Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1225 | 0.1225 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.1225 | 0.1225 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0759 | 0.6441 | 0.6441 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.1225 | 0.1225 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0182 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1078 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.1225 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1078 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.246 | 0.246 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0182 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1225 | 0.1225 |
Brugia malayi | Carboxylesterase family protein | 0.1078 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 0.1225 | 1 | |
Echinococcus granulosus | microtubule associated protein 2 | 0.0759 | 0.6441 | 0.6441 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.1225 | 0.1225 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0403 | 0.246 | 0.246 |
Echinococcus granulosus | acetylcholinesterase | 0.1078 | 1 | 1 |
Brugia malayi | GH02984p | 0.0403 | 0.246 | 0.246 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0403 | 0.246 | 0.246 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1078 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0182 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1225 | 0.1225 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0759 | 0.6441 | 0.6441 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0182 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0182 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1078 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.1225 | 0.1225 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1078 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0182 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 1 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0403 | 0.246 | 0.246 |
Echinococcus multilocularis | acetylcholinesterase | 0.1078 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
behavior (functional) | W 0 | Gross behavioral effects ascertained in mice; W indicates weak stimulant or depressant activity of little significance. | ChEMBL. | 3039136 |
ED50 (functional) | > 60 mg kg-1 | Antagonism of tetrabenazine(TBZ)-induced depression measured in mice by motor activity | ChEMBL. | 3039136 |
ED50 (functional) | > 60 mg kg-1 | Antagonism of tetrabenazine(TBZ)-induced depression in mice measured for ptosis | ChEMBL. | 3039136 |
Inhibition (functional) | = 35 % | Inhibition of tritiated dopamine (DA) uptake at 0.1 uM concentration | ChEMBL. | 3039136 |
Ki (binding) | = 16.1 nM | Inhibition of uptake of tritiated norepinephrine(NE) in rat synaptosomes | ChEMBL. | 3039136 |
Ki (binding) | = 166 nM | Inhibition the uptake of tritiated serotonin(5-HT)by the serotonin transporter SERT in rat synaptosomes | ChEMBL. | 3039136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.