Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.7306 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.2299 | 0.3146 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0128 | 0.7306 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0033 | 0.0949 | 0.0949 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0033 | 0.0949 | 0.1299 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.2299 | 0.3146 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.7701 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0949 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0949 | 0.1299 |
Leishmania major | trypanothione reductase | 0.0053 | 0.2299 | 0.3146 |
Echinococcus granulosus | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0949 | 0.1299 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0115 | 0.6401 | 0.8762 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0949 | 0.1299 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0949 | 0.1299 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0037 | 0.1213 | 0.1213 |
Echinococcus granulosus | histone deacetylase 7 | 0.0037 | 0.1213 | 0.166 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0033 | 0.0949 | 0.1299 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Trypanosoma brucei | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Histone deacetylase family protein | 0.0037 | 0.1213 | 0.166 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0949 | 0.1299 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.0949 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.018 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.6806 | 0.8837 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.018 | 0.018 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0949 | 0.1299 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0949 | 0.1079 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.3821 | 0.523 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0033 | 0.0949 | 0.0949 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0037 | 0.1213 | 0.166 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0949 | 0.1299 |
Giardia lamblia | Histone deacetylase | 0.0128 | 0.7306 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0033 | 0.0949 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Loa Loa (eye worm) | histone deacetylase | 0.0037 | 0.1213 | 0.1449 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1449 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.018 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0033 | 0.0949 | 0.1079 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.3821 | 0.511 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0115 | 0.6401 | 0.6401 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0128 | 0.7306 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.3821 | 0.3821 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3863 | 0.5168 |
Trypanosoma brucei | histone deacetylase 2 | 0.0037 | 0.1213 | 0.166 |
Echinococcus multilocularis | histone deacetylase | 0.0037 | 0.1213 | 0.166 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.018 | 0.0247 |
Echinococcus granulosus | histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.018 | 0.0247 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0128 | 0.7306 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.018 | 0.0247 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.3821 | 0.511 |
Brugia malayi | nuclear receptor NHR-88 | 0.0033 | 0.0949 | 0.1299 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0033 | 0.0949 | 0.1079 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.018 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Trypanosoma brucei | histone deacetylase 4 | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0033 | 0.0949 | 0.1299 |
Brugia malayi | nuclear hormone receptor | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0115 | 0.6401 | 0.6401 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0033 | 0.0949 | 0.0949 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0949 | 0.1299 |
Trypanosoma brucei | histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.018 | 0.0247 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0033 | 0.0949 | 0.1299 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 0.7306 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0949 | 0.1079 |
Echinococcus granulosus | FTZ F1 alpha | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | histone deacetylase | 0.0128 | 0.7306 | 0.7306 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0033 | 0.0949 | 0.1299 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0949 | 0.1299 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.2299 | 0.3146 |
Echinococcus granulosus | histone deacetylase | 0.0037 | 0.1213 | 0.166 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.018 | 0.018 |
Brugia malayi | steroid hormone receptor | 0.0033 | 0.0949 | 0.1299 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0033 | 0.0949 | 0.0949 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0949 | 0.1299 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.3821 | 0.3821 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0115 | 0.6401 | 0.6401 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0949 | 0.1299 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.7701 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | coup transcription factor | 0.0033 | 0.0949 | 0.0949 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.2299 | 0.3146 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.2299 | 0.2973 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0128 | 0.7306 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0037 | 0.1213 | 0.1449 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0115 | 0.6401 | 0.8762 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0037 | 0.1213 | 0.1213 |
Toxoplasma gondii | melibiase subfamily protein | 0.0115 | 0.6401 | 0.8762 |
Schistosoma mansoni | histone deacetylase | 0.0128 | 0.7306 | 0.7306 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0037 | 0.1213 | 0.166 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0076 | 0.3863 | 0.3863 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0949 | 0.1079 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0949 | 0.1299 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.018 | 0.0247 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.6806 | 0.8837 |
Leishmania major | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Histone deacetylase family protein | 0.0037 | 0.1213 | 0.166 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.018 | 0.0247 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.2299 | 0.2973 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0033 | 0.0949 | 0.0949 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.0949 | 0.0949 |
Plasmodium falciparum | histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.018 | 0.0247 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0949 | 0.1079 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0128 | 0.7306 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.018 | 0.0247 |
Plasmodium falciparum | histone deacetylase 2 | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0949 | 0.1299 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.018 | 0.0247 |
Brugia malayi | ecdysteroid receptor | 0.0033 | 0.0949 | 0.1299 |
Trypanosoma brucei | histone deacetylase 3 | 0.0037 | 0.1213 | 0.166 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.2299 | 0.3146 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0037 | 0.1213 | 0.166 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0037 | 0.1213 | 0.166 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.018 | 0.0247 |
Brugia malayi | histone deacetylase 11 | 0.0037 | 0.1213 | 0.166 |
Leishmania major | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0033 | 0.0949 | 0.1299 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0949 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0949 | 0.1299 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0128 | 0.7306 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 0.7306 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.7701 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.018 | 0.0234 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.018 | 0.0247 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0037 | 0.1213 | 0.1449 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0037 | 0.1213 | 0.1213 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0033 | 0.0949 | 0.0949 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0949 | 0.1299 |
Brugia malayi | glutathione reductase | 0.0053 | 0.2299 | 0.3146 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.2299 | 0.3146 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0037 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Brugia malayi | Melibiase family protein | 0.0076 | 0.3863 | 0.5287 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0949 | 0.1299 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0128 | 0.7306 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.3821 | 0.511 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.2299 | 0.3146 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0949 | 0.1299 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0037 | 0.1213 | 0.166 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 0.7306 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0128 | 0.7306 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.2299 | 0.3146 |
Echinococcus granulosus | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0115 | 0.6401 | 0.6401 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.2299 | 0.3146 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0033 | 0.0949 | 0.0949 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0033 | 0.0949 | 0.1299 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.018 | 0.0247 |
Brugia malayi | hypothetical protein | 0.0076 | 0.3821 | 0.523 |
Echinococcus granulosus | histone deacetylase 3 | 0.0128 | 0.7306 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.6806 | 0.8837 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0037 | 0.1213 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0033 | 0.0949 | 0.1299 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0949 | 0.1299 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.6806 | 0.8837 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0949 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.2299 | 0.3146 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.018 | 0.0247 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.0949 | 0.0949 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0115 | 0.6401 | 0.8762 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0033 | 0.0949 | 0.1299 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0949 | 0.0949 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0128 | 0.7306 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.6806 | 0.8837 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.3821 | 0.511 |
Leishmania major | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.3821 | 0.523 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.6806 | 0.8837 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0076 | 0.3863 | 0.5287 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0949 | 0.1299 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0033 | 0.0949 | 0.1299 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0128 | 0.7306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.2299 | 0.2985 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0037 | 0.1213 | 0.1213 |
Leishmania major | histone deacetylase, putative | 0.0037 | 0.1213 | 0.166 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0037 | 0.1213 | 0.166 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.7701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0949 | 0.1079 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0076 | 0.3863 | 0.3863 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 0.7306 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0037 | 0.1213 | 0.166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.