Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.4045 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0121 | 0.3627 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0095 | 0.2707 | 0.7022 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0033 | 0.0531 | 0.1557 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0095 | 0.2727 | 0.7516 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0033 | 0.0536 | 0.1162 |
Loa Loa (eye worm) | glutathione reductase | 0.0095 | 0.2707 | 0.6692 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0033 | 0.0536 | 0.0536 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0536 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0536 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0095 | 0.2707 | 0.6692 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Loa Loa (eye worm) | phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0033 | 0.0536 | 0.1162 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0715 | 0.0715 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0121 | 0.3627 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0095 | 0.2707 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0121 | 0.3627 | 0.4251 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0715 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0715 | 0.1767 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0121 | 0.3627 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0095 | 0.2707 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.0531 | 0.1557 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0033 | 0.0536 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.4045 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.4045 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0121 | 0.3627 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0033 | 0.0536 | 0.0016 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0033 | 0.0536 | 0.1477 |
Leishmania major | trypanothione reductase | 0.0095 | 0.2707 | 0.7368 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0021 | 0.0129 | 0.0356 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0033 | 0.0531 | 0.1557 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0095 | 0.2707 | 0.7368 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0033 | 0.0536 | 0.1576 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0121 | 0.3627 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0241 | 0.7809 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0024 | 0.023 | 0.0569 |
Mycobacterium tuberculosis | Probable reductase | 0.0216 | 0.6963 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0095 | 0.2707 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0.0129 | 0.032 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0095 | 0.2707 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0033 | 0.0536 | 0.1576 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0216 | 0.6963 | 0.8837 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.133 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0129 | 0.032 |
Treponema pallidum | NADH oxidase | 0.0033 | 0.0536 | 0.0016 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0095 | 0.2727 | 0.7516 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0241 | 0.7809 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0033 | 0.0531 | 0.1557 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.133 | 0.3289 |
Brugia malayi | glutathione reductase | 0.0095 | 0.2707 | 0.6692 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0121 | 0.3627 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0033 | 0.0536 | 0.0016 |
Brugia malayi | Kringle domain containing protein | 0.0021 | 0.0129 | 0.032 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0033 | 0.0536 | 0.1576 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.0531 | 0.1557 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0033 | 0.0536 | 0.1324 |
Onchocerca volvulus | 0.0021 | 0.0129 | 0.5 | |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0021 | 0.0129 | 0.032 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0024 | 0.023 | 0.0569 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0033 | 0.0536 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0033 | 0.0536 | 0.1162 |
Brugia malayi | phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0121 | 0.3627 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0033 | 0.0536 | 0.1576 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.3627 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0095 | 0.2707 | 0.2985 |
Brugia malayi | Thioredoxin reductase | 0.0095 | 0.2707 | 0.6692 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0241 | 0.7809 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0033 | 0.0531 | 0.1557 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.3627 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0033 | 0.0536 | 0.1576 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0129 | 0.0129 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0033 | 0.0536 | 0.1477 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.133 | 0.3289 |
Plasmodium falciparum | thioredoxin reductase | 0.0095 | 0.2707 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0216 | 0.6963 | 0.7977 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0033 | 0.0536 | 0.1576 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0033 | 0.0536 | 0.1576 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0033 | 0.0536 | 0.1576 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0021 | 0.0129 | 0.0356 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.3627 | 0.8968 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.3627 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0536 | 0.1162 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0033 | 0.0531 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.133 | 0.3289 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0216 | 0.6963 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0216 | 0.6963 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0216 | 0.6963 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0216 | 0.6963 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0241 | 0.7809 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.