Detailed information for compound 458325

Basic information

Technical information
  • TDR Targets ID: 458325
  • Name: ethyl 2-[2-(benzenesulfonamido)-2,3-dihydro-1 H-inden-5-yl]indole-1-carboxylate
  • MW: 460.545 | Formula: C26H24N2O4S
  • H donors: 1 H acceptors: 3 LogP: 5.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)n1c(cc2c1cccc2)c1ccc2c(c1)CC(C2)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C26H24N2O4S/c1-2-32-26(29)28-24-11-7-6-8-19(24)17-25(28)20-13-12-18-15-22(16-21(18)14-20)27-33(30,31)23-9-4-3-5-10-23/h3-14,17,22,27H,2,15-16H2,1H3
  • InChiKey: NIMFRIUMYBJXEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[2-(benzenesulfonamido)indan-5-yl]indole-1-carboxylate
  • 2-[2-(benzenesulfonamido)-5-indanyl]-1-indolecarboxylic acid ethyl ester
  • ethyl 2-[2-(phenylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]indole-1-carboxylate
  • 2-[2-(benzenesulfonamido)indan-5-yl]indole-1-carboxylic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0467 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Onchocerca volvulus 0.0348 0.0439 0.1323
Loa Loa (eye worm) hypothetical protein 0.0433 0.0549 0.0549
Brugia malayi hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0091 0.0103 0.0103
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3018 0.392 1
Echinococcus multilocularis Nicastrin 0.0109 0.0126 0.0261
Loa Loa (eye worm) hypothetical protein 0.007 0.0076 0.0076
Loa Loa (eye worm) histone deacetylase 0.0044 0.0042 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0031 0.0439
Loa Loa (eye worm) acetylcholine receptor protein 0.0348 0.0439 0.0439
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0 0.0006
Echinococcus granulosus glycine receptor subunit beta 0.0755 0.0969 0.2005
Echinococcus granulosus glycine receptor subunit beta 0.0755 0.0969 0.2005
Leishmania major hypothetical protein, conserved 0.0063 0.0066 0.0168
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0755 0.0969 0.2005
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0015
Brugia malayi Presenilin spe-4 0.0078 0.0086 0.0086
Onchocerca volvulus 0.0832 0.1069 0.3225
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Trypanosoma cruzi histone deacetylase 1, putative 0.0013 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0107 0.0123 0.2392
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0013 0.0026
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0077 0.016
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0038
Echinococcus granulosus histone deacetylase 1 0.0013 0.0002 0.0003
Leishmania major histone deacetylase, putative 0.0044 0.0042 0.0106
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0755 0.0969 0.2005
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Echinococcus granulosus histone deacetylase 6 0.0044 0.0042 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.004
Schistosoma mansoni nAChR subunit 0.0348 0.0439 0.0907
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0013 0.0026
Leishmania major hypothetical protein, conserved 0.0049 0.0048 0.0122
Echinococcus granulosus histone deacetylase 0.0044 0.0042 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0003 0.0005
Echinococcus granulosus nAChR subunit 0.0755 0.0969 0.2005
Brugia malayi Histone deacetylase family protein 0.0044 0.0042 0.0042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0013 0.0039
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0007 0.0313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0013 0.0026
Brugia malayi gamma-secretase subunit aph-1 0.3719 0.4834 0.4834
Brugia malayi hypothetical protein 0.0049 0.0048 0.0048
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0 0.0001
Trypanosoma cruzi histone deacetylase 1, putative 0.0013 0.0002 0.0003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis ankyrin repeat protein 0.0162 0.0196 0.0406
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis gamma secretase subunit aph 1 0.3719 0.4834 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0015 0.0038
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.0223 0.315
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0755 0.0969 0.0969
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0123 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0115 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0099 0.0113 0.0113
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0348 0.0439 0.0907
Plasmodium falciparum histone deacetylase 1 0.0013 0.0002 0.005
Entamoeba histolytica peptidase, C54 family 0.0023 0.0014 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0034
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0223 0.0275 0.0702
Loa Loa (eye worm) carboxylesterase 0.0071 0.0077 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0313
Schistosoma mansoni nAChR subunit 0.0348 0.0439 0.0907
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0002 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0077 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0102 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.0005
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Trichomonas vaginalis Nicastrin precursor, putative 0.0109 0.0126 0.4581
Brugia malayi hypothetical protein 0.0109 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0071 0.0077 0.0077
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0078
