Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen-related receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | estrogen-related receptor beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen-related receptor beta | 508 aa | 461 aa | 25.2 % |
Brugia malayi | Steroid receptor seven-up type 2 | estrogen-related receptor alpha | 423 aa | 358 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of human ERalpha | ChEMBL. | 17482813 |
IC50 (binding) | = 22 nM | Inhibition of human ERalpha | ChEMBL. | 17482813 |
IC50 (binding) | = 526 nM | Inhibition of human ERbeta | ChEMBL. | 17482813 |
IC50 (binding) | = 526 nM | Inhibition of human ERbeta | ChEMBL. | 17482813 |
Ratio IC50 (binding) | = 24 | Selectivity for human ERalpha over ERbeta | ChEMBL. | 17482813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.