Detailed information for compound 457707

Basic information

Technical information
  • TDR Targets ID: 457707
  • Name: (3E)-1-(pyridin-3-ylmethyl)-3-(pyridin-3-ylme thylcarbamoylimino)urea
  • MW: 298.3 | Formula: C14H14N6O2
  • H donors: 2 H acceptors: 4 LogP: 0.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1cccnc1)/N=N/C(=O)NCc1cccnc1
  • InChi: 1S/C14H14N6O2/c21-13(17-9-11-3-1-5-15-7-11)19-20-14(22)18-10-12-4-2-6-16-8-12/h1-8H,9-10H2,(H,17,21)(H,18,22)/b20-19+
  • InChiKey: CNGVIYAOLIUYCL-FMQUCBEESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3E)-1-(3-pyridylmethyl)-3-(3-pyridylmethylcarbamoylimino)urea
  • (1E)-1-[oxo-(3-pyridylmethylamino)methyl]imino-3-(3-pyridylmethyl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.0066
Plasmodium falciparum flap endonuclease 1 0.0027 0.0078 0.235
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0048 0.0048
Entamoeba histolytica phosphofructokinase, putative 0.0233 0.0927 0.0923
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0123
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0099
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0032
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0094 0.4036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.013 0.0332
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0039 0.0379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0162
Echinococcus multilocularis musashi 0.0058 0.0205 0.0205
Schistosoma mansoni DNA helicase recq5 0.0019 0.0044 0.0112
Mycobacterium leprae conserved hypothetical protein 0.004 0.013 0.0263
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0039 0.0039
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0075 0.0075
Plasmodium vivax hypothetical protein, conserved 0.004 0.013 0.5693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0269 0.0269
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0422 0.1709 0.1668
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.013 0.1
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0039
Schistosoma mansoni regulator of G protein signaling 0.002 0.0048 0.0123
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0032 0.0032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0226 1
Trypanosoma brucei adenosine transporter 2, putative 0.0422 0.1709 0.4307
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0039 0.0039
Echinococcus multilocularis 6 phosphofructokinase 0.0233 0.0927 0.0927
Giardia lamblia Ribokinase 0.0109 0.0417 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Trichomonas vaginalis ribokinase, putative 0.0109 0.0417 0.0371
Schistosoma mansoni protein kinase 0.0422 0.1709 0.4353
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1739 0.7137 0.7137
Loa Loa (eye worm) phosphofructokinase 0.0233 0.0927 0.0927
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0048 0.0123
Trichomonas vaginalis ribokinase, putative 0.0109 0.0417 0.0371
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.2433 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0048 0.0048
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0048 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0044
Brugia malayi Cytochrome P450 family protein 0.0026 0.0075 0.0075
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0109 0.0417 0.0417
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0032
Schistosoma mansoni intermediate filament proteins 0.0058 0.0205 0.0521
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Brugia malayi isocitrate dehydrogenase 0.0016 0.0032 0.0032
Brugia malayi 6-phosphofructokinase 0.0233 0.0927 0.0927
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0044 0.0044
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.013 0.0318
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.013 0.013
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.2433 1 1
Brugia malayi beta-lactamase family protein 0.004 0.013 0.013
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0048 0.0048
Echinococcus granulosus equilibrative nucleoside transporter 0.2433 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0159 0.0111
Trichomonas vaginalis esterase, putative 0.004 0.013 0.0083
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0048 0.0048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.013 0.1
Schistosoma mansoni zinc finger protein 0.0024 0.0065 0.0166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0109 0.0417 0.0417
Trypanosoma cruzi nucleobase transporter, putative 0.0422 0.1709 0.4344
Brugia malayi intermediate filament protein 0.0058 0.0205 0.0205
Entamoeba histolytica hypothetical protein 0.002 0.0048 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0237 0.0237
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.0002
Brugia malayi hypothetical protein 0.0422 0.1709 0.1709
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0172 0.0172
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0063 0.0226 0.0222
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0067
Schistosoma mansoni survival motor neuron protein 0.005 0.0172 0.0439
Schistosoma mansoni DNA helicase recq1 0.0019 0.0044 0.0112
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0597 0.0597
Brugia malayi hypothetical protein 0.2433 1 1
Trypanosoma cruzi nucleoside transporter-like, putative 0.0422 0.1709 0.4344