Loa Loa (eye worm) GABA receptor subunit 0.0407 0.0515 0.0515
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0024 0.0015 0.0665
Echinococcus granulosus histone deacetylase 7 0.0044 0.0042 0.0087
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0407 0.0515 0.0515
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0005 0.0005
Echinococcus granulosus cpg binding protein 0.006 0.0062 0.0128
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0077 0.0077
Echinococcus granulosus nAChR subunit 0.0407 0.0515 0.1065
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0078
Loa Loa (eye worm) hypothetical protein 0.0467 0.0594 0.0594
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0012 0 0.0006
Trypanosoma cruzi Nicastrin, putative 0.004 0.0036 0.0092
Brugia malayi nuclear receptor NHR-88 0.0022 0.0013 0.0013
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.0223 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0113 0.2189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0013 0.0013
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0014 0.0607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0102 0.0212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0065 0.0134
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0407 0.0515 0.0515
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.004 0.0082
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0755 0.0969 0.0969
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0223 0.0275 0.0702
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0348 0.0439 0.0439
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Onchocerca volvulus Histone deacetylase 10 homolog 0.0013 0.0002 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.2554 0.3315 0.6858
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Trypanosoma cruzi Nicastrin, putative 0.004 0.0036 0.0092
Schistosoma mansoni hypothetical protein 0.033 0.0415 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.0223 1
Brugia malayi Cation transporter family protein 0.0755 0.0969 0.0969
Echinococcus granulosus nicalin 0.004 0.0036 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0013 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0048 0.2148
Trypanosoma brucei Nicastrin, putative 0.004 0.0036 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0013 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0013 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0078
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0013 0.0013
Brugia malayi Presenilin spe-4 0.0078 0.0086 0.0086
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0348 0.0439 0.0907
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0102 0.0212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0015 0.0288
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0026 0.1155
Trypanosoma brucei oxidoreductase-like protein 0.0024 0.0015 0.0038
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni histone deacetylase 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Plasmodium vivax histone deacetylase, putative 0.0013 0.0002 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Entamoeba histolytica hypothetical protein 0.0107 0.0123 0.2392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0102 0.0212
Brugia malayi Presenilin-like protein At2g29900 0.0078 0.0086 0.0086
Brugia malayi hypothetical protein 0.0348 0.0439 0.0439
Echinococcus granulosus transient receptor potential cation channel 0.0166 0.02 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Toxoplasma gondii histone deacetylase HDAC4 0.0013 0.0002 0.005
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0013 0.0026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0013 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0013 0.0026
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.0042 0.0106
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0026 0.037
Entamoeba histolytica presenilin 1 peptidase, putative 0.0223 0.0275 0.5345
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0832 0.1069 0.2212
Leishmania major oxidoreductase-like protein 0.0024 0.0015 0.0038
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.0063 0.0066 0.0168
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0121 0.0142 0.0294
Echinococcus granulosus histone deacetylase 8 0.0013 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0407 0.0515 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0141 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0049 0.0048 0.0048
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Brugia malayi excitatory GABA receptor EXP-1A 0.0755 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.006 0.2196
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0755 0.0969 0.0969
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1013 0.1305 0.27
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0028 0.0028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0109 0.0109
Brugia malayi histone deacetylase 1 (HD1) 0.0013 0.0002 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0123 0.0255
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.006 0.0125
Echinococcus multilocularis histone deacetylase 1 0.0013 0.0002 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0556 0.0709 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0015 0.0288
