.0087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.006 0.0081 0.0081
Schistosoma mansoni voltage-gated cation channel 0.0132 0.0232 0.0232
Wolbachia endosymbiont of Brugia malayi recombinase A 0.015 0.027 0.2229
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0041 0.0041
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.006 0.0081 0.2475
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0036 0.0031 0.0031

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -5.4 Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells ChEMBL. 17234406
Log IC50 (binding) = 5.4 Inhibition of [3H]glycine uptake in human GlyT1c expressed in HEK293 cells ChEMBL. 17234406

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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