Detailed information for compound 457572

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.363 | Formula: C21H14F3N5O2
  • H donors: 1 H acceptors: 4 LogP: 4.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cnc2n(c1N)nc1c2c(cc(c1C#N)C(F)(F)F)c1ccccc1
  • InChi: 1S/C21H14F3N5O2/c1-2-31-20(30)14-10-27-19-16-12(11-6-4-3-5-7-11)8-15(21(22,23)24)13(9-25)17(16)28-29(19)18(14)26/h3-8,10H,2,26H2,1H3
  • InChiKey: LFBBMZDTDAIFTO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0069 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0513 0.1925
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Echinococcus granulosus lamin dm0 0.0052 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0024 0.0369 0.0802
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0485
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0204 0.3297
Echinococcus granulosus lamin 0.0052 0.0942 0.0942
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0007 0.002 0.002
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0046 0.01
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0188
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0369 0.1382
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0188
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0133 0.0498
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0008 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0369 0.1382
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0069 0.015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0188 0.0188
Echinococcus granulosus heat shock protein 90 0.0025 0.0382 0.0382
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.2498 0.9367
Entamoeba histolytica hypothetical protein 0.007 0.131 0.4912
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.003 0.0065
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0223 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0343 0.8976
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0382 0.6183
Echinococcus multilocularis transcription factor btf3 0.0137 0.2666 0.2666
Echinococcus granulosus smad 0.0008 0.003 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0513 0.1925
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0069 0.0069
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0128 0.2498 0.2498
Schistosoma mansoni tar DNA-binding protein 0.0185 0.3656 0.3656
Brugia malayi RNA recognition motif domain containing protein 0.0185 0.3656 0.7953
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0618 0.2317
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Schistosoma mansoni endoplasmin 0.0031 0.0513 0.0513
Brugia malayi intermediate filament protein 0.0052 0.0942 0.2049
Brugia malayi isocitrate dehydrogenase 0.0016 0.0188 0.041
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0008 0.0129
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0369 0.1382
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.002 0.0043
Echinococcus multilocularis traf and tnf receptor associated protein 0.0007 0.002 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0223 0.361
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0007 0.002 0.0075
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0008 0.003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.2498 0.9367
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0017
Plasmodium vivax endoplasmin, putative 0.0031 0.0513 0.1925
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0822 1
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Brugia malayi hypothetical protein 0.007 0.131 0.2849
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0047 0.0822 0.3081
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.002 0.0075
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0188 0.0706
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0513 0.1116
Schistosoma mansoni hypothetical protein 0.0399 0.8035 0.8035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0069 0.015
Loa Loa (eye worm) oxidoreductase 0.0007 0.0008 0.0017
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0513 0.1925
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Leishmania major hypothetical protein, conserved 0.0007 0.002 0.0075
Echinococcus multilocularis heat shock protein 90 0.0031 0.0513 0.0513
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0382 0.6183
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0007 0.002 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0877 0.1908
Schistosoma mansoni coup transcription factor 0.001 0.0069 0.0069
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0133 0.0498
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0044 0.0095
Trichomonas vaginalis Phospholipase C precursor, putative 0.0007 0.002 0.0075
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0188 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0069 0.015
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0047 0.0822 0.3081
Leishmania major heat shock protein, putative 0.0013 0.0133 0.0498
Echinococcus granulosus FTZ F1 alpha 0.001 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.007 0.131 0.4912
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.2666 1
Trypanosoma brucei RNA editing exonuclease 2 0.0007 0.002 0.0075
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0008 0.0008
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0008 0.003
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Echinococcus granulosus cpg binding protein 0.003 0.0475 0.0475
Brugia malayi RNA binding protein 0.0185 0.3656 0.7953
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0618 0.7519
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0382 0.4649
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0133 0.0289
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0093 0.0093
Echinococcus granulosus transcription factor Dp 1 0.0074 0.139 0.139
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0444 0.0965
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0008 0.0017
Trypanosoma cruzi transcription factor btf3, putative 0.0137 0.2666 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0188 0.0706
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0442 0.0962
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0069 0.0298
Plasmodium falciparum glycogen synthase kinase 3 0.0047 0.0822 0.3081
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Schistosoma mansoni Smad4 0.0008 0.003 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0069 0.0069
Plasmodium falciparum basic transcription factor 3b, putative 0.0137 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0558 0.1214
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.002 0.0075
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.2498 0.9367
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0382 0.1432
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0188 0.0188