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0233 0.0927 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0048 0.0123
Mycobacterium ulcerans hypothetical protein 0.004 0.013 0.0651
Trichomonas vaginalis phosphofructokinase, putative 0.0233 0.0927 0.0883
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni regulator of G protein signaling 0.002 0.0048 0.0123
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0133 0.0094
Loa Loa (eye worm) hypothetical protein 0.032 0.1287 0.1287
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.013 0.0083
Schistosoma mansoni zinc finger protein 0.0016 0.0032 0.008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0233 0.0927 0.2301
Schistosoma mansoni pyruvate kinase 0.0035 0.0109 0.0277
Loa Loa (eye worm) hypothetical protein 0.032 0.1287 0.1287
Giardia lamblia Hypothetical protein 0.2433 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0044 0.0044
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0067 0.0156
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.2433 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0044 0.0617
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0075 0.0075
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0109 0.0109
Onchocerca volvulus Putative pyridoxal kinase 0.0109 0.0417 0.0312
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0044
Mycobacterium ulcerans fructokinase, PfkB 0.0109 0.0417 0.4016
Schistosoma mansoni adenosine kinase 0.096 0.3925 1
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0048 0.0048
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0109 0.0263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0077
Brugia malayi Adenosine kinase-like 0.096 0.3925 0.3925
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0109
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0012 0.0012
Trypanosoma cruzi nucleoside transporter 1, putative 0.0422 0.1709 0.4344
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0078 0.0038
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0012 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0032 0.0082
Brugia malayi PHD-finger family protein 0.003 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0156
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0078 0.0183
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0114 0.0066
Mycobacterium tuberculosis Ribokinase RbsK 0.0109 0.0417 0.3916
Trypanosoma brucei unspecified product 0.0422 0.1709 0.4307
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0048 0.0048
Trypanosoma cruzi nucleobase transporter, putative 0.0422 0.1709 0.4344
Schistosoma mansoni hypothetical protein 0.0359 0.1447 0.3685
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.013 0.013
Schistosoma mansoni bromodomain containing protein 0.0069 0.0252 0.0642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Toxoplasma gondii kinase, pfkB family protein 0.096 0.3925 1
Echinococcus granulosus geminin 0.0359 0.1447 0.1447
Loa Loa (eye worm) beta-lactamase 0.004 0.013 0.013
Echinococcus granulosus bloom syndrome protein 0.0046 0.0155 0.0155
Echinococcus multilocularis expressed protein 0.0387 0.1564 0.1564
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0078 0.3308
Loa Loa (eye worm) runx1 0.0058 0.0204 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.013 0.0083
Loa Loa (eye worm) hypothetical protein 0.0109 0.0417 0.0417
Trypanosoma brucei nucleoside transporter 1, putative 0.0422 0.1709 0.4307
Brugia malayi hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis lamin 0.0058 0.0205 0.0205
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0164
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0063 0.0159
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.003
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0109 0.0061
Echinococcus multilocularis geminin 0.0359 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0048 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0092 0.022
Trypanosoma cruzi nucleoside transporter 1, putative 0.0422 0.1709 0.4344
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.013 0.0318
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0039 0.1584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0162
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0237 0.0237
Echinococcus granulosus expressed protein 0.0387 0.1564 0.1564
Mycobacterium tuberculosis Conserved protein 0.004 0.013 0.1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0123
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0422 0.1709 0.4307
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0124 0.0124
Echinococcus granulosus 6 phosphofructokinase 0.0233 0.0927 0.0927
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0032 0.0067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0081 0.0081
Schistosoma mansoni ribokinase 0.0109 0.0417 0.1063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0162 0.0162
Leishmania major nucleobase transporter 0.0422 0.1709 0.4307
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0078 0.0078
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0109 0.0109
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.201 0.8258 0.8258
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0032 0.0032