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0031 0.0596
Loa Loa (eye worm) presenilin spe-4 0.0078 0.0086 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0013 0.0026
Echinococcus granulosus geminin 0.033 0.0415 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0015 0.0215
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Schistosoma mansoni survival motor neuron protein 0.0095 0.0109 0.0225
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0048 0.2148
Onchocerca volvulus 0.0348 0.0439 0.1323
Loa Loa (eye worm) ACC-1 protein 0.0755 0.0969 0.0969
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.001
Onchocerca volvulus 0.0755 0.0969 0.2924
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.768 1 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0031 0.0064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis nicalin 0.004 0.0036 0.0075
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0755 0.0969 0.0969
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0013 0.0013
Schistosoma mansoni histone deacetylase 1 2 3 0.0013 0.0002 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0065 0.0134
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Schistosoma mansoni hypothetical protein 0.0107 0.0123 0.0255
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0013 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0031 0.1376
Echinococcus granulosus acetylcholinesterase 0.0071 0.0077 0.016
Entamoeba histolytica peptidase, C54 family 0.0058 0.006 0.1167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Brugia malayi Carboxylesterase family protein 0.0071 0.0077 0.0077
Brugia malayi hypothetical protein 0.0109 0.0126 0.0126
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0014 0.0607
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0013 0.0013
Onchocerca volvulus 0.0056 0.0058 0.0174
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0031 0.0064
Onchocerca volvulus 0.0024 0.0015 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.014 0.029
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Brugia malayi RNA binding protein 0.0062 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0832 0.1069 0.1069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0107 0.0123 0.2392
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.0223 1
Echinococcus multilocularis presenilin 0.0223 0.0275 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Schistosoma mansoni patched 1 0.0042 0.004 0.0082
Onchocerca volvulus 0.0407 0.0515 0.1553
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0755 0.0969 0.2005
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.0594 0.1228
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0005 0.0005
Schistosoma mansoni histone deacetylase 4 5 0.0044 0.0042 0.0087
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0003 0.0005
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0348 0.0439 0.0439
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0348 0.0439 0.0439
Toxoplasma gondii hypothetical protein 0.0078 0.0086 0.3846
Brugia malayi Histone deacetylase family protein 0.0044 0.0042 0.0042
Echinococcus granulosus presenilin enhancer 2 0.021 0.0258 0.0533
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.001
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.0223 0.315
Echinococcus multilocularis Peptidase C54 0.0058 0.006 0.0125
Trypanosoma brucei histone deacetylase 2 0.0013 0.0002 0.0003
Echinococcus granulosus histone deacetylase 6 0.0044 0.0042 0.0087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0078
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0031 0.113
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0049 0.0049
Brugia malayi gamma-secretase subunit pen-2 0.021 0.0258 0.0258
Brugia malayi histone deacetylase 11 0.0013 0.0002 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0013 0.0013
Onchocerca volvulus 0.0022 0.0013 0.0039
Schistosoma mansoni neurotransmitter gated ion channel 0.0407 0.0515 0.1065
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.2554 0.3315 0.3315
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0065 0.0065
Echinococcus granulosus acetylcholinesterase 0.0071 0.0077 0.016
Brugia malayi CHE-14 protein 0.0042 0.004 0.004
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis histone deacetylase 0.0044 0.0042 0.0087
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis histone deacetylase 8 0.0013 0.0002 0.0003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0077 0.016
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0332 0.0418 0.0418
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0804 0.1032 0.2135
Schistosoma mansoni histone deacetylase hda2 0.0051 0.0051 0.0105
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0348 0.0439 0.0439
Echinococcus multilocularis transient receptor potential cation channel 0.0166 0.0201 0.0415
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0162 0.0196 0.0406
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.005 0.0049 0.0049
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0348 0.0439 0.0907
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0012 0 0.0006
Brugia malayi nuclear hormone receptor 0.0022 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0049 0.0101
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0 0.0006