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0513 0.1925
Brugia malayi MH2 domain containing protein 0.0008 0.003 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0069 0.015
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0188 0.0706
Schistosoma mansoni intermediate filament proteins 0.0052 0.0942 0.0942
Schistosoma mansoni synaptojanin 0.0007 0.002 0.002
Schistosoma mansoni neutral sphingomyelinase 0.0007 0.002 0.002
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0513 0.1925
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0133 0.0498
Onchocerca volvulus 0.0007 0.0008 0.0034
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0007 0.002 0.0075
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0133 0.0498
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0444 0.0965
Onchocerca volvulus Huntingtin homolog 0.012 0.2319 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0618 0.2317
Schistosoma mansoni heat shock protein 0.0031 0.0513 0.0513
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0133 0.0498
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0513 0.1925
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0618 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0008 0.0129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0069 0.0069
Schistosoma mansoni synaptojanin 0.0007 0.002 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0618 0.0618
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0513 0.1925
Echinococcus multilocularis smad 0.0008 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0185 0.3656 0.3656
Schistosoma mansoni cript-related 0.0007 0.002 0.002
Schistosoma mansoni survival motor neuron protein 0.0047 0.0833 0.0833
Schistosoma mansoni lamin 0.0052 0.0942 0.0942
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0007 0.002 0.0075
Schistosoma mansoni carbon catabolite repressor protein 0.0007 0.002 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0069 0.015
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0007 0.002 0.0075
Leishmania major endonuclease/exonuclease protein-like protein 0.0007 0.002 0.0075
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Brugia malayi intracellular kinase 0.0047 0.0822 0.1787
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0618 1
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0133 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0185 0.3656 0.3656
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0387 0.0387
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0513 0.1925
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0822 0.1787
Leishmania major hypothetical protein, conserved 0.0007 0.002 0.0075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.131 0.131
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Schistosoma mansoni ap endonuclease 0.0037 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0485
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0008 0.0008
Echinococcus granulosus traf and tnf receptor associated protein 0.0007 0.002 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0249 0.0934
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0128 0.2498 0.2498
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0007 0.002 0.0075
Schistosoma mansoni lamin 0.0052 0.0942 0.0942
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0188 0.0706
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.003 0.003
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.002 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0382 0.1432
Loa Loa (eye worm) Smad1 0.0008 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0188 0.0408
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0128 0.2498 0.9367
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0798
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0008 0.003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0069 0.0069
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0822 0.3081
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.002 0.0075
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0188 0.0706
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0008 0.0129
Echinococcus granulosus Smad4 0.0008 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0618 0.1344
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0008 0.0129
Echinococcus granulosus heat shock protein 0.0031 0.0513 0.0513
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.002 0.0043
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0343 0.0746
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0343 0.555
Leishmania major RNA-editing complex protein MP100, putative 0.0007 0.002 0.0075
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0047 0.0822 0.3081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0204 0.3297
Schistosoma mansoni thyroid hormone receptor 0.001 0.0069 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0008 0.003
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0369 0.1382
Entamoeba histolytica protein kinase, putative 0.0047 0.0822 0.3081
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0069 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0485
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0069 0.0069
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0133 0.0573
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0133 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0069 0.015
Schistosoma mansoni cpg binding protein 0.003 0.0475 0.0475
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.002 0.0043
Brugia malayi hypothetical protein 0.012 0.2319 0.5043
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0343 0.555
Echinococcus multilocularis musashi 0.0052 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0023 0.0343 0.0746
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.002 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0343 0.0746
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0513 0.1925
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0069 0.0069
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0188 0.0706
Onchocerca volvulus 0.0007 0.0008 0.0034
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0007 0.002 0.002
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0513 0.1925
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0069 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0046
Brugia malayi MH1 domain containing protein 0.0008 0.003 0.0065
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0007 0.002 0.0075
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0343 0.555
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0343 0.0746
Onchocerca volvulus 0.0052 0.0942 0.4062
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0618 0.2317
Giardia lamblia Inositol 5-phosphatase 4 0.0007 0.002 0.0243
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0382 0.6183
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0007 0.002 0.0075
