Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1248 | 0.5 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 0.1248 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0146 | 0.1248 | 0.5 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 0.1248 | 0.5 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0333 | 1 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0333 | 1 | 1 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0333 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 0.1248 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 0.1248 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0146 | 0.1248 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0146 | 0.1248 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.1248 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1248 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 0.1248 | 0.5 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0119 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 8.5 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17583504 |
Ki (binding) | = 2 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17583504 |
Ki (binding) | = 2 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17583504 |
Ki (binding) | = 39 nM | Binding affinity to rat SERT | ChEMBL. | 17583504 |
Ki (binding) | = 39 nM | Binding affinity to rat SERT | ChEMBL. | 17583504 |
Ki (binding) | = 119 nM | Binding affinity to human SERT | ChEMBL. | 17583504 |
Ki (binding) | = 119 nM | Binding affinity to human SERT | ChEMBL. | 17583504 |
pA2 (functional) | = 8.5 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17583504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.