Detailed information for compound 458962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.131 | Formula: C26H40ClN3O4S
  • H donors: 0 H acceptors: 3 LogP: 5.34 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC([C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(cc1)Cl)COC(=O)N1CCC(CC1)N1CCCCC1)C
  • InChi: 1S/C26H40ClN3O4S/c1-20(2)25-8-6-7-23(30(25)35(32,33)24-11-9-21(27)10-12-24)19-34-26(31)29-17-13-22(14-18-29)28-15-4-3-5-16-28/h9-12,20,22-23,25H,3-8,13-19H2,1-2H3/t23-,25+/m1/s1
  • InChiKey: IDOAKQMETXZJBC-NOZRDPDXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1A gamma secretase subunit References
Homo sapiens nicastrin References
Homo sapiens presenilin 2 References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens presenilin 1 References
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References
Homo sapiens presenilin enhancer gamma secretase subunit References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase Get druggable targets OG5_128959 All targets in OG5_128959
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) Get druggable targets OG5_128959 All targets in OG5_128959
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131095 All targets in OG5_131095
Echinococcus granulosus presenilin enhancer 2 Get druggable targets OG5_132844 All targets in OG5_132844
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi hypothetical protein Get druggable targets OG5_131095 All targets in OG5_131095
Echinococcus multilocularis Nicastrin Get druggable targets OG5_131095 All targets in OG5_131095
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase Get druggable targets OG5_128959 All targets in OG5_128959
Schistosoma japonicum ko:K06171 nicastrin, putative Get druggable targets OG5_131095 All targets in OG5_131095
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Nicastrin precursor, putative Get druggable targets OG5_131095 All targets in OG5_131095
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase Get druggable targets OG5_128959 All targets in OG5_128959
Echinococcus multilocularis presenilin enhancer 2 Get druggable targets OG5_132844 All targets in OG5_132844
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative Get druggable targets OG5_128959 All targets in OG5_128959
Echinococcus granulosus Nicastrin Get druggable targets OG5_131095 All targets in OG5_131095
Leishmania mexicana presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative Get druggable targets OG5_128959 All targets in OG5_128959
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica presenilin 1 peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Brugia malayi Presenilin family protein Get druggable targets OG5_128959 All targets in OG5_128959
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis Nicastrin Get druggable targets OG5_131095 All targets in OG5_131095
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus presenilin Get druggable targets OG5_128959 All targets in OG5_128959
Brugia malayi hypothetical protein Get druggable targets OG5_131095 All targets in OG5_131095
Trypanosoma brucei gambiense presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative Get druggable targets OG5_128959 All targets in OG5_128959
Trypanosoma cruzi presenilin-like aspartic peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Leishmania donovani presenilin-like aspartic peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense presenilin-like aspartic peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi presenilin-like aspartic peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Schistosoma japonicum ko:K04505 presenilin-1, putative Get druggable targets OG5_128959 All targets in OG5_128959
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis presenilin Get druggable targets OG5_128959 All targets in OG5_128959
Loa Loa (eye worm) gamma-secretase subunit pen-2 Get druggable targets OG5_132844 All targets in OG5_132844
Trypanosoma brucei presenilin-like aspartic peptidase, putative Get druggable targets OG5_128959 All targets in OG5_128959
Brugia malayi gamma-secretase subunit pen-2 Get druggable targets OG5_132844 All targets in OG5_132844
Leishmania braziliensis presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative Get druggable targets OG5_128959 All targets in OG5_128959
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative Get druggable targets OG5_128959 All targets in OG5_128959
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Trichomonas vaginalis Nicastrin precursor, putative Get druggable targets OG5_131095 All targets in OG5_131095
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131095 All targets in OG5_131095
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus oxalate:formate antiporter presenilin enhancer gamma secretase subunit 101 aa 98 aa 29.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0013 0.0093 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0249
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0018 0.0177 0.0368
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0018 0.0177 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) glutaminase 0.0221 0.3219 0.3219
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0386 0.0803
Schistosoma mansoni peptidase 0.0018 0.0177 0.0122
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0013 0.0093 0.0093
Mycobacterium ulcerans hypothetical protein 0.0307 0.4523 1
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0222 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0986 0.2123
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0033 0.0033
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0307 0.4523 1
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Schistosoma mansoni gamma-secretase subunit aph-1 0.0592 0.8789 0.8783
