Detailed information for compound 457093

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.009 | Formula: C25H25ClN4O3S
  • H donors: 2 H acceptors: 4 LogP: 3.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C[C@H](c1ccccn1)O)Cc1sc2c(c1)c(=O)c(cn2C)C(=O)NCc1cccc(c1)Cl
  • InChi: 1S/C25H25ClN4O3S/c1-29(15-22(31)21-8-3-4-9-27-21)13-18-11-19-23(32)20(14-30(2)25(19)34-18)24(33)28-12-16-6-5-7-17(26)10-16/h3-11,14,22,31H,12-13,15H2,1-2H3,(H,28,33)/t22-/m1/s1
  • InChiKey: TUOXSRSZGSCDAC-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 DNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus granulosus DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma congolense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Loa Loa (eye worm) DNA-directed DNA polymerase III Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium parvum DNA polymerase delta catalytic subunit. DNAQ-like 3-5 exonuclease; RNAseH fold Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium falciparum DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Theileria parva DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Giardia lamblia DNA polymerase delta, catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Toxoplasma gondii DNA polymerase Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium vivax DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma japonicum ko:K02327 DNA polymerase delta subunit 1, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium hominis DNA polymerase family B subunit Get druggable targets OG5_127429 All targets in OG5_127429
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Brugia malayi DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania infantum DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania donovani DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania mexicana DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium knowlesi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans hypothetical protein Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus multilocularis DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Babesia bovis DNA polymerase delta subunit Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma mansoni DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium berghei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium yoelii DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania braziliensis DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Neospora caninum DNA polymerase (EC 2.7.7.7), related Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei gambiense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0212 0.0376
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0212 0.0668
Echinococcus multilocularis dna polymerase eta 0.0019 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.6198
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0133
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0212 0.0668
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0323 0.5624
Schistosoma mansoni amine GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus geminin 0.0877 0.5643 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0153 0.0271
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0212 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0785 0.139
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0153 0.0153
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0416 0.0736
Brugia malayi MH2 domain containing protein 0.0243 0.1481 0.4665
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0029
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0104 0.0574 0.1018
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0043 0.017 0.017
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0212 0.0668
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0043 0.017 0.2956
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0574 0.0566
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0104 0.0574 0.0566
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0104 0.0574 0.0566
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0212 0.0668
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0212 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0153 0.2662
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0104 0.0574 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Brugia malayi DNA polymerase alpha catalytic subunit 0.003 0.0089 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.003 0.0089 0.0158
Echinococcus granulosus neuropeptide s receptor 0.0562 0.3574 0.6334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0104 0.0574 0.0428
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0785 0.139
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.1521 0.4791
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0016 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0153 0.0144
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1542 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0212 0.0376
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0323 0.5624
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0281
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0153 0.0144
Schistosoma mansoni adenoreceptor 0.0049 0.0212 0.0376
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0153 0.0144
Brugia malayi Dopamine receptor 0.0049 0.0212 0.0668
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0212 0.0376
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0212 0.0668
Onchocerca volvulus Huntingtin homolog 0.0123 0.0696 0.7872
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0212 0.0376
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0043 0.017 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0009 0.0155
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0574 0.0566
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0501 0.3175 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0323 0.5624
Schistosoma mansoni amine GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0029
Mycobacterium ulcerans lipase LipD 0.004 0.0153 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0312 0.0553
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0212 0.0376
Brugia malayi DNA polymerase family B containing protein 0.003 0.0089 0.0281
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0153 0.0271
Schistosoma mansoni protein phosphatase-2b 0.0043 0.017 0.0301