Onchocerca volvulus 0.004 0.013 0.0022
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0133 0.0129
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0039
Brugia malayi PXA domain containing protein 0.002 0.0048 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0155 0.0107
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0124 0.0124
Trypanosoma cruzi adenosine kinase, putative 0.096 0.3925 1
Mycobacterium ulcerans beta-lactamase 0.004 0.013 0.0651
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.013 0.1
Trypanosoma brucei adenosine transporter 2 0.0422 0.1709 0.4307
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0109 0.0199
Entamoeba histolytica hypothetical protein 0.002 0.0048 0.0044
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0226 1
Echinococcus multilocularis pyruvate kinase 0.0035 0.0109 0.0109
Leishmania major adenosine kinase-like protein 0.0109 0.0417 0.099
Loa Loa (eye worm) hypothetical protein 0.0422 0.1709 0.1709
Echinococcus granulosus muscleblind protein 0.032 0.1287 0.1287
Echinococcus multilocularis muscleblind protein 1 0.032 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0048 0.0048
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.2433 1 1
Trypanosoma brucei adenosine transporter 2, putative 0.0422 0.1709 0.4307
Onchocerca volvulus 0.0058 0.0205 0.0097
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0124 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Leishmania major tagatose-6-phosphate kinase-like protein 0.0109 0.0417 0.099
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0159 0.0111
Trypanosoma cruzi nucleoside transporter 1, putative 0.0422 0.1709 0.4344
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0133 0.5228
Trypanosoma brucei adenosine kinase, putative 0.096 0.3925 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0132 0.5153
Trypanosoma brucei unspecified product 0.0422 0.1709 0.4307
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0138 0.0353
Mycobacterium tuberculosis Adenosine kinase 0.0109 0.0417 0.3916
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0009 0.0009
Echinococcus granulosus lamin 0.0058 0.0205 0.0205
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.012 0.012
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0044 0.0044
Brugia malayi STAT protein, DNA binding domain containing protein 0.0133 0.0515 0.0515
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.046 0.1862 0.1862
Onchocerca volvulus 0.0851 0.3474 0.3402
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0048 0.0048
Onchocerca volvulus 0.0055 0.0192 0.0084
Brugia malayi PXA domain containing protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.02
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0012 0.0012
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0118
Trypanosoma cruzi adenosine kinase, putative 0.0109 0.0417 0.105
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0159 0.039
Leishmania major nucleobase transporter 0.0422 0.1709 0.4307
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.002 0.0048 0.0044
Brugia malayi beta-lactamase 0.004 0.013 0.013
Toxoplasma gondii kinase, pfkB family protein 0.0109 0.0417 0.105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0044
Trypanosoma cruzi adenosine kinase, putative 0.096 0.3925 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0044 0.0005
Leishmania major pyruvate kinase 0.0035 0.0109 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0066 0.0066
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0226 1
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0597 0.0597
Schistosoma mansoni axis inhibition protein axin 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.2433 1 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0048 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0097
Schistosoma mansoni hypothetical protein 0.005 0.0172 0.0439
Echinococcus multilocularis pyruvate kinase 0.0027 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0058 0.0205 0.0205
Trypanosoma brucei purine nucleoside transporter 0.0422 0.1709 0.4307
Leishmania major nucleoside transporter 1, putative 0.0422 0.1709 0.4307
Schistosoma mansoni 6-phosphofructokinase 0.0233 0.0927 0.2362
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.2433 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.013 0.0651
Onchocerca volvulus 0.005 0.0172 0.0064
Onchocerca volvulus 0.046 0.1862 0.1772
Brugia malayi hypothetical protein 0.0109 0.0417 0.0417
Echinococcus multilocularis ribokinase 0.0109 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.046 0.1862 0.1862
Schistosoma mansoni regulator of G protein signaling 0.002 0.0048 0.0123
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0048 0.0048
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0048 0.0048
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0063 0.0063
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0067 0.0019
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0067 0.0091
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0422 0.1709 0.4307
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0155 0.0155
Giardia lamblia Pyruvate kinase 0.0035 0.0109 0.007
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0422 0.1709 0.4307