Trypanosoma brucei Aph-1 protein, putative 0.1449 0.1874 0.478
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0168 0.0348
Echinococcus granulosus histone deacetylase 6 0.0051 0.0051 0.0105
Echinococcus granulosus Protein patched homolog 1 0.0042 0.004 0.0082
Onchocerca volvulus Phospholipase A2 homolog 0.0433 0.0549 0.1657
Echinococcus granulosus Peptidase C54 0.0058 0.006 0.0125
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Schistosoma mansoni histone deacetylase 4 5 0.0044 0.0042 0.0087
Brugia malayi Phospholipase A2 family protein 0.0091 0.0103 0.0103
Onchocerca volvulus 0.0755 0.0969 0.2924
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0013 0.0013
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0313
Onchocerca volvulus Huntingtin homolog 0.0119 0.014 0.0422
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.0103 0.0311
Toxoplasma gondii histone deacetylase HDAC1 0.0044 0.0042 0.1855
Echinococcus granulosus gamma secretase subunit aph 1 0.3719 0.4834 1
Trichomonas vaginalis hypothetical protein 0.0183 0.0223 0.8113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0014 0.0035
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.2554 0.3315 0.6858
Brugia malayi CXXC zinc finger family protein 0.0056 0.0058 0.0058
Toxoplasma gondii hypothetical protein 0.0063 0.0066 0.2961
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0407 0.0515 0.1065
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0002 0.0057
Plasmodium vivax histone deacetylase 1, putative 0.0013 0.0002 0.005
Schistosoma mansoni coup transcription factor 0.0022 0.0013 0.0026
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0013 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0102 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0005 0.0005
Loa Loa (eye worm) histone deacetylase 11 0.0013 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.0223 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0015 0.0216
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.0126
Brugia malayi Carboxylesterase family protein 0.0071 0.0077 0.0077
Brugia malayi ecdysteroid receptor 0.0207 0.0254 0.0254
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0755 0.0969 0.2005
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.004 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0102 0.0102
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.006 0.0125
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0348 0.0439 0.0907
Trichomonas vaginalis Nicastrin precursor, putative 0.0109 0.0126 0.4581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0013 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.768 1 1
Echinococcus granulosus expressed conserved protein 0.0093 0.0105 0.0218
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0015 0.0288
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0078
Brugia malayi hypothetical protein 0.0348 0.0439 0.0439
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0015 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0078
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0113 0.0234
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0013 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.1435
Echinococcus multilocularis geminin 0.033 0.0415 0.0859
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0077 0.016
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus granulosus glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Trichomonas vaginalis helicase, putative 0.0013 0.0001 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0348 0.0439 0.0439
Toxoplasma gondii histone deacetylase HDAC2 0.0013 0.0002 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0014 0.0035
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.0223 1
Brugia malayi Inositol-1 0.0036 0.0031 0.0031
Echinococcus granulosus dnaJ subfamily B 0.0804 0.1032 0.2135
Brugia malayi hypothetical protein 0.0348 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0049 0.0049 0.0049
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0123 0.0255
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0024 0.0015 0.0216
Loa Loa (eye worm) hypothetical protein 0.0058 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Echinococcus multilocularis protein dispatched 1 0.0048 0.0047 0.0098
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0003 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0013 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.004 0.0036 0.0699
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0755 0.0969 0.0969
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0013 0.0027
Schistosoma mansoni hypothetical protein 0.0804 0.1032 0.2135
Brugia malayi steroid hormone receptor 0.0022 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.006 0.2196
Loa Loa (eye worm) histone deacetylase 1 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0207 0.0254 0.0254
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0015 0.0216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0048 0.2148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Brugia malayi hypothetical protein 0.0078 0.0086 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0013 0.0026
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0031 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Echinococcus multilocularis Nicastrin 0.0109 0.0126 0.0261