Echinococcus granulosus presenilin 0.0248 0.3631 0.3631
Schistosoma mansoni zinc finger protein 0.0011 0.0067 0.0012
Onchocerca volvulus 0.0021 0.0213 0.0298
Brugia malayi steroid hormone receptor 0.0023 0.0249 0.0238
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0086 0.0086
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Leishmania major cytochrome p450-like protein 0.0015 0.0128 0.0229
Echinococcus multilocularis gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0013 0.0093 0.0093
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Toxoplasma gondii hypothetical protein 0.0087 0.121 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus granulosus Nicastrin 0.0121 0.1721 0.1721
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0249
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0249 0.0194
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0222 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0013 0.0105 0.0179
Brugia malayi TAR-binding protein 0.0045 0.0585 0.0575
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0713 0.1233
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0243 0.0485
Brugia malayi nuclear hormone receptor 0.0011 0.0067 0.0056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0067 0.0067
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0021 0.0225 0.169
Plasmodium falciparum transporter, putative 0.0057 0.0767 0.1358
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0366 0.5395 0.5395
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0018 0.0177 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Trypanosoma brucei calcium-translocating P-type ATPase 0.0019 0.0187 0.0362
Echinococcus granulosus serotonin transporter 0.0338 0.4984 0.4984
Brugia malayi Presenilin family protein 0.0248 0.3631 0.3624
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0067 0.0067
Brugia malayi ecdysteroid receptor 0.0023 0.0249 0.0238
Loa Loa (eye worm) serotonin transporter b 0.0338 0.4984 0.4984
Trypanosoma brucei Nicastrin, putative 0.0044 0.0572 0.1217
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Giardia lamblia DINP protein human, muc B family 0.0014 0.0112 0.4658
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0067 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0249 0.0194
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0128 0.0128
Schistosoma mansoni DNA polymerase eta 0.0032 0.0386 0.0332
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0249 0.0249
Brugia malayi tailless protein 0.0011 0.0067 0.0056
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Onchocerca volvulus 0.0021 0.0222 0.0315
Echinococcus multilocularis microtubule associated protein 2 0.0494 0.7322 0.7322
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Toxoplasma gondii P-type ATPase4, putative 0.0013 0.0093 0.0579
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0015 0.0127 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0592 0.8789 0.8789
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0222 0.0211
Brugia malayi RNA binding protein 0.0045 0.0585 0.0575
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.001 0.0055 0.0261
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0249 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0249
Entamoeba histolytica ;Alias 0.0018 0.0177 0.0368
Plasmodium falciparum calcium-transporting ATPase 0.0019 0.0187 0.0024
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0187 0.0177
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Toxoplasma gondii phospholipase/carboxylesterase 0.0018 0.0177 0.1284
Loa Loa (eye worm) hypothetical protein 0.0672 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0338 0.4984 0.4956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.0112 0.0194
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152
Toxoplasma gondii histone lysine methyltransferase SET1 0.0039 0.0489 0.3923
Echinococcus granulosus microtubule associated protein 2 0.0494 0.7322 0.7322
Trypanosoma brucei unspecified product 0.0014 0.0112 0.0194
Onchocerca volvulus 0.0338 0.4984 1
Schistosoma mansoni glutaminase 0.0221 0.3219 0.3181
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0067 0.0067
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Echinococcus multilocularis geminin 0.0253 0.3703 0.3703
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Echinococcus multilocularis serotonin transporter 0.0338 0.4984 0.4984
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0557 0.1168
Leishmania major P-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus multilocularis abhydrolase domain containing 3 0.0018 0.0177 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0112 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0067 0.0056
Brugia malayi gamma-secretase subunit aph-1 0.0592 0.8789 0.8788
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.001 0.0055 0.0055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0986 0.2123
Loa Loa (eye worm) norepinephrine transporter 0.0338 0.4984 0.4984
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0013 0.0093 0.0135
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0081 0.1122 0.2427
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0097
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Brugia malayi Na,K-ATPase alpha subunit 0.0013 0.0093 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Trichomonas vaginalis glutaminase, putative 0.0221 0.3219 0.7102
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Onchocerca volvulus 0.0021 0.0222 0.0315
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0018 0.0177 0.0338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0013 0.0093 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0338 0.4984 0.4979
Mycobacterium ulcerans lysophospholipase 0.0307 0.4523 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0238
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Brugia malayi nuclear receptor NHR-67 0.0011 0.0067 0.0056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.2176
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0222 0.0422
Echinococcus granulosus dnaJ subfamily B 0.0293 0.4301 0.4301
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0013 0.0093 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0249 0.0249
Echinococcus granulosus cpg binding protein 0.0022 0.0231 0.0231
Schistosoma mansoni fatty-acid amide hydrolase 0.0081 0.1122 0.1073
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.0386 0.0803
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0112 0.0101
Treponema pallidum sodium- and chloride- dependent transporter 0.0338 0.4984 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0249 0.0194
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0249 0.037
Leishmania major hypothetical protein, conserved 0.0081 0.1122 0.244
Onchocerca volvulus 0.0072 0.0986 0.1869
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium ulcerans hypothetical protein 0.0072 0.0986 0.2123
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Brugia malayi gamma-secretase subunit pen-2 0.0233 0.3402 0.3395
Loa Loa (eye worm) DR-78 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0767 0.1358
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0112 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Onchocerca volvulus 0.0075 0.1024 0.1947
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.007 0.0957 0.2073
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0222 0.1667
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0013 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.007 0.0957 0.7868
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0222 0.0468
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0094 0.1313 0.1313
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0128 0.0212
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0025 0.0025
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Schistosoma mansoni hypothetical protein 0.0293 0.4301 0.4269
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0307 0.4523 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Mycobacterium ulcerans glutaminase 0.0221 0.3219 0.7097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0222 0.0211
Plasmodium falciparum esterase, putative 0.0307 0.4523 1
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Echinococcus granulosus Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Echinococcus multilocularis nicalin 0.0044 0.0572 0.0572
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.001 0.0055 0.0055
Echinococcus multilocularis survival motor neuron protein 1 0.0366 0.5395 0.5395
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0233 0.3402 0.3402
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0086 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0086 0.0031
Brugia malayi nuclear receptor NHR-88 0.0023 0.0249 0.0238
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0249 0.037
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0009 0.0036 0.0008
Brugia malayi ecdysone receptor 0.0011 0.0067 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0067 0.0067
Brugia malayi nuclear receptor NHR-88 0.0011 0.0067 0.0056
Schistosoma mansoni hypothetical protein 0.0094 0.1313 0.1265
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Trichomonas vaginalis cation-transporting ATPase, putative 0.0013 0.0093 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0248 0.3631 0.3595
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Brugia malayi nuclear receptor RXR 0.0012 0.0086 0.0076
Leishmania major calcium-translocating P-type ATPase 0.0021 0.0225 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0249 0.0238
Echinococcus granulosus calcium transporting atpase 0.0019 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0249 0.0238
Brugia malayi MGC79044 protein 0.0018 0.0177 0.0166
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0032 0.0386 0.0386
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0249 0.0194
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0067 0.0067
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0986 0.2123
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0178 0.0324
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0222 0.0422
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0557 0.1184
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0033 0.0022
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0081 0.1122 0.2176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0081 0.1122 0.2427
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0249 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi Protein C20orf22 0.0018 0.0177 0.0166
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Loa Loa (eye worm) calcium ATPase 0.0007 0.0011 0.0011
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0013 0.0093 0.0152
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0093 0.3106
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0222 0.0422
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0222 0.0222
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0557 0.4495
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0019 0.0187 0.0132
Echinococcus granulosus dna polymerase kappa 0.0014 0.0112 0.0112
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0713 0.1514
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Echinococcus multilocularis dna polymerase eta 0.0032 0.0386 0.0386
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0222 0.0422
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0112 0.0177
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0986 0.2123
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0249 0.0194
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0249 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0013 0.0093 0.0038
Onchocerca volvulus 0.0057 0.0767 0.1423
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0222 0.0422
Schistosoma mansoni coup transcription factor 0.0023 0.0249 0.0194
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Loa Loa (eye worm) solute carrier family 6 member 4 0.0338 0.4984 0.4984
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0249 0.0194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0222 0.0422
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0238
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0081 0.1122 0.2427
Schistosoma mansoni microtubule-associated protein tau 0.0494 0.7322 0.7307
Brugia malayi MGC83647 protein 0.0018 0.0177 0.0166
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0222 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0713 0.1514
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0067 0.0056
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Schistosoma mansoni hypothetical protein 0.0121 0.1721 0.1675
Echinococcus granulosus dna polymerase eta 0.0032 0.0386 0.0386
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0081 0.1122 0.1122
Onchocerca volvulus 0.0057 0.0767 0.1423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Echinococcus granulosus abhydrolase domain containing protein 13 0.0018 0.0177 0.0177
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0081 0.1122 0.2427
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0075 0.1024 0.1015
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) presenilin spe-4 0.0087 0.121 0.121
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0222 0.0422
Brugia malayi hypothetical protein 0.0057 0.0767 0.0757
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0249 0.0249
Leishmania major hypothetical protein, conserved 0.007 0.0957 0.2073
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus granulosus survival motor neuron protein 1 0.0366 0.5395 0.5395
Leishmania major DNA polymerase eta, putative 0.0023 0.0243 0.0485
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0081 0.1122 0.2427
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0112 0.0224
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0222 0.1667
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0249 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0249
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0067 0.0012
Brugia malayi Presenilin-like protein At2g29900 0.0087 0.121 0.12
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0249 0.0249
Echinococcus multilocularis presenilin enhancer 2 0.0233 0.3402 0.3402
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0222 0.0422
Schistosoma mansoni amidase 0.0672 1 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Loa Loa (eye worm) glutaminase 2 0.0221 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0121 0.1721 0.1721
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni hypothetical protein 0.0075 0.1024 0.0974
Onchocerca volvulus 0.0021 0.0222 0.0315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0559 0.0507
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0112 0.0177
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0585 0.0585
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0249 0.0194
Onchocerca volvulus 0.0021 0.0222 0.0315
Toxoplasma gondii peptidase S15, putative 0.0018 0.0177 0.1284
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0713 0.5667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0249
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0067 0.0056
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0767 0.0757
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0249 0.0249
Echinococcus multilocularis dnaJ subfamily B 0.0293 0.4301 0.4301
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0338 0.4984 0.4956
Echinococcus granulosus presenilin enhancer 2 0.0233 0.3402 0.3402
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Toxoplasma gondii phospholipase 0.0018 0.0177 0.1284
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0986 0.2161
Loa Loa (eye worm) oxidoreductase 0.0021 0.0222 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus granulosus Na:K ATPase alpha subunit 0.001 0.0055 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Leishmania major DNA polymerase eta, putative 0.0032 0.0386 0.0803
Brugia malayi Membrane calcium atpase protein 3 0.001 0.0055 0.0045
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0767 0.0715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0249 0.0249
Trypanosoma cruzi monoglyceride lipase, putative 0.0307 0.4523 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Entamoeba histolytica presenilin 1 peptidase, putative 0.0248 0.3631 0.8023
Echinococcus multilocularis cpg binding protein 0.0022 0.0231 0.0231
Onchocerca volvulus 0.0057 0.0767 0.1423
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi conserved hypotetical protein 0.0011 0.0067 0.0056
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0767 0.1358
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0386 0.0375
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0021 0.0225 0.0428
Toxoplasma gondii protein c14orf29, putative 0.0018 0.0177 0.1284
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Onchocerca volvulus 0.0023 0.0249 0.037
Echinococcus granulosus tar DNA binding protein 0.0045 0.0585 0.0585
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0067 0.0012
Echinococcus granulosus nicalin 0.0044 0.0572 0.0572
Plasmodium vivax P-type ATPase4, putative 0.0021 0.0225 0.0111
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Brugia malayi CXXC zinc finger family protein 0.0021 0.0213 0.0203
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Echinococcus granulosus geminin 0.0253 0.3703 0.3703
Echinococcus granulosus abhydrolase domain containing 3 0.0018 0.0177 0.0177
Brugia malayi nuclear receptor RXR 0.0011 0.0067 0.0056
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Echinococcus multilocularis presenilin 0.0248 0.3631 0.3631
Brugia malayi hypothetical protein 0.0366 0.5395 0.539
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Brugia malayi nuclear hormone receptor 0.0023 0.0249 0.0238
Echinococcus granulosus fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium tuberculosis Possible lysophospholipase 0.0307 0.4523 1
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Leishmania major DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0021 0.0225 0.0445
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0128 0.0229
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0081 0.1122 0.244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0063
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0067 0.0067
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni cpg binding protein 0.0021 0.0213 0.0159
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0222 0.0422
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1122
Mycobacterium ulcerans peptide amidase, GatA 0.0081 0.1122 0.2427
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0177 0.0321
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0222 0.0222
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0713 0.1233
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0557 0.0557
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0249
Mycobacterium ulcerans hydrolase 0.0018 0.0177 0.0321
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0081 0.1122 0.2427
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0249 0.0238
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0238
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0013 0.0093 0.0152
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0249 0.037
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0013 0.0093 0.0579
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0557 0.0557
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0018 0.0177 0.1284
Entamoeba histolytica hypothetical protein 0.0044 0.0572 0.1244
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Leishmania major calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.001 0.0055 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Brugia malayi glutaminase DH11.1 0.0221 0.3219 0.3212
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Echinococcus multilocularis thyroid hormone receptor alpha 0.0117 0.1658 0.1658
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0213 0.0213
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.2427
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Plasmodium vivax PST-A protein 0.0307 0.4523 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0243 0.1841
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0222 0.0422
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0993 0.0983
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0222 0.1667
Leishmania major calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus multilocularis calcium transporting atpase 0.0019 0.0187 0.0187
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Schistosoma mansoni survival motor neuron protein 0.0075 0.1024 0.0974
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0986 0.2123
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0767 0.6241
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0067 0.0012
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0021 0.0225 0.0111
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0025 0.0014
Schistosoma mansoni fatty-acid amide hydrolase 0.0672 1 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0222 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus multilocularis Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0585 0.0585
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Loa Loa (eye worm) RNA binding protein 0.0045 0.0585 0.0585
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0585 0.0575
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0094 0.1313 0.1313
Brugia malayi putative amidase 0.0081 0.1122 0.1113
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0112 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0067 0.0056
Echinococcus granulosus gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Plasmodium vivax amine transporter, putative 0.0057 0.0767 0.1358
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0986 0.2123
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Leishmania major monoglyceride lipase, putative 0.0307 0.4523 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Plasmodium vivax calcium-transporting ATPase, putative 0.0021 0.0225 0.0111
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0248 0.3631 0.8017
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Trypanosoma brucei calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0225 0.0225
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Trypanosoma brucei Aph-1 protein, putative 0.0231 0.3367 0.743
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0222 0.0422
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0015 0.0127 0.0127

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18.5 nM Inhibition of gamma secretase mediated amyloid beta40 production ChEMBL. 17890085
IC50 (binding) = 18.5 nM Inhibition of gamma secretase mediated amyloid beta40 production ChEMBL. 17890085
IC50 (ADMET) = 1.3 uM Inhibition of CYP3A4 after 30 mins ChEMBL. 17890085
IC50 (ADMET) = 1.3 uM Inhibition of CYP3A4 after 30 mins ChEMBL. 17890085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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