Schistosoma mansoni lamin 0.0058 0.0205 0.0521
Entamoeba histolytica nucleoside transporter, putative 0.0422 0.1709 0.1705
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0123
Loa Loa (eye worm) acetyltransferase 0.0153 0.0597 0.0597
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0159 0.697
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.013 0.1
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0048 0.0048
Onchocerca volvulus 0.0109 0.0417 0.0312
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0412
Schistosoma mansoni pyruvate kinase 0.0035 0.0109 0.0277
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0044 0.0044
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0183
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0032 0.1253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0032
Echinococcus multilocularis adenosine kinase 0.096 0.3925 0.3925
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0124 0.0124
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.013 0.013
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0039 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.013 0.0083
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0097
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0063 0.0226 0.0561
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0226 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0039 0.0099
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0048 0.0048
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0063 0.0226 0.0187
Leishmania major ribokinase, putative 0.0109 0.0417 0.099
Loa Loa (eye worm) hypothetical protein 0.0055 0.0192 0.0192
Echinococcus granulosus pyruvate kinase 0.0035 0.0109 0.0109
Toxoplasma gondii nucleoside transporter protein 0.0422 0.1709 0.4344
Entamoeba histolytica kinase, PfkB family 0.0109 0.0417 0.0413
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0067 0.0091
Trypanosoma brucei adenosine transporter 2, putative 0.0422 0.1709 0.4307
Leishmania major putative PfkB family sugar kinase 0.0109 0.0417 0.099
Schistosoma mansoni equilibrative nucleoside transporter 0.0422 0.1709 0.4353
Brugia malayi MH2 domain containing protein 0.0121 0.0464 0.0464
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0048 0.0048
Echinococcus multilocularis zinc finger protein 0.0024 0.0065 0.0065
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0048 0.0123
Trichomonas vaginalis ribokinase, putative 0.0109 0.0417 0.0371
Entamoeba histolytica phosphofructokinase, putative 0.0233 0.0927 0.0923
Trypanosoma cruzi nucleoside transporter-like, putative 0.0422 0.1709 0.4344
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.013 0.1
Onchocerca volvulus 0.004 0.013 0.0022
Echinococcus granulosus pyruvate kinase 0.0035 0.0109 0.0109
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0066 0.0061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0226 0.0179
Echinococcus granulosus zinc finger protein 0.0024 0.0065 0.0065
Entamoeba histolytica fructokinase, putative 0.0109 0.0417 0.0413
Toxoplasma gondii nucleoside transporter protein 0.0422 0.1709 0.4344
Entamoeba histolytica ribokinase, putative 0.0109 0.0417 0.0413
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0039 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0464 0.0464
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0569 0.0569
Brugia malayi beta-lactamase family protein 0.004 0.013 0.013
Echinococcus granulosus equilibrative nucleoside transporter 3 0.2433 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0417 0.0371
Loa Loa (eye worm) hypothetical protein 0.096 0.3925 0.3925
Trypanosoma brucei ribokinase, putative 0.0109 0.0417 0.099
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0109 0.0417 0.4016
Brugia malayi hypothetical protein 0.046 0.1862 0.1862
Trypanosoma brucei adenosine transporter 2 0.0422 0.1709 0.4307
Schistosoma mansoni regulator of G protein signaling 0.002 0.0048 0.0123
Leishmania major pyruvate kinase 0.0035 0.0109 0.0199
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Schistosoma mansoni pyruvate kinase 0.0018 0.0039 0.01
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.0066
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0233 0.0927 0.2351
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0464 0.0464
Brugia malayi Ribokinase 0.0109 0.0417 0.0417
Trypanosoma brucei adenosine transporter, putative 0.0422 0.1709 0.4307
Toxoplasma gondii phosphofructokinase PFKII 0.0063 0.0226 0.0561
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0109 0.0263
Echinococcus granulosus flap endonuclease 1 0.0027 0.0078 0.0078
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0192 0.0488
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0048 0.0048
Brugia malayi Bromodomain containing protein 0.0043 0.0145 0.0145
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0422 0.1709 0.4307
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0422 0.1709 0.4307
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.0978 0.0978
Entamoeba histolytica nucleoside transporter, putative 0.0422 0.1709 0.1705
Loa Loa (eye worm) 6-phosphofructokinase 0.0233 0.0927 0.0927
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0138 0.0353
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.0978 0.0978