Brugia malayi nuclear receptor RXR 0.0016 0.0005 0.0005
Echinococcus multilocularis nAChR subunit 0.0755 0.0969 0.2005
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0348 0.0439 0.0907
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0013 0.0013
Onchocerca volvulus 0.0832 0.1069 0.3225
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0755 0.0969 0.0969
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0168 0.0348
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0013 0.0013
Echinococcus granulosus glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Echinococcus granulosus tumor protein p63 0.0339 0.0426 0.0882
Brugia malayi hypothetical protein 0.0032 0.0026 0.0026
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0223 0.0275 0.057
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0119 0.014 0.014
Echinococcus multilocularis cpg binding protein 0.006 0.0062 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0124 0.5524
Brugia malayi Cation transporter family protein 0.0832 0.1069 0.1069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0065 0.0134
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.2554 0.3315 0.6858
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0013 0.0026
Onchocerca volvulus 0.0095 0.0109 0.0327
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0013 0.0026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0407 0.0515 0.0515
Echinococcus multilocularis histone deacetylase 6 0.0044 0.0042 0.0087
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) ACC-1 protein 0.0755 0.0969 0.0969
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0077 0.016
Schistosoma mansoni cpg binding protein 0.0056 0.0058 0.012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0407 0.0515 0.0515
Loa Loa (eye worm) inositol-1 0.0036 0.0031 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0065 0.0134
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0077 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0003 0.0005
Entamoeba histolytica histone deacetylase, putative 0.0013 0.0002 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.1013 0.1305 0.27
Brugia malayi Presenilin spe-4 0.0078 0.0086 0.0086
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.0594 0.1228
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0048 0.0122
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0051 0.0105
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.001
Plasmodium falciparum histone deacetylase, putative 0.0044 0.0042 0.1855
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Schistosoma mansoni acetylcholine receptor subunit beta 0.0348 0.0439 0.0907
Echinococcus granulosus Nicastrin 0.0109 0.0126 0.0261
Echinococcus multilocularis histone deacetylase 6 0.0044 0.0042 0.0087
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Plasmodium vivax histone deacetylase, putative 0.0044 0.0042 0.1855
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0223 0.0275 1
Schistosoma mansoni histone deacetylase hda2 0.0013 0.0002 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0049 0.0049
Mycobacterium ulcerans oxidoreductase 0.0012 0 0.0006
Schistosoma mansoni acetylcholine receptor-related 0.0348 0.0439 0.0907
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0012 0 0.0006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Brugia malayi TAR-binding protein 0.0062 0.0065 0.0065
Echinococcus multilocularis nAChR subunit 0.0407 0.0515 0.1065
Trypanosoma brucei histone deacetylase 3 0.0044 0.0042 0.0106
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0013 0.0026
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.006 0.0153
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis protein patched 0.0042 0.004 0.0082
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0348 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0119 0.014 0.014
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Echinococcus multilocularis glycine receptor subunit beta 0.0755 0.0969 0.2005
Brugia malayi hypothetical protein 0.0348 0.0439 0.0439
Onchocerca volvulus Bile acid receptor homolog 0.0207 0.0254 0.0767
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0005
Trypanosoma brucei histone deacetylase, putative 0.0044 0.0042 0.0106
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0348 0.0439 0.0439
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.0042 0.0106
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0065 0.0065
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus multilocularis expressed conserved protein 0.0093 0.0105 0.0218
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0013 0.0013
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0 0.0006
Trypanosoma cruzi Aph-1 protein, putative 0.1449 0.1874 0.478
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Entamoeba histolytica peptidase, C54 family 0.0023 0.0014 0.0263
Brugia malayi Peptidase family C54 containing protein 0.0058 0.006 0.006
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0755 0.0969 0.0969
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0048 0.2148
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.006 0.0125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Leishmania major histone deacetylase, putative 0.0013 0.0002 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.001
