Detailed information for compound 458320

Basic information

Technical information
  • TDR Targets ID: 458320
  • Name: tert-butyl 2-[2-(benzenesulfonamido)-2,3-dihy dro-1H-inden-5-yl]-6-hydroxyindole-1-carboxyl ate
  • MW: 504.597 | Formula: C28H28N2O5S
  • H donors: 2 H acceptors: 4 LogP: 5.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc2c(c1)n(C(=O)OC(C)(C)C)c(c2)c1ccc2c(c1)CC(C2)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C28H28N2O5S/c1-28(2,3)35-27(32)30-25(16-20-11-12-23(31)17-26(20)30)19-10-9-18-14-22(15-21(18)13-19)29-36(33,34)24-7-5-4-6-8-24/h4-13,16-17,22,29,31H,14-15H2,1-3H3
  • InChiKey: KYJBKJMDJLPNHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl 2-[2-(benzenesulfonamido)indan-5-yl]-6-hydroxy-indole-1-carboxylate
  • 2-[2-(benzenesulfonamido)-5-indanyl]-6-hydroxy-1-indolecarboxylic acid tert-butyl ester
  • tert-butyl 6-hydroxy-2-[2-(phenylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]indole-1-carboxylate
  • 2-[2-(benzenesulfonamido)indan-5-yl]-6-hydroxy-indole-1-carboxylic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) histone deacetylase 3 0.0013 0.0003 0.0003
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0016 0.068
Echinococcus granulosus histone deacetylase 7 0.0045 0.0046 0.0277
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0035 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0109 0.0332
Giardia lamblia Histone deacetylase 0.0013 0.0003 0.2133
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0008 0.0107
Echinococcus granulosus snurportin 1 0.0299 0.0397 0.2385
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0035 0.1429
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Toxoplasma gondii histone deacetylase HDAC1 0.0045 0.0046 0.1902
Leishmania major GTP-binding protein, putative 0.0021 0.0012 0.0032
Echinococcus multilocularis carboxylesterase 5A 0.0139 0.0176 0.0536
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0181 0.1086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0188 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0016 0.0214
Brugia malayi Carboxylesterase family protein 0.0139 0.0176 0.0176
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0066 0.2737
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0001 0.0004
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0035 0.0208
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0015 0.0634
Plasmodium vivax histone deacetylase 1, putative 0.0013 0.0003 0.011
Leishmania major histone deacetylase, putative 0.0045 0.0046 0.0118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0299 0.0397 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Onchocerca volvulus 0.0023 0.0016 0.0277
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0024 0.0017 0.0722
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0016 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0071 0.0427
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0437
Onchocerca volvulus 0.0095 0.0116 0.1953
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0119 0.6557
Loa Loa (eye worm) hypothetical protein 0.7242 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0011 0.0442
Brugia malayi hypothetical protein 0.0121 0.0152 0.0152
Entamoeba histolytica peptidase, C54 family 0.0023 0.0016 0.089
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0013 0.008
Echinococcus granulosus histone deacetylase 6 0.0052 0.0056 0.0334
Schistosoma mansoni cpg binding protein 0.009 0.0109 0.0653
Brugia malayi hypothetical protein 0.0023 0.0016 0.0016
Onchocerca volvulus 0.0085 0.0102 0.1716
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0116 0.0116
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.002 0.0062
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0001 0.0019
Schistosoma mansoni DNA ligase IV 0.0019 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0139 0.0176 0.0176
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0016 0.068
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0023 0.0058
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0.0001 0.0004
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0001 0.0009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0015 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0214
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0011 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0016 0.0041
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0001 0.0019
Trichomonas vaginalis ran, putative 0.0021 0.0012 0.0514
Schistosoma mansoni hypothetical protein 0.004 0.004 0.0238
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0023 0.0935
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0042 0.0127
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0001 0.0009
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0052 0.031
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0011 0.0437
Schistosoma mansoni ferritin 0.0017 0.0007 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0035 0.0452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0181 0.0549
Trichomonas vaginalis hypothetical protein 0.0187 0.0242 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.0152 0.2558
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0042
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi CXXC zinc finger family protein 0.0085 0.0102 0.0102
Plasmodium falciparum histone deacetylase 1 0.0013 0.0003 0.011
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0292
