Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.223 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.223 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.223 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0918 | 0.3234 | 0.3234 |
Brugia malayi | Matrixin family protein | 0.0703 | 0.2127 | 0.2127 |
Loa Loa (eye worm) | hypothetical protein | 0.0918 | 0.3234 | 0.3234 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1046 | 0.3895 | 1 |
Brugia malayi | Hemopexin family protein | 0.0413 | 0.0627 | 0.0627 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0354 | 0.0327 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0918 | 0.3234 | 0.3234 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.223 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1046 | 0.3895 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0354 | 0.0327 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0645 | 0.1827 | 1 |
Brugia malayi | CHE-14 protein | 0.0918 | 0.3234 | 0.3234 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0425 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0918 | 0.3234 | 0.3234 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0354 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.0327 | 0.0327 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.223 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1046 | 0.3895 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1046 | 0.3895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.223 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.223 | 1 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1058 | 0.3955 | 0.1065 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.223 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0645 | 0.1827 | 0.1827 |
Onchocerca volvulus | Matrilysin homolog | 0.0645 | 0.1827 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0413 | 0.0627 | 0.0627 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1058 | 0.3955 | 0.1065 |
Onchocerca volvulus | 0.0413 | 0.0627 | 0.3431 | |
Loa Loa (eye worm) | matrixin family protein | 0.0703 | 0.2127 | 0.2127 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.223 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.