Activity (binding)
|
= 42 nM
|
Tested for in vitro binding affinity against AMPA receptor using [3H]-AMPA binding assay
|
ChEMBL.
|
9871630
|
Activity (binding)
|
= 42 nM
|
Tested for in vitro binding affinity against AMPA receptor using [3H]-AMPA binding assay
|
ChEMBL.
|
9871630
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Anticonvulsant activity in mice was determined from maximal electroshock assay
|
ChEMBL.
|
10377233
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Mouse maximum electroshock induced test seizure test in mice
|
ChEMBL.
|
9357535
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Effective dose required for the action of AMPA receptor antagonistic activity in maximal electroshock anticonvulsant assay
|
ChEMBL.
|
No reference
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Effective dose required for the action of AMPA receptor antagonistic activity in maximal electroshock anticonvulsant assay
|
ChEMBL.
|
No reference
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Anticonvulsant activity in mice was determined from maximal electroshock assay
|
ChEMBL.
|
10377233
|
ED50 (functional)
|
= 0.44 mg kg-1
|
Mouse maximum electroshock induced test seizure test in mice
|
ChEMBL.
|
9357535
|
IC50 (functional)
|
= 63 nM
|
Inhibitory concentration required for antagonistic activity against AMPA receptor in neuronal cultures
|
ChEMBL.
|
No reference
|
IC50 (functional)
|
= 63 nM
|
Inhibitory concentration required for antagonistic activity against AMPA receptor in neuronal cultures
|
ChEMBL.
|
No reference
|
IC50 (functional)
|
= 370 nM
|
Inhibitory concentration required for antagonistic activity against NMDA receptor in rat cortical wedge
|
ChEMBL.
|
No reference
|
IC50 (functional)
|
= 370 nM
|
Inhibitory concentration required for antagonistic activity against NMDA receptor in rat cortical wedge
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 0.063 uM
|
Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.063 uM
|
In vitro binding affinity against Ionotropic glutamate receptor AMPA binding site using [3H]- AMPA as radioligand on rat cortical synaptosomal membranes
|
ChEMBL.
|
10377233
|
IC50 (binding)
|
= 0.063 uM
|
Binding affinity in rat brain cortical membranes by the displacement of [3H]-AMPA at Ionotropic glutamate receptor AMPA
|
ChEMBL.
|
9357535
|
IC50 (binding)
|
= 0.063 uM
|
Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.063 uM
|
In vitro binding affinity against Ionotropic glutamate receptor AMPA binding site using [3H]- AMPA as radioligand on rat cortical synaptosomal membranes
|
ChEMBL.
|
10377233
|
IC50 (binding)
|
= 0.063 uM
|
Binding affinity in rat brain cortical membranes by the displacement of [3H]-AMPA at Ionotropic glutamate receptor AMPA
|
ChEMBL.
|
9357535
|
IC50 (binding)
|
= 0.08 uM
|
Binding affinity against AMPA receptor using [3H]- AMPA radioligand
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 0.08 uM
|
Binding affinity against AMPA receptor using [3H]- AMPA radioligand
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 0.36 uM
|
Displacement of [3H]-Kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate
|
ChEMBL.
|
9357535
|
IC50 (binding)
|
= 0.36 uM
|
Displacement of [3H]-Kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate
|
ChEMBL.
|
9357535
|
IC50 (binding)
|
= 0.368 uM
|
Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.368 uM
|
Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.37 uM
|
Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.37 uM
|
In vitro binding affinity against glycine receptor binding site using [3H]- Glycine as radioligand on rat cortical synaptosomal membranes
|
ChEMBL.
|
10377233
|
IC50 (binding)
|
= 0.37 uM
|
Displacement of [3H]-DCKA at N-methyl-D-aspartate glutamate receptor 1
|
ChEMBL.
|
9357535
|
IC50 (binding)
|
= 0.37 uM
|
Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.37 uM
|
Displacement of [3H]-DCKA at N-methyl-D-aspartate glutamate receptor 1
|
ChEMBL.
|
9357535
|
IC50 (functional)
|
= 0.5 uM
|
Concentration of compound that inhibits by 50% depolarizations induced by 10 uM AMPA
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.5 uM
|
Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA
|
ChEMBL.
|
7562904
|
IC50 (binding)
|
= 0.5 uM
|
Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 2.5 uM
|
Concentration of compound that inhibits by 50% LDH released by 24 hr application of 100 uM AMPA
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 2.5 uM
|
Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 2.5 uM
|
Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 4 uM
|
Concentration of compound that inhibits by 50% LDH released by 24 hr application of 500 uM kainate
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 4 uM
|
Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate
|
ChEMBL.
|
7562904
|
IC50 (functional)
|
= 4 uM
|
Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate
|
ChEMBL.
|
7562904
|
Solubility |
= 8.6 ug ml-1
|
Solubility of the compound was measured in 50 mM phosphate buffer at pH 7.4
|
ChEMBL.
|
10377233
|