Echinococcus multilocularis histone deacetylase 6 0.0045 0.0046 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.009 0.0109 0.0653
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0011 0.0064
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0066 0.0169
Echinococcus multilocularis cpg binding protein 0.009 0.0109 0.033
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0071 0.0427
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0035 0.0035
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0016 0.005
Echinococcus granulosus histone deacetylase 0.0045 0.0046 0.0277
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0019 0.0011 0.0437
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0042 0.0251
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0001 0.0061
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0066 0.2737
Loa Loa (eye worm) hypothetical protein 0.0468 0.0631 0.0631
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0042
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0016 0.0676
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0011 0.0586
Treponema pallidum DNA ligase (lig) 0.0019 0.0011 1
Schistosoma mansoni ran 0.0021 0.0012 0.0075
Echinococcus granulosus cpg binding protein 0.009 0.0109 0.0653
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0016 0.005
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0015 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Onchocerca volvulus Phospholipase A2 homolog 0.0093 0.0112 0.1893
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0011 0.0437
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0012
Echinococcus multilocularis GPCR, family 2 0.0047 0.0049 0.0147
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0035 0.1429
Echinococcus granulosus carboxylesterase 5A 0.0139 0.0176 0.1059
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0012 0.0514
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0035 0.0088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0049 0.0292
Echinococcus multilocularis histone deacetylase 7 0.0045 0.0046 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0053 0.2196
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0187 0.0242 0.3162
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0035 0.0105
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.0441 0.0594 0.0594
Brugia malayi RNA binding protein 0.0063 0.0071 0.0071
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0011 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0071 0.0071
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0016 0.0099
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0011 0.0138
Onchocerca volvulus 0.0023 0.0016 0.0277
Schistosoma mansoni hypothetical protein 0.004 0.004 0.0238
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2845 0.3919 1
Trypanosoma brucei histone deacetylase 2 0.0013 0.0003 0.0007
Trypanosoma cruzi histone deacetylase 1, putative 0.0013 0.0003 0.0007
Echinococcus granulosus geminin 0.0501 0.0677 0.4066
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0066 0.0398
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0119 0.0119
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0016 0.0907
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0029 0.121
Echinococcus multilocularis histone deacetylase 0.0045 0.0046 0.014
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0013 0.0001 0.0061
Onchocerca volvulus 0.0023 0.0016 0.0277
Echinococcus granulosus tm gpcr rhodopsin 0.1032 0.1411 0.8481
Brugia malayi TAR-binding protein 0.0063 0.0071 0.0071
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0053 0.0136
Leishmania major hypothetical protein, conserved 0.005 0.0053 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0071 0.0427
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0016 0.0214
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0011 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Echinococcus granulosus acetylcholinesterase 0.0139 0.0176 0.1059
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0016 0.0099
Loa Loa (eye worm) hypothetical protein 0.0101 0.0123 0.0123
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0008 0.0279
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0015 0.0634
Plasmodium falciparum enoyl-acyl carrier reductase 0.0187 0.0242 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.002 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0109 0.0657
Loa Loa (eye worm) hypothetical protein 0.0121 0.0152 0.0152
Echinococcus granulosus histone deacetylase 1 0.0013 0.0003 0.0016
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0011 0.0437
Brugia malayi DKFZp564C0469 protein 0.0019 0.0011 0.0011
Echinococcus granulosus histone deacetylase 8 0.0013 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0008 0.0338
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis acetylcholinesterase 0.0139 0.0176 0.0536
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Echinococcus granulosus ankyrin repeat protein 0.0165 0.0213 0.1278
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0013 0.0001 0.0061
Echinococcus multilocularis histone deacetylase 1 0.0013 0.0003 0.0008
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0066 0.0169
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0011 0.0437
Loa Loa (eye worm) hypothetical protein 0.0051 0.0055 0.0055
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0032
Schistosoma mansoni topbp1 0.0019 0.0011 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0001