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0069 0.0069
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0343 0.1286
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0039 0.0147
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0513 0.1925
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0069 0.0069
Brugia malayi CCR4 0.0007 0.002 0.0043
Trypanosoma cruzi transcription factor btf3, putative 0.0137 0.2666 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0133 0.0133
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0008 0.003
Echinococcus granulosus endoplasmin 0.0025 0.0382 0.0382
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0382 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0008 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0007 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0024 0.0369 0.1382
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0007 0.002 0.0075
Plasmodium vivax heat shock protein, putative 0.0013 0.0133 0.0498
Echinococcus multilocularis lamin dm0 0.0052 0.0942 0.0942
Loa Loa (eye worm) endoplasmin 0.0031 0.0513 0.1116
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0188 0.0706
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0011 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0069 0.015
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0822 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.003 0.003
Echinococcus multilocularis tar DNA binding protein 0.0185 0.3656 0.3656
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0069 0.015
Onchocerca volvulus 0.0007 0.0008 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0822 0.3081
Plasmodium falciparum endoplasmin, putative 0.0019 0.0264 0.099
Echinococcus granulosus transcription factor btf3 0.0137 0.2666 0.2666
Schistosoma mansoni hypothetical protein 0.0007 0.002 0.002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0188 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0069 0.0069
Trypanosoma cruzi mitochondrial protein 99, putative 0.0007 0.002 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0188 0.0188
Brugia malayi nuclear receptor NHR-88 0.001 0.0069 0.015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0128 0.2498 0.9367
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0008 0.003
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.0008 0.0208
Echinococcus multilocularis GPCR, family 2 0.0016 0.0188 0.0188
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0822 0.1787
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0008 0.0129
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.4597 0.4597
Trypanosoma brucei transcription factor BTF3, putative 0.0137 0.2666 1
Schistosoma mansoni hypothetical protein 0.007 0.131 0.131
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0188
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Loa Loa (eye worm) RNA binding protein 0.0185 0.3656 0.7953
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0188 0.0188
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0007 0.002 0.0075
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0007 0.002 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0369 0.1382
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0007 0.002 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0343 0.555
Echinococcus granulosus GPCR family 2 0.0016 0.0188 0.0188
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0007 0.002 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0382 0.1432
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0007 0.002 0.0075
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0188 0.3049
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2236 0.4863
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0798
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0188 0.0408
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.012 0.2319 0.5043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0204 0.3297
Leishmania major hypothetical protein, conserved 0.0007 0.002 0.0075
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0039 0.0147
Onchocerca volvulus 0.0023 0.0343 0.1479
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0047 0.0822 0.0822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0204 0.3297
Treponema pallidum hypothetical protein 0.0007 0.002 0.0323
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0942 0.2049
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0008 0.0008
Onchocerca volvulus 0.0007 0.002 0.0086
Onchocerca volvulus Putative neutral sphingomyelinase 0.0007 0.002 0.0086
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0618 0.1344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0387 0.0841
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0069 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0618 0.2317
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0343 0.555
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0343 0.555
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.8035 0.8035
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0008 0.0129
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0069 0.0298
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0513 0.1925
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0188 0.0188
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0046
Plasmodium falciparum DNase I-like protein, putative 0.0007 0.002 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0008 0.003
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0369 0.1382
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.003 0.003
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.002 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0069 0.0069
Schistosoma mansoni smad 0.0008 0.003 0.003
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0047 0.0822 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0069 0.015
Giardia lamblia Grp94/Hsp90 0.0025 0.0382 0.4649
Brugia malayi ecdysteroid receptor 0.001 0.0069 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0618 0.2317
Entamoeba histolytica hypothetical protein 0.007 0.131 0.4912
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0822 0.3081
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0133 0.0133
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1085 0.1085
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.002 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.003 0.0065
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0007 0.002 0.0075
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0047 0.0822 0.0822
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0008 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0343 0.555
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0343 0.1286
Entamoeba histolytica hypothetical protein 0.007 0.131 0.4912
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0093 0.0093