Echinococcus granulosus intermediate filament protein 0.0058 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0422 0.1709 0.4307
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0067
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0422 0.1709 0.4307
Echinococcus granulosus adenosine kinase 0.096 0.3925 0.3925
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0048 0.0048
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0422 0.1709 0.1668
Loa Loa (eye worm) STAT protein 0.0133 0.0515 0.0515
Trichomonas vaginalis phosphofructokinase, putative 0.0233 0.0927 0.0883
Toxoplasma gondii 6-phosphofructokinase 0.0063 0.0226 0.0561
Leishmania major adenosine kinase, putative 0.096 0.3925 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.2433 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0075 0.0176
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0155 0.0155
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0081
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.1016 1
Schistosoma mansoni adenosine kinase 0.096 0.3925 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Onchocerca volvulus 0.004 0.013 0.0022
Onchocerca volvulus 0.0058 0.0205 0.0097
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0109 0.0399
Echinococcus multilocularis lamin dm0 0.0058 0.0205 0.0205
Echinococcus granulosus axis inhibition protein axin 0.002 0.0048 0.0048
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0109 0.0109
Entamoeba histolytica phosphofructokinase, putative 0.0233 0.0927 0.0923
Trichomonas vaginalis phosphofructokinase, putative 0.0233 0.0927 0.0883
Trypanosoma cruzi nucleobase transporter, putative 0.0422 0.1709 0.4344
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0067
Mycobacterium leprae Probable adenosine kinase adk 0.0109 0.0417 0.3767
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0078 0.0078
Mycobacterium ulcerans 6-phosphofructokinase 0.0233 0.0927 1
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0075 0.0111
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.013 0.0083
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0233 0.0927 0.0883
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0205 0.0205
Leishmania major tagatose-6-phosphate kinase-like protein 0.0109 0.0417 0.099
Trypanosoma brucei adenosine kinase, putative 0.096 0.3925 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0063 0.0226 0.0179
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0109 0.0109
Trypanosoma brucei adenosine transporter, putative 0.0422 0.1709 0.4307
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0109 0.0199
Loa Loa (eye worm) RecQ helicase 0.0046 0.0155 0.0155
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0422 0.1709 0.1668
Trypanosoma brucei hypothetical protein, conserved 0.004 0.013 0.0254
Trypanosoma brucei ribokinase, putative 0.0109 0.0417 0.099
Mycobacterium tuberculosis Probable hydrolase 0.004 0.013 0.1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0075 0.0075
Echinococcus multilocularis pyruvate kinase 0.0035 0.0109 0.0109
Trypanosoma cruzi adenosine kinase, putative 0.0109 0.0417 0.105
Brugia malayi Flap endonuclease-1 0.0027 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0359 0.1447 0.3685
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0063 0.0226 0.2387
Brugia malayi hypothetical protein 0.0245 0.0978 0.0978
Trypanosoma brucei adenosine transporter 2, putative 0.0422 0.1709 0.4307
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0057 0.0057
Schistosoma mansoni regulator of G protein signaling 0.002 0.0048 0.0123
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0109 0.0417 0.0417
Entamoeba histolytica nucleoside transporter, putative 0.2433 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0081 0.0081
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0109 0.0417 0.0413
Loa Loa (eye worm) RGS-3 protein 0.002 0.0048 0.0048
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0226 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0233 0.0927 0.9101
Brugia malayi 6-phosphofructokinase 0.0233 0.0927 0.0927
Mycobacterium ulcerans lipase LipD 0.004 0.013 0.0651
Loa Loa (eye worm) hypothetical protein 0.0245 0.0978 0.0978
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0422 0.1709 0.4307
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Mycobacterium tuberculosis Conserved protein 0.004 0.013 0.1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0099
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.2433 1 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0155 0.0107
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0114 0.0066
Trypanosoma brucei nucleoside transporter 1, putative 0.0422 0.1709 0.4307
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0422 0.1709 0.1668
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0412
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0078 0.003
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0067 0.0063
Plasmodium falciparum pyruvate kinase 0.0035 0.0109 0.3966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0412
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0054 0.0054
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0109 0.0263
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0048 0.0048