Schistosoma mansoni histone deacetylase hda2 0.0052 0.0056 0.0334
Schistosoma mansoni inositol monophosphatase 0.0037 0.0035 0.0208
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0007 0.0091
Leishmania major malonyl-coa decarboxylase-like protein 0.2845 0.3919 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0109 0.0657
Schistosoma mansoni hypothetical protein 0.0142 0.0181 0.1086
Schistosoma mansoni inositol monophosphatase 0.0037 0.0035 0.0208
Onchocerca volvulus 0.0049 0.0052 0.0868
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2845 0.3919 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0049 0.0292
Leishmania major histone deacetylase, putative 0.0013 0.0003 0.0007
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0001 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0437
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0109 0.0109
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0017 0.0228
Echinococcus multilocularis ankyrin repeat protein 0.0165 0.0213 0.0646
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0017 0.0228
Echinococcus multilocularis expressed protein 0.0017 0.0007 0.0021
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0024 0.0017 0.0228
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0016 0.0215
Trypanosoma cruzi histone deacetylase, putative 0.0013 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0292
Brugia malayi Peptidase family C54 containing protein 0.006 0.0066 0.0066
Plasmodium vivax histone deacetylase, putative 0.0045 0.0046 0.1902
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0109 0.0109
Plasmodium vivax importin-beta 2, putative 0.0028 0.0023 0.0935
Schistosoma mansoni importin beta-1 0.0028 0.0023 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Trichomonas vaginalis helicase, putative 0.0019 0.0011 0.0442
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0007 0.0091
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0066 0.2737
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0066 0.2737
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0011 0.0027
Loa Loa (eye worm) histone deacetylase 11 0.0013 0.0003 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0016 0.0214
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0066 0.0169
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0011 0.0437
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0071 0.0427
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0016 0.0099
Loa Loa (eye worm) carboxylesterase 0.0023 0.0016 0.0016
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0.0001 0.0004
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0001 0.0005
Onchocerca volvulus 0.0023 0.0016 0.0277
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0035 0.1429
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0013 0.0001 0.0061
Onchocerca volvulus 0.0024 0.0017 0.0294
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0121 0.0725
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus granulosus histone deacetylase 6 0.0045 0.0046 0.0277
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0292
Echinococcus granulosus tar DNA binding protein 0.0063 0.0071 0.0427
Onchocerca volvulus 0.0019 0.0011 0.0178
Schistosoma mansoni survival motor neuron protein 0.0095 0.0116 0.0697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0109 0.0657
Schistosoma mansoni hypothetical protein 0.0095 0.0116 0.0697
Trypanosoma cruzi histone deacetylase 1, putative 0.0013 0.0003 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0139 0.0176 0.1059
Schistosoma mansoni hypothetical protein 0.004 0.004 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Loa Loa (eye worm) carboxylesterase 0.0139 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0501 0.0677 0.4066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Leishmania major histone deacetylase, putative 0.0045 0.0046 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0165 0.0213 0.1278
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0066 0.2737
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0001 0.0009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.011
Schistosoma mansoni histone deacetylase 0.0013 0.0003 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Mycobacterium ulcerans oxidoreductase 0.0013 0.0001 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0017 0.0228
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0217 0.1306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0053 0.2196
Echinococcus multilocularis neuroligin 0.0023 0.0016 0.005
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0001 0.0004
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.011
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0066
Loa Loa (eye worm) histone methyltransferase 0.0026 0.002 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.0907
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0109 0.0332
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0181 0.1086
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus granulosus acetylcholinesterase 0.0139 0.0176 0.1059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0016 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0013 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.0907
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0123 0.0123
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0053 0.2196
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0001 0.0004
