Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxycarboxylic acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | hydroxycarboxylic acid receptor 2 | 363 aa | 294 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.0365 | 0.2477 | 0.2477 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0365 | 0.2477 | 0.2477 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0365 | 0.2477 | 0.2477 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0886 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0365 | 0.2477 | 0.2477 |
Echinococcus multilocularis | protein dispatched 1 | 0.0365 | 0.2477 | 0.2477 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0886 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0886 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0886 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0886 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0886 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0886 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0365 | 0.2477 | 0.2477 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0886 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0365 | 0.2477 | 0.2477 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0365 | 0.2477 | 0.2477 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0365 | 0.2477 | 0.2477 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0416 | 0.3211 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0416 | 0.3211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0416 | 0.3211 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0416 | 0.3211 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.7 uM | Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test | ChEMBL. | 17588745 |
EC50 (functional) | = 8.7 uM | Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test | ChEMBL. | 17588745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.