Trypanosoma brucei histone deacetylase 4 0.0044 0.0042 0.0106
Onchocerca volvulus Putative nachr subunit 0.2554 0.3315 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0005 0.0011
Schistosoma mansoni neurotransmitter gated ion channel 0.0348 0.0439 0.0907
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0015 0.0664
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0015 0.0216
Leishmania major malonyl-coa decarboxylase-like protein 0.3018 0.392 1
Echinococcus multilocularis histone deacetylase 3 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0031 0.0031
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0007 0.0007
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0002 0.0057
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.3719 0.4834 0.4834
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.033 0.0415 0.0859
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0223 0.0275 0.0702
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0113 0.0234
Loa Loa (eye worm) hypothetical protein 0.0262 0.0326 0.0326
Mycobacterium ulcerans short chain dehydrogenase 0.0556 0.0709 1
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0013 0.0026
Echinococcus granulosus presenilin 0.0223 0.0275 0.057
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0013 0.0026
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0 0.0001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0015 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.006 0.2196
Onchocerca volvulus 0.0012 0 0.0001
Onchocerca volvulus 0.0832 0.1069 0.3225
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.001
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0755 0.0969 0.0969
Schistosoma mansoni hypothetical protein 0.0109 0.0126 0.0261
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0013 0.0026
Plasmodium falciparum histone deacetylase 2 0.0044 0.0042 0.1855
Plasmodium vivax histone deacetylase 2, putative 0.0044 0.0042 0.1855
Echinococcus multilocularis glycine receptor subunit beta 0.0755 0.0969 0.2005
Loa Loa (eye worm) RNA binding protein 0.0062 0.0065 0.0065
Trypanosoma brucei histone deacetylase 1 0.0013 0.0002 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0013 0.0013
Brugia malayi hypothetical protein 0.0078 0.0086 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0007 0.0015
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.006 0.0125
Loa Loa (eye worm) histone deacetylase 7A 0.0044 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0052 0.0052
Echinococcus granulosus histone deacetylase 3 0.0013 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0013 0.0013
Onchocerca volvulus 0.0018 0.0008 0.0025
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0755 0.0969 0.0969
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0015 0.0215
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0031 0.113
Brugia malayi histone deacetylase 3 (HD3) 0.0013 0.0002 0.0002
Brugia malayi hypothetical protein 0.0107 0.0123 0.0123
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3018 0.392 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0065 0.0134
Loa Loa (eye worm) hypothetical protein 0.0407 0.0515 0.0515
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0031 0.113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0013 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0048 0.0122
Schistosoma mansoni dihydropteridine reductase 0.0012 0 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0013 0.0026
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.001
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.2554 0.3315 0.3315
Echinococcus multilocularis tumor protein p63 0.0339 0.0426 0.0882
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.004 0.0082
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0407 0.0515 0.1065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0015 0.0215
Onchocerca volvulus 0.0348 0.0439 0.1323
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.006 0.2196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0013 0.0013
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0015 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0755 0.0969 0.0969
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0215
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0014 0.0035
Schistosoma mansoni cpg binding protein 0.006 0.0062 0.0128
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0058 0.0058
Trypanosoma cruzi histone deacetylase, putative 0.0013 0.0002 0.0003
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1603 0.2074 0.4291
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.2554 0.3315 0.6858
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0102 0.0212
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0013 0.0026
Schistosoma mansoni neurotransmitter gated ion channel 0.0348 0.0439 0.0907
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0832 0.1069 0.2212
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.006 0.0153
Schistosoma mansoni gamma-secretase subunit aph-1 0.3719 0.4834 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0015 0.0215
Brugia malayi hypothetical protein 0.0078 0.0086 0.0086
Leishmania major pteridine reductase 1 0.0024 0.0015 0.0038
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.001