Entamoeba histolytica peptidase, C54 family 0.0023 0.0016 0.089
Echinococcus multilocularis tumor protein p63 0.0334 0.0446 0.1354
Toxoplasma gondii histone deacetylase HDAC5 0.0014 0.0003 0.0124
Schistosoma mansoni hypothetical protein 0.1215 0.1664 1
Plasmodium vivax histone deacetylase, putative 0.0013 0.0003 0.011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus multilocularis survival motor neuron protein 1 0.0468 0.0631 0.1918
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0011 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0109 0.0657
Schistosoma mansoni histone deacetylase hda2 0.0013 0.0003 0.0016
Loa Loa (eye worm) histone deacetylase 0.0045 0.0046 0.0046
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0071 0.0427
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0053 0.0136
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.0046 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2391 0.3291 1
Brugia malayi Histone deacetylase 1 0.0013 0.0003 0.0003
Plasmodium vivax histone deacetylase 2, putative 0.0045 0.0046 0.1902
Plasmodium falciparum histone deacetylase, putative 0.0045 0.0046 0.1902
Leishmania major oxidoreductase-like protein 0.0024 0.0017 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0162 0.0208 0.8563
Echinococcus multilocularis snurportin 1 0.0299 0.0397 0.1206
Plasmodium falciparum importin beta, putative 0.0028 0.0023 0.0935
Trypanosoma brucei pteridine reductase 1 0.0013 0.0001 0.0004
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0011 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0119 0.0712
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0011 0.0011
Echinococcus multilocularis ferritin 0.0017 0.0007 0.0021
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0001 0.0001
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0016 0.0099
Entamoeba histolytica peptidase, C54 family 0.0023 0.0016 0.089
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0011 0.0027
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0015 0.0046
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0176 0.0536
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0001 0.0019
Echinococcus multilocularis histone deacetylase 3 0.0013 0.0003 0.0008
Brugia malayi Carboxylesterase family protein 0.0023 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0292
Schistosoma mansoni histone deacetylase 0.0013 0.0003 0.0016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0016 0.0214
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0001 0.0019
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.0046 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0566 0.0766 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0437
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0071 0.0216
Trichomonas vaginalis ferritin, putative 0.0017 0.0007 0.0287
Echinococcus multilocularis protein dispatched 1 0.0048 0.005 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0109 0.0657
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.002 0.002
Echinococcus multilocularis dnaJ subfamily B 0.1215 0.1664 0.5057
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0007 0.0287
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0016 0.0099
Echinococcus granulosus cysteine protease atg4b 0.006 0.0066 0.0398
Echinococcus granulosus nibrin 0.0019 0.0011 0.0064
Schistosoma mansoni histone deacetylase 1 2 3 0.0013 0.0003 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0013 0.008
Toxoplasma gondii histone deacetylase HDAC2 0.0013 0.0003 0.011
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0016 0.0099
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0015 0.009
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0016 0.0664
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Toxoplasma gondii histone deacetylase HDAC4 0.0013 0.0003 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.009
Schistosoma mansoni ferritin 0.0017 0.0007 0.0042
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0187 0.0242 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0016 0.0215
Brugia malayi histone deacetylase 11 0.0013 0.0003 0.0003
Echinococcus multilocularis histone deacetylase 6 0.0052 0.0056 0.0169
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0016 0.0664
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0187 0.0242 0.0242
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2845 0.3919 1
Schistosoma mansoni ferritin 0.0017 0.0007 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0119 0.036
Echinococcus granulosus survival motor neuron protein 1 0.0468 0.0631 0.3794
Brugia malayi histone deacetylase 3 (HD3) 0.0013 0.0003 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0566 0.0766 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1032 0.1411 0.4289
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Trypanosoma brucei histone deacetylase 4 0.0045 0.0046 0.0118
Schistosoma mansoni patched 1 0.0042 0.0042 0.0251
Schistosoma mansoni ran 0.0021 0.0012 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.009
Loa Loa (eye worm) hypothetical protein 0.0093 0.0112 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0102 0.0102
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0042
Echinococcus granulosus histone deacetylase 3 0.0013 0.0003 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0012
Schistosoma mansoni gliotactin 0.0023 0.0016 0.0099
Schistosoma mansoni topbp1 0.0019 0.0011 0.0064
Trypanosoma brucei histone deacetylase 1 0.0013 0.0003 0.0007