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0008 0.0129
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0618 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0008 0.0017
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0877 0.1908
Toxoplasma gondii NAC domain-containing protein 0.0137 0.2666 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0833 0.1812
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0069 0.0069
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Trypanosoma cruzi mitochondrial protein 99, putative 0.0007 0.002 0.0075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.131 0.131
Schistosoma mansoni hypothetical protein 0.0047 0.0833 0.0833
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0188 0.041
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0017
Echinococcus granulosus neutral sphingomyelinase 0.0007 0.002 0.002
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0069 0.015
Echinococcus granulosus intermediate filament protein 0.0052 0.0942 0.0942
Onchocerca volvulus 0.0047 0.0833 0.3594
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0188 0.0188
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0128 0.2498 0.2498
Plasmodium vivax glycogen synthase kinase 3, putative 0.0047 0.0822 0.3081
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0343 0.1286
Entamoeba histolytica transcription factor BTF3, putative 0.0137 0.2666 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0343 0.555
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.002 0.0075
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.002 0.0075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0128 0.2498 0.5433
Toxoplasma gondii exonuclease III APE 0.0037 0.0618 0.2317
Schistosoma mansoni transcription factor btf3 0.0137 0.2666 0.2666
Brugia malayi steroid hormone receptor 0.001 0.0069 0.015
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.002 0.002
Brugia malayi Hsp90 protein 0.0013 0.0133 0.0289
Brugia malayi hypothetical protein 0.0016 0.0191 0.0416
Schistosoma mansoni endoplasmin 0.0031 0.0513 0.0513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0008 0.0129
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0942 0.2049
Onchocerca volvulus 0.0028 0.0442 0.1907
Plasmodium vivax exodeoxyribonuclease III, putative 0.0007 0.002 0.0075
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.003 0.0475 0.0475
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.0008 0.0208
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0069 0.0069
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0008 0.0129
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0008 0.0129
Loa Loa (eye worm) hypothetical protein 0.0051 0.0922 0.2006
Onchocerca volvulus 0.0007 0.0008 0.0034
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Brugia malayi beta-NAC-like protein 0.0137 0.2666 0.58
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0069 0.0069
Echinococcus granulosus tar DNA binding protein 0.0185 0.3656 0.3656
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0618 0.2317
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0007 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0069 0.015
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Brugia malayi MH2 domain containing protein 0.0116 0.2236 0.4863
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0485
Plasmodium falciparum heat shock protein 90 0.0031 0.0513 0.1925
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0343 0.555
Echinococcus multilocularis deoxyribonuclease 1 2 0.0007 0.002 0.002
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0185 0.3656 0.3656
Schistosoma mansoni tar DNA-binding protein 0.0185 0.3656 0.3656
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0618 0.2317
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0008 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0877 0.1908
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0069 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0133 0.0498
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0188 0.0408
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0008 0.0208
Schistosoma mansoni thyroid hormone receptor 0.001 0.0069 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0188 0.0408
Schistosoma mansoni heat shock protein 0.0013 0.0133 0.0133
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0128 0.2498 0.5433
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0822 0.3081
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0264 0.099
Onchocerca volvulus 0.0052 0.0942 0.4062
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0008 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.139 0.139
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0007 0.002 0.0075
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0007 0.002 0.0075
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0343 0.1286
Mycobacterium ulcerans hypothetical protein 0.0023 0.0343 0.555
Echinococcus multilocularis Smad4 0.0008 0.003 0.003
Trypanosoma brucei heat shock protein, putative 0.0031 0.0513 0.1925
Entamoeba histolytica hypothetical protein 0.0137 0.2666 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0387 0.0387
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0558 0.1214
Loa Loa (eye worm) hypothetical protein 0.0231 0.4597 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0264 0.099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0955 0.3582
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0382 0.1432
Echinococcus multilocularis cpg binding protein 0.003 0.0475 0.0475
Loa Loa (eye worm) TAR-binding protein 0.0185 0.3656 0.7953
Echinococcus multilocularis endoplasmin 0.0025 0.0382 0.0382
Onchocerca volvulus 0.0047 0.0822 0.3543
Mycobacterium tuberculosis Probable exported protein 0.0007 0.002 0.0323
Brugia malayi Smad1 0.0008 0.003 0.0065
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.002 0.0075
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0008 0.0129
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0513 0.6247
Schistosoma mansoni transcription factor LCR-F1 0.007 0.131 0.131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0069 0.0069
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.002 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0618 1
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0007 0.002 0.0075
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2236 0.4863
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0513 0.1925
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0069 0.0069
Leishmania major basic transcription factor 3a, putative 0.0137 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.015
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0223 0.0836
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0188 0.0188
Schistosoma mansoni smad1 5 8 and 0.0008 0.003 0.003