Leishmania major nucleoside transporter 1, putative 0.0422 0.1709 0.4307
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0075 0.0176
Schistosoma mansoni lamin 0.0058 0.0205 0.0521
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.2433 1 1
Brugia malayi Muscleblind-like protein 0.032 0.1287 0.1287
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0205 0.0205
Schistosoma mansoni 6-phosphofructokinase 0.0233 0.0927 0.2362
Schistosoma mansoni axis inhibition protein axin 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0117
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0233 0.0927 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0162
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0109 0.0417 0.3916
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.2433 1 1
Leishmania major cytochrome p450-like protein 0.0026 0.0075 0.0111
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0048 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0044
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0048 0.0123
Leishmania major ATP-dependent phosphofructokinase 0.0233 0.0927 0.2301
Echinococcus granulosus ribokinase 0.0109 0.0417 0.0417
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Toxoplasma gondii ABC1 family protein 0.004 0.013 0.0318
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0048 0.0048
Echinococcus granulosus tumor protein p63 0.0374 0.1508 0.1508
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0048 0.0048
Echinococcus multilocularis muscleblind protein 0.032 0.1287 0.1287
Echinococcus granulosus axis inhibition protein axin 0.002 0.0048 0.0048
Toxoplasma gondii nucleoside transporter protein 0.0422 0.1709 0.4344
Loa Loa (eye worm) 6-phosphofructokinase 0.0233 0.0927 0.0927
Leishmania major adenosine kinase-like protein 0.0109 0.0417 0.099
Loa Loa (eye worm) hypothetical protein 0.2433 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.013 0.0651
Brugia malayi Bromodomain containing protein 0.0082 0.0302 0.0302
Schistosoma mansoni lozenge 0.0058 0.0204 0.0519
Onchocerca volvulus Ribokinase homolog 0.0109 0.0417 0.0312
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.013
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0109 0.0781
Trypanosoma brucei purine nucleoside transporter 0.0422 0.1709 0.4307
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0597 0.152
Echinococcus multilocularis tumor protein p63 0.0374 0.1508 0.1508
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0115 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.013 0.0332
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0109 0.4722
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0226 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.013 0.1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.013 0.0083
Leishmania major hypothetical protein, conserved 0.004 0.013 0.0254
Echinococcus granulosus lamin dm0 0.0058 0.0205 0.0205
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0109 0.0061
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0205 0.0205
Brugia malayi hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0032 0.0032
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0109 0.0109
Trypanosoma brucei adenosine transporter 2, putative 0.0422 0.1709 0.4307
Echinococcus multilocularis Protein lozenge 0.0058 0.0204 0.0204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.013 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0039 0.0099
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0159 0.0159
Schistosoma mansoni flap endonuclease-1 0.0024 0.0067 0.017
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.0139
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.008
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0048 0.0048
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Mycobacterium leprae Probable lipase LipE 0.004 0.013 0.0263
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0075 0.0075
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0032 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.012 0.012
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0048 0.0048
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0109 0.0417 0.0413
Mycobacterium tuberculosis Conserved protein 0.004 0.013 0.1
Trypanosoma cruzi ribokinase, putative 0.0109 0.0417 0.105
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0159 0.039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0422 0.1709 0.1668
Brugia malayi phosphofructokinase 0.0233 0.0927 0.0927

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 123 uM Inhibition of Escherichia coli DdlB ChEMBL. 17267218
MIC (functional) > 256 ug ml-1 Antibacterial activity against Escherichia coli 1411 ChEMBL. 17267218
MIC (functional) > 256 ug ml-1 Antibacterial activity against acrAB deficient Escherichia coli 1411 ChEMBL. 17267218
MIC (functional) > 256 ug ml-1 Antibacterial activity against Staphylococcus aureus 8325-4 ChEMBL. 17267218
MIC (functional) > 256 ug ml-1 Antibacterial activity against Escherichia coli 1411 ChEMBL. 17267218
MIC (functional) > 256 ug ml-1 Antibacterial activity against acrAB deficient Escherichia coli 1411 ChEMBL. 17267218

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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