Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 12 % | Increase in heart weight in C57BL/6J mouse at 0.1 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 12 % | Increase in heart weight in C57BL/6J mouse at 0.1 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 17 % | Increase in heart weight in C57BL/6J mouse at 0.3 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 17 % | Increase in heart weight in C57BL/6J mouse at 0.3 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 27 % | Increase in heart weight in C57BL/6J mouse at 3.0 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 27 % | Increase in heart weight in C57BL/6J mouse at 3.0 mg/kg, po after 11 days | ChEMBL. | 17499989 |
Activity (functional) | = 32 % | Reduction in serum cholesterol in NMIR mouse at 0.1 mg/kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 32 % | Reduction in serum cholesterol in NMIR mouse at 0.1 mg/kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 34 % | Reduction in serum cholesterol in NMIR mouse at 0.3 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 34 % | Reduction in serum cholesterol in NMIR mouse at 0.3 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 39 % | Reduction in serum cholesterol in NMIR mouse at 1.0 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 39 % | Reduction in serum cholesterol in NMIR mouse at 1.0 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 41 % | Reduction in serum cholesterol in NMIR mouse at 3.0 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
Activity (functional) | = 41 % | Reduction in serum cholesterol in NMIR mouse at 3.0 mg/ kg, po after 7 days | ChEMBL. | 17499989 |
EC50 (functional) | = 0.3 nM | Agonist activity at THR in HepG2 cells by whole cell assay | ChEMBL. | 17499989 |
EC50 (functional) | = 0.3 nM | Agonist activity at THR in HepG2 cells by whole cell assay | ChEMBL. | 17499989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.