Brugia malayi Phospholipase A2 family protein 0.0093 0.0112 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0016 0.0215
Schistosoma mansoni autophagin-1 (C54 family) 0.006 0.0066 0.0398
Brugia malayi hypothetical protein 0.0032 0.0029 0.0029
Trypanosoma brucei oxidoreductase-like protein 0.0024 0.0017 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.009
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0042 0.0251
Echinococcus multilocularis acetylcholinesterase 0.0139 0.0176 0.0536
Echinococcus granulosus expressed protein 0.0017 0.0007 0.0042
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0007 0.0007
Onchocerca volvulus Histone deacetylase 10 homolog 0.0013 0.0003 0.0045
Brugia malayi CHE-14 protein 0.0042 0.0042 0.0042
Echinococcus multilocularis geminin 0.0501 0.0677 0.2056
Plasmodium falciparum histone deacetylase 2 0.0045 0.0046 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0437
Entamoeba histolytica peptidase, C54 family 0.0023 0.0016 0.089
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0397 0.0397
Schistosoma mansoni acetylcholinesterase 0.0023 0.0016 0.0099
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0176 0.1059
Onchocerca volvulus Phospholipase A2 homolog 0.0441 0.0594 1
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0013 0.0001 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0142 0.0181 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0049 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0035 0.1429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.009
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0016 0.0099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0035 0.1916
Echinococcus multilocularis nibrin 0.0019 0.0011 0.0032
Loa Loa (eye worm) inositol-1 0.0037 0.0035 0.0035
Brugia malayi Carboxylesterase family protein 0.0023 0.0016 0.0016
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0001 0.0019
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.0046 0.0277
Onchocerca volvulus 0.0013 0.0001 0.0025
Loa Loa (eye worm) carboxylesterase 0.0023 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0101 0.0123 0.0742
Onchocerca volvulus 0.0023 0.0016 0.0277
Brugia malayi hypothetical protein 0.0468 0.0631 0.0631
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0049 0.0049
Brugia malayi topoisomerase 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0139 0.0176 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0181 0.0234 0.1407
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0071 0.0071
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0001 0.0019
Brugia malayi hypothetical protein 0.0142 0.0181 0.0181
Brugia malayi Carboxylesterase family protein 0.0139 0.0176 0.0176
Echinococcus granulosus dnaJ subfamily B 0.1215 0.1664 1
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Schistosoma mansoni cpg binding protein 0.0085 0.0102 0.0613
Onchocerca volvulus 0.0023 0.0016 0.0276
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0016 0.0041
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0016 0.0214
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0066 0.0398
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0001 0.0082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0037
Trypanosoma cruzi histone deacetylase, putative 0.0013 0.0003 0.0007
Echinococcus multilocularis histone deacetylase 8 0.0013 0.0003 0.0008
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0023 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0001 0.0005
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.7242 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Schistosoma mansoni ferritin 0.0017 0.0007 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Onchocerca volvulus 0.0018 0.001 0.016
Brugia malayi Histone deacetylase family protein 0.0045 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0042 0.1722
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0188 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0442
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0016 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0053 0.0053
Brugia malayi Importin beta-1 subunit 0.0028 0.0023 0.0023
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Entamoeba histolytica histone deacetylase, putative 0.0013 0.0003 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0011 0.0437
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0017 0.0045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0035 0.0088
Entamoeba histolytica hypothetical protein 0.0019 0.0011 0.0586
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0187 0.0242 0.3162
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.0046 0.0118
Trypanosoma brucei histone deacetylase 3 0.0045 0.0046 0.0118
Mycobacterium ulcerans hypothetical protein 0.0023 0.0016 0.0214
Echinococcus granulosus GPCR family 2 0.0047 0.0049 0.0292
Echinococcus multilocularis expressed conserved protein 0.0091 0.011 0.0335
Brugia malayi Histone deacetylase family protein 0.0045 0.0046 0.0046
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0001 0.0019
Echinococcus granulosus ferritin 0.0017 0.0007 0.0042
Loa Loa (eye worm) histone deacetylase 1 0.0013 0.0003 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0011 0.0442
Loa Loa (eye worm) acetylcholinesterase 1 0.0139 0.0176 0.0176
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0001 0.0019
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0012 0.0514
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0007 0.0091
