Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.2406 | 0.2406 |
Brugia malayi | RNA binding protein | 0.0061 | 0.2406 | 0.2406 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.2406 | 0.2406 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2406 | 0.7749 |
Loa Loa (eye worm) | ICD-1 protein | 0.0069 | 0.3105 | 0.3105 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.2406 | 0.2406 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.3105 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0069 | 0.3105 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1423 | 0.1423 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0069 | 0.3105 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.3105 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0069 | 0.3105 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2406 | 0.7749 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.3105 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0069 | 0.3105 | 0.5 |
Brugia malayi | beta-NAC-like protein | 0.0069 | 0.3105 | 0.3105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2406 | 0.7749 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2406 | 0.7749 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0171 | 0.0552 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1423 | 0.1423 |
Leishmania major | basic transcription factor 3a, putative | 0.0069 | 0.3105 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0069 | 0.3105 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0069 | 0.3105 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.2406 | 0.2406 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.2406 | 0.2406 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.2406 | 0.7617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2406 | 0.7749 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.2406 | 0.7617 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0069 | 0.3105 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1423 | 0.1423 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0069 | 0.3105 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0171 | 0.0171 |
Onchocerca volvulus | 0.0146 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0171 | 0.0552 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.3105 | 0.5 |
Schistosoma mansoni | transcription factor btf3 | 0.0069 | 0.3105 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0069 | 0.3105 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.446 uM | Displacement of [3H]PG2 from human CRTh2 receptor expressed in CHO cells | ChEMBL. | 17531480 |
Ki (binding) | = 0.446 uM | Displacement of [3H]PG2 from human CRTh2 receptor expressed in CHO cells | ChEMBL. | 17531480 |
Ki (binding) | > 10 uM | Binding affinity at prostanoid DP receptor | ChEMBL. | 17531480 |
Ki (binding) | > 10 uM | Binding affinity at prostanoid DP receptor | ChEMBL. | 17531480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.