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi GnHR receptor homolog 0.0049 0.0212 0.0668
Schistosoma mansoni hypothetical protein 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0059 0.0274 0.3093
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0153 0.2662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0785 0.139
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0029
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0312 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0153 0.0144
Trypanosoma brucei protein phosphatase 2B, putative 0.0043 0.017 0.2845
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.056 0.1763
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0356 0.0631
Echinococcus granulosus orexin receptor type 2 0.0049 0.0212 0.0376
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0212 0.0668
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0212 0.0376
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0043 0.017 0.2956
Loa Loa (eye worm) hypothetical protein 0.0123 0.0696 0.2193
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0043 0.017 0.2956
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0212 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2858 0.5065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0212 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0104 0.0574 0.181
Loa Loa (eye worm) beta-lactamase 0.004 0.0153 0.0482
Schistosoma mansoni biogenic amine receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus granulosus fmrfamide receptor 0.0049 0.0212 0.0376
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0212 0.0376
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.003 0.0089 0.0281
Echinococcus multilocularis serotonin receptor 0.0411 0.2587 0.4585
Schistosoma mansoni hypothetical protein 0.0079 0.0406 0.0719
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.003 0.0089 0.1551
Leishmania major cathepsin L-like protease 0.0064 0.031 0.5391
Loa Loa (eye worm) hypothetical protein 0.0042 0.0166 0.0522
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Loa Loa (eye worm) hypothetical protein 0.0057 0.0267 0.084
Onchocerca volvulus 0.004 0.0153 0.1729
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Schistosoma mansoni lamin 0.0059 0.0274 0.0485
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Schistosoma mansoni histamine h1 receptor 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.0133
Leishmania major DNA polymerase eta, putative 0.0019 0.0016 0.0286
Onchocerca volvulus 0.0049 0.0212 0.2396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0312 0.0303
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.003 0.0089 0.0089
Brugia malayi putative neuropeptide receptor 0.0049 0.0212 0.0668
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.0286
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0535
Brugia malayi hypothetical protein 0.0123 0.0696 0.2193
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0075 0.0133
Echinococcus granulosus lamin dm0 0.0059 0.0274 0.0485
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0092 0.0494 0.1556
Loa Loa (eye worm) hypothetical protein 0.0411 0.2587 0.815
Schistosoma mansoni opsin-like receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0153 0.0271
Loa Loa (eye worm) hypothetical protein 0.008 0.0416 0.1309
Echinococcus multilocularis neuropeptide receptor A26 0.0562 0.3574 0.6334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0286
Schistosoma mansoni hypothetical protein 0.0102 0.056 0.0992
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0323 0.1018
Schistosoma mansoni hypothetical protein 0.0877 0.5643 1
Brugia malayi beta-lactamase family protein 0.004 0.0153 0.0482
Echinococcus multilocularis neuropeptide s receptor 0.0562 0.3574 0.6334
Brugia malayi ORL1-like opioid receptor 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.003 0.0089 0.1418
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0043 0.017 0.2956
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.003 0.0089 0.0158
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.005 0.005
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0049 0.0212 0.2396
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0212 0.0376
Schistosoma mansoni neuropeptide receptor 0.0049 0.0212 0.0376
Brugia malayi neuropeptide F receptor 0.0049 0.0212 0.0668
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0574 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Toxoplasma gondii exonuclease III APE 0.0018 0.0009 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0785 0.139
Echinococcus granulosus biogenic amine 5HT receptor 0.0411 0.2587 0.4585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) oxidoreductase 0.0104 0.0574 0.181
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0574 0.0566
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0092 0.0494 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0323 0.1018
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Brugia malayi Dopamine receptor protein 1 0.0049 0.0212 0.0668
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0043 0.017 0.0301
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0104 0.0574 0.1018
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Leishmania major serine/threonine protein phosphatase, putative 0.0043 0.017 0.2956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0785 0.139
Onchocerca volvulus 0.0049 0.0212 0.2396
Loa Loa (eye worm) retinol dehydrogenase 12 0.0104 0.0574 0.181
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.0286
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0153 0.0144
Schistosoma mansoni neuropeptide receptor 0.0049 0.0212 0.0376
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0312 0.0312
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0574 0.0566
Schistosoma mansoni amine GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0212 0.0376
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0212 0.0376
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0104 0.0574 1
Brugia malayi hypothetical protein 0.0024 0.005 0.0157
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0016 0.0008
Brugia malayi G protein-coupled receptor 0.0049 0.0212 0.0668
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Echinococcus multilocularis conserved hypothetical protein 0.0669 0.4275 0.7576
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0323 0.5555
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0092 0.0494 0.0875
Schistosoma mansoni survival motor neuron protein 0.0102 0.056 0.0992
Loa Loa (eye worm) hypothetical protein 0.0249 0.1521 0.4791
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.005
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1542 1 1
Brugia malayi G-protein coupled receptor 0.0049 0.0212 0.0668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0212 0.0376
Toxoplasma gondii DNA polymerase family B protein 0.003 0.0089 0.0089
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0153 0.0482
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Echinococcus granulosus GPCR family 2 0.0079 0.0406 0.0719
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0153 0.0144
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0157
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0092 0.0494 0.0494
Mycobacterium tuberculosis Conserved protein 0.004 0.0153 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0141 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0212 0.0376
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0323 0.5624
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.1571 0.1564
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0009 0.0028
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0212 0.0668
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0016
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0016 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0453 0.2858 0.5065
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0104 0.0574 1
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0133
Onchocerca volvulus Huntingtin homolog 0.0123 0.0696 0.7872
Schistosoma mansoni amine GPCR 0.0049 0.0212 0.0376
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.003 0.0089 0.0158
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0574 0.0566
Brugia malayi Serotonin receptor 0.0049 0.0212 0.0668
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Plasmodium vivax hypothetical protein, conserved 0.004 0.0153 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0016 0.0008
Echinococcus multilocularis GPCR, family 2 0.0079 0.0406 0.0719
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2858 0.5065
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0212 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2858 0.5065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0212 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni hypothetical protein 0.0079 0.0406 0.0719
Schistosoma mansoni hypothetical protein 0.0049 0.0212 0.0376
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0104 0.0574 0.0574
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1542 1 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0323 0.0572
Echinococcus multilocularis lamin dm0 0.0059 0.0274 0.0485
Onchocerca volvulus 0.0049 0.0212 0.2396
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0153 0.0144
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus multilocularis lamin 0.0059 0.0274 0.0485
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0095 0.03
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0406 0.0719
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0274 0.0862
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0104 0.0574 0.0566
Echinococcus granulosus intermediate filament protein 0.0059 0.0274 0.0485
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0212 0.0668
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0212 0.0376
Brugia malayi TAR-binding protein 0.0453 0.2858 0.9003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0104 0.0574 0.0574
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0104 0.0574 0.1018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Echinococcus multilocularis sex peptide receptor 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0133
Brugia malayi DNA polymerase delta catalytic subunit 0.0092 0.0494 0.1556
Schistosoma mansoni opsin-like receptor 0.0049 0.0212 0.0376
Schistosoma mansoni DNA polymerase eta 0.0019 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0574 0.181
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0212 0.0668
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0075 0.0383 0.6671
Echinococcus granulosus hypothetical protein 0.0718 0.4598 0.8147
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1481 0.4665
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.6198
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1542 1 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0696 0.2193
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0212 0.0376
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0092 0.0494 0.0494
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0212 0.0376
Echinococcus granulosus survival motor neuron protein 1 0.0501 0.3175 0.5626
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.0009
Echinococcus multilocularis geminin 0.0877 0.5643 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0212 0.0376
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0092 0.0494 0.0875
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0104 0.0574 0.0566
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0212 0.0376
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.003 0.0089 0.1654
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1542 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0416 0.0736
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0212 0.0376
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0416 0.0736
Echinococcus granulosus neuropeptide receptor 0.0049 0.0212 0.0376
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0212 0.0376
Toxoplasma gondii ABC1 family protein 0.004 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0406 0.0719
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0104 0.0574 0.181
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0785 0.2471
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Leishmania major pteridine reductase 1 0.0104 0.0574 1
Schistosoma mansoni opsin-like receptor 0.0049 0.0212 0.0376
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0312 0.5433
Mycobacterium tuberculosis Conserved protein 0.004 0.0153 0.0144
Trichomonas vaginalis DNA polymerase II, putative 0.003 0.0089 0.0089
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0079 0.0406 0.1279
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0104 0.0574 0.0566
Onchocerca volvulus 0.0049 0.0212 0.2396
Toxoplasma gondii DNA polymerase 0.0092 0.0494 0.0494
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0092 0.0494 0.0494
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0153 0.0153
Trichomonas vaginalis hypothetical protein 0.1542 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0052
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0049 0.0212 0.2396
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0043 0.017 0.2956
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi follicle stimulating hormone receptor 0.0306 0.1893 0.5963
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0052
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0212 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0306 0.1893 0.5963
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0104 0.0574 0.181
Schistosoma mansoni dihydropteridine reductase 0.0104 0.0574 0.1018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Echinococcus granulosus lamin 0.0059 0.0274 0.0485
Echinococcus granulosus g protein coupled receptor 0.0049 0.0212 0.0376
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0043 0.017 0.2956
Brugia malayi beta-lactamase family protein 0.004 0.0153 0.0482
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0152 0.0884 0.2786
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.0009
Brugia malayi sulfakinin receptor protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0274 0.0862
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.003 0.0089 0.0089
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0212 0.0376
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0212 0.0376
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0153 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0212 0.2396
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0104 0.0574 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Echinococcus multilocularis musashi 0.0059 0.0274 0.0485
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0212 0.0376
Echinococcus granulosus g protein coupled receptor 0.0049 0.0212 0.0376
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0104 0.0574 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0323 0.0572
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0406 0.1279
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0153 0.0482
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0009 0.0155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0212 0.0376
Leishmania major cathepsin L-like protease 0.0064 0.031 0.5391
Onchocerca volvulus 0.0152 0.0884 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0095 0.03
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0212 0.0376
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0029
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0411 0.2587 0.815
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0212 0.0376
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.003 0.0089 0.1008
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Trichomonas vaginalis esterase, putative 0.004 0.0153 0.0153
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.003 0.0089 0.0089
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0212 0.0376
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0212 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0029
Schistosoma mansoni neuropeptide receptor 0.0049 0.0212 0.0376
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0104 0.0574 0.0566
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.553 0.9799
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0212 0.2396
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0092 0.0494 0.8597
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0312 0.0553
Schistosoma mansoni neuropeptide receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus sex peptide receptor 0.0049 0.0212 0.0376
Brugia malayi Serotonin receptor 0.0495 0.3136 0.9877
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0312 0.0553
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.003 0.0089 0.0158
Brugia malayi G-protein coupled receptor 0.0049 0.0212 0.0668
Trypanosoma brucei oxidoreductase-like protein 0.0104 0.0574 1
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0104 0.0574 0.0574
Leishmania major cathepsin L-like protease 0.0064 0.031 0.5391
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0212 0.0376
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0212 0.0376
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.003 0.0089 0.1008
Onchocerca volvulus 0.0049 0.0212 0.2396
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0133
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0212 0.0668
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0212 0.0668
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.031 0.5391
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0104 0.0574 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0312 0.0303
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.003 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.031 0.5391
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.1521 0.4791
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0104 0.0574 0.0566
Schistosoma mansoni hypothetical protein 0.0049 0.0212 0.0376
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0153 0.0144
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0092 0.0494 0.5584
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.003 0.0089 0.0089
Onchocerca volvulus 0.0049 0.0212 0.2396
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.003 0.0089 0.1551
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.003 0.0089 0.1551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0356 0.0631
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.6198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Loa Loa (eye worm) TAR-binding protein 0.0453 0.2858 0.9003
Plasmodium vivax DNA polymerase alpha, putative 0.003 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0416 0.0736
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0092 0.0494 0.8597
Schistosoma mansoni hypothetical protein 0.017 0.1005 0.1781
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0009 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.031 0.5391
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0153 0.0153
Echinococcus multilocularis somatostatin receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0212 0.0376
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.6198
Echinococcus granulosus tar DNA binding protein 0.0453 0.2858 0.5065
Onchocerca volvulus 0.004 0.0153 0.1729
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0212 0.0376
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0212 0.0376
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.1005 0.3165
Echinococcus granulosus dna polymerase eta 0.0019 0.0016 0.0029
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0212 0.0376
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.0155
Leishmania major hypothetical protein, conserved 0.004 0.0153 0.2662
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.003 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.004 0.0153 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.003 0.0089 0.0158
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi hypothetical protein 0.0152 0.0884 0.2786
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0574 0.0566
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.003 0.0089 0.1551
Echinococcus granulosus allatostatin A receptor 0.0049 0.0212 0.0376
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0043 0.017 0.017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0411 0.2587 0.4585
Leishmania major hypothetical protein, conserved 0.0024 0.005 0.0869
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0092 0.0494 0.8597
Brugia malayi hypothetical protein 0.0071 0.0356 0.1122
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1542 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.031 0.5391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0212 0.0376
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0286
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0043 0.017 0.2956
Brugia malayi RNA recognition motif domain containing protein 0.0453 0.2858 0.9003
Schistosoma mansoni hypothetical protein 0.0049 0.0212 0.0376
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.1521 0.4791
Brugia malayi AKH receptor 0.0049 0.0212 0.0668
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0075 0.0133
Schistosoma mansoni biogenic amine receptor 0.0049 0.0212 0.0376
Onchocerca volvulus 0.004 0.0153 0.1729
Plasmodium falciparum enoyl-acyl carrier reductase 0.1542 1 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.003 0.0089 0.0158
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0043 0.017 0.2956
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0212 0.0376
Mycobacterium ulcerans oxidoreductase 0.0104 0.0574 0.0566
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0286
Onchocerca volvulus 0.0049 0.0212 0.2396
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0212 0.0376
Echinococcus granulosus g protein coupled receptor 0.0049 0.0212 0.0376
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0274 0.0862
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0212 0.0376
Echinococcus multilocularis serotonin receptor 0.0411 0.2587 0.4585
Loa Loa (eye worm) hypothetical protein 0.0059 0.0274 0.0862
Leishmania major oxidoreductase-like protein 0.0104 0.0574 1
Loa Loa (eye worm) RNA binding protein 0.0453 0.2858 0.9003
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.022 0.3827
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.0286
Schistosoma mansoni biogenic amine receptor 0.0049 0.0212 0.0376
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 0.0155
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0092 0.0494 0.8575
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0416 0.0736
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Brugia malayi Melatonin receptor type 1A 0.0049 0.0212 0.0668
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0406 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0133
Echinococcus granulosus neuropeptide receptor 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0104 0.0574 0.6495
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0416 0.1309
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0043 0.017 0.0301
Mycobacterium ulcerans beta-lactamase 0.004 0.0153 0.0144
Schistosoma mansoni lamin 0.0059 0.0274 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Onchocerca volvulus 0.0102 0.056 0.6329
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0236
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0009 0.0155
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0052
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.003 0.0089 0.0158
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0406 0.0719
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0212 0.0376
Schistosoma mansoni protein phosphatase-2b 0.0043 0.017 0.0301
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0482
Loa Loa (eye worm) hypothetical protein 0.017 0.1005 0.3165
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0212 0.0376
Brugia malayi beta-lactamase 0.004 0.0153 0.0482
Echinococcus granulosus somatostatin receptor 0.0049 0.0212 0.0376
Echinococcus multilocularis survival motor neuron protein 1 0.0501 0.3175 0.5626
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0212 0.0376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0785 0.139
Schistosoma mansoni hypothetical protein 0.0877 0.5643 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0009 0.0016
Onchocerca volvulus 0.0059 0.0274 0.3093
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Onchocerca volvulus DNA polymerase homolog 0.003 0.0089 0.1008
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1481 0.4665
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.003 0.0089 0.1551
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.008 0.0416 0.1309
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0043 0.017 0.2956
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0043 0.017 0.0535
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0212 0.0376
Mycobacterium ulcerans hypothetical protein 0.004 0.0153 0.0144
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0043 0.017 0.2956
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0016 0.0286
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0785 0.2471
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni amine GPCR 0.0049 0.0212 0.0376
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0273 0.4757
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0416 0.0736
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0043 0.017 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0043 0.017 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0212 0.0376
Schistosoma mansoni hypothetical protein 0.0079 0.0406 0.0719
Brugia malayi neuropeptide F receptor 0.0049 0.0212 0.0668
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0212 0.0376
Schistosoma mansoni intermediate filament proteins 0.0059 0.0274 0.0485
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0153 0.2547
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.005 0.0725
Echinococcus granulosus neuropeptide receptor A26 0.0562 0.3574 0.6334
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0009 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0212 0.0668
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0104 0.0574 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0104 0.0574 0.0566
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0212 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.031 0.5319
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0212 0.0668
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0104 0.0574 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0153 0.0271
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0212 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0153 0.0153
Brugia malayi hypothetical protein 0.0501 0.3175 1
Schistosoma mansoni hypothetical protein 0.0071 0.0356 0.0631
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0869
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0286
Echinococcus granulosus serotonin receptor 0.0049 0.0212 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.003 0.0089 0.0158
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0212 0.0376
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0212 0.0376
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0212 0.0668
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0092 0.0494 0.0875
Onchocerca volvulus 0.0049 0.0212 0.2396
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0104 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.003 0.0089 0.0158
Brugia malayi Dopamine receptor protein 2 0.0049 0.0212 0.0668
Onchocerca volvulus 0.0049 0.0212 0.2396
Schistosoma mansoni myosin xvIII 0.0049 0.0212 0.0376
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.003 0.0089 0.1418
Onchocerca volvulus 0.0049 0.0212 0.2396
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0323 0.0572
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0104 0.0574 0.0566
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0312 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0212 0.0376
Brugia malayi RE15519p 0.0049 0.0212 0.0668
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0312 0.0553
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.003 0.0089 0.1418
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2858 0.5065
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0356 0.0631
Brugia malayi larval opioid receptor 0.0049 0.0212 0.0668
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0017 0 0.0001
Brugia malayi hypothetical protein 0.0049 0.0212 0.0668
Trypanosoma brucei pteridine reductase 1 0.0104 0.0574 1
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0212 0.0376
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0406 0.1279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0785 0.139
Schistosoma mansoni hypothetical protein 0.0079 0.0406 0.0719
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0406 0.1279
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0416 0.1309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.0016
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0104 0.0574 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0141 0.0249
Onchocerca volvulus 0.0104 0.0574 0.6495
Brugia malayi RNA binding protein 0.0453 0.2858 0.9003
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0212 0.0376
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0212 0.0668
Brugia malayi intermediate filament protein 0.0059 0.0274 0.0862
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0104 0.0574 0.0574
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0453 0.2858 0.9003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0104 0.0574 0.0566
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2858 0.5065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668
Mycobacterium ulcerans short chain dehydrogenase 0.0104 0.0574 0.0566
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0668

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 uM Cytotoxicity against HFF cells after 3 days ChEMBL. 17434304
CC50 (ADMET) > 100 uM Cytotoxicity against HFF cells after 3 days ChEMBL. 17434304
F (ADMET) = 45 % Oral bioavailability in rat at 15 mg/kg ChEMBL. 17434304
F (ADMET) = 76 % Oral bioavailability in dog at 15 mg/kg ChEMBL. 17434304
IC50 (functional) = 2 nM Antiviral activity against VZV Webster in HFF cells by plaque reduction assay ChEMBL. 17434304
IC50 (binding) = 21 nM Inhibition of VZV DNA polymerase by scintillation proximity assay ChEMBL. 17434304
IC50 (binding) = 61 nM Inhibition of HCMV DNA polymerase by scintillation proximity assay ChEMBL. 17434304
IC50 (binding) = 61 nM Inhibition of HCMV DNA polymerase by scintillation proximity assay ChEMBL. 17434304
IC50 (binding) = 70 nM Inhibition of EBV DNA polymerase by T7 quick-coupled transcription-translation system ChEMBL. 17434304
IC50 (binding) = 76 nM Inhibition of HSV1 DNA polymerase by scintillation proximity assay ChEMBL. 17434304
IC50 (functional) = 100 nM Antiviral activity against HCMV Davis in HFF cells by plaque reduction assay ChEMBL. 17434304
IC50 (functional) = 200 nM Antiviral activity against EBV in GG68 cells after 72 hrs ChEMBL. 17434304
IC50 (functional) = 3000 nM Antiviral activity against HSV1 KOS in Vero cells by plaque reduction assay ChEMBL. 17434304
IC50 (binding) > 40000 nM Inhibition of human DNA polymerase alpha by scintillation proximity assay ChEMBL. 17434304
IC50 (binding) > 40000 nM Inhibition of human DNA polymerase gamma by scintillation proximity assay ChEMBL. 17434304
IC50 (binding) > 40000 nM Inhibition of human DNA polymerase delta by scintillation proximity assay ChEMBL. 17434304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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