Leishmania major pteridine reductase 1 0.0024 0.0017 0.0045
Entamoeba histolytica hypothetical protein 0.0023 0.0015 0.0849
Toxoplasma gondii histone deacetylase HDAC3 0.0013 0.0003 0.011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0012 0.0075
Brugia malayi Carboxylesterase family protein 0.0023 0.0016 0.0016
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0013 0.0001 0.0019
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0187 0.0242 1
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0013 0.0001 0.0061
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0001 0.0019
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0049 0.0049
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0008 0.0338
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0042
Entamoeba histolytica Ran family GTPase 0.0021 0.0012 0.0689
Chlamydia trachomatis DNA ligase 0.0019 0.0011 0.0378
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0013 0.0001 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0442
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0023 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.0188 0.0188
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.011
Echinococcus granulosus histone deacetylase 6 0.0045 0.0046 0.0277
Echinococcus granulosus expressed conserved protein 0.0091 0.011 0.0663
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0008 0.0107
Trypanosoma brucei histone deacetylase, putative 0.0045 0.0046 0.0118
Loa Loa (eye worm) hypothetical protein 0.0097 0.0119 0.0119
Brugia malayi hypothetical protein 0.005 0.0053 0.0053
Leishmania major histone deacetylase, putative 0.0013 0.0003 0.0007
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0187 0.0242 1
Entamoeba histolytica hypothetical protein 0.0142 0.0181 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0035 0.0088
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0001 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0017 0.0228
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0001 0.0004
Echinococcus multilocularis Peptidase C54 0.006 0.0066 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0188 0.0188
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0011 0.0032
Entamoeba histolytica hypothetical protein 0.0142 0.0181 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0016 0.005
Brugia malayi Carboxylesterase family protein 0.0023 0.0016 0.0016
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0218 0.0662
Onchocerca volvulus Huntingtin homolog 0.0121 0.0152 0.2558
Brugia malayi Inositol-1 0.0037 0.0035 0.0035
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0016 0.0215
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0187 0.0242 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0023 0.0136
Schistosoma mansoni hypothetical protein 0.0501 0.0677 0.4066
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Echinococcus granulosus Peptidase C54 0.006 0.0066 0.0398
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0011 0.8512
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0011 0.0027
Entamoeba histolytica hypothetical protein 0.0142 0.0181 1
Brugia malayi RNA, U transporter 1 0.008 0.0094 0.0094
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0011 0.0437
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0053 0.2196
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus granulosus tumor protein p63 0.0334 0.0446 0.2678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Loa Loa (eye worm) RNA binding protein 0.0063 0.0071 0.0071
Echinococcus multilocularis cysteine protease atg4b 0.006 0.0066 0.0202
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0012 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0013 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0049 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0053 0.0136
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0071 0.0071
Leishmania major importin beta-1 subunit, putative 0.0023 0.0015 0.0039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0001 0.0019
Echinococcus granulosus neuroligin 0.0023 0.0016 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis protein patched 0.0042 0.0042 0.0127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0032
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0001 0.0019
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.0046 0.0118
Brugia malayi histone deacetylase 1 (HD1) 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0029 0.0383
Loa Loa (eye worm) hypothetical protein 0.0121 0.0152 0.0152
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0049 0.0147
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0011 0.0064
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0016 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0437
Entamoeba histolytica peptidase, C54 family 0.006 0.0066 0.3669
Schistosoma mansoni hypothetical protein 0.004 0.004 0.0238
Loa Loa (eye worm) histone deacetylase 7A 0.0045 0.0046 0.0046
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0011 0.0011
Echinococcus multilocularis histone deacetylase 6 0.0045 0.0046 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.67 uM Agonist activity at LXRbeta LBD by HTRF cofactor peptide recruitment assay ChEMBL. 17416521
EC50 (functional) = 0.67 uM Agonist activity at LXRbeta LBD by HTRF cofactor peptide recruitment assay ChEMBL. 17416521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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