Onchocerca volvulus 0.0755 0.0969 0.2924
Loa Loa (eye worm) hypothetical protein 0.2554 0.3315 0.3315
Brugia malayi Presenilin family protein 0.0223 0.0275 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0013 0.0013
Giardia lamblia Histone deacetylase 0.0013 0.0002 0.5
Echinococcus multilocularis presenilin enhancer 2 0.021 0.0258 0.0533
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0048 0.0122
Leishmania major histone deacetylase, putative 0.0044 0.0042 0.0106
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0005 0.0011
Schistosoma mansoni cpg binding protein 0.006 0.0062 0.0128
Schistosoma mansoni inositol monophosphatase 0.0036 0.0031 0.0064
Brugia malayi Histone deacetylase 1 0.0013 0.0002 0.0002
Onchocerca volvulus 0.005 0.0049 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0065 0.0134
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0013 0.0026
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0755 0.0969 0.2005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0007 0.0105
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0755 0.0969 0.0969
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0015 0.0215
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0013 0.0026
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.021 0.0258 0.0258
Mycobacterium ulcerans hypothetical protein 0.0024 0.0015 0.0215
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0755 0.0969 0.0969
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Echinococcus granulosus cysteine protease atg4b 0.0058 0.006 0.0125
Onchocerca volvulus 0.0407 0.0515 0.1553
Onchocerca volvulus Huntingtin homolog 0.0119 0.014 0.0422
Entamoeba histolytica hypothetical protein 0.0107 0.0123 0.2392
Schistosoma mansoni hypothetical protein 0.0095 0.0109 0.0225
Loa Loa (eye worm) hypothetical protein 0.0832 0.1069 0.1069
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.006 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0034
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0755 0.0969 0.0969
Trypanosoma cruzi Aph-1 protein, putative 0.1449 0.1874 0.478
Onchocerca volvulus 0.0024 0.0015 0.0046
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0015 0.0015
Entamoeba histolytica peptidase, C54 family 0.0023 0.0014 0.0263
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.2554 0.3315 0.6858
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0223 0.0275 1
Leishmania major histone deacetylase, putative 0.0013 0.0002 0.0003
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0223 0.0275 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0078
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0348 0.0439 0.0439
Brugia malayi Cation transporter family protein 0.0755 0.0969 0.0969
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0015 0.0215
Echinococcus granulosus ankyrin repeat protein 0.0162 0.0196 0.0406
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.006 0.2196
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0014 0.0035
Echinococcus granulosus tar DNA binding protein 0.0062 0.0065 0.0134
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.001
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0223 0.0275 0.0702
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0015 0.0664
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0102 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0 0.0006
Schistosoma mansoni nAChR subunit 0.0755 0.0969 0.2005
Loa Loa (eye worm) histone deacetylase 3 0.0013 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.0223 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0034
Brugia malayi hypothetical protein 0.0119 0.014 0.014
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.0042 0.0106
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0065 0.0065
Entamoeba histolytica peptidase, C54 family 0.0023 0.0014 0.0263
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0484 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0013 0.0026
Toxoplasma gondii histone deacetylase HDAC5 0.0014 0.0002 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0102 0.0212
Toxoplasma gondii histone deacetylase HDAC3 0.0013 0.0002 0.005
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.2554 0.3315 0.6858
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0348 0.0439 0.0439
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0003 0.0005
Echinococcus multilocularis histone deacetylase 7 0.0044 0.0042 0.0087
Loa Loa (eye worm) LGC-31 protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0755 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Schistosoma mansoni histone deacetylase 0.0013 0.0002 0.0003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0755 0.0969 0.2005
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3018 0.392 1
Trypanosoma cruzi histone deacetylase, putative 0.0013 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.001
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0755 0.0969 0.0969

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.6 uM Agonist activity at LXRbeta LBD by HTRF cofactor peptide recruitment assay ChEMBL. 17416521
EC50 (functional) = 1.6 uM Agonist activity at LXRbeta LBD by HTRF cofactor peptide recruitment assay ChEMBL. 17416521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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