Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | fms-related tyrosine kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nephrin | 0.005 | 0.0264 | 0.9487 |
Schistosoma mansoni | vesicular amine transporter | 0.0044 | 0.0212 | 0.7634 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0044 | 0.0212 | 0.7634 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0044 | 0.0212 | 0.7634 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.043 | 0.3292 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1271 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1271 | 1 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0059 | 0.0329 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0329 | 0.0381 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0384 | 0.2926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0329 | 0.0381 |
Echinococcus granulosus | twitchin | 0.005 | 0.0264 | 0.0103 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.043 | 0.3292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0278 | 0.0214 |
Echinococcus multilocularis | neuroglian | 0.005 | 0.0264 | 0.4393 |
Schistosoma mansoni | cell adhesion molecule | 0.0052 | 0.0278 | 1 |
Echinococcus granulosus | neuroglian | 0.005 | 0.0264 | 0.0103 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0052 | 0.0278 | 0.0132 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0669 | 0.5202 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0059 | 0.0329 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | Inhibition of KDR by HTRF assay | ChEMBL. | 17391959 |
IC50 (binding) | = 0.05 uM | Inhibition of KDR by HTRF assay | ChEMBL. | 17391959 |
IC50 (binding) | = 0.08 uM | Inhibition of Flt1 by HTRF assay | ChEMBL. | 17391959 |
IC50 (binding) | = 0.08 uM | Inhibition of Flt1 by HTRF assay | ChEMBL. | 17391959 |
IC50 (binding) | = 1.12 uM | Inhibition of c-Kit by HTRF assay | ChEMBL. | 17391959 |
IC50 (binding) | = 1.12 uM | Inhibition of c-Kit by HTRF assay | ChEMBL. | 17391959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.