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0618 0.2317
Loa Loa (eye worm) hypothetical protein 0.0049 0.0877 0.1908
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0008 0.0129
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0188 0.0188
Echinococcus granulosus protein kinase shaggy 0.0047 0.0822 0.0822
Giardia lamblia hypothetical protein 0.0007 0.002 0.0243
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0043
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0188
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0069 0.0298
Schistosoma mansoni smad1 5 8 and 0.0008 0.003 0.003
Echinococcus multilocularis protein kinase shaggy 0.0047 0.0822 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0069 0.015
Schistosoma mansoni hypothetical protein 0.0034 0.0558 0.0558
Echinococcus multilocularis heat shock protein 0.0031 0.0513 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0069 0.015
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0007 0.002 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.4597 0.4597
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0618 0.0618
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0007 0.002 0.0075
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0382 0.1432
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0007 0.002 0.0075
Schistosoma mansoni heat shock protein 0.0031 0.0513 0.0513
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0008 0.0129
Loa Loa (eye worm) ICD-1 protein 0.0137 0.2666 0.58
Loa Loa (eye worm) hypothetical protein 0.012 0.2319 0.5043
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0008 0.0129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Schistosoma mansoni smad1 5 8 and 0.0008 0.003 0.003
Treponema pallidum heat shock protein 90 0.0025 0.0382 0.6183
Brugia malayi MH2 domain containing protein 0.0008 0.003 0.0065
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Echinococcus multilocularis lamin 0.0052 0.0942 0.0942
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0008 0.0129
Onchocerca volvulus 0.0007 0.002 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0069 0.015
Plasmodium vivax basic transcription factor 3b, putative 0.0137 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0343 0.0746
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.003 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0369 0.1382
Echinococcus multilocularis geminin 0.0494 1 1
Plasmodium vivax hypothetical protein, conserved 0.0007 0.002 0.0075
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0942 0.2049
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0008 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0188 0.0706
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0133 0.0498
Onchocerca volvulus 0.001 0.0069 0.0298
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0007 0.002 0.0075
Brugia malayi heat shock protein 90 0.0031 0.0513 0.1116
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0382 0.0382
Schistosoma mansoni ap endonuclease 0.0037 0.0618 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0069 0.015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0343 0.8976
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0485
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0017
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0382 0.1432
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.002 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0343 0.1286
Brugia malayi MH1 domain containing protein 0.0008 0.003 0.0065
Schistosoma mansoni cpg binding protein 0.0028 0.0442 0.0442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0069 0.015
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0069 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0069 0.015
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.002 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0343 0.1286
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0007 0.002 0.0075
Echinococcus multilocularis heat shock protein 90 0.0025 0.0382 0.0382
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0513 0.1925
Loa Loa (eye worm) hypothetical protein 0.0052 0.0942 0.2049
Schistosoma mansoni nocturnin 0.0007 0.002 0.002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0618 0.2317
Brugia malayi Endoplasmin precursor 0.0031 0.0513 0.1116
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0188 0.041
Brugia malayi hypothetical protein 0.0024 0.0369 0.0802
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0185 0.3656 0.7953
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0043
Echinococcus multilocularis synaptojanin 1 0.0007 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0069 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0008 0.0129
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0007 0.002 0.0075
Trypanosoma brucei protein kinase, putative 0.0047 0.0822 0.3081
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0008 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.2666 1
Schistosoma mansoni hypothetical protein 0.0011 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0343 0.0746
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0069 0.0069
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Brugia malayi hypothetical protein 0.0231 0.4597 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0442 0.0962
Schistosoma mansoni nuclear hormone receptor 0.001 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0069 0.015
Leishmania major heat shock protein 83-1 0.0031 0.0513 0.1925
Echinococcus granulosus dnaJ subfamily B 0.0399 0.8035 0.8035
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.002 0.0075
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0008 0.003
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0223 0.361
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Echinococcus granulosus synaptojanin 1 0.0007 0.002 0.002
Brugia malayi nuclear hormone receptor 0.001 0.0069 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.2666 1
Onchocerca volvulus Huntingtin homolog 0.012 0.2319 1
Echinococcus multilocularis neutral sphingomyelinase 0.0007 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0069 0.015
Brugia malayi TAR-binding protein 0.0185 0.3656 0.7953
Echinococcus granulosus heat shock protein 90 0.0031 0.0513 0.0513
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0223 0.0836
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0008 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0069 0.0069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0069 0.0069

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 11 % Anticancer activity against human A549 cells at 1 nM after 12 hrs ChEMBL. 17428660
Inhibition (functional) = 11 % Anticancer activity against human A549 cells at 1 nM after 12 hrs ChEMBL. 17428660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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