Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.2992 | 0.2992 |
Schistosoma mansoni | lamin | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1914 | 0.1914 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.917 | 0.917 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0031 | 0.2992 | 0.2992 |
Loa Loa (eye worm) | intermediate filament protein | 0.0057 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0057 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | lamin | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0057 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.219 | 0.219 |
Echinococcus multilocularis | lamin dm0 | 0.0057 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.219 | 0.219 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0057 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.219 | 0.219 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1914 | 0.1914 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.9724 | 0.9724 |
Echinococcus granulosus | lamin dm0 | 0.0057 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0057 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.917 | 0.917 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.917 | 0.917 |
Echinococcus granulosus | intermediate filament protein | 0.0057 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0057 | 1 | 1 | |
Schistosoma mansoni | lamin | 0.0057 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | > 1 % | Minimum plaque inhibitory concentration using a standard test organism, Streptococcus mutans OMZ-61 | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Minimum antimicrobial inhibitory concentration against S. aureus | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Minimum inhibitory concentration against Escherichia coli (Vogel) | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Antimicrobial minimum inhibitory concentration against Escherichia coli AB1932-1 | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Antimicrobial minimum inhibitory concentration against Escherichia coli 100/B22 | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Minimum inhibitory concentration against Escherichia coli (Vogel) | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Antimicrobial minimum inhibitory concentration against Escherichia coli AB1932-1 | ChEMBL. | 6492075 |
MIC (functional) | = 125 ug ml-1 | Antimicrobial minimum inhibitory concentration against Escherichia coli 100/B22 | ChEMBL. | 6492075 |
MIC (functional) | > 500 ug ml-1 | Minimum inhibitory concentration against Klebsiella pneumonia 39645 | ChEMBL. | 6492075 |
MIC (functional) | > 500 ug ml-1 | Minimum antimicrobial inhibitory concentration against Proteus mirabilis MGH-1 | ChEMBL. | 6492075 |
MIC (functional) | > 500 ug ml-1 | Minimum antimicrobial inhibitory concentration against Pseudomonas aeruginosa MGH-2 | ChEMBL. | 6492075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.