Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0604 | 0.7501 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0328 | 0.0221 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0759 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0399 | 1 |
Schistosoma mansoni | lamin | 0.0054 | 0.0328 | 0.0573 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0109 | 0.0671 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0328 | 0.0573 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0254 | 0.038 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0041 | 0.0155 | 0.0047 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0153 | 0.1621 | 1 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3932 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0041 | 0.0155 | 0.0063 |
Leishmania major | pteridine reductase 1 | 0.0041 | 0.0155 | 0.1603 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.2734 | 0.3551 |
Echinococcus granulosus | geminin | 0.033 | 0.3932 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1333 | 0.3202 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.02 | 0.0238 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Trichomonas vaginalis | hypothetical protein | 0.0604 | 0.7501 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.02 | 0.0238 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0328 | 0.0573 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.1319 | 0.8136 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1333 | 0.3202 |
Onchocerca volvulus | 0.0054 | 0.0328 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0254 | 0.038 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.1333 | 0.3202 |
Onchocerca volvulus | 0.0041 | 0.0155 | 0.2121 | |
Echinococcus multilocularis | musashi | 0.0054 | 0.0328 | 0.0221 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0254 | 0.0147 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0254 | 0.1569 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.02 | 0.0238 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0315 | 0.1943 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0759 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.1333 | 0.8223 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0155 | 0.0958 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0254 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0392 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0109 | 0.0671 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0109 | 0.0671 |
Echinococcus multilocularis | geminin | 0.033 | 0.3932 | 0.3865 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Schistosoma mansoni | lamin | 0.0054 | 0.0328 | 0.0573 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0041 | 0.0155 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0254 | 0.1569 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.1333 | 0.8223 |
Trypanosoma brucei | pteridine reductase 1 | 0.0041 | 0.0155 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0041 | 0.0155 | 0.0958 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0604 | 0.7501 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0604 | 0.7501 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0604 | 0.7501 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0604 | 0.7501 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0041 | 0.0155 | 0.0063 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.02 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0254 | 0.1569 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0254 | 0.1569 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3932 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0328 | 0.2023 |
Brugia malayi | RNA binding protein | 0.0131 | 0.1333 | 0.8223 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0041 | 0.0155 | 0.0063 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.0328 | 0.0573 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0041 | 0.0155 | 0.1603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1333 | 0.3202 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0392 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0041 | 0.0155 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0254 | 0.038 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.1333 | 0.8223 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0041 | 0.0155 | 0.0063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1333 | 0.3202 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0109 | 0.0671 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.02 | 0.0092 |
Leishmania major | oxidoreductase-like protein | 0.0041 | 0.0155 | 0.1603 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0254 | 0.038 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.02 | 0.0238 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0604 | 0.7501 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0041 | 0.0155 | 0.0063 |
Onchocerca volvulus | 0.0041 | 0.0155 | 0.2121 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0399 | 0.0759 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0328 | 0.2023 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.02 | 0.0092 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0041 | 0.0155 | 0.0958 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0254 | 0.0147 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.1333 | 0.1238 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0392 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0399 | 0.0293 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Onchocerca volvulus | 0.0054 | 0.0328 | 1 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0328 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0988 | 0.6097 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0041 | 0.0155 | 0.1603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.1333 | 0.3202 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0153 | 0.1621 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0041 | 0.0155 | 0.0122 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0041 | 0.0155 | 0.0958 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0041 | 0.0155 | 0.0063 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0041 | 0.0155 | 0.0063 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0328 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Echinococcus granulosus | lamin | 0.0054 | 0.0328 | 0.0573 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.1333 | 0.8223 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0041 | 0.0155 | 0.0122 |
Loa Loa (eye worm) | oxidoreductase | 0.0041 | 0.0155 | 0.0958 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.1319 | 0.8136 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0041 | 0.0155 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0109 | 0.0671 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0041 | 0.0155 | 0.0958 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.1333 | 0.8223 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.0988 | 0.6097 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0041 | 0.0155 | 0.0063 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0604 | 0.7501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0109 | 0.0671 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0328 | 0.0221 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.1319 | 0.8136 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.02 | 0.1232 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0392 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0041 | 0.0155 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0328 | 0.2023 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0254 | 0.038 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0153 | 0.1621 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0254 | 0.038 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0109 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1621 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0254 | 0.0147 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.02 | 0.1232 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0604 | 0.7501 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0399 | 0.0392 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0041 | 0.0155 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0988 | 0.2301 |
Schistosoma mansoni | dihydropteridine reductase | 0.0041 | 0.0155 | 0.0122 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0041 | 0.0155 | 0.0063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.