Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.0827 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0146 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0146 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.0827 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0827 | 1 | 1 |
Onchocerca volvulus | 0.0146 | 0 | 0.5 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0146 | 0 | 0.5 |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.0827 | 1 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.0827 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0827 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 7.48 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17127059 |
Ki (binding) | = 8.3 nM | Binding affinity at rat SERT | ChEMBL. | 17127059 |
Ki (binding) | = 8.3 nM | Binding affinity at rat SERT | ChEMBL. | 17127059 |
Ki (binding) | = 21 nM | Binding affinity at human SERT | ChEMBL. | 17127059 |
Ki (binding) | = 21 nM | Binding affinity at human SERT | ChEMBL. | 17127059 |
Ki (binding) | = 31 nM | Binding affinity at human histamine H3 receptor | ChEMBL. | 17127059 |
Ki (binding) | = 31 nM | Binding affinity at human histamine H3 receptor | ChEMBL. | 17127059 |
pA2 (functional) | = 7.48 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17127059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.