Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.8245 | 0.8026 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0054 | 0.4618 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.8245 | 0.8245 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4618 | 0.3945 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0054 | 0.4618 | 0.3945 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0033 | 0.1112 | 0.1112 |
Leishmania major | p450 reductase, putative | 0.0054 | 0.4618 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0054 | 0.4618 | 0.3945 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0048 | 0.3576 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0085 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0054 | 0.4618 | 0.3945 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0085 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0085 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0085 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0054 | 0.4618 | 0.3945 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.8245 | 0.8026 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0085 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0054 | 0.4618 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0085 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0054 | 0.4618 | 0.3945 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0054 | 0.4618 | 0.3945 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0027 | 0.007 | 0.007 |
Chlamydia trachomatis | sulfite reductase | 0.0033 | 0.1112 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0085 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0085 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0054 | 0.4618 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0054 | 0.4618 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0085 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0085 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0085 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0054 | 0.4618 | 0.4618 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0085 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0085 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0054 | 0.4618 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0085 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0048 | 0.3576 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0054 | 0.4618 | 0.3945 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0085 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0085 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 7.9 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 12.1 | Antinociceptive effect in mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 12.9 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 25 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 15 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 12.5 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 23 | Reversal of antinociceptive effect in L-arginine pretreated mouse assessed as number or writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 7.9 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 12.1 | Antinociceptive effect in mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 12.9 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 25 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 15 | Antinociceptive effect in acetic acid-induced mouse assessed as number of writhes for 10 mins at 12.5 mg/kg, ip | ChEMBL. | 17395463 |
Activity (functional) | = 23 | Reversal of antinociceptive effect in L-arginine pretreated mouse assessed as number or writhes for 10 mins at 50 mg/kg, ip | ChEMBL. | 17395463 |
IC50 (binding) | = 4.2 uM | Inhibition of rat neuronal NOS | ChEMBL. | 17395463 |
IC50 (binding) | = 4.2 uM | Inhibition of rat neuronal NOS | ChEMBL. | 17395463 |
IC50 (binding) | = 4.2 uM | Inhibition of NOS1 | ChEMBL. | 19679481 |
Inhibition (binding) | = 100 % | Inhibition of rat neuronal NOS at 100 uM | ChEMBL. | 17395463 |
Inhibition (binding) | = 100 % | Inhibition of rat neuronal NOS at 100 uM | ChEMBL